Four sporadic pediatric cases of Yersinia enterocolitica O:8 infection in rural area of Japan.
Abstract In the spring of 2015, we experienced a cluster of four sporadic Yersiniosis of children in Nagano prefecture, rural area of Japan. Two patients had developed appendicitis-like episodes, one had acute gastroenteritis, and the other one had bacteremia associated with liver abscess. Causative agent of these infections was Yersinia enterocolitica serogroup O:8. None of the patients had underlying illness, and all had recovered completely. The patients had no relationship between each other, neither socially nor geographically. These four consecutive cases suggest that Y. enterocolitica O:8 had spread substan...
Source: Japanese Journal of Infectious Diseases - May 9, 2016 Category: Infectious Diseases Authors: Minami K, Yasuda R, Terakawa R, Koike Y, Takeuchi K, Higuchi T, Horiuchi A, Kubota N, Hidaka E, Kawakami Y Tags: Jpn J Infect Dis Source Type: research

High prevalence of diarrheagenic Escherichia coli among children with diarrhea in Kenya.
Abstract Diarrheagenic Escherichia coli (DEC) is an important agent of endemic and epidemic diarrhea worldwide, particularly in developing countries. DEC cannot be differentiated from the commensal E. coli on selective media with few exceptions. Most studies based on colony isolation method, which cannot detect presence of low numbers of DEC, might underestimate the incidence of DEC. In the present study, we employed colony sweep method with real-time PCR targeting virulence genes of 5 categories of DEC, which can detect very low numbers of DEC among hundreds of commensal E. coli. DEC was detected in 171 (55.9%) o...
Source: Japanese Journal of Infectious Diseases - May 9, 2016 Category: Infectious Diseases Authors: Iijima Y, Oundo JO, Hibino T, Saidi SM, Hinenoya A, Osawa K, Shirakawa T, Osawa R, Yamasaki S Tags: Jpn J Infect Dis Source Type: research

Whole genome sequencing-based molecular epidemiologic analysis of autochthonous dengue virus type 1 strains circulating in Japan in 2014.
Abstract Cases of autochthonous dengue virus type 1 (DENV-1) infections were detected in Japan following a 70-year period devoid of dengue outbreaks. We have previously shown that E gene sequences are identical in 11 of 12 DENV-1 strains autochthonous to Japan. However, the E sequence represents only 14% of the genome. In the present study, we sequenced the entire genome of 6 autochthonous DENV-1 strains isolated from patients during the 2014 outbreak. Sequencing of 5 Yoyogi group strains with identical E sequences and 1 Shizuoka strain with a different E sequence revealed that the first Yoyogi group strain identi...
Source: Japanese Journal of Infectious Diseases - May 9, 2016 Category: Infectious Diseases Authors: Tajima S, Nakayama E, Kotaki A, Moi ML, Ikeda M, Yagasaki K, Saito Y, Shibasaki KI, Saijo M, Takasaki T Tags: Jpn J Infect Dis Source Type: research

Detection and molecular typing of human adenovirus associated with respiratory illness in Kerala.
Abstract Adenoviruses are responsible for approximately 5-10% of acute respiratory infections globally. However, there are limited reports on circulating respiratory human adenovirus (HAdV) types in India. We detected HAdV in the post mortem specimens of a young child died due to acute febrile illness. In order to know the circulating adenovirus types in the Alappuzha region, retrospectively, the samples (n=235) collected from influenza-like illness patients for influenza surveillance program were screened for HAdV. Fourteen samples were positive for adenovirus by PCR. Adenovirus was isolated from three out of fou...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Thounaojam AD, Balakrishnan A, Mun AB Tags: Jpn J Infect Dis Source Type: research

Ureaplasma urealyticum: thepresence among sexually transmitted diseases.
UREAPLASMA UREALYTICUM: THEPRESENCE AMONG SEXUALLY TRANSMITTED DISEASES. Jpn J Infect Dis. 2016 Mar 18; Authors: Esen B, Gozalan A, Sevindi DF, Demirbas A, Onde U, Erkayıran U, Karakoc AE, Hasçiçek AM, Ergün Y, Adiloglu AK Abstract The study was aimed to detect Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Ureaplasma urealyticum, Mycoplasma hominis, and Trichomonas vaginalis in genital samples of symptomatic patients and to remark the presence of U.urealyticum infections in lower genital tract. Cervical and urethral samples from 96 patients (46 males, 50 fema...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Esen B, Gozalan A, Sevindi DF, Demirbas A, Onde U, Erkayıran U, Karakoc AE, Hasçiçek AM, Ergün Y, Adiloglu AK Tags: Jpn J Infect Dis Source Type: research

