Dengue Virus Serotype 1 Exported to Japan from Cote d'Ivoire, 2019.
Abstract Dengue fever outbreaks have been repeatedly reported in Cote d'Ivoire. In 2019 outbreak, DENV-1 was predominant and phylogenetic analysis of the DENV-1 strain detected in a present patient who returning to Japan in January 2019 revealed high homology with the 2013-2014 Southeast Asian strains. Previous outbreak in 2017, DENV-1 accounted for 5% of the DENV serotypes. The endemic DENV-1 strain in Abidjan in 2019 could be a strain that was imported from Southeast Asia. Dengue virus spreads intercontinentally and imported dengue fever case could be an alert for the outbreaks in the exporting country. PMI...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Suzuki T, Kutsuna S, Nakamoto T, Ota M, Ishikane M, Yamamoto K, Maeki T, Tajima S, Nakayama E, Taniguchi S, Lim CK, Saijo M, Ohmagari N Tags: Jpn J Infect Dis Source Type: research

Pulmonary nocardiosis with superior vena cava syndrome in HIV-infected patient: A rare case report in the world.
Abstract Pulmonary nocardiosis is a common disease among HIV-infected patients. In most cases, the disease progresses slowly. Here, we present a case whose disease progressed rapidly. A 35-year-old female with AIDS and superior vena cava (SVC) syndrome who was lost to follow-up visited our hospital. She presented with a chronic non-productive cough and her CD4 count was 33 (4%). Her chest x-ray showed opacity in the right upper lobe of her lung and her sputum acid-fast stain was negative. Anti-tuberculosis agents were prescribed. Two weeks later, superficial vein dilatation appeared on her chest wall and her chest...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Kiatsuranon P, Suwanpimolkul G Tags: Jpn J Infect Dis Source Type: research

Isolation of Serratia fonticola producing FONA, a minor extended-spectrum β-lactamase (ESBL), from imported chicken meat in Japan.
Isolation of Serratia fonticola producing FONA, a minor extended-spectrum β-lactamase (ESBL), from imported chicken meat in Japan. Jpn J Infect Dis. 2020 Aug 01;: Authors: Tanimoto K, Nomura T, Hashimoto Y, Hirakawa H, Watanabe H, Tomita H Abstract Five novel strains of Serratia fonticola that produce FONA, a minor extended spectrum beta-lactamase (ESBL), were isolated during the routine surveillance of ESBLproducing Enterobacteriaceae in imported chicken meat in Japan in 2017 and 2018. These strains exhibited a clear ESBL phenotype in susceptibility tests carried out in the presence of clavulani...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Tanimoto K, Nomura T, Hashimoto Y, Hirakawa H, Watanabe H, Tomita H Tags: Jpn J Infect Dis Source Type: research

Preterm twins from the mother with miliary tuberculosis: Importance of early recognition and prompt response in infection control to manage congenital tuberculosis exposure in a neonatal intensive care unit.
Abstract Delayed diagnosis of congenital tuberculosis (TB) in a neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in NICU. Added to this, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after recognizing miliary TB of the mother, the index twins were isolated before their TB diagnosis and received preemptive antiTB medication, and contact investigations were also conducted....
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Ryu BH, Baek EH, Kim DH, Kim SE, Kim HJ, Cho OH, Hong SI, Do HJ, Park CH Tags: Jpn J Infect Dis Source Type: research

Positive stool test suggests that the discharge standard of COVID-19 needs to be improved.
We report a hospitalized patient with COVID-19 whose fecal samples turned negative 22 days later than the respiratory samples. It highlights that the duration of virus release from patients is longer than previously expected. Current clinical examinations for treatment and discharge standard are limited to respiratory samples. However, we believe that nucleic acid testing of both respiratory and fecal samples is necessary for discharged patients. Further studies are needed to confirm the potential for fecal-oral transmission or fecal-respiratory transmission via aerosols. PMID: 32741930 [PubMed - as supplied by publis...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Ge R, Chen Z, Liu X, Zhang Q, Zhu G, Xiao Q Tags: Jpn J Infect Dis Source Type: research

Predictors of coronavirus disease 2019 severity: A retrospective study of 64 cases.
Abstract To analyze clinical characteristics and potential predictors of disease severity in patients with COVID-19.Clinical data from 64 patients with COVID-19 were retrospectively analyzed. Of the 64 patients, 37 were male and 27 were female. Their mean age was 47.8 years, 43 (67.2%) cases were non-severe, 21 (32.8%) were severe, and 2 patients (3.1%) died. Age and serum ferritin were significantly associated with COVID-19 severity. Repeated monitoring of ferritin, interleukin-6, C-reactive protein, lactic acid dehydrogenase, and erythrocyte sedimentation rate during COVID-19 treatment may assist the prediction ...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Huang H, Song B, Xu Z, Jiao Y, Huang L, Zhao P, Huang J, Zhou Z, Zhao Z, Tian J, Zhou Y, Wang FS, Jiang T Tags: Jpn J Infect Dis Source Type: research

