Antibiotic Susceptibility of Neisseria gonorrhoeae Isolates from Guangzhou, China, during 2002-2011.
Abstract Antibiotic susceptibility of Neisseria gonorrhoeae in Guangzhou during 2002-2011 showed that resistance to penicillin and ciprofloxacin was high, while ceftriaxone remained effective although there was a trend towards reduced sensitivity. PMID: 25056075 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Zheng H, Yang B, Wu X, Huang J, Zeng W, Xue Y, Qin X, Lan Y, Tang S, Ou J, Li Y Tags: Jpn J Infect Dis Source Type: research

Varicella infection complicated by marked thrombocytopenia.
We report a rare case of adult varicella complicated by marked thrombocytopenia. A 49-year-old woman presented with fever and rash for 3 days. Blood examination revealed marked thrombocytopenia (2.7 × 10(4)/μL). Varicella infection was diagnosed after elevated levels of varicella zoster virus IgM and IgG antibodies were observed 2 weeks later. In this case, thrombocytopenia was due to varicella infection, and the mechanism was estimated to be non-immunological. Because varicella infection complicated by thrombocytopenia may result in fatal bleeding, thrombocytopenia in patients with varicella warrants close attent...
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Shibusawa M, Motomura S, Hidai H, Tsutsumi H, Fujita A Tags: Jpn J Infect Dis Source Type: research

Evaluation of clinical and laboratory findings of pediatric and adult patients with oropharyngeal tularemia in Turkey: a combination of surgical drainage and antibiotic therapy increases treatment success.
Abstract We analyzed the clinical and laboratory findings of both pediatric and adult patients with oropharyngeal tularemia. We also compared the therapeutic outcomes of patients who underwent surgical drainage of lymph nodes early or late during antibiotic therapy. A total of 68 patients with oropharyngeal tularemia, including 26 children and 42 adults, were enrolled in this study. The average duration between symptom onset and hospital admission was 20.8 days (4-60 days) in the pediatric group and 32.6 days (4-90 days) in the adult group (P = 0.009). The most frequently observed clinical symptoms were sore throa...
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Gozel MG, Engin A, Altuntas EE, Salk I, Kaya A, Celik C, Dokmetas I, Bakir M, Elaldi N Tags: Jpn J Infect Dis Source Type: research

The first measles outbreak caused by imported genotype d9 measles virus in shandong province, china, 2013.
This study represents a measles outbreak caused by the genotype D9 measles virus (MeV), which was imported by Burmese individuals. Urine and throat swab specimens were collected from suspected measles cases. Viruses were isolated, and a 634-bp target fragment of the N gene was amplified by reverse transcription-PCR and sequenced. Phylogenetic results indicated that the 6 isolates belonged to genotype D9 MeV. Through appropriate prevention and control measures, the transmission of genotype D9 MeV was interrupted. Genotype D9 MeV was isolated for the first time in Shandong and was imported by Burmese individuals. PMID: ...
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Fang X, Sun J, Zhang Y, Wang C, Song Y, Song L, Xu Q, Li B, Chen P, Li H, Xu A Tags: Jpn J Infect Dis Source Type: research

The Occurrence of Severe Rotavirus Gastroenteritis in Children under 3 Years of Age before and after the Introduction of Rotavirus Vaccine: a Prospective Observational Study in Three Pediatric Clinics in Shibata City, Niigata Prefecture, Japan.
Abstract The occurrence of severe rotavirus gastroenteritis (RVGE) in children under 3 years of age before and after the introduction of rotavirus vaccine was prospectively surveyed in three pediatric clinics in Shibata City, Niigata Prefecture, Japan, during the 2011 and 2012 RVGE epidemic seasons. In this observational study, a significantly lower occurrence of severe RVGE among severe gastroenteritis cases was observed in 2012. The incidence rate of severe RVGE among outpatients in 2012 was significantly lower than that in 2011. Despite the significant reduction in severe RVGE, the results must be interpreted w...
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Oishi T, Taguchi T, Nakano T, Sudo S, Kuwajima H, Shibata RVGE Study Group Tags: Jpn J Infect Dis Source Type: research

Stability of JC Virus DNA in Cerebrospinal Fluid Specimens Preserved with Guanidine Lysis Buffer for Quantitative PCR Testing.
Abstract Quantitative PCR testing for JC virus (JCV) DNA in the cerebrospinal fluid (CSF) is one of the diagnostic standards for progressive multifocal leukoencephalopathy (PML). The present study was conducted to examine its reliability using CSF specimens that had been preserved with guanidine lysis buffers in commercial nucleic acid extraction kits under different conditions. When CSFs were mixed with guanidine buffers, JCV DNA levels were not statistically reduced even after storage for 1 month at room temperature or for 3 months at -80℃, compared with the control samples. In addition, the JCV DNA level was ...
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Nakamichi K, Lim CK, Saijo M Tags: Jpn J Infect Dis Source Type: research

