Nafamostat mesylate monotherapy in patients with moderate COVID-19 : A single-center retrospective study
In conclusion, nafamostat mesylate monotherapy did not improve clinical outcomes in patients with moderate COVID-19. The therapeutic potential of the combination of nafamostat mesylate and other antiviral agents has not been examined in the present study, and further investigation is required. Because of high incidence of hyperkalemia, regular laboratory tests are required during the use of nafamostat mesylate.PMID:35491224 | DOI:10.7883/yoken.JJID.2021.699 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Tomomi Soma Kentaro Fujii Ayumi Yoshifuji Taketomo Maruki Kazuto Itoh Daisuke Taniyama Takahide Kikuchi Naoki Hasegawa Morio Nakamura Source Type: research

Longitudinal trends of neutralizing antibody prevalence against human cytomegalovirus (HCMV) over the past 30 years in Japanese women
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2021.726. Online ahead of print.ABSTRACTThe neutralizing antibodies (NAb) to HCMV in women are associated with the risk of transplacental infection of the fetus with HCMV in pregnant women. The IgG-positive rate determined with enzyme immunoassay (EIA) or indirect immunofluorescence assay has decreased approximately from 100% to 70% over the past 30 years in Japan. We tested serum samples from 630 women in Japan aged 20 to 49 years from whom blood had been drawn between 1980 and 2015. We measured the IgG titer using an EIA-based assay and the HCMV-NAb titer with neutra...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Miho Shibamura Souichi Yamada Tomoki Yoshikawa Takuya Inagaki Phu Hoang Anh Nguyen Hikaru Fujii Shizuko Harada Shuetsu Fukushi Akira Oka Masashi Mizuguchi Masayuki Saijo Source Type: research

Intradermal Hepatitis B Vaccination in Non-Responder People Living with HIV in Japan
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2021.834. Online ahead of print.ABSTRACTWe performed this pilot study to assess the immunogenicity and safety of intradermal hepatitis B (HB) virus vaccines in people living with HIV (PLWH). A single-center prospective study was conducted in Yokohama, Japan. Adult PLWH with serum antibodies against hepatitis B surface antigen (anti-HBs) < 10 mIU/mL at all the points after standard HB vaccination were included. We administered hepatitis B surface antigen (total dose 10 μg) at five separate sites intradermally at baseline, 1 month, and 6-9 months and measured anti-HB...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Yukihiro Yoshimura Hiroaki Sasaki Nobuyuki Miyata Natsuo Tachikawa Source Type: research

Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS) - Suspected Cases in Sri Lanka; Clinical Picture and Epidemiology from 2013-2021
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2021.837. Online ahead of print.ABSTRACTHantavirus; Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic disease in Euro-Asia which is clinically indistinguishable from leptospirosis. A total number of 1032 patients were included in the analysis from March 2013 to March 2021 with the clinical suspicion of HFRS-like illness. Of them, 168 patients were positive for hantavirus IgM antibodies. Thirty-one patients out of 35 patients had given a four-fold rise IgG antibody titre with paired serum confirming the acute hantavirus infections. Detected antibodies...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Rohitha Muthugala Kalpa Dheerasekara Aresha Manamperi Sunethra Gunasena Geethani Galagoda Source Type: research

Risk factors for candidiasis as an intra-abdominal infection after gastrectomy in patients with gastric cancer
This study aimed to identify the microorganisms causing IAIs after gastrectomy and the risk factors for Candida-related IAI. The records of patients who underwent gastrectomy for gastric cancer between January 2009 and December 2019 at Shizuoka General Hospital were retrospectively collected. Patients with IAIs of grade 2 or higher as measured by the Clavien-Dindo classification were included in the analysis. The selected patients were divided into a Candida group and a non-Candida group according to the presence or absence of Candida as the causative organism. Fifty-six (4.1%) of 1379 patients were diagnosed with IAIs aft...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Kyota Tatsuta Yusuke Taki Eiji Nakatani Kazuya Higashizono Erina Nagai Masato Nishida Shinsuke Sato Ko Ohata Masaya Watanabe Hideyuki Kanemoto Noriyuki Oba Source Type: research

