Dengue virus-induced reactive oxygen species production in rat microglia cells.
In conclusion, DV2 and DV4 have the capability to induce ROS production and activate microglia, which have been reported as the key components for neuronal damage. PMID: 28003593 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Suwanprinya L, Morales NP, Sanvarinda P, Dieng H, Okabayashi T, Vargas RE Tags: Jpn J Infect Dis Source Type: research

First Isolation of Hybrid Shigatoxigenic and Enterotoxigenic Escherichia coli (STEC/ETEC) Strain Harboring stx2 and elt Genes in Republic of Korea.
PMID: 28003594 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Oh KH, Shin E, Jung SM, Im J, Cho SH, Hong S, Yoo CK, Chung GT Tags: Jpn J Infect Dis Source Type: research

Detection of measles virus genotypes B3, D4, D5, D8, and H1 in the surveillance system in Hokkaido, Japan, during pre- and post-elimination Era, 2006-2015.
Abstract Measles is an acute and highly contagious disease caused by measles virus (MeV). In Japan, since the last epidemic in 2007 and 2008 caused by the genotype D5 strains, the government introduced a catch-up-vaccination program for teenagers during fiscal years of Japan 2008-2012 and the mandatory case-based reporting system for the nationwide elimination. Furthermore, the laboratory confirmation based on genotyping has been performed to clarify the source of infection and to support the interruption of measles cases. While such preventive measure have been conducted, the number of measles cases decreased ste...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Miyoshi M, Komagome R, Yamaguchi H, Ohnishi A, Kikuchi M, Ishida S, Nagano H, Okano M Tags: Jpn J Infect Dis Source Type: research

A case of rat bite fever caused by Streptobacillus moniliformis.
We report a case of rat bite fever (RBF) diagnosed by detection of Streptobacillus moniliformis from blood culture and synovial fluid. The patient was a 45-year-old man with alcoholic liver cirrhosis. He was bitten on his third finger by a rat, which was caught in a mousetrap installed in his house. After the bite, fever, rash and arthralgia developed over a period of about two weeks. The patient was admitted to our hospital and treated with combination of Ampicillin- Sulbactam (SAM), Vancomycin (VAN) and Minocycline (MIN). The Anaerobic/F resin blood culture bottle became positive with gram negative bacillus in overnight ...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Hayakawa Y, Suzuki J, Suzuki M, Sugiura W, Ohkusu K Tags: Jpn J Infect Dis Source Type: research

Safety and Immunogenicity Study of a 9-Valent Human Papillomavirus Vaccine Administered to 9-To-15 Year-Old Japanese Girls.
We report here the results of an open-label phase III study conducted to bridge the findings in women age 16 to 26 years to Japanese girls aged 9 to 15 years. All subjects (n = 100) received a 3-dose regimen of 9vHPV vaccine at day 1, month 2 and month 6. Anti-HPV serologic assays were performed at day 1, month 7, month 12, month 24 and month 30. At month 7 (4 weeks after dose 3), 100% of subjects seroconverted for each vaccine HPV type. Increases in geometric mean titers of anti-HPV 6/11/16/18/31/33/45/52/58 in girls were similar to those in Japanese women aged 16 to 26 years in the pivotal phase III study. Persistence of...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Iwata S, Murata S, Han SR, Wakana A, Sawata M, Tanaka Y Tags: Jpn J Infect Dis Source Type: research

An iTRAQ-based quantitative proteomics study of refractory mycoplasma pneumoniae pneumonia patients.
In this study, we applied the quantitative proteomic technique(iTRAQ) to globally analyze MP-related proteins in serum samples from five RMPP and five non-refractory MP pneumonia(NRMPP) patients, and five healthy children. Functional classification, sub-cellular localization, and protein interaction network were carried out based on PANTHER and cytoscape analysis. A total of 260 differentially expressed proteins were identified in the RMPP and NRMPP groups. Compared with the control group, there were 134(70 up-regulated and 64 down-regulated) and 126(63 up-regulated and 63 down-regulated) differentially expressed proteins ...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Yu JL, Song QF, Xie ZW, Jiang WH, Chen JH, Fan HF, Xie YP, Lu G Tags: Jpn J Infect Dis Source Type: research

Establishment of Subclones of Severe Fever with Thrombocytopenia Syndrome Virus YG1 Strain Selected by the Degree of Low-pH-dependent Cell Fusion Activity.
Abstract Severe fever with thrombocytopenia syndrome virus YG1 strain was isolated from the first clinical case in Japan. We found that only some of the cells underwent low-pH-dependent cell fusion, though all of the cells were confirmed to have been infected with viruses, suggesting that YG1 strain consists of heterogeneous mixtures of related viruses. Here, we established three subclones, E3, A4 and B7, from YG1 strain by the limiting dilution method with pH-dependent cell fusion activities. Subclone E3 showed weak fusion activity and cytopathic effect (CPE) in Vero E6 cells. It has an amino acid sequence identi...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Nishio S, Tsuda Y, Ito R, Shimizu K, Yoshimatsu K, Arikawa J Tags: Jpn J Infect Dis Source Type: research