High Rates of Hepatitis B, Hepatitis C and Human Immunodeficiency Virus (HBV, HCV, HIV) Infections and Their Uncommon HBV Genotype/Subtype and HCV Subtype Distributions among Transgender Individuals in Surabaya, Indonesia.
Abstract Transgender people are at high risk of sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover, Indonesia has a moderate to high rate of HBV infection and a rapid epidemic growth of HIV. Because hepatitis C virus (HCV) can co-occur with HBV and HIV, it was also evaluated in this study. Ten of 107 individuals (9.3%) were Hepatitis B surface antigen (HBsAg) positive and/or HBV DNA positive, whereas nineteen of 101 individuals (18.8%) with negative HBsAg were Hepatitis B core antibody (anti-HBc)-positive. Seven of 107 individuals (6.5%) were anti-HCV posi...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Hadikusumo AA, Utsumi T, Amin M, Khairunisa SQ, Istimagfirah A, Wahyuni RM, Lusida MI, Soetjipto, Rianto E, Juniastuti, Hayashi Y Tags: Jpn J Infect Dis Source Type: research

Presepsin levels of patients with crimean-congo hemorrhagic fever.
PRESEPSIN LEVELS OF PATIENTS WITH CRIMEAN-CONGO HEMORRHAGIC FEVER. Jpn J Infect Dis. 2016 Mar 18; Authors: Demirpençe Ö, Doğan HO, Erşan S, Şahin M, Şahin H, Bakır M Abstract The presepsin level (a soluble CD14 subtype) is thought to increase in cases of bacterial infection. It has been stated that CD 14 also plays a role in the pathogenesis of various viral diseases. Crimean-Congo Hemorrhagic Fever (CCHF) is an arboviral zoonotic infection. Our study focuses on the presepsin level as a biomarker for CCHF. Serum presepsin levels in CCHF group (n=59) and control (n=28) have been compar...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Demirpençe Ö, Doğan HO, Erşan S, Şahin M, Şahin H, Bakır M Tags: Jpn J Infect Dis Source Type: research

Effects of 1,25-dihydroxyvitamin D3 on Macrophage Cytokine Secretion Stimulated by Porphyromonas gingivalis.
Abstract Vitamin D has been known to be closely associated with periodontitis while the exact mechanisms remain to be clarified. The present study aimed to investigate the influence of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on porphyromonas gingivalis (Pg)-stimulated cytokine production by macrophages and the involved signaling pathways. The main observation was that 1,25(OH)2D3 inhibited Pg-induced IL-6 cytokine expression while improved the expression of anti-inflammatory cytokine IL-10. Further analyses showed that 1,25(OH)2D3 decreased the p38 MAPK and ERK1/2 phosphorylation. Inhibited phosphorylation of p38 M...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Xu QA, Li ZF, Zhang P, Cao LH, Fan MW Tags: Jpn J Infect Dis Source Type: research

Monthly Distribution of Norovirus and Sapovirus in Viral Gastroenteritis in Thailand.
Abstract A total of 1,141 rotavirus-negative stool specimens collected from diarrheic children in four distinct regions under sentinel surveillance in Thailand between 2006 and 2008 were examined by RT-PCR for norovirus (NoV) and sapovirus (SaV). Three hundred three specimens (26.6%) were positive for NoV, and 34 and 269 NoVs belonged to genogroup I (GI) and genogroup II (GII), respectively. Twelve specimens (1.1%) were positive for SaV. Mixed infections were found in 5 specimens; 3 contained both NoV GI and GII, and 2 both NoV GII and SaV. Regarding the monthly distribution of NoV and SaV, NoV GII was clustered b...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Pongsuwanna Y, Tacharoenmuang R, Prapanpoj M, Sakon N, Komoto S, Guntapong R, Taniguchi K Tags: Jpn J Infect Dis Source Type: research

Saffold cardiovirus infection in a 2-year-old boy with acute pancreatitis.
This report presents a unique case which developed a relapsing acute pancreatitis (AP) after hand, foot and mouth disease and suspected of SAFV-1 infection. A 2-year-old boy was admitted to the hospital because of severe abdominal pain. His serum amylase and lipase levels were elevated. Enhanced computed tomography showed pancreatic swelling and dilation of main pancreatic duct, leading to the diagnosis of severe AP. The viral genome of SAFV-1 was detected by RT-PCR from fecal samples. Furthermore, serum neutralization titer against SAFV was elevated during the AP and decreased after 1 year. These findings strongly suggest...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Ito H, Miyagaki S, Sakaue S, Matsui F, Katsumi Y, Otabe O, Torii J, Itagaki T, Himeda T, Okuwa T, Ohara Y Tags: Jpn J Infect Dis Source Type: research