Characterziation of JC polyomavirus derived from COS-IMRb cells.
In this study, we carried out long term cultivation of COS-7 cells (designated as COS-IMRb cells) transfected with PML type M1-IMRb, an adapted viral DNA with a rearranged non-coding control region (NCCR). The JCPyV derived from COS-IMRb cells was characterized by analyzing viral replication, amount of virus by hemagglutination (HA), production of viral protein 1 (VP1), and structure of the NCCR. HA assays indicated that a high amount of PML type JCPyV was present in COS-IMRb cells. Immunostaining showed that VP1-positive cells were a small population in COS-IMRb cells that represented a JCPyV carrier cell culture. Sequenc...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Nukuzuma S, Nukuzuma C, Kameoka M, Sugiura S, Nakamichi K, Tasaki T, Hidaka K, Takegami T Tags: Jpn J Infect Dis Source Type: research

Threat of dissemination, Panton-Valentine leukocidin-positive livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) CC398 clone in Tokyo, Japan.
Abstract In the last decade, methicillin-resistant Staphylococcus aureus (MRSA) has been identified in livestock animals, such as swine, poultry, and veal calves, and termed livestock-associated MRSA (LA-MRSA). LA-MRSA sequence type (ST) 398 strains can effectively colonize and infect humans, with subsequent transmission in both community and hospital settings. Unlike other countries, LA-MRSA was not yet reported in Japanese patients until 2019. However, we recently reported a case of intractable arthritis caused by a LA-MRSA CC398 (ST1232) clone, which is a single locus variant of ST398, in a patient in Tokyo, Ja...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Nakaminami H, Kawasaki H, Takadama S, Kaneko H, Suzuki Y, Maruyama H, Noguchi N Tags: Jpn J Infect Dis Source Type: research

Seasonality of human coronavirus OC43, NL63, HKU1, and 229E infection in Yamagata, Japan, 2010-2019.
PMID: 32741934 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Komabayashi K, Seto J, Matoba Y, Aoki Y, Tanaka S, Ikeda T, Matsuzaki Y, Itagaki T, Mizuta K Tags: Jpn J Infect Dis Source Type: research

Development of Genetic Diagnostic Methods for Detection for Novel Coronavirus 2019(nCoV-2019) in Japan.
Abstract During the emergence of novel coronavirus 2019 (nCoV) outbreak in Wuhan city, China at the end of 2019, there was movement of many airline travelers between Wuhan and Japan, suggesting that the Japanese population was at high risk of infection by the virus. Hence, we urgently developed diagnostic systems for detection of 2019 nCoV. Two nested RT-PCR and two real-time RT-PCR assays were adapted for use in Japan. As of February 8, 2020, these assays have successfully detected 25 positive cases of infection in Japan. PMID: 32074516 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 22, 2020 Category: Infectious Diseases Authors: Shirato K, Nao N, Katano H, Takayama I, Saito S, Kato F, Katoh H, Sakata M, Nakatsu Y, Mori Y, Kageyama T, Matsuyama S, Takeda M Tags: Jpn J Infect Dis Source Type: research

Characteristics of SARS-CoV-2 Isolated from Asymptomatic Carriers in Tokyo.
PMID: 32350227 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 22, 2020 Category: Infectious Diseases Authors: Nagashima M, Kumagai R, Yoshida I, Kawakami M, Nagano M, Asakura H, Kaku E, Kitamura Y, Hasegawa M, Hayashi Y, Chiba T, Sadamasu K, Yoshimura K Tags: Jpn J Infect Dis Source Type: research

Prevalence of high-level aminoglycoside resistance and genes encoding aminoglycoside-modifying enzymes in Enterococcus faecalis and Enterococcus faecium isolated in a university hospital in Tokyo.
We examined the prevalence of HLAR by disk diffusion method, carriage of genes for aminoglycoside-modifying enzymes by PCR, and production of β-lactamase by nitrocefin-based test in Enterococcus faecalis and Enterococcus faecium isolated from patients at a university hospital in Tokyo in 2010. Of the 100 E. faecalis isolates analyzed, 30 isolates had high-level resistance (HLR) to gentamicin and 22 isolates had HLR to streptomycin. Of the 40 E. faecium isolates analyzed, nine isolates had HLR to gentamicin and nine isolates had HLR to streptomycin. Of the 39 gentamicin-HLR enterococcal isolates, 24 isolates were non-H...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Harada S, Shibue Y, Aoki K, Ishii Y, Tateda K Tags: Jpn J Infect Dis Source Type: research