Identification of Group G Streptococci Isolates from Companion Animals in Japan and Their Antimicrobial Resistance.
This study determined species-level identification and antimicrobial resistance (AMR) properties in group G streptococci (GGS) isolates from companion animals in Japan. Strains were isolated from sterile/non-sterile specimens of 72 animals with clinical symptoms or signs in April-May, 2015. We identified them based on 16S rRNA sequencing, mass spectrometry (MS), and an automated method based on their biochemical properties. Antimicrobial susceptibility was determined with broth microdilution method and Etest. AMR determinants [erm(A), erm(B), mef(A), tet(M), tet(O), tet(K), tet(L), and tet(S)] were amplified by polymerase ...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Tsuyuki Y, Kurita G, Murata Y, Goto M, Takahashi T Tags: Jpn J Infect Dis Source Type: research

Molecular epidemiological study of mumps epidemics of 2015 in Okinawa, Japan.
Abstract In Okinawa Prefecture in Japan, although major mumps epidemics have occurred every 4-5 years, no laboratory diagnoses have been conducted. The mumps epidemic spread in Okinawa from October 2014, and we collected clinical materials from 31 mumps patients in 4 areas (Hokubu, Nanbu, Miyako and Yaeyama) from July to December 2015 for virus isolation and RT-PCR, whose positive ratios were 52% and 87%, respectively. The phylogenetic analyses showed that all isolates were classified into genotype G, most of which, except for 1, consisted of two subgenotypes, Ge (55.6%) and Gw (40.7%), which have been prominent i...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Kuba Y, Kyan H, Arakaki E, Takara T, Kato T, Okano S, Oshiro Y, Kudaka J, Kidokoro M Tags: Jpn J Infect Dis Source Type: research

Evaluation of Immunochromatography Tests and New Enzyme Immunoassay for Detection of Novel GII.17 Norovirus in Stool Samples.
In this study, the sensitivity of seven brands of immunochromatography (IC) test kits, 6 are on the market in Japan and 1 in Europe, were evaluated by testing with confirmed GII.17 NoV positive stool samples. The stool samples were also tested by bioluminescent enzyme immunoassay (BLEIA). Real-time RT-PCR was used as a gold standard method. Among seven brands IC kits, RIDA QUICK, was the most sensitive kit with the detection rate of 10(7) copies/ml while those of other IC kits ranged from 10(8)-10(9) copies/ml. Nevertheless, it should be pointed out that the detection rate of BLEIA was about 100-1,000 times (10(4)-10(5) co...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Ushijima H, Thongprachum A, Khamrin P, Takanashi S, Okitsu S, Maneekarn N, Hayakawa S Tags: Jpn J Infect Dis Source Type: research

A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox.
Abstract Monkeypox virus (MPXV) causes human monkeypox (human MPX), which is a similar disease with smallpox in humans. A previous study showed that a single vaccination of monkeys with LC16m8, a highly attenuated smallpox vaccine, protected them from MPX at 4-5 weeks after vaccination. In the present study, we evaluated the long-term efficacy of a single vaccination with LC16m8 in a nonhuman primate model of MPXV infection. The monkeys were inoculated with LC16m8, Lister (parental strain of LC16m8), or mock and then challenged with MPXV via the subcutaneous route at 6 and 12 months after vaccination, which we com...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Iizuka I, Ami Y, Suzaki Y, Nagata N, Fukushi S, Ogata M, Morikawa S, Hasegawa H, Mizuguchi M, Kurane I, Saijo M Tags: Jpn J Infect Dis Source Type: research

Genetic characterization of rare genotype GII.5 sapovirus strain detected from food-borne suspected gastroenteritis outbreak among adults in Japan, 2010.
PMID: 28003604 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Oka T, Doan YH, Haga K, Mori K, Ogawa T, Yamazaki A Tags: Jpn J Infect Dis Source Type: research

Contribution of Streptococcus gordonii Hsa adhesin to biofilm formation.
Abstract Adhesion of oral mitis group streptococci such as Streptococcus gordonii to acquired pellicle of the tooth surface is the initial step of oral biofilm formation. S. gordonii wild type strain DL1 possesses Hsa adhesin, recognizing terminal sialic acid of the host sialoglycoconjugates. The aim of the present study was to investigate the role of Hsa adhesin in biofilm formation. Biofilm-forming ability of the S. gordonii hsa mutant in microtiter plates pre-coated with saliva, fetuin and mucin was significantly reduced, compared to that of DL1. In contrast, no significant difference in biofilm-forming ability...
Source: Japanese Journal of Infectious Diseases - December 21, 2016 Category: Infectious Diseases Authors: Oguchi R, Takahashi Y, Shimazu K, Urano-Tashiro Y, Kawarai T, Konishi K, Karibe H Tags: Jpn J Infect Dis Source Type: research