Dengue virus type 1 strain isolated in Indonesia shows a close phylogenetic relationship with the strains that caused the autochthonous dengue outbreak in Japan in 2014.
PMID: 27000455 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Churrotin S, Kotaki T, Sucipto TH, Ahwanah NL, Deka PT, Mulyatno KC, Utami DA, Ranasasmita R, Soegijanto S, Kameoka M Tags: Jpn J Infect Dis Source Type: research

Genetic diversity in Streptococcus dysgalactiae subsp. equisimilis isolates from patients with invasive and noninvasive infections in a Japanese university hospital (2014-2015).
Abstract Streptococcus dysgalactiae subsp. equisimilis (SDSE) isolates with β-hemolysis and carbohydrate groups G/C are recovered increasingly from invasive infections in Japan. The aim of this study was to determine epidemiological characteristics of SDSE isolates circulating locally among patients with invasive and noninvasive infections. We selected groups G/C β-hemolytic streptococci from a database at the Clinical Laboratory of Kitasato University Medical Center from May 2014 through April 2015. Thirteen isolates were identified as SDSE based on the data from API-20 Strep and 16S rRNA sequencing. Th...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Fujita T, Horiuchi A, Ogawa M, Yoshida H, Hirose Y, Nagano N, Takahashi T Tags: Jpn J Infect Dis Source Type: research

Assessment of Accuracy of LAMP-TB Method for Diagnosing Tuberculosis in Haiti.
Abstract The procedure for ultra-rapid extraction (PURE) and loop-mediated isothermal amplification for tuberculosis (LAMP-TB) is a simple and rapid manual tuberculosis diagnostic with medium-throughput capability. Because of its simplicity, this method could be useful under resource-limited conditions such as microscopy centers in developing countries. The study was conducted to evaluate the clinical performance of this method in point of care setting. The performance was compared with those of smear microscopy and a liquid culture, in a hospital laboratory in Haiti, which is considered to be a representative fac...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Kaku T, Minamoto F, D'Meza R, Morose W, Boncy J, Bijou J, Geffrard H, Yoshida M, Mori T Tags: Jpn J Infect Dis Source Type: research

Epidemiological Characteristics of Sapovirus and Human Astrovirus Detected among Children in the Nara Prefecture, Japan, during 2009/2010-2014/2015 Seasons.
This report provides an epidemiological overview of SaV and HAstV infection in the Nara Prefecture, Japan. PMID: 27000458 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Yoneda M, Nakano M, Sugimoto D, Inada M, Fujitani M, Kitahori Y Tags: Jpn J Infect Dis Source Type: research

No susceptibility of neonatal and adult rats against the Middle East respiratory syndrome coronavirus.
Abstract The present study examined the susceptibility of rats to Middle East respiratory syndrome coronavirus (MERS-CoV) and determined whether this animal is a suitable model for MERS-CoV infection. Immunohistochemical analysis identified dipeptidyl peptidase 4 (DPP4), a known receptor for MERS-CoV, on type I pneumocytes from infected rats. While adult rats developed antibodies against MERS-CoV spike protein after intranasal inoculation, there was no evidence of virus replication in the lungs of adult, young, or neonatal rats after intranasal inoculation with MERS-CoV. In addition, human DPP4-expressing rat kidn...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Iwata-Yoshikawa N, Fukushi S, Fukuma A, Suzuki T, Takeda M, Tashiro M, Hasegawa H, Nagata N Tags: Jpn J Infect Dis Source Type: research

Mycobacterium conceptionense bloodstream infection in a patient with advanced gastric carcinoma.
Abstract A 65-year-old Japanese male farmer with advanced gastric adenocarcinoma and multiple hepatic metastases was admitted to our hospital. A blood culture was positive on the fifth day, and a gram-positive rod was detected. According to the results of Ziehl-Neelen staining and a cultured colony of this bacterium, we suspected mycobacterial infection. With a suspicion of rapidly growing mycobacterium, we started multidrug therapy with levofloxacin, clarithromycin, and ethambutol and he recovered from the bloodstream infection. Further gene examination (16S rRNA, hsp65, and sodA) revealed an isolate of Mycobacte...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Yaita K, Matsunaga M, Tashiro N, Sakai Y, Masunaga K, Miyoshi H, Oshima K, Chikamatsu K, Takaki A, Mitarai S, Watanabe H Tags: Jpn J Infect Dis Source Type: research