An Intracranial Tuberculoma With Discharging Scalp Sinus.
PMID: 32611970 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Li L, Cheng C, Shetty R, Li S, Wu T, Zhao N Tags: Jpn J Infect Dis Source Type: research

Circulation of Various Dengue Serotypes in Community Based Study in Jakarta, Indonesia.
In this study, we developed active DENV cases finding in the community in Jakarta to study circulating dengue serotypes where adult febrile patients with fever less than 48 hours were recruited. Disease severities were defined using the World Health Organization (WHO) 1997 guideline. Rapid NS1 dengue antigen detection were used to screen DENV patients in the community. Viral isolation in C6/36 cell line or increased antibody titer by HI and ELISA or RT-PCR were performed to confirm DENV infection.Viral serotype was investigated through RT-PCR. From 102 patients, 68 (66.7%) patients were confirmed DENV infection with DENV-2...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Dewi BE, Nainggolan L, Sudiro TM, Chenderawasi S, Goentoro PL, Sjatha F Tags: Jpn J Infect Dis Source Type: research

Serum 25-hydroxy vitamin D levels in Japanese infants younger than 3-months old with respiratory syncytial virus infection.
Abstract Low levels of blood vitamin D have been reported in children who have frequent respiratory tract infections. We measured serum concentrations of 25-hydroxy (OH) vitamin D in Japanese infants less than 3-months old infected with respiratory syncytial virus (RSV). Serum levels of 25-OH vitamin D of the 10 infants, excluding those with underlying diseases, were between less than 4 to 29.8 ng/mL. In 8 out of 10 subjects (80.0%), serum 25-OH vitamin D levels were less than 20 ng/mL. There was no statistically significant association between levels of 25-OH vitamin D and age, duration of admission, respiratory ...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Kawashima H, Kimura M, Morichi S, Nishimata S, Yamanaka G, Kashiwagi Y Tags: Jpn J Infect Dis Source Type: research

Changing demography of genital chlamydia, gonorrhea, genital herpes, condyloma and syphilis infections in Japan.
Abstract There was epidemiological correlation in time and in space between gonorrhea and genital chlamydia and between condyloma and genital herpes. There was, however, no correlation in other combinations, such as, gonorrhea and condyloma, genital herpes and chlamydia, etc. The annual incidence of gonorrhea and that of genital chlamydia were mono-phasic with a peak in 2005-2006. The annual incidence of condyloma and that of genital herpes were biphasic with the first distinct peak in 2004-2006 borne by younger generation and the second broad peak borne by the older generation that experienced the first wave.The ...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Spatiotemporal variability of Zoonotic Cutaneous Leishmaniasis based on sociodemographic heterogeneity. The case of Northeastern Iran, 2011-2016.
Abstract Zoonotic Cutaneous Leishmaniasis (ZCL) is one of the most prevalent zoonoses in Iran, especially in its central and northeast parts. This research aims to examine if there are spatiotemporal clusters of the ZCL cases, and if so, whether there are disparities in clustering according to age, gender, home situation, and occupation. The spatial analysis, including global and local spatial autocorrelations, inverse distance weighting, and space-time scan statistics were applied to determine potential clusters in Golestan villages during 2011-2016. Several spatially significant (p
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Tabasi M, Alesheikh AA Tags: Jpn J Infect Dis Source Type: research

Analysis of HPV genotypes and liquid-based cervical cytology: Results from a tertiary academic center in northwestern Turkey.
uml;r Ş, Önal B Abstract High-risk human papilloma virus (hrHPV) plays an important role in the cause of cervical cancer. The aim of this study is to investigate the distribution of HPV genotypes in the region and to correlate with the liquid-based-cytology (LBC) and colposcopic biopsy results. Furthermore, the potential relationship between HPV infections and bacterial vaginosis (BV) was investigated. HPV genotypes were determined by real-time PCR using a commercial kit at molecular microbiology. LBC, biopsies and BV examinations were performed at Pathology& Cytology. The consecutive cervical specimens ...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: ÇaliŞkan E, CoŞkun SK, ÖztÜrk CE, CangÜr Ş, Önal B Tags: Jpn J Infect Dis Source Type: research