Pseudomonas aeruginosa Bacteremia among Immunocompetent and Immunocompromised Patients: Relation to Initial Antibiotic Therapy and Survival.
Abstract Pseudomonas aeruginosa bacteremia occurs mainly in immunocompromised patients. However, P. aeruginosa bacteremia in immunocompetent patients has also been reported. The aim of this study was to evaluate the clinical characteristics of P. aeruginosa bacteremia in relation to the immune status of the patients. The medical records of 126 adult patients with P. aeruginosa bacteremia in Nagasaki University Hospital were retrospectively reviewed between January 2003 and December 2012. Of 126 patients with P. aeruginosa bacteremia, 60 patients (47.6%) were classified as immunocompetent. Mortality in immunocompet...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Migiyama Y, Yanagihara K, Kaku N, Harada Y, Yamada K, Nagaoka K, Morinaga Y, Akamatsu N, Matsuda J, Izumikawa K, Kohrogi H, Kohno S Tags: Jpn J Infect Dis Source Type: research

Geo-Demography of HIV/AIDS in Japan from 1985 to 2011: Incidence and Transmission Mode under Influence of Population Size/Density.
Abstract A stable relation was found between number of HIV/AIDS patients (P) and population size (N) and between HIV/AIDS incidence (I) and population density (D). The relation could be expressed as P = kN(m) or I = hD(n), where k, h, m, and n are constants. For "AIDS"/"AIDS diagnosis", the constant m was 1.5 for Japan and 1.3 for the United States of America (USA); n was 0.38 for both Japan and the USA. These observations indicated that larger population sizes related to disproportionately larger numbers of HIV/AIDS patients, and denser populations had disproportionately higher incidences of H...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Sporogonic Cycles Calculated Using Degree-Days, as a Basis for Comparison of Malaria Parasite Development in Different Eco-Epidemiological Settings in India.
Abstract In India, malaria transmission is prevalent across diverse geologies and ecologies. Temperature is one of the key determinants of malarial transmission, causing low endemicity in some areas than in others. Using a degree-day model, we estimated the maximum and minimum possible number of days needed to complete a malarial sporogonic cycle (SC), in addition to the possible number of SCs for Plasmodium vivax and Plasmodium falciparum under two different ecological settings with either low or high endemicity for malaria at different elevations. In Raikhalkhatta (in the Himalayan foothills) SCs were modeled as...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Singh P, Dhiman RC Tags: Jpn J Infect Dis Source Type: research

Field and Laboratory Evaluations of the Efficacy of DEET Repellent against Ixodes Ticks.
The objective of this study was to clarify the efficacy of a currently available N,N-diethyl-m-toluamide (DEET) repellent against tick species in Japan. We performed 2 different field trials: "human trap," and "flag-dragging." In total, 482 ticks were collected from white flannel cloths in the field studies. The collected tick species were Ixodes persulcatus and I. ovatus, which accounted for 5.3% and 94.7% of the ticks in the human trap test and 31.4% and 68.6% in the flag-dragging test, respectively. The repellency levels of DEET-treated flannel cloths in the human trap and flag-dragging tests were 84...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Ogawa K, Komagata O, Hayashi T, Itokawa K, Morikawa S, Sawabe K, Tomita T Tags: Jpn J Infect Dis Source Type: research

A Epidemiological Investigation of a Nosocomial Outbreak of Multidrug-Resistant Acinetobacter baumannii in a Critical Care Center in Japan, 2011-2012.
Abstract In 2011, a multidrug-resistant Acinetobacter baumannii (MDRAB) outbreak occurred at a Japanese critical care center (CCC) in a tertiary care hospital. Multidrug-resistance in Japan is defined as resistance to the antimicrobials amikacin, carbapenem, and fluoroquinolone. We conducted a retrospective epidemiological investigation of this outbreak to identify the risk factors for MDRAB respiratory tract acquisition in this hospital. Cases were defined as hospitalized patients with MDRAB-positive cultures at least 3 days post admission to the CCC between June 1, 2011 and April 20, 2012. Fifteen MDRAB cases we...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Ushizawa H, Yahata Y, Endo T, Iwashima T, Misawa M, Sonobe M, Yamagishi T, Kamiya H, Nakashima K, Matsui T, Matsui M, Suzuki S, Shibayama K, Doi M, Irie F, Yamato S, Otomo Y, Oishi K Tags: Jpn J Infect Dis Source Type: research