Linezolid as a potentially effective drug for the treatment of multidrug-resistant tuberculosis in Japan.
Abstract Linezolid (LZD) is classified as a WHO group 5 drug used in the treatment of tuberculosis (TB). Although its efficacy and long-term safety have not yet been established, it is being increasingly used in the treatment of multidrug resistant tuberculosis (MDR-TB) and extensive multidrug-resistant tuberculosis (XDR-TB). The current study is a single-center retrospective clinical analysis of hospitalized M/XDR-TB patients in Fukujuji Hospital involving 26 patients (18 males and 8 females) consecutively treated with combinations of anti-TB drugs including LZD from 2009 to 2015. The sputum culture results were ...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Yi L, Yoshiyama T, Okumura M, Morimoto K, Sasaki Y, Shiraishi Y, Ogata H, Mitarai S Tags: Jpn J Infect Dis Source Type: research

Epidemiology of Multi Drug Resistant Uropathogenic Escherichia coli in Iran: a Systematic Review and Meta-analysis.
Abstract The urinary tract infection (UTI) is one of the most common infections in human, primarily caused by uropathogenic Escherichia coli (UPEC) that has a high multidrug resistance (MDR). Considering the prevalence of MDR-UPEC strains the aim of the present study was to systematically review published data about the prevalence rate of MDR-UPEC from different parts of Iran and provide an overall relative frequency (RF) for Iran. We searched several databases including PubMed, ISI Web of Science, Scopus, google scholar, IranMedex and Iranian Scientific Information Database by using the following keywords: "...
Source: Japanese Journal of Infectious Diseases - March 18, 2016 Category: Infectious Diseases Authors: Hadifar S, Moghoofei M, Nematollahi S, Ramazanzadeh R, Sedighi M, Salehi-Abargouei A, Miri A Tags: Jpn J Infect Dis Source Type: research

The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus.
PMID: 26902209 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Salehi-Vaziri M, Baniasadi V, Jalali T, Mirghiasi SM, Azad-Manjiri S, Zarandi R, Mohammadi T, Khakifirouz S, Fazlalipour M Tags: Jpn J Infect Dis Source Type: research

Analysis of the death due to infectious diseases in the patients hospitalized in the pediatric ward of a single Japanese tertiary medical facility.
Abstract In developed countries, mortality rates due to infection in children hospitalized in tertiary medical facilities, in which many patients with underlying disease are hospitalized, are uncertain. We investigated the characteristics of fatal cases due to infectious diseases in the pediatric ward of a Japanese tertiary medical facility. A total of 188 patients who died in the pediatric ward or intensive care unit at Kyushu University Hospital from 2002 to 2011was enrolled. The characteristics of the patients were investigated based on the medical records. Thirty-five patients died of infections, 31 of whom ha...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Toda N, Hoshina T, Koga Y, Ochiai M, Kaku N, Yamamura K, Torisu H, Ihara K, Takada H, Maehara Y, Hara T Tags: Jpn J Infect Dis Source Type: research

A rapid and simple real-time polymerase chain reaction assay for detecting foodborne pathogenic bacteria in human feces.
We examined the efficacy of the combination of a commercial polymerase chain reaction (PCR) master mix, which was insensitive to PCR inhibitors, and a DNA extraction method which used sodium dodecyl benzene sulfonate (SDBS) and Tween 20 to counteract the inhibitory effects of SDBS on the PCR assay. This method detected target genes (stx1 and stx2 of enterohemorrhagic Escherichia coli, invA of Salmonella Enteritidis, tdh of Vibrio parahaemolyticus, gyrA of Campylobacter jejuni, ceuE of C. coli, SEA of Staphylococcus aureus, ces of Bacillus cereus and cpe of Clostridium perfringens) from 1.0 × 10(1) to 1.0 × 10(3...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Hanabara Y, Ueda Y Tags: Jpn J Infect Dis Source Type: research

Detection of human parechoviruses in clinical and municipal wastewater samples in Miyagi, Japan, 2012-2014.
Abstract In order to study the epidemiology of human parechovirus (HPeV) infections and evaluate the feasibility of environmental surveillance, we investigated HPeV in 281 stool, 265 nasopharyngeal swab, and 79 municipal wastewater samples collected in Miyagi Prefecture, Japan between April 2012 and March 2014. HPeV was detected by reverse transcription-PCR targeting the partial 5' untranslated region and genotyped by sequencing the capsid VP1 region. Seven stool (2.5%) and one nasopharyngeal swab (0.4%) samples, all of which were from children under 2 years old, and 14 wastewater (18%) samples were positive for H...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Abe M, Ueki Y, Miura T, Kimura S, Suzuki Y, Sugawara N, Masago Y, Omura T, Watanabe S Tags: Jpn J Infect Dis Source Type: research

