Proton pump inhibitors and risk of bloodstream infection without an identifiable source: a hospital-based case-control study
In conclusion, PPI use is associated with higher risk of BSI without an identifiable source and therefore, PPI use may increase the risk of septic morbidity secondary to bacterial translocation.PMID:38296545 | DOI:10.7883/yoken.JJID.2023.253 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 31, 2024 Category: Infectious Diseases Authors: Shintaro Hayashi Tomohito Moriyama Yuichiro Ito Yuta Harada Hiroki Dodo Kana Kumahara Tatsuji Yogi Noritsugu Ohashi Reiji Higashi Akihiro Mori Source Type: research

Importance of Toxin Genes and Polymerase Chain Reaction-Based Open Reading Frame Type Analyses for Severe Staphylococcus aureus Infection in Children
Jpn J Infect Dis. 2024;77(1):59-60. doi: 10.7883/yoken.Erratum.2024.E001.NO ABSTRACTPMID:38267044 | DOI:10.7883/yoken.Erratum.2024.E001 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 24, 2024 Category: Infectious Diseases Authors: Noriko Takeuchi Naruhiko Ishiwada Source Type: research

Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.400. Online ahead of print.ABSTRACTSome lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutra...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Yusuke Inoue Yoshihiro Kaku Michiko Harada Keita Ishijima Yudai Kuroda Kango Tatemoto Milagros Virhuez-Mendoza Ayano Nishino Tsukasa Yamamoto Satoshi Inoue Aya Matsuu Ken Maeda Source Type: research

Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017-2022
In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Ja...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Kazuya Shirato Reiko Suwa Naganori Nao Miyuki Kawase Satoko Sugimoto Yohei Kume Mina Chishiki Takashi Ono Hisao Okabe Sakurako Norito Masatoki Sato Hiroko Sakuma Shigeo Suzuki Mitsuaki Hosoya Makoto Takeda Koichi Hashimoto Source Type: research

First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan
This report is the first to detect JMTV in the Kanto region. Further studies are required to elucidate the potential risk of infection by this tick-borne virus in Japan. In particular, the prevalence of JMTV in wild animals should be examined to clarify its geographical distribution, host range, and transmission cycle in nature.PMID:38171848 | DOI:10.7883/yoken.JJID.2023.347 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Ryo Matsumura Daisuke Kobayashi Kyo Itoyama Haruhiko Isawa Source Type: research

Dysregulated leukotriene metabolism in covid-19 patients
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.211. Online ahead of print.ABSTRACTThe aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Halef Okan Do ğan Mahir Budak K übra Doğan G özde Ertürk Zararsız Serra İlayda Yerlitaş Serkan Bolat Onur Şenol Seyit Ali B üyüktuna Ergun P ınarbaşı Ra ğıp Sarıismailoğlu Hayrettin Yavuz Source Type: research

Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2022.571. Online ahead of print.ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were included in the analysis from April 2016 to April 2022. Multivariable logistic regression analysis showed that pancreatic injury (OR...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Mengke Yang Yang Yang Aiping Zhang Mingyue Ni Manman Liang Bin Quan Wenzheng Han Jianghua Yang Source Type: research

Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.400. Online ahead of print.ABSTRACTSome lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutra...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Yusuke Inoue Yoshihiro Kaku Michiko Harada Keita Ishijima Yudai Kuroda Kango Tatemoto Milagros Virhuez-Mendoza Ayano Nishino Tsukasa Yamamoto Satoshi Inoue Aya Matsuu Ken Maeda Source Type: research

Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017-2022
In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Ja...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Kazuya Shirato Reiko Suwa Naganori Nao Miyuki Kawase Satoko Sugimoto Yohei Kume Mina Chishiki Takashi Ono Hisao Okabe Sakurako Norito Masatoki Sato Hiroko Sakuma Shigeo Suzuki Mitsuaki Hosoya Makoto Takeda Koichi Hashimoto Source Type: research

First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan
This report is the first to detect JMTV in the Kanto region. Further studies are required to elucidate the potential risk of infection by this tick-borne virus in Japan. In particular, the prevalence of JMTV in wild animals should be examined to clarify its geographical distribution, host range, and transmission cycle in nature.PMID:38171848 | DOI:10.7883/yoken.JJID.2023.347 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Ryo Matsumura Daisuke Kobayashi Kyo Itoyama Haruhiko Isawa Source Type: research

Dysregulated leukotriene metabolism in covid-19 patients
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.211. Online ahead of print.ABSTRACTThe aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Halef Okan Do ğan Mahir Budak K übra Doğan G özde Ertürk Zararsız Serra İlayda Yerlitaş Serkan Bolat Onur Şenol Seyit Ali B üyüktuna Ergun P ınarbaşı Ra ğıp Sarıismailoğlu Hayrettin Yavuz Source Type: research

Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2022.571. Online ahead of print.ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were included in the analysis from April 2016 to April 2022. Multivariable logistic regression analysis showed that pancreatic injury (OR...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Mengke Yang Yang Yang Aiping Zhang Mingyue Ni Manman Liang Bin Quan Wenzheng Han Jianghua Yang Source Type: research

Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.400. Online ahead of print.ABSTRACTSome lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutra...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Yusuke Inoue Yoshihiro Kaku Michiko Harada Keita Ishijima Yudai Kuroda Kango Tatemoto Milagros Virhuez-Mendoza Ayano Nishino Tsukasa Yamamoto Satoshi Inoue Aya Matsuu Ken Maeda Source Type: research

Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017-2022
In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Ja...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Kazuya Shirato Reiko Suwa Naganori Nao Miyuki Kawase Satoko Sugimoto Yohei Kume Mina Chishiki Takashi Ono Hisao Okabe Sakurako Norito Masatoki Sato Hiroko Sakuma Shigeo Suzuki Mitsuaki Hosoya Makoto Takeda Koichi Hashimoto Source Type: research

First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan
This report is the first to detect JMTV in the Kanto region. Further studies are required to elucidate the potential risk of infection by this tick-borne virus in Japan. In particular, the prevalence of JMTV in wild animals should be examined to clarify its geographical distribution, host range, and transmission cycle in nature.PMID:38171848 | DOI:10.7883/yoken.JJID.2023.347 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Ryo Matsumura Daisuke Kobayashi Kyo Itoyama Haruhiko Isawa Source Type: research