Risk Factors for Colistin-Associated Acute Kidney Injury: A Multicenter Study from Turkey.
Abstract The aim of this study was to investigate the incidence of acute kidney injury (AKI) and risk factors due to colistin use in patients infected with multidrug-resistant pathogens. This multicenter, retrospective, observational study was conducted in Turkey, at 5 different research and university hospitals. Cox regression analyses were performed, to determine independent predictors of AKI. From April 2012 to July 2014, a total of 216 patients aged between 18-94 years, treated with colistimethate sodium (CMS) were included in the study. The mean age of the patients was 60.3 ± 20.1 years. The overall in...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Gul S, Kuscu F, Aydemir H, Ozturk DB, Deveci O, Duygu F, Kacmaz B, Yaman F, Aslan E Tags: Jpn J Infect Dis Source Type: research

In Vivo Efficacy of Drugs against Toxoplasma gondii Combined with Immunomodulators.
k M Abstract The aim of this study is to evaluate the effects of pyrimethamine (PYR) and sulfadiazine (SDZ) combined with levamisole and echinacea on the survival of mice infected with Toxoplasma gondii. For this, we used 99 specific pathogen-free BALB/c mice. All the mice were infected intraperitoneally with 10(5) T. gondii tachyzoites and were divided into 11 groups, each including 9 mice. Except for the control group, oral treatment was initiated in all groups 24 h post infection and was continued for 10 days. The treatment regimen included dual combinations of PYR (dose, 6.25 and 12.5 mg/kg/day) and SDZ (dose,...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Köksal ZŞ, Yanik K, Bilgin K, Yılmaz EM, Hokelek M Tags: Jpn J Infect Dis Source Type: research

Pathophysiological Implication of Computed Tomography Images of Chronic Pulmonary Aspergillosis.
Abstract Chronic pulmonary aspergillosis (CPA) is a refractory disorder that needs long-term antifungal treatment and occasionally results in fatal respiratory failure and hemoptysis. However, the pathological features of the disorder have not been thoroughly delineated. Thirty cases were therefore analyzed clinically and histologically to elucidate the pathophysiology of CPA. The subjects comprised 14 individuals who underwent surgical removal and 16 patients who died. No subject exhibited a severely immunocompromised state. The main symptoms included cough, hemosputum, and dyspnea. Chest computed tomography (CT)...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Ando T, Tochigi N, Gocho K, Moriya A, Ikushima S, Kumasaka T, Takemura T, Shibuya K Tags: Jpn J Infect Dis Source Type: research

Chikungunya Fever in Japan Imported from the Caribbean Islands.
Abstract A 53-year-old Japanese woman who was working as a volunteer in the Commonwealth of Dominica in the Caribbean islands presented with a high-grade fever and severe incapacitating generalized arthralgia. The Asian genotype of the chikungunya virus was confirmed using reverse transcription-PCR and serology, based on the presence of a specific neutralization titer and immunoglobulin M antibodies. She was diagnosed with post-chikungunya chronic arthritis based on persistence of her polyarthritis for 3 months and the presence of rheumatoid factor, immunoglobulin G-rheumatoid factor, and matrix metalloproteinase-...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Imai K, Nakayama E, Maeda T, Mikita K, Kobayashi Y, Mitarai A, Honma Y, Miyake S, Kaku K, Miyahira Y, Kawana A Tags: Jpn J Infect Dis Source Type: research

Clonal Spread of Enterotoxigenic Escherichia coli O128:H45 Strain in the Neonate Unit.
Abstract Enterotoxigenic Escherichia coli (ETEC) has the potential to cause nosocomial infantile diarrhea in a hospital setting. We detected 12 ETEC serotype O128:H45 isolates from diarrheal neonates in our neonatal unit from July through October 2012. These infants developed hospital-acquired and epidemiologically related diarrhea. Pulsed-field gel electrophoresis analysis and multilocus sequence typing of these 12 isolates suggested that a specific clone of ETEC serotype O128:H45-CS21-ST2332 caused nosocomial diarrhea among neonates. Of concern, this ETEC clone strain was resistant to multiple drugs, particularl...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Zeng M, Shi W, Chang H, Wang A, He L, Fu P, Xu X, Wang C Tags: Jpn J Infect Dis Source Type: research

Nontuberculous Mycobacterial Osteomyelitis in Human Immunodeficiency Virus-Negative Patients: A Case Series.
Abstract Nontuberculous mycobacterial bone infections among human immunodeficiency virus (HIV)-negative patients are rare, although a few studies have described such infections. We retrospectively reviewed the medical and microbiological data of HIV-negative osteomyelitis cases caused by nontuberculous mycobacteria treated in our tertiary-care hospital over 14 years from January 1, 2000, to December 31, 2013. Three HIV-negative patients had contracted bone infections due to nontuberculous mycobacteria. All of the patients had at least 1 predisposing condition that led to the infections: idiopathic CD4-positive lym...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Kobayashi T, Morino E, Takasaki J, Nagahara Y, Sugiyama H Tags: Jpn J Infect Dis Source Type: research

Pentagalloylglucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection.
In this study, we found that PGG treatment delays the nuclear transport process of HSV-1 particles by inhibiting the upregulation of dynein (a cellular major motor protein) induced by HSV-1 infection. Furthermore, PGG treatment affects the nucleocapsid egress of HSV-1 by inhibiting the expression and disrupting the cellular localization of pEGFP-UL31 and pEGFP-UL34, which are indispensable for HSV-1 nucleocapsid egress from the nucleus. However, the over-expression of pEGFP-UL31 and pEGFP-UL34 could decrease the antiviral effect of PGG. In this study, for the first time, the antiviral activity of PGG against acyclovir-resi...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Jin F, Ma K, Chen M, Zou M, Wu Y, Li F, Wang Y Tags: Jpn J Infect Dis Source Type: research

Increase in Primary and Secondary Syphilis Notifications in Men in Tokyo, 2007-2013.
Abstract The number of notified syphilis cases in Tokyo has more than doubled in recent years. The number of reported primary and secondary syphilis cases increased from 108 cases (0.8 per 100,000 population) in 2007 to 245 cases in 2013 (1.9 per 100,000 population). During this period, the majority of cases was male (905/1,024), and the recent increase among primary and secondary syphilis cases was attributed to the increase among males (90/108 [83%] cases in 2007 to 218/245 [89%] cases in 2013); men aged 20-49 years contributed most to the increase, with those aged 30-34 years having the highest notification rat...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Sugishita Y, Yamagishi T, Arima Y, Hori N, Seki N Tags: Jpn J Infect Dis Source Type: research

Molecular Characterization of Imipenem-Resistant, Meropenem-Susceptible Pseudomonas aeruginosa with blaVIM ₋₂ Phenotype: Potential for Dissemination.
Molecular Characterization of Imipenem-Resistant, Meropenem-Susceptible Pseudomonas aeruginosa with blaVIM₋₂ Phenotype: Potential for Dissemination. Jpn J Infect Dis. 2016;69(2):159-60 Authors: Pragasam AK, Raghanivedha M, Anandan S, Veeraraghavan B PMID: 26567829 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Pragasam AK, Raghanivedha M, Anandan S, Veeraraghavan B Tags: Jpn J Infect Dis Source Type: research

Distribution of Chlamydia trachomatis Infection Determined by Nucleic Acid Amplification Tests in Pregnant Women in Japan.
PMID: 26743152 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Suzuki S, Tanaka M, Sekizawa A, Kinoshita K Tags: Jpn J Infect Dis Source Type: research

Molecular Epidemiology of Monophasic Salmonella enterica serovar O7: -: 1, 5 Isolates in Akita Prefecture, Japan.
PMID: 26743153 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Konno T, Takahashi S, Kumagai Y Tags: Jpn J Infect Dis Source Type: research

The characteristics of extended-spectrum β-lactamases-producing Escherichia coli in hospital faecal carriage in Beijing Tongren Hospital.
The characteristics of extended-spectrum β-lactamases-producing Escherichia coli in hospital faecal carriage in Beijing Tongren Hospital. Jpn J Infect Dis. 2016 Oct 31; Authors: Xu M, Fan Y, Wang M, Lu X Abstract We aimed to investigate the prevalence of extended-spectrum β-lactamases (ESBL)-producing Escherichia coli (E. coli) in Beijing Tongren hospital and find the relationship between colonization and infection. The clinical data of 650 inpatients included between March 2012 and July 2012 were retrospectively reviewed. The prevalence of ESBL-producing E. coli among inpatients was 25.7% (...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Xu M, Fan Y, Wang M, Lu X Tags: Jpn J Infect Dis Source Type: research

Bloodstream infection due to CTX-M-15 and TEM-1 extended spectrum β-lactamase-producing Salmonella enterica serovar Virchow ST16.
Bloodstream infection due to CTX-M-15 and TEM-1 extended spectrum β-lactamase-producing Salmonella enterica serovar Virchow ST16. Jpn J Infect Dis. 2016 Oct 31; Authors: Hwang JH, Shin GW, Hwang JH, Lee CS Abstract A 57-year-old man presented with a high fever and diarrhea. A blood culture showed the presence of a Group C nontyphoidal Salmonella isolate. On Salmonella serotyping, the isolate was Salmonella enterica serovar Virchow. Its sequence type was determined to be ST16 by sequence analysis of seven different housekeeping genes. The blaCTX-M group 1 and blaTEM genes were amplified by multipl...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Hwang JH, Shin GW, Hwang JH, Lee CS Tags: Jpn J Infect Dis Source Type: research