Characterization of the Shiga toxin-producing Escherichia coli isolated from human between 2011 and 2014.
This study demonstrated the wide distribution of non-O157 STEC strains in our patient group. Further studies should be performed to better understand the real situation. PMID: 26902213 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Gulesen R, Levent B, Demir T, Akgeyik M, Kuran S Tags: Jpn J Infect Dis Source Type: research

Contribution of Lewis X carbohydrate structure to neuropathogenic murine coronaviral spread.
Abstract Although Lewis X (Le(x)), a carbohydrate structure, is involved in innate immunity through cell-to-cell and pathogen recognition, Le(x) expression has not been observed in mouse monocytes/macrophages (Mo/Mas). The Mo/Mas that infiltrate the meninges after infection with the neuropathogenic murine coronavirus strain srr7 are an initial target of infection. Furthermore, higher inflammatory responses were observed in gene-manipulated mice lacking α1,3-fucosyltransferase 9, which determines the expression of the Le(x) structure, than those in wild-type mice after infection. We investigated Le(x) express...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Kakizaki M, Togayachi A, Narimatsu H, Watanabe R Tags: Jpn J Infect Dis Source Type: research

In vitro inhibition of cholera toxin production in Vibrio cholerae by methanol extract of sweet fennel seeds and its components.
In this study, we examined the potential of sweet fennel seed (Foeniculum vulgare Miller var. dulce) methanol extract to inhibit the CT production in V. cholerae without affecting their viability. The methanol extract of sweet fennel seeds significantly inhibited CT production in various V. cholerae strains regardless of serogroups and biotypes. Interestingly, trans-anethole and 4-allylanisole, essential oil components of sweet fennel seeds, also demonstrated the similar effects. Here, we report that sub-bactericidal concentration of sweet fennel seeds methanol extract and its major components could drastically inhibit CT ...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Chatterjee S, Zahid MS, Awasthi SP, Chowdhury N, Asakura M, Hinenoya A, Ramamurthy T, Iwaoka E, Aoki S, Yamasaki S Tags: Jpn J Infect Dis Source Type: research

Prevalence and virulence factors of Shigella spp. isolated from patients with diarrhoea in Rosario, Argentina.
This study provides initial data on the prevalence and distribution in a wide variety of Shigella strains of the set, sen, ipaH, virA and ial genes. PMID: 26902216 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Casabonne C, González A, Aquili V, Balagué C Tags: Jpn J Infect Dis Source Type: research

Carbapenemase-Producing Enterobacteriaceae in Yunnan Province, China.
Abstract Among 144 carbapenem-nonsusceptible Enterobacteriaceae isolated from 4 hospitals in Yunnan province, 113 were carbapenemase-producing Enterobacteriaceae (CPE). BlaKPC-2 (99/113, 87.6%) was the most common carbapenemase gene and Klebsiella pneumoniae (100/113, 88.5%) was the most common species. BlaNDM-1 (11/113, 9.7%), blaIMP-4 (10/113, 8.8%), and blaIMP-1 (1/113, 0.9%) genes were also detected. The extended-spectrum β-lactamase (ESBL) is common in CPE, SHV- and CTX-M- were the predominant type. PMID: 26902217 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Rui Z, Dehua L, Hua N, Yue F, Yunmin X, Jianhua L, Xueshan X Tags: Jpn J Infect Dis Source Type: research

Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report.
PMID: 26902218 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Negishi T, Matsumoto T, Saito S, Kasuga E, Horiuchi K, Natori T, Takehara K, Sugano M, Honda T Tags: Jpn J Infect Dis Source Type: research

Use of peripheral parenteral nutrition solutions as a risk factor for Bacillus cereus peripheral venous catheter-associated bloodstream infection at a Japanese tertiary care hospital: A case-control study.
In conclusion, use of PPN solutions or steroids was independent risk factors for B. cereus PVCBSI. Appropriate use of PPN solutions may help prevent B. cereus PVCBSI. Prospective studies are needed to confirm these results. PMID: 26902219 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Sakihama T, Tokuda Y Tags: Jpn J Infect Dis Source Type: research

Average income has an influence on epidemics of seasonal influenza.
Abstract Understanding the local factors influencing the transmission of communicable disease is important to minimize social damage; the aim of this study was to investigate local factors influencing seasonal influenza epidemics. Four indices (epidemic onset, duration, scale, and steepness of epidemic curves) were defined, and then correlations with regional characteristics and meteorological factors were investigated in Aomori prefecture consisting of six regions, i.e. Seihoku, Chunan and Tosei on the west side, and Sanpachi, Kamikita and Shimokita on the east side. Data was collected from the 2006-2007 to 2014-...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Seike I, Saito N, Saito S, Itoga M, Kayaba H Tags: Jpn J Infect Dis Source Type: research