Multiple-locus variable-number tandem repeat analysis for non-O157 Shiga toxin-producing Escherichia coli : focus on serogroups O103, O121, O145, O165, and O91.
In this study, we designed an MLVA scheme (MLVA43) by adding 26 loci to an MLVA scheme (MLVA17) previously developed by our group for O157, O26, and O111 using 17 loci; the current scheme focused on serogroups O103, O121, O145, O165, and O91. Discriminatory power of MLVA43 was comparable to that of pulsed-field gel electrophoresis (PFGE) for serogroups O103, O145, O165, and O91, and superior to that of PFGE for O121. MLVA43 identified more profiles than did MLVA17, except for serogroup O111 with 707 isolates. The new MLVA43 scheme would enable rapid identification of clusters and outbreaks, which will help rapid measure ag...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Izumiya H, Lee K, Ishijima N, Iyoda S, Ohnishi M Tags: Jpn J Infect Dis Source Type: research

The epidemiology of admission-requiring pediatric respiratory infections in a Japanese community hospital using multiplex PCR.
This study aimed to assess the epidemiology of admission-requiring pediatric RTI cases and to evaluate the effect of pathogen type on length of hospital stay (LOS) using the FilmArray® respiratory panel, a multiplex PCR test. The age-specific distribution and seasonality of viruses were investigated between March 26, 2018 and April 12, 2019. Multivariable linear regression analyses were performed to evaluate the effect of pathogen type and coinfection on LOS. Among 153 hospitalized RTI patients, respiratory syncytial virus (RSV) was the leading cause of hospitalization in infants
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Inagaki A, Kitano T, Nishikawa H, Suzuki R, Onaka M, Nishiyama A, Kitagawa D, Oka M, Masuo K, Yoshida S Tags: Jpn J Infect Dis Source Type: research

SARS-CoV-2 in Italy: Population Density correlates with Morbidity and Mortality.
Abstract Since the beginning of the SARS-CoV-2/COVID-19 epidemic in China, elderly and multimorbid subjects showed a higher mortality rate. However, other factors could influence the mortality and the spread of contagion such as the population density. An archival research based on the Italian data stratified by region was performed in order to quantify the association between the population density, ageing index, number of positive cases, number of deaths, case-fatality rate, and medical equipment (gloves, masks, and ventilators). Results showed a significant positive linear relationship between the population de...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Ilardi A, Chieffi S, Iavarone A, Ilardi CR Tags: Jpn J Infect Dis Source Type: research

Risk factors analysis and nomogram construction of non-survivors in critical patients with COVID-19.
Abstract A pandemic named coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbroke in China since December 2019. This disease has caused more than 70000 deaths worldwide. We intend to analyze the risk factors of death and establish a prognosis nomogram for critical patients with COVID-19. We analyzed the clinical data of COVID-19 patients in Zhongnan Hospital of Wuhan University who were critical cases with COVID-19 before March 20, 2020. Data were collected at admission and compared between survivors and non-survivors and analyzed by univariable and multi...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Wang B, Zhong F, Zhang H, An W, Liao M, Cao Y Tags: Jpn J Infect Dis Source Type: research

Chest CT evaluation of 11 persistent asymptomatic patients with SARS-CoV-2 infection.
In conclusion, typical CT findings can be detected in over 70% of asymptomatic SARS-CoV-2 carriers. It mainly starts as GGO along subpleural regions and bronchi, and absorbs in nearly 5 days. PMID: 32611980 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Yan S, Chen H, Xie RM, Guan CS, Xue M, Lv ZB, Wei LG, Bai Y, Chen BD Tags: Jpn J Infect Dis Source Type: research

Molecular identification of parasites isolated from the stomach of patients with Anisakis food poisoning in Toyama Prefecture, Japan, in 2018.
PMID: 32611981 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Watahiki M, Uchida K, Kanatani JI, Kato T, Kimata K, Isobe J, Oishi K, Tozaki K, Sekiguchi K, Horita Y, Morishima Y, Sugiyama H Tags: Jpn J Infect Dis Source Type: research

New Mechanism of Acyclovir Resistance of Herpes Simplex Virus 1, Which Has an Amber UAG Codon Between the First and Second AUG Initiation Codons.
Abstract The morphological changes in structure of HSV-1 viral thymidine kinase (vTK) polypeptide usually leads to conferring acyclovir (ACV)-resistance. HSV-1 I4-2, in which an amber UAG stop codon is present at the 8th position between the 1st initiation AUG codon (1st position) and the 2nd initiation AUG codon (46th position) of HSV-1 vTK gene, showed sensitivity to acyclovir (ACV), whereas HSV-1 KG111, in which an amber codon was artificially inserted at the 44th position, showed resistance to ACV at 39˚C. The mechanism for the difference in the sensitivity profiles was elucidated. The virus recombinants HSV-...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Nguyen PHA, Yamada S, Shibamura M, Inagaki T, Fujii H, Harada S, Fukushi S, Mizuguchi M, Saijo M Tags: Jpn J Infect Dis Source Type: research