Rapid spread of unusual G9P[8] human rotavirus strains possessing NSP4 genes of the E2 genotype in Japan
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2022.020. Online ahead of print.ABSTRACTThe emergence of unusual G9P[8]-E2 human rotaviruses in the Tokyo metropolis, Japan in 2018 has been reported. During rotavirus strain surveillance in different regions of Japan (Mie, Okayama, and Chiba prefectures), G9P[8]-E2 strains were detected in diarrheic children in all three prefectures. Here, we characterized the whole genomes of seven representative G9P[8]-E2 strains. On full-genome-based analysis, the seven study strains exhibited a unique genotype configuration having the NSP4 gene of genogroup 2 in a genogroup 1 geno...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Saori Fukuda Yuki Akari Riona Hatazawa Manami Negoro Takaaki Tanaka Kazutoyo Asada Haruna Nakamura Katsumi Sugiura Masakazu Umemoto Haruo Kuroki Hiroaki Ito Shigeki Tanaka Mitsue Ito Tomihiko Ide Takayuki Murata Kiyosu Taniguchi Shigeru Suga Hajime Kamiya Source Type: research

Detection of respiratory viruses during the early phase of the COVID-19 pandemic in Ibaraki and Gunma Prefectures, Japan
In this study, to clarify what kind of virus is involved in suspected cases of COVID-19 in the early stages of the pandemic, we attempted to detect various respiratory viruses from 613 specimens that tested negative for SARS-CoV-2 using RT- PCR method. Viruses were detected from 59 (9.6%) patients. Human rhinovirus (HRV), human metapneumovirus (HMPV), human respiratory syncytial virus, and human parechovirus were detected in 29 cases, 25 cases, 3 cases, and 2 cases, respectively. Although this study was conducted in a short period of time and not all specimens were tested, these results indicate that various respiratory vi...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Daisuke Shinoda Hiroyuki Tsukagoshi Keiko Komuro Daisuke Yoshida Toshikazu Yanaoka Mariko Saito Nobuhiro Saruki Source Type: research

Finding a needle in a haystack - in silico search for environmental traces of Candida auris
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2022.068. Online ahead of print.ABSTRACTCandida auris, first described from an ear infection in Japan, is the most talked about multidrug resistant emerging pathogenic fungal species. Its environmental niche remained a mystery until its first isolation from wetlands of the Andaman Islands, India in 2020. We screened a subset of the world's largest sequence repository, the Sequence Read Archive at NCBI using a DNA metabarcoding approach, based on either the ITS1 or ITS2 region of the official primary fungal DNA barcode, to identify potential environmental sources of C. ...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Laszlo Irinyi Michael Roper Richard Malik Wieland Meyer Source Type: research

Clinical analysis of non-AIDS patients with pulmonary cryptococcosis and the change in their clinical features over 30 years in a tertiary hospital in Beijing, China
In conclusion, more and more patients have been diagnosed of PC in the last 30 years. The timing of PC diagnosis has shifted to early in disease progression. Pulmonary lesions caused by cryptococcosis are easily misdiagnosed and may lead to unnecessary surgical treatment. Further research is needed to identify lung lesions caused by cryptococcosis.PMID:35491232 | DOI:10.7883/yoken.JJID.2022.141 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Zhenfei Mo Chunsun Li Zhixin Liang Jiewei Cui Ling Yu Liangan Chen Source Type: research

Nafamostat mesylate monotherapy in patients with moderate COVID-19 : A single-center retrospective study
In conclusion, nafamostat mesylate monotherapy did not improve clinical outcomes in patients with moderate COVID-19. The therapeutic potential of the combination of nafamostat mesylate and other antiviral agents has not been examined in the present study, and further investigation is required. Because of high incidence of hyperkalemia, regular laboratory tests are required during the use of nafamostat mesylate.PMID:35491224 | DOI:10.7883/yoken.JJID.2021.699 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Tomomi Soma Kentaro Fujii Ayumi Yoshifuji Taketomo Maruki Kazuto Itoh Daisuke Taniyama Takahide Kikuchi Naoki Hasegawa Morio Nakamura Source Type: research