Current Status of Condylomata Acuminata in Japanese Pregnant Women.
PMID: 26902221 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Suzuki S, Sekizawa A, Tanaka M, Matsuda H, Okai T, Kinoshita K, Kitamura T Tags: Jpn J Infect Dis Source Type: research

Isolation of vaccine-derived measles and rubella viruses, not as pathogens but by chance, from children with acute respiratory infections.
PMID: 26902222 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Aoki Y, Matoba Y, Tanaka S, Yahagi K, Ito S, Yoshida H, Itagaki T, Mizuta K Tags: Jpn J Infect Dis Source Type: research

Cross-neutralization activity of single-chain variable fragment (scFv) derived from anti-V3 monoclonal antibodies mediated by post-attachment binding.
Abstract The V3 loop in the envelope (Env) of HIV-1 is one of the major targets of neutralizing antibodies. However, this antigen is hidden inside the Env trimer in most isolates and is only fully exposed during CD4-gp120 interaction. Thus, primary HIV-1 isolates are relatively resistant to anti-V3 antibodies because IgG is too large to access the V3 loop. To overcome this obstacle, we constructed single-chain variable fragments (scFvs) from anti-V3 monoclonal antibodies 0.5γ, 5G2, and 16G6. Enhanced neutralization by 0.5γ and 5G2 scFvs was observed in strains that were resistant to their IgG counterpa...
Source: Japanese Journal of Infectious Diseases - February 19, 2016 Category: Infectious Diseases Authors: Maruta Y, Kuwata T, Tanaka K, Alam M, Valdez KP, Egami Y, Suwa Y, Morioka H, Matsushita S Tags: Jpn J Infect Dis Source Type: research

Diagnostic value of common inflammatory markers on fever of unknown origin.
This study aimed to evaluate the diagnostic value of common inflammatory markers on fever of unknown origin (FUO). We investigated 383 patients with FUO hospitalized at the Henan Province People's hospital between January 2009 and June 2015. Of all the cases, infectious diseases accounted for 33.9%, neoplasms 21.1%, collagen vascular diseases 25.1%, miscellaneous diseases 4.7% and no diagnosis 15.1%. Patients in neoplasm group is older than that in infectious disease, collagen vascular disease and miscellaneous disease group (p=0.006, p
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Liu CP, Liu ZY, Liu JP, Kang Y, Mao CS, Shang J Tags: Jpn J Infect Dis Source Type: research

The rapid induction of carbapenem-resistance in an Aeromonas dhakensis blood isolate.
Abstract Meropenem-susceptible and -resistant Aeromonas dhakensis isolates from blood cultures of a fatal case with septicemia was analyzed. The two isolates were homologous and the gene expression of metallo-β-lactamase of the resistant strain was upregulated. Physicians should pay attention to the possibility of the induction of carbapenem-resistance after the use of carbapenems in the treatment of Aeromonas infections. PMID: 26743140 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Murata M, Morinaga Y, Akamatsu N, Matsuda J, Uno N, Kosai K, Hasegawa H, Okada M, Moriuchi H, Yanagihara K Tags: Jpn J Infect Dis Source Type: research

Molecular characterization of mosquitoes (Diptera: Culicidae) of Northwestern Iran using rDNA-ITS2.
In this study, mosquitoes of the West Azerbaijan Province in Northwestern Iran were characterized based on their rDNA-ITS2 sequences. Nine populations of Six species of mosquitoes belonging to Anopheles, Culex, Culiseta and Ochlerotatus genera were studied. For the first time, the ITS2 sequences of Culiseta longiareolata and Culex hortensis are reported. In addition, ITS2 of Culex theileri and Ochlerotatus caspius are for the first time reported from Iran. phylogenetic analysis based on ITS2 fragment showed that both Subfamilies (Anophelinae and Culicinae) of this family (Culicidae) could be differentiated successfully, an...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Khoshdel-Nezamiha F, Vatandoost H, Oshaghi MA, Azari-Hamidian S, Mianroodi RA, Dabiri F, Bagheri M, Terenius O, Chavshin AR Tags: Jpn J Infect Dis Source Type: research