Prevalence and determinants of HSV-2/syphilis co-infection and HSV-2 mono-infection among HIV-positive men who have sex with men: a cross-sectional study in Northeast China.
Abstract We aimed to assess the prevalence and determinants of herpes simplex virus type 2 (HSV-2) mono-infection and HSV-2/syphilis co-infection in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in China. A cross-sectional study was conducted on 545 HIV-positive MSM in Shenyang between February 2009 and October 2014. Participants received physical examinations and serological tests for HSV-2 and syphilis. A multinomial logistic regression was used to identify risk factors associated with HSV-2/syphilis co-infection and HSV-2 mono-infection. The HSV-2 mono-infection, syphilis mono-infe...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Hu QH, Xu JJ, Chu ZX, Zhang J, Yu YQ, Yu H, Ding HB, Jiang YJ, Geng WQ, Wang N, Shang H Tags: Jpn J Infect Dis Source Type: research

Impaired thiol-disulphide balance in acute brucellosis.
The objective of this study was to examine a novel profile: thiol-disulphide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulphide profile tests were analysed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 ± 48.20 µmol/L in the acute brucellosis group and 461.13 ± 45.37 µmol/L in the healthy group, and total thiol levels were 298.58 ± 51.78 µmol/L in the acute brucellosis group and 504.83 ± 51.05 µmol/L in the healthy group (p
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Kolgelier S, Ergin M, Demir LS, Inkaya AC, Demir NA, Alisik M, Erel O Tags: Jpn J Infect Dis Source Type: research

Predictors of Hospitalization and Admission to Intensive Care Units of Influenza Patients in Serbia through Four Influenza Seasons from 2010/2011 to 2013/2014.
jićić SŠ Abstract Retrospective analysis of the surveillance of laboratory confirmed cases of influenza in four post pandemic seasons in Serbia, was performed to evaluate predictors of hospitalization and admission to intensive care units (ICU). The specimens, which combined nasal and throat swabs were tested for influenza. For statistical analysis univariate and multivariate logistic regression analyses were used. 777 confirmed influenza cases were analyzed. Age over 65 years, the presence of any co-morbidity or the presence of two or more comorbidities, infection with influenza A(H1)pdm09 and the interv...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Dimitrijević D, Ilić D, Adrović SR, Šuljagić V, Pelemiš M, Stevanović G, Milinković M, Grujićić SŠ Tags: Jpn J Infect Dis Source Type: research

Difference of the change of the hospitalization for pneumonia in children between Japanese secondary and tertiary medical facilities after the introduction of pneumococcal conjugate vaccine.
Abstract The aim of this study is to compare pneumonia hospitalization in children between secondary and tertiary medical facilities, hospitalizing many children without and with underlying diseases, respectively, after the introduction of pneumococcal conjugate vaccine (PCV). Our retrospective study was performed on the children who were admitted to the Department of Pediatrics at Kitakyushu General Hospital, a secondary medical facility, and at Hospital of the University of Occupational and Environment Health, Japan, a tertiary medical facility, from 2009 to 2013 for pneumonia. The variation of hospitalization r...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Haro K, Ogawa M, Hoshina T, Kojiro M, Kusuhara K Tags: Jpn J Infect Dis Source Type: research

Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution.
Abstract Population size dependency of measles, syphilis and amebiasis was expressed as P = kN(m), where P, N and m were respectively number of patients, population size and a constant (~2 for measles and 1.3~1.4 for syphilis and amebiases). The population size dependency emerged only when conditions other than the population size, such as, infant mortality, hygienic condition, vaccination practices, etc., were improved to the same level in all the prefectures in Japan. Formation of prefectures and municipalities was well simulated by the random coin toss assuming that people are attracted to a community with a pr...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Yoshikura H, Takeuchi F Tags: Jpn J Infect Dis Source Type: research

Dengue-associated acute encephalitis syndrome cases in Son La Province, Vietnam in 2014.
The objectives of this paper were to determine the proportion of encephalitic patients due to JEV during the 2014 outbreak in Son La Province in Vietnam and to find the association of DENV in non-JEV viral encephalitis cases. Out of 90 patients, 6 (6.7%) were positive for anti-JEV IgM, 5 (5.6%) were positive for anti-DENV IgM, 30 (33.3%) were positive for both anti-JEV and anti-DENV IgM and 56 (62.2%) were positive for flavi IgG. Five AES patients positive with anti-DENV IgM in at least one of paired serum samples were confirmed to have DENV by neutralization tests. The incidence of JEV infection rate was high. There is st...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Ngwe Tun MM, Muthugala RV, Thuy NT, Ly PH, Thu LT, Dinh DT, Hoang NV, Mai LT, Moi ML, Buerano CC, Morita K, Hasebe F Tags: Jpn J Infect Dis Source Type: research

An ecological survey of mosquitoes and the distribution of Japanese encephalitis virus in Ishikawa Prefecture, Japan between 2010 and 2014.
We report the seasonal dynamics of mosquitoes between 2010 and 2014 in Ishikawa Prefecture, Japan. We collected 39,308 female adult mosquitoes, 98.2% of which were classified as Culex tritaeniorhynchus Giles. We identified JEV genomic RNA belonging to genotype 1 among the homogenate of Cx. tritaeniorhynchus collected during our study using reverse transcription-polymerase chain reaction and nucleotide sequencing methods. Our results indicated that mosquito vectors for JEV are distributed not only in areas in Ishikawa but also throughout Japan and suggest that we must be careful regarding JEV outbreaks in Japan in the futur...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Murakami M, Hori K, Kitagawa Y, Oikawa Y, Kamimura K, Takagemi T Tags: Jpn J Infect Dis Source Type: research