Longitudinal trends of neutralizing antibody prevalence against human cytomegalovirus (HCMV) over the past 30 years in Japanese women
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2021.726. Online ahead of print.ABSTRACTThe neutralizing antibodies (NAb) to HCMV in women are associated with the risk of transplacental infection of the fetus with HCMV in pregnant women. The IgG-positive rate determined with enzyme immunoassay (EIA) or indirect immunofluorescence assay has decreased approximately from 100% to 70% over the past 30 years in Japan. We tested serum samples from 630 women in Japan aged 20 to 49 years from whom blood had been drawn between 1980 and 2015. We measured the IgG titer using an EIA-based assay and the HCMV-NAb titer with neutra...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Miho Shibamura Souichi Yamada Tomoki Yoshikawa Takuya Inagaki Phu Hoang Anh Nguyen Hikaru Fujii Shizuko Harada Shuetsu Fukushi Akira Oka Masashi Mizuguchi Masayuki Saijo Source Type: research

Intradermal Hepatitis B Vaccination in Non-Responder People Living with HIV in Japan
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2021.834. Online ahead of print.ABSTRACTWe performed this pilot study to assess the immunogenicity and safety of intradermal hepatitis B (HB) virus vaccines in people living with HIV (PLWH). A single-center prospective study was conducted in Yokohama, Japan. Adult PLWH with serum antibodies against hepatitis B surface antigen (anti-HBs) < 10 mIU/mL at all the points after standard HB vaccination were included. We administered hepatitis B surface antigen (total dose 10 μg) at five separate sites intradermally at baseline, 1 month, and 6-9 months and measured anti-HB...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Yukihiro Yoshimura Hiroaki Sasaki Nobuyuki Miyata Natsuo Tachikawa Source Type: research

Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS) - Suspected Cases in Sri Lanka; Clinical Picture and Epidemiology from 2013-2021
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2021.837. Online ahead of print.ABSTRACTHantavirus; Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic disease in Euro-Asia which is clinically indistinguishable from leptospirosis. A total number of 1032 patients were included in the analysis from March 2013 to March 2021 with the clinical suspicion of HFRS-like illness. Of them, 168 patients were positive for hantavirus IgM antibodies. Thirty-one patients out of 35 patients had given a four-fold rise IgG antibody titre with paired serum confirming the acute hantavirus infections. Detected antibodies...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Rohitha Muthugala Kalpa Dheerasekara Aresha Manamperi Sunethra Gunasena Geethani Galagoda Source Type: research

Risk factors for candidiasis as an intra-abdominal infection after gastrectomy in patients with gastric cancer
This study aimed to identify the microorganisms causing IAIs after gastrectomy and the risk factors for Candida-related IAI. The records of patients who underwent gastrectomy for gastric cancer between January 2009 and December 2019 at Shizuoka General Hospital were retrospectively collected. Patients with IAIs of grade 2 or higher as measured by the Clavien-Dindo classification were included in the analysis. The selected patients were divided into a Candida group and a non-Candida group according to the presence or absence of Candida as the causative organism. Fifty-six (4.1%) of 1379 patients were diagnosed with IAIs aft...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Kyota Tatsuta Yusuke Taki Eiji Nakatani Kazuya Higashizono Erina Nagai Masato Nishida Shinsuke Sato Ko Ohata Masaya Watanabe Hideyuki Kanemoto Noriyuki Oba Source Type: research

Rapid spread of unusual G9P[8] human rotavirus strains possessing NSP4 genes of the E2 genotype in Japan
Jpn J Infect Dis. 2022 Apr 28. doi: 10.7883/yoken.JJID.2022.020. Online ahead of print.ABSTRACTThe emergence of unusual G9P[8]-E2 human rotaviruses in the Tokyo metropolis, Japan in 2018 has been reported. During rotavirus strain surveillance in different regions of Japan (Mie, Okayama, and Chiba prefectures), G9P[8]-E2 strains were detected in diarrheic children in all three prefectures. Here, we characterized the whole genomes of seven representative G9P[8]-E2 strains. On full-genome-based analysis, the seven study strains exhibited a unique genotype configuration having the NSP4 gene of genogroup 2 in a genogroup 1 geno...
Source: Japanese Journal of Infectious Diseases - May 1, 2022 Category: Infectious Diseases Authors: Saori Fukuda Yuki Akari Riona Hatazawa Manami Negoro Takaaki Tanaka Kazutoyo Asada Haruna Nakamura Katsumi Sugiura Masakazu Umemoto Haruo Kuroki Hiroaki Ito Shigeki Tanaka Mitsue Ito Tomihiko Ide Takayuki Murata Kiyosu Taniguchi Shigeru Suga Hajime Kamiya Source Type: research