An ultra-rapid real-time RT-PCR method using the PCR1100 to detect Severe Acute Respiratory Syndrome Coronavirus-2.
Abstract The disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan, China, in December 2019 is currently spreading rapidly worldwide. SARS-CoV-2 is usually detected via real-time RT-PCR. However, as institutions/hospitals deal with increasing numbers of specimens, a simpler detection system is required. Here, we present an ultra-rapid, real-time RT-PCR assay for SARS-CoV-2 using the PCR1100 device. Although this tests only one specimen at any one time, the amplification period is
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Shirato K, Nao N, Matsuyama S, Takeda M, Kageyama T Tags: Jpn J Infect Dis Source Type: research

Trends in COVID-19 outbreak in Tokyo and Osaka from January 25 to May 06, 2020: a joinpoint regression analysis of the outbreak data.
Abstract We analyzed the trends in the coronavirus disease 2019 (COVID-19) outbreak in Tokyo and Osaka from January 25 to May 06, 2020. To analyze the trends and to identify significant changes in trends we performed a joinpoint regression analysis. Since the last of March, COVID-19 cases soared up in Tokyo (β = 103.51) and Osaka (β = 28.07). During the 2nd and 3rd weeks of April, both Tokyo (β = 157.53) and Osaka (β = 60.96) experienced the peak growth in COVID-19 cases. Since then, with some hope, almost after 14 days of the state of emergency declaration, the cases showed a containment trend...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Hasan SMA, Saulam J, Kanda K, Ngatu NR, Hirao T Tags: Jpn J Infect Dis Source Type: research

Cluster-based approach to Coronavirus Disease 2019 (COVID-19) response in Japan-February-April 2020.
PMID: 32611985 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Oshitani H, Experts Members of The National COVID-19 Cluster Taskforce at Ministry of Health, Labour and Welfare, Japan Tags: Jpn J Infect Dis Source Type: research

Fecal microbiome composition in healthy adults in Ghana.
Abstract Current studies have indicated association of gut microbiome composition with varieties of disorders including infectious diseases. The microbiome composition is different among races and countries, possibly resulting in diversified interaction between host immune and gut microbiome. Characterization of the baseline microbiota in healthy people is an essential step to understand this biological interaction in individual populations. However, data on gut/fecal microbiome has not been accumulated in West Africa. In the present study, we examined fecal microbiome composition in healthy adults in Ghana. The 1...
Source: Japanese Journal of Infectious Diseases - June 30, 2020 Category: Infectious Diseases Authors: Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Uematsu S, Imoto S, Kimura Y, Kiyono H, Ishikawa K, Ampofo WK, Matano T Tags: Jpn J Infect Dis Source Type: research

Polymerase acidic subunit I38T mutant influenza A(H3N2) virus isolated from a child patient without prior baloxavir marboxil treatment in the Mie prefecture (November 2018).
PMID: 32475868 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Yano T, Ochiai H, Akachi S, Matsumura Y Tags: Jpn J Infect Dis Source Type: research

A case of human granulocytic anaplasmosis diagnosed by a peripheral blood smear test in South Korea.
We report the case of a 76-year-old woman whose infection was rapidly diagnosed as human granulocytic anaplasmosis (HGA) through a peripheral blood smear that showed characteristic intragranulocytic morulae. The smear was prepared on the day of hospitalization, which was 1-2 weeks before results were available from serology or the polymerase chain reaction (PCR). On the basis of the blood smear test, we started timely and appropriate antimicrobial treatment. The peripheral blood smear is known to have the lowest sensitivity when compared with serological or PCR tests for the diagnosis of HGA, but we suggest that the sensit...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Park HS, Shin KS, Son BR, Kim DM, Kim HS, Jeong HW Tags: Jpn J Infect Dis Source Type: research

Prevalence and characteristics of carbapenemase-producing Enterobacteriaceae in three tertiary-care Korean university hospitals between 2017 and 2018.
Abstract The aim of this study was to evaluate the prevalence and characteristics of carbapenemase-producing Enterobacteriaceae (CPE) from three tertiary-care Korean university hospitals between 2017 and 2018. Non-duplicated clinical isolates of Enterobacteriaceae revealing resistance to any carbapenem agents were collected prospectively from three tertiary university hospitals between 2017 and 2018. The presence of carbapenemase genes was detected by multiplex PCR and sequencing for blaKPC, blaVIM, blaNDM, blaIMP, blaOXA, and blaGES. Among the 690 carbapenem-resistant Enterobacteriaceae (CRE) isolates, 66.8% (N=4...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Kim SH, Kim GR, Jeong J, Kim S, Shin JH Tags: Jpn J Infect Dis Source Type: research