Detection of antibodies to Borna disease virus proteins in an autistic child and her mother.
PMID: 27795475 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, Tomonaga K Tags: Jpn J Infect Dis Source Type: research

A decennium of etiology and antimicrobial susceptibility patterns in patients with infective endocarditis at a university hospital, Thailand.
In conclusion, Group B streptococcus isolates increased in patients with infective endocarditis in Thailand. Streptococcus suis had the highest MIC90 and penicillin-nonsusceptible isolates. Rigorously restrict using of antimicrobial agents in animal feeds should more concern. PMID: 27795476 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Nakaranurack C, Puttilerpong C, Suwanpimolkul G Tags: Jpn J Infect Dis Source Type: research

First human case of Rickettsia sibirica mongolotimonae infection in Northern Greece in a teenager from Thrace.
We describe herein a male adolescent from Thrace, Northern Greece with clinical and serological evidence of infection due to this rickettsia species, who recovered uneventfully with appropriate therapy. The patient got infected in the island of Samothraki, the most northern island of the Aegean Sea, during a recent trip. Although R. sibirica mongolitimonae was neither cultivated nor was a PCR performed in a cutaneous specimen from the inoculation eschar, serological testing along with the typical clinical picture makes the diagnosis highly probable. Rickettsia sibirica mongolitimonae appears to be an emerging pathogen in b...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Chochlakis D, Mantadakis E, Thomaidis S, Tselentis Y, Chatzimichael A, Psaroulaki A Tags: Jpn J Infect Dis Source Type: research

High rates of contamination of poultry meat products with drug resistant Campylobacter in Metro Manila, Philippines.
Abstract A total of 265 chicken parts were collected from 15 wet markets and 15 supermarkets in Metro Manila, Philippines. Campylobacter spp. was isolated on modified charcoal cefoperazone deoxycholate agar plates and identified through biochemical tests and PCR amplification of genus and species specific genes. Antimicrobial resistance profiles were determined following Clinical and Laboratory Standards Institute protocols. Two hundred seven (78%) Campylobacter spp. were isolated. C. jejuni and C. coli were detected from 170 (64%) and 32 (12%) of the samples, respectively. Liver and skin samples had the greatest ...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Lim PW, Tiam-Lee DC, Paclibare PA, Subejano MS, Cabero-Palma JA, Penuliar GM Tags: Jpn J Infect Dis Source Type: research

Orbital Cellulitis with Endogenous Panophthalmitis caused by Methicillin-Sensitive Staphylococcus aureus in pregnancy.
Abstract Orbital cellulitis along with panophthalmitis is uncommon. The causes are usually trauma-related or endogenous. The prognosis in terms of globe salvage is very poor with most cases usually requiring enucleation or evisceration of the affected eye. Immunosuppression in some form is usually present, which accounts for the aggressive course of the infection. In this communication, we report a case of a 25-year-old female, in the second trimester of pregnancy, who developed orbital cellulitis and panophthalmitis caused by Methicillin sensitive Staphylococcus aureus (MSSA); with the primary source of infection...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Aulakh S, Nair AG, Gandhi R, Palkar AH, Trivedi MG, Potdar NA, Shinde CA Tags: Jpn J Infect Dis Source Type: research

Poliovirus study in the endgame of the polio eradication program.
Abstract Since the start of Global Polio Eradication Initiative in 1988, poliomyelitis cases caused by wild poliovirus (PV) were drastically reduced to only 74 cases in 2 endemic countries in 2015. With established vaccine campaign, current limited PV transmission suggested the endgame of the polio eradication program. In the endgame, we have emerging challenges specific to the endgame; tight budget, switching of the vaccines, and changes in the biorisk management. To overcome these challenges, several projects of PV study attract attention in the eradication program. Some of these emerging challenges/projects of ...
Source: Japanese Journal of Infectious Diseases - October 30, 2016 Category: Infectious Diseases Authors: Arita M Tags: Jpn J Infect Dis Source Type: research

Biting Density and Distribution of Aedes albopictus during the September 2014 Outbreak of Dengue Fever in Yoyogi Park and the Vicinity of Tokyo Metropolis, Japan.
This study aimed to collect referential data to estimate the transmission threshold of dengue virus in terms of biting density of Ae. albopictus and determined high transmission risk areas of dengue virus in Yoyogi Park and its vicinity. The overall mean density of biting Ae. albopictus (7.13/man/8 min) was sufficiently high for successful transmission of dengue virus, and areas with biting densities higher than the overall mean density were classified as high risk areas for the transmission of dengue virus in Yoyogi Park. PMID: 25766613 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Tsuda Y, Maekawa Y, Ogawa K, Itokawa K, Komagata O, Sasaki T, Isawa H, Tomita T, Sawabe K Tags: Jpn J Infect Dis Source Type: research