Catheter-related bloodstream infection due to Lodderomyces elongisporus.
Abstract Lodderomyces elongisporus is known to cause infrequent bloodstream infections and has been isolated from Asia and Mexico. We encountered a catheter-related blood stream infection, which involved some risk factors, due to L. elongisporus masquerading as Candida parapsilosis. A 39-year-old man who received a total arch and thoracoabdominal aortic replacement was admitted under the diagnosis of aorto-esophageal fistula. After thoracic drainage for aorto-esophageal fistula, catheter-related blood stream infection was diagnosed. Micafungin (100 mg per day) was successfully administered to treat catheter-relate...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Hatanaka S, Nakamura I, Fukushima S, Ohkusu K, Matsumoto T Tags: Jpn J Infect Dis Source Type: research

A Qualitative Real-time PCR assay for HIV-1 and HIV-2 RNA.
Abstract Since Western blot occasionally causes cross-reactions between HIV-1 and HIV-2, it is difficult to distinguish a coinfection status from a false-positive result. Therefore, we developed a qualitative real-time PCR assay for detecting HIV-1 and HIV-2 RNA that can be performed in parallel. Viral RNA extracted from 500 µl of plasma was examined using real-time PCR with minor groove binder probes. Bovine leukemia virus was used as an internal standard. The sensitivity was determined by probit regression analysis using the World Health Organization international standards for HIV-1 and HIV-2. The lower d...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Yamazaki S, Kondo M, Sudo K, Ueda T, Fujiwara H, Hasegawa N, Kato S Tags: Jpn J Infect Dis Source Type: research

Crimean-Congo Hemorrhagic Fever due to Consumption of Raw Meat: A Case Reports From East-North of Iran.
PMID: 26743144 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Fazlalipour M, Baniasadi V, Mirghiasi SM, Jalali T, Khakifirouz S, Azad-Manjiri S, Mahmoodi V, Naderi HR, Zarandi R, Salehi-Vaziri M Tags: Jpn J Infect Dis Source Type: research

Epidemiological Analysis of Nosocomial MRSA Outbreaks Using Phage Open-Reading Frame Typing in a Tertiary-care Hospital.
Abstract Pulsed-field gel electrophoresis (PFGE) is a reliable method for analyzing outbreaks of methicillin-resistant Staphylococcus aureus (MRSA); however, it is time-consuming and technically demanding. A new strain differentiation method for MRSA, the phage open- reading frame (ORF) typing (POT) method, is a rapid PCR-based technique, in which the ORFs of the phage genomes lysogenized in MRSA are amplified. The aim of this study was to evaluate the utility of the POT method for the epidemiological analysis of nosocomial MRSA outbreaks. Forty-four strains from 12 episodes of three or more nosocomial MRSA infect...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Kawamura H, Tokuda K, Imuta N, Kubota T, Koriyama T, Miyanohara H, Hashiguchi T, Kawano Y, Nishi J Tags: Jpn J Infect Dis Source Type: research

Multilocus sequence types and virulence determinants of hypermucoviscosity-positive Klebsiella pneumoniae isolated from community-acquired infection cases in Harbin, North China.
Abstract We investigated the molecular epidemiologic characteristics and virulence of hypermucoviscosity-positive K. pneumoniae in mainland of China. 24.62% (16/65) hypermucoviscosity-positive strains were detected in total 65 clinical isolates. 68.75% (11/16) of these were genotype K2 and carried rmpA and iucA genes. MLST revealed five sequence types (STs): ST65 (7), ST23 (4), ST86 (3), ST412 (1), ST375 (1), while the other four isolates were defined as other STs. The order of lethal dose 50 (LD50) values of ST types was ST23 (2.19×10(3)CFU/mouse)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Zhao J, Chen J, Zhao M, Qiu X, Chen X, Zhang W, Sun R, Ogutu JO, Zhang F Tags: Jpn J Infect Dis Source Type: research

Application of PCR-RFLP provides as discrimination as totalflaA sequence analysis among C. jejuniisolates of clinical origin.
Abstract The aim of this study was to determinethegenetic relatedness amongtwenty clinical Campylobacterjejuniisolated from children with diarrhea in Iran,and to introduce the best discriminatory method based on flaA sequence divergence.A total of 400 stool specimens were obtained from children under five years of age during July 2012 to June 2013. Primers were designedbased on conserved sequences flanking the flaA gene which encompass and amplify entire flaAgenefollowed bysequencing and analysis with MEGA version 6.0.6 software.Ninetyamino acid versus 560 nucleotidepolymorphic sequenceswere detectedwithin 1681bp ...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Ghorbanalizadgan M, Bakhshi B, Najar-Peerayeh S Tags: Jpn J Infect Dis Source Type: research