Molecular characteristics of dengue viruses in patients hospitalized at the Bamrasnaradura Infectious Diseases Institute, Thailand.
The objective of the present study, conducted in 2018 at the Bamrasnaradura Infectious Diseases Institute, was to characterize the DENV genotype distribution among severe dengue patients. A total of 100 hospitalized severe dengue patients were enrolled with written informed consent. Serum specimens were tested by multiplex real-time reverse transcription-polymerase chain reaction. A total of 94 cases were DENV detected, with 46 DENV-1, 38 DENV-2, 10 DENV-4, and no DENV-3 cases. Sequence determination of the DENV envelope-protein gene was successful in 73 cases. Genotyping of the resultant sequences revealed 40 DENV-1 genot...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Uttayamakul S, Reawrang S, Nitiyanontakij R, Phadungsombat J, Nakayama E, Suttha P, Moolasart V, Shioda T Tags: Jpn J Infect Dis Source Type: research

Characterization of colibactin-producing Escherichia coli isolated from Japanese patients with colorectal cancer.
Abstract We investigated the relationship between colibactin-producing (clb+) Escherichia coli and colorectal adenocarcinoma. In total, 729 E. coli colonies were isolated from tumor and surrounding non-tumor regions in resected specimens from 34 Japanese patients; 450 colonies were from tumor regions and 279 from non-tumor regions. clb+ bacteria were found in tumor regions of 11 patients (11/34, 32.4%) and in non-tumor regions of seven of the 11 (7/34, 20.6%). The prevalence of clb+ isolates was 72.7% (327/450) and 44.1% (123/279) in tumor and non-tumor regions, respectively. All the recovered clb+ isolates belong...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Yoshikawa Y, Tsunematsu Y, Matsuzaki N, Hirayama Y, Higashiguchi F, Sato M, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K Tags: Jpn J Infect Dis Source Type: research

Epidemic characteristics of COVID-19 in four Chinese cities.
Abstract In December 2019, there was an outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. The number of patients in China has risen to 31,000. We collected patient data from four Chinese cities (Hefei, Hangzhou, Wenzhou, Shenzhen) and described epidemiologic characteristics. As of 6 February 2020, we extracted data from 950 patients from the four cities. There were 477 (50.21%) males and 473 (49.79%) females of age (mean ± SD) 45.64 ± 15.59 years. Before contracting COVID-19, 299 patients had contact with Wuhan residents or contact with patients diagnosed with COVID-19 (31.47%). Also, ...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Hu J, Rao S, Hu X Tags: Jpn J Infect Dis Source Type: research

Prevalence of Eleven Infectious Viruses Causing Diarrhea in Korea.
Abstract Rotavirus and norovirus are well-known causes of viral infectious diarrhea. There are few reports about diarrhea caused by other viruses in Korea, although gastroenteritis attributable to other viruses is increasing worldwide. The aims of this study were to detect various causes of viral diarrhea and to investigate their prevalence. A total of 801 fecal specimens submitted to a clinical microbiology laboratory for the detection of diarrhea viruses were included. We sought to detect rotavirus A/B/C, adenovirus, astrovirus, norovirus GI/GII, sapovirus, Aichi virus, human parechovirus, enterovirus, human cos...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Kim GR, Kim SH, Jeon GW, Shin JH Tags: Jpn J Infect Dis Source Type: research

Detection of a peramivir-resistant influenza B/Yamagata-lineage virus imported from Indonesia in Aichi, Japan, March 2019.
PMID: 32475875 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Takashita E, Yasui Y, Nagata S, Morita H, Fujisaki S, Miura H, Shirakura M, Kishida N, Nakamura K, Kuwahara T, Sugawara H, Sato A, Akimoto M, Kaido T, Watanabe S, Hasegawa H, Influenza Virus Surveillance Group of Japan Tags: Jpn J Infect Dis Source Type: research

Coronavirus disease 2019: initial high resolution computed tomography imaging feature analysis: report of seven cases.
Abstract The number of reported cases of the new coronavirus disease named "severe acute respiratory syndrome-coronavirus 2" (SARS-CoV-2) has increased since December 2019. The initial high-resolution computed tomography (HRCT) images of seven patients with diagnosed COVID-19 in the Affiliated Hospital of Hangzhou Normal University, China, were collected and analyzed. The study showed that all patients had close contact with COVID-19 patient and presented with fever. The initial white blood cell counts of all patients were normal. The percentage of lymphocytes decreased in three patients. In all seven pa...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Huang J, Ding J Tags: Jpn J Infect Dis Source Type: research