Evaluation of Non-Viral Surrogate Markers as Predictive Indicators for Monitoring Progression of Human Immunodeficiency Virus Infection: An Eight-Year Analysis in a Regional Center.
Abstract Suitable methods for clinical monitoring of HIV-infected patients are crucial in resource-poor settings. Demographic data, clinical staging, and laboratory findings for 112 asymptomatic subjects positive for HIV were assessed at the first admission and the last visit from 2002 to 2010. Cox regression analysis showed hemoglobin (Hb) (HR = 0.643, P = 0.021) to be a predictive indicator for disease progression, while CD4, CD8, and platelet counts showed low HRs, despite having significant probability values. Hb and total lymphocyte count (TLC) rapidly declined from stage II to III (10.9 and 29.6%, respective...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Rafatpanah H, Essmailian L, Hedayati-Moghaddam MR, Vakili R, Norouzi M, Sarvghad MR, Hosseinpour AM, Sharebiani H, Rezaee SA Tags: Jpn J Infect Dis Source Type: research

Raltegravir and Abacavir/Lamivudine in Japanese Treatment-Na ïve and Treatment-Experienced Patients with HIV Infection: a 48-Week Retrospective Pilot Analysis.
Raltegravir and Abacavir/Lamivudine in Japanese Treatment-Naïve and Treatment-Experienced Patients with HIV Infection: a 48-Week Retrospective Pilot Analysis. Jpn J Infect Dis. 2016;69(1):33-8 Authors: Suzuki A, Uehara Y, Saita M, Inui A, Isonuma H, Naito T Abstract Abacavir/lamivudine (ABC/3TC) is a nucleoside reverse transcriptase inhibitor used for treating human immunodeficiency viral (HIV) infections. Hypersensitivity reactions such as skin eruptions caused by ABC are well-known, but rarely occur in Asians. Raltegravir (RAL) is an integrase strand transfer inhibitor, that is now increasingly...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Suzuki A, Uehara Y, Saita M, Inui A, Isonuma H, Naito T Tags: Jpn J Infect Dis Source Type: research

What We Have Learned from the Influenza A pH1N1 2009/10 Pandemic: High Clinical Impact of Human Metapneumovirus and Respiratory Syncytial Virus in Hospitalized Pediatric Patients.
Abstract The influenza pandemic in 2009/2010 shifted public awareness to respiratory tract infections caused by the influenza virus. A prospective study was conducted during the influenza pandemic from November 2009 through April 2010 to determine the causative pathogens and clinical symptoms present in all children and adolescents admitted to the University Children's Hospital, Duesseldorf, Germany, with signs and symptoms of respiratory tract infection. A total of 272 children and adolescents were admitted with symptoms of acute respiratory tract infection (ARI) or influenza-like illness. Viral pathogens were de...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Vogel M, Grund S, Pandey S, Mayatepek E, Schroten H, Tenenbaum T, Adams O Tags: Jpn J Infect Dis Source Type: research

The Economic Burden of Hepatitis A, B, and C in South Korea.
This study was performed in order to estimate the individual economic costs of the hepatitis A, B, and C viruses as well as to determine, using nationally representative data, the trends in South Korea with respect to these viruses during the 2008-2011 period. The study found that the prevalence of hepatitis A had decreased, but those of hepatitis B and C had increased overall. The mortality rate of hepatitis C was higher than that of the other two types. The mortality rate of hepatitis B had changed little, whereas that of hepatitis C had risen. The total cost of hepatitis A had decreased, from US $62.2 million to US $45....
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Shon C, Choi HY, Shim JJ, Park SY, Lee KS, Yoon SJ, Oh IH Tags: Jpn J Infect Dis Source Type: research

The First Report of Vibrio parahaemolyticus Strain O10:K60 in Japan, a New Combination of O and K Serotypes Isolated from a Patient with Gastroenteritis.
In this study, we examined V. parahaemolyticus isolated from a gastroenteritis patient's stool at a hospital in Saitama City, Japan in 2013. Serotyping of the O and K antigens identified the strain as O10:K60. To our knowledge, this is the first reported case of a V. parahaemolyticus strain with this antigen combination in Japan. Subsequently, we used PCR to assay for pathogenicity-associated genes, and found that it was positive for tdh, T3SS1, and T3SS2α genes. Antibiotic susceptibility tests showed that the strain was susceptible to all selected antibiotics except ampicillin. Moreover, we detected specific marker ...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Ueno H, Tomari K, Kikuchi K, Kobori S, Miyazaki M Tags: Jpn J Infect Dis Source Type: research