Infectious spondylitis in a patient with chronic kidney disease: identification of Campylobacter fetus subsp. testudinum with 16S ribosomal RNA sequencing.
We report the first case in which spondylitis with bacteremia caused by Campylobacter fetus subsp. testudinum, which was identified by 16S ribosomal ribonucleic acid (rRNA) gene sequencing. An 81 year-old man presented with fever and general weakness. His medical history included end-stage renal disease, hypertension, and type 2 diabetes. Despite empirical antibiotic treatment, fever and back pain persisted. Magnetic resonance imaging with gadolinium enhancement showed a low-signal-intensity lesion in T1-weighted imaging and a high-signal-intensity lesion in T2-weighted imaging at the L3 vertebra body. Campylobacter fetus ...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Choi HS, Shin SU, Bae EH, Ma SK, Kim SW Tags: Jpn J Infect Dis Source Type: research

Ulcerative lesions with hemorrhage in a patient with severe fever with thrombocytopenia syndrome observed via upper gastrointestinal endoscopy.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a novel bunyavirus infection caused by SFTS virus (SFTSV, Family Bunyaviridae, Genus Phlebovirus) with high case fatality rate. A previously healthy man aged 72 showed symptoms of fever, general fatigue, and altered consciousness. He was hospitalized for treatment. On day 3, taking the day on which fever appeared first during the disease course as day 0, he experienced bloody vomit. An emergency upper gastrointestinal endoscopic examination revealed the presence of multiple ulcerative lesions with continuous oozing hemorrhage in the stomach. He died on...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Kaneyuki S, Yoshikawa T, Tani H, Fukushi S, Taniguchi S, Fukuma A, Shimojima M, Kurosu T, Morikawa S, Saijo M Tags: Jpn J Infect Dis Source Type: research

Strong Correlation between Annual Incidence of Male Amebiasis and that of Male Homosexual HIV.
PMID: 26743150 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak.
Abstract The first Korea Middle East respiratory syndrome coronavirus (MERS-CoV) was confirmed on 20 May 2015, with a subsequent outbreak in Korea. Five patients suspected of MERS-CoA infection were admitted to our hospital during this outbreak. One patient had no symptoms at admission pneumonia was identified on chest X-ray. Two patients required ventilator-assisted respiration because of rapid progression to acute respiratory failure. One patient needed extracorporeal membrane oxygenation due to refractory hypoxemia. One patient died of shock with multiorgan failure. All patients had fever, myalgia, leucopenia, ...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Rhee JY, Hong G, Ryu KM Tags: Jpn J Infect Dis Source Type: research

Distribution of Chlamydia trachomatis infection among pregnant women by nucleic acid amplification tests in Japan.
PMID: 26743152 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Suzuki S, Tanaka M, Sekizawa A, Kinoshita K Tags: Jpn J Infect Dis Source Type: research

Molecular epidemiological analyses of Monophasic Salmonella enterica serovar O7: -: 1, 5 isolates in Akita prefecture, Japan.
PMID: 26743153 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Konno T, Takahashi S, Kumagai Y Tags: Jpn J Infect Dis Source Type: research

Fatal outcome of coinfection of Crimean-Congo hemorrhagic fever and malaria.
Abstract Here, we report a case of a Bulgarian patient with imported falciparum malaria that manifested 6 days after his arrival in Bulgaria, which was complicated by bloody diarrhea 2 days later. Blood smear revealed high parasitemia, with annular forms and gametocytes of Plasmodium falciparum. In addition, RNA of the Crimean-Congo hemorrhagic fever (CCHF) virus was detected in the blood sample by real-time reverse transcription (RT)-PCR and nested RT-PCR. The obtained sequence was found to be clustered within the Europe 1 lineage close to the other Bulgarian strains. Notably, the two infectious diseases may appe...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Christova I, Petrov A, Papa A, Vutchev D, Kalvatchev N, Vatev N, Stoycheva M Tags: Jpn J Infect Dis Source Type: research

Rapid and sensitive identification of glycoprotein H genotypes in clinical human cytomegalovirus samples.
Abstract Human cytomegalovirus (HCMV) is a common pathogen that causes persistent infections in immune deficient patients and results in significant morbidity and mortality, particularly among transplant recipients and children. Different HCMV glycoprotein H (gH) genotypes may cause different diseases and affect the severity of these diseases. To develop a sensitive quantitative real-time PCR assay that could rapidly distinguish between two HCMV gH genotypes, primers were designed to target the conserved region of the gH gene. gH1 and gH2 probes were designed to target the two variable regions. Standard HCMV strai...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Li W, Tao R, Zhang X, Shu Q, Gao HH, Shang SQ, Peng ZY, Li HM Tags: Jpn J Infect Dis Source Type: research