The potential transmission of SARS-CoV-2 from patients with negative RT-PCR swab tests to others: two related clusters of COVID-19 outbreak.
This study evaluated two clusters of COVID-19 in six patients. Four of six (66.7%) showed negative RNA of SARS-CoV-2 by nasopharyngeal swabs. All epidemiological, clinical and laboratory information was collected. The first cluster was a nosocomial infection of four health care providers at early January. One of them made sequential familial cluster of infection. All patients received either selfquarantined at home or were admitted to hospital for isolated treatment. All recovered and had anti-SARS-CoV-2 IgG and/or IgM positive (100%) for serological detection of SARS-CoV-2 at recovery stage. Our study provides a cautionar...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Cao G, Tang S, Yang D, Shi W, Wang X, Wang H, Li C, Wei J, Ma L Tags: Jpn J Infect Dis Source Type: research

The first pediatric patients with coronavirus disease 2019 (COVID-19) in Japan; The risk of co-infection with other respiratory viruses.
Abstract Coronavirus disease 2019 (COVID-19) is a severe infectious disease of the respiratory tract caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2, and has a high mortality rate. The disease emerged from Wuhan, China, in late 2019, and spread to Japan, including Hokkaido, in January 2020. In February 2020, three children were diagnosed with COVID-19 in Furano, Hokkaido, Japan. During this period, influenza and human metapneumovirus infections were prevalent among children in the Furano region. Two of the three cases experienced co-infection with other respiratory viruses, including...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Kakuya F, Okubo H, Fujiyasu H, Wakabayashi I, Syouji M, Kinebuchi T Tags: Jpn J Infect Dis Source Type: research

An ultra-rapid real-time RT-PCR method for detecting human orthopneumovirus using PCR1100.
In this study, an ultra-rapid real-time RT-PCR method for the rapid detection of RSV was developed using the PCR1100 device based on the US CDC assay in order to detect RSV in comparable time to rapid test kits. The ultra-rapid real-time RT-PCR could detect RSV viral RNA in less than 20 min while maintaining sensitivity and specificity comparable to conventional real-time RT-PCR using large installed instruments. Furthermore, combining ultra-rapid real-time RT-PCR with the M1 Sample Prep kit reduced the total working time for the detection of RSV from clinical specimen to less than 25 min, suggesting this method could be u...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Shirato K, Nao N, Kawase M, Kageyama T Tags: Jpn J Infect Dis Source Type: research

Prediction of the severity of Corona Virus Disease 2019 and its adverse clinical outcomes.
This study aims to investigate blood and biochemical laboratory findings in patients with severe Corona Virus Disease 2019 (COVID-19) and to develop a joint predictor for predicting the likelihood of severe COVID-19 and its adverse clinical outcomes, to provide more information for treatment. We collected the data of 88 patients with laboratory-confirmed COVID-19. Then patients were divided into a non-severe group and a critical group (including critically ill cases). Univariate analysis showed that the absolute lymphocyte count, albumin level, albumin/globulin (A/G) ratio, lactate dehydrogenase (LDH) level, interleukin-6 ...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Liu X, Shi S, Xiao J, Wang H, Chen L, Li J, Han K Tags: Jpn J Infect Dis Source Type: research

A Case of COVID-19 Patient with False-negative for SARS-CoV-2 of Pharyngeal Swab, from a Chinese traveller Returning from Wuhan, Hubei Province, China, January 2020.
We report a case of patient in Japan with Coronavirus disease 2019 (COVID-19) with false-negative of reverse transcription polymerase chain reaction for Severe Acute Respiratory Syndrome Coronavirus 2 of pharyngeal swab, from a Chinese traveller returning from Wuhan, Hubei Province, China. If a patient is clinically or epidemiologically suspected of COVID-19, appropriate infection and prevention control measures such as standard, contact, and droplet precaution are needed until the patient is proven to be true-negative. PMID: 32475881 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Ishikane M, Miyazato Y, Kustuna S, Suzuki T, Ide S, Nakamura K, Morioka S, Katano H, Suzuki T, Ohmagari N Tags: Jpn J Infect Dis Source Type: research

A healthcare-associated outbreak of urinary tract infections due to Myroides odoratimimus.
We report a healthcare-associated outbreak of urinary tract infections caused by Myroides odoratimimus in a Turkish hospital. From March to May 2019, six strains of M. odoratimimus were isolated from the urine samples of patients hospitalized in the intensive care units (ICUs). After identification and antibiotic susceptibility testing with VITEK 2 system, MALDI-TOF-MS and 16S rRNA based sequencing methods were performed for confirmation and species level identification. Pulsed-field gel electrophoresis (PFGE) was used to investigate clonal relatedness of the isolates. All the patients were immunocompromised and underwent ...
Source: Japanese Journal of Infectious Diseases - May 29, 2020 Category: Infectious Diseases Authors: Kutlu HH, Avcı M, Dal T, Arı O, Durmaz R Tags: Jpn J Infect Dis Source Type: research

Nonmetabolizable arabinose inhibits Vibrio cholerae growth in M9 medium with gluconate as sole carbon source.
In this study, arabinose mediated V. cholerae growth interference has been assessed in M9 minimal medium containing gluconate as sole carbon source in the light of Entner-Doudoroff (ED) pathway, an obligatory metabolic route for gluconate utilization. V. cholerae O1 and O139 strains failed to grow in presence of ≥0.3% arabinose in M9 with 0.2% gluconate but no growth inhibition in presence of arabinose in M9 with 0.2% glucose. Transcriptional analysis of edd and eda, the genes constituting the ED pathway, showed ~100 and ~17 folds increase, respectively, in M9-gluconate. Minor increase of ~4 and ~2 folds for the edd and...
Source: Japanese Journal of Infectious Diseases - April 30, 2020 Category: Infectious Diseases Authors: Golder T, Mukhopadhyay AK, Koley H, Nandy RK Tags: Jpn J Infect Dis Source Type: research

Acute flaccid paralysis as the initial manifestation of Japanese encephalitis: a case report.
Abstract Japanese encephalitis (JE) is an inflammation of the central nervous system resulting in clinical disease, with symptoms ranging broadly in severity from mild febrile illness to acute meningomyeloencephalitis. JE has been associated with a variety of neurological abnormalities such as altered sensorium, seizures, focal neurological deficit, and acute flaccid paralysis (AFP). However, AFP has never been reported as the initial manifestation of JE. Here we present a case of AFP as the initial manifestation of JE in a Chinese patient. A 30-year-old Chinese man was admitted to West China Hospital of Sichuan U...
Source: Japanese Journal of Infectious Diseases - April 30, 2020 Category: Infectious Diseases Authors: Shen Q, Li Y, Lu H, Ning P, Huang H, Zhao Q, Xu Y Tags: Jpn J Infect Dis Source Type: research

Evaluation of recombinant type-specific antigens of Orientia tsutsugamushi which were expressed by baculovirus-insect cell system as antigens for indirect immunofluorescent assay in the serological diagnosis of scrub typhus.
In this study, sf-9 insect cells infected with the recombinant type-specific antigens (rTSA)-expressing baculovirus were applied for IFA. The paired sera samples of 15 scrub typhus-patients, 10 rickettsiosis-patients, and 10 control individuals were used. Both IgM and IgG IFA titers determined by the rTSA based IFA were correlated with those determined with the OTS-infected cell-based IFA (R 2 = 0.7319 to 0.7956). Based on the criteria for serological diagnosis, such as the suitable cutoff for single serum (IgM ≥ 1:160) and/or significant increase in IgG titer between paired sera (≥ 4 times), all of the 15 scrub typh...
Source: Japanese Journal of Infectious Diseases - April 30, 2020 Category: Infectious Diseases Authors: Ogawa M, Ando S, Saijo M Tags: Jpn J Infect Dis Source Type: research

The first report of isolation of macrolide-resistant Bordetella pertussis in Japan.
PMID: 32350216 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - April 30, 2020 Category: Infectious Diseases Authors: Yamaguchi T, Kawasaki Y, Katsukawa C, Kawahara R, Kawatsu K Tags: Jpn J Infect Dis Source Type: research

A Pediatric Case of Septic Arthritis due to methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin and toxic shock syndrome toxin-1.
PMID: 32350217 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - April 30, 2020 Category: Infectious Diseases Authors: Uda K, Uehara Y, Hiramatsu K, Isao M Tags: Jpn J Infect Dis Source Type: research

The second case of deceased donor liver transplantation in a patient coinfected with HIV and HCV in Japan: Special reference to the management of complicated coagulopathy due to a diverse spectrum of preformed anti-HLA antibodies.
We report the second case of deceased donor liver transplantation in a patient co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) in Japan. A 48- year-old patient with hemophilia A was infected with HIV and HCV through a contaminated factor VIII concentrate in his childhood and developed cirrhosis and hepatocellular carcinoma. The patient was on the transplant list for a deceased donor liver. The patient had broad spectrum anti-HLA class I and II antibodies, which may have been due to repeated whole blood transfusions in the past. Catastrophic coagulopathy during the surgery was predicted becau...
Source: Japanese Journal of Infectious Diseases - April 30, 2020 Category: Infectious Diseases Authors: Kawamura N, Goto R, Koshizuka Y, Watanabe M, Suzuki T, Endo T, Kondo T, Taketomi A, Shimamura T Tags: Jpn J Infect Dis Source Type: research