Recent Progress toward Measles Elimination in Hokkaido, Japan, during 2011-2012.
Abstract Laboratory diagnoses for measles were performed in a total of 97 cases in Hokkaido, Japan, during 2011-2012. Two patients were confirmed to be positive for measles virus (MV), both of whom lived in the Iburi district of Hokkaido. Molecular analysis of the nucleotide sequences of the nucleoprotein (N) gene revealed that these 2 strains had high homology with each other and belonged to the genotype D8. The onset interval of these cases and epidemiological data suggested that MV transmission had occurred between them and then terminated. Phylogenetic analysis of the N gene revealed that the strains identifie...
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Miyoshi M, Komagome R, Ishida S, Kikuchi M, Sato H, Ito H, Nagano H, Okano M Tags: Jpn J Infect Dis Source Type: research

Antimicrobial Resistance among Campylobacter Isolates Obtained from Retail Chicken Meat and Offal Products in Japan.
In this study, we aimed to demonstrate the overall trend in antimicrobial resistance among Campylobacter isolates obtained from chicken meat and offal products collected from a wide geographic area throughout Japan. Resistance to Enrofloxacin was most frequently observed, with significantly higher rate of resistance among isolates obtained from offal (55.6%) than from meat (27.3%) samples (p = 0.05). These results highlight need for a better understanding of the characteristics of Campylobacter isolates obtained from chicken meat and offal products. PMID: 25056082 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Hidano A, Yamamoto T, Hayama Y, Muroga N, Kobayashi S, Nishida T, Tsutsui T Tags: Jpn J Infect Dis Source Type: research

Outbreak of Human Metapneumovirus Infection in a Severe Motor-and-Intellectual Disabilities Ward in Japan.
PMID: 25056083 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Yang Z, Suzuki A, Watanabe O, Okamoto M, Ohmi A, Huang W, Nishimura H Tags: Jpn J Infect Dis Source Type: research

A foodborne outbreak of group a streptococcal infection in fukuoka prefecture, Japan.
PMID: 25056084 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Okamoto F, Murakami K, Maeda E, Oishi A, Etoh Y, Kaida M, Makigusa M, Nakashima K, Jinnouchi Y, Takemoto H, Kakegawa H, Yamasaki C, Manabe S, Sasaki M, Ogata K, Ikebe T, Sera N Tags: Jpn J Infect Dis Source Type: research

Genotyping of mumps virus strains detected in kobe city from 1991 to 2012.
PMID: 25056085 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Akiyoshi K, Suga T Tags: Jpn J Infect Dis Source Type: research

An Outbreak of Acute Respiratory Infections due to Human Respiratory Syncytial Virus in a Nursing Home for the Elderly in Ibaraki, Japan, 2014.
PMID: 25056086 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 29, 2014 Category: Infectious Diseases Authors: Doi I, Nagata N, Tsukagoshi H, Komori H, Motoya T, Watanabe M, Keta T, Kawakami M, Tsukano T, Honda M, Ishioka T, Takeda M, Ryo A, Kuroda M, Oishi K, Kimura H Tags: Jpn J Infect Dis Source Type: research

Cholera outbreaks in South and southeast Asia: descriptive analysis, 2003-2012.
Abstract We conducted descriptive analysis of available information regarding the epidemiology of cholera outbreaks in South and Southeast Asia during 2003-2012. Information from 58 articles, 8 reports, and World Health Organization databases were analyzed. Overall, 113 cholera outbreaks were studied in South and Southeast Asia during the past 10 years. The majority of the outbreaks (69%) occurred in Southeast Asia, including India (52%). The highest number of outbreaks was observed in 2004 (25.7%). The most commonly identified source was contaminated water: however, in some countries, the spread of cholera was fa...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Mahapatra T, Mahapatra S, Babu GR, Tang W, Banerjee B, Mahapatra U, Das A Tags: Jpn J Infect Dis Source Type: research

Molecular Analysis of Ciprofloxacin Resistance among Non-Typhoidal Salmonella with Reduced Susceptibility to Ciprofloxacin Isolated from Patients at a Tertiary Care Hospital in Kuala Lumpur, Malaysia.
Abstract We investigated the prevalence of non-typhoidal Salmonella (NTS) with "reduced susceptibility to ciprofloxacin" (RS-Cip) (minimum inhibitory concentration [MIC], 0.12-1.0 μg/mL) as well as their resistance genes in 75 NTS isolates (53 from stool, 21 from blood, and 1 from urine) from patients at a tertiary care Malaysian hospital between January and December 2009. RS-Cip was detected in 24/75 (32.0%) isolates. Using the ciprofloxacin MIC interpretive criteria for Salmonella in the Clinical and Laboratory Standards Institute 2013 guidelines, 51/75 (68.0%) isolates were found to be sensitive, 2...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Karunakaran R, Tay ST, Rahim FF, Lim BB, Puthucheary SD Tags: Jpn J Infect Dis Source Type: research

Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009-2010).
inguez A, CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain Abstract The present study aimed to compare the main features of infection with pandemic influenza A virus in pregnant and nonpregnant women admitted to hospitals in Spain during the first waves of the 2009-2010 influenza pandemic. This was a prospective (November 2009 to June 2010), multicenter observational study. All cases were women of reproductive age who had not been vaccinated against seasonal or pandemic influenza A. Influenza infection was confirmed by reverse transcription-polymerase chain reaction (RT-PCR). The sociodemogra...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Suárez-Varela MM, González-Candelas F, Astray J, Alonso J, Garin O, Castro A, Galán JC, Baricot M, Castilla J, Godoy P, Delgado-Rodríguez M, Martin V, Mayoral JM, Pumarola T, Quintana JM, Tamames S, Llopis-González A, Dominguez A, CIBERESP Cases and Tags: Jpn J Infect Dis Source Type: research

Effect of Serum Components on Biofilm Formation by Aspergillus fumigatus and Other Aspergillus Species.
Abstract Biofilm production by microorganisms is critical for their pathogenicity. Serum promotes biofilm production by Aspergillus fumigatus; however, its effects on other Aspergillus spp. have not been reported. We analyzed biofilm formation by five Aspergillus spp., i.e., A. fumigatus, A. flavus, A. nidulans, A. niger, and A. terreus, and examined the effects of serum/serum proteins such as fetal bovine serum (FBS), fetuin A, and bovine serum albumin (BSA) on hyphal growth, hyphal branching, and extracellular matrix (ECM) formation. The antifungal susceptibility of A. fumigatus isolates that formed biofilms was...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Wuren T, Toyotome T, Yamaguchi M, Takahashi-Nakaguchi A, Muraosa Y, Yahiro M, Wang DN, Watanabe A, Taguchi H, Kamei K Tags: Jpn J Infect Dis Source Type: research

Vaccine-Associated Measles in the Low-Incidence Country of Korea over a 10-Year Period.
In this study, we assessed vaccine-associated measles cases reported in Korea between 2002 and 2012 using a standardized assessment and following by the World Health Organization case definition criteria. We retrospectively analyzed data regarding (i) wild-type measles and (ii) vaccine-associated measles in patients aged 12-23 months. The presence or absence of fever, rash, cough, coryza, conjunctivitis, and Koplik spots were reviewed. Males were more likely to be reported with vaccine-associated measles than with wild-type measles (68% vs. 47%, P
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Choe YJ, Eom HS, Bae GR Tags: Jpn J Infect Dis Source Type: research

Avian-Like A (H1N1) Swine Influenza Virus Antibodies among Swine Farm Residents and Pigs in Southern China.
Abstract Infection of human with avian-like A (H1N1) swine influenza virus (SIV) occasionally occurs in China, suggesting a potential risk of cross-species transmission of the swine influenza H1N1 virus from pigs to humans, particularly to those having direct contact with pigs. A seroepidemiological study was conducted to assess the prevalence of antibodies against the avian-like A (H1N1) SIV among swine farm residents and pigs in southern China to evaluate the risk of infection to swine farm workers. Hemagglutination inhibition (HI) assays revealed that 11.17% (61/546) of the sera samples from swine farm resident...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Zhou H, Cao Z, Tan L, Fu X, Lu G, Qi W, Ke C, Wang H, Sun L, Zhang G Tags: Jpn J Infect Dis Source Type: research

High-Risk Behavior of HIV/AIDS among Females Sex Workers in Bangladesh: Survey in Rajshahi City.
Abstract Female sex workers (FSWs) and their clients are one of the major sources of spread of HIV/AIDS in Bangladesh. The purpose of this study was to determine the rate of unprotected sex among FSWs in Rajshahi City, Bangladesh. A total of 200 FSWs were randomly selected for the survey from February to September 2012. The age range of FSWs was 16-41 years (average age, 24.52 ± 6.26 years), and the majority of these women (84.4%) were married. More than 88% of FSWs reported practicing unprotected sex because of clients' insistence. Further analysis showed a significantly higher rate of protected sex among unmarried FSWs (P
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Uddin SM, Hossain MG, Islam MA, Islam MN, Aik S, Kamarul T Tags: Jpn J Infect Dis Source Type: research

Epidemiology and etiology of acute encephalitis syndrome in north India.
Abstract Acute encephalitis syndrome (AES) is a major public health problem in eastern Uttar Pradesh, claiming thousands of lives every year. Here we report the common viral etiologic agents of AES and its epidemiology in the vicinity of Lucknow in Uttar Pradesh, North India. Cerebrospinal fluid (CSF) samples collected from patients with AES, who were referred to a viral diagnostic laboratory from January 2011 to December 2012, were tested for IgM antibodies against Japanese encephalitis virus (JEV), dengue virus (DV), herpes simplex virus (HSV), measles virus, mumps virus, varicella zoster virus (VZV), and entero...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Jain P, Jain A, Kumar A, Prakash S, Khan DN, Singh KP, Garg RK, Kumar R, Kumar GA Tags: Jpn J Infect Dis Source Type: research

Shiga Toxin 2f-Producing Escherichia albertii from a Symptomatic Human.
Abstract The previously identified Shiga toxin (Stx) 2f-producing Escherichia coli O115:HNM strain F08/101-31, isolated from a symptomatic human, was confirmed to be E. albertii in the present study by whole genome DNA-DNA hybridizations, by sequencing (cpn60, dnaJ, and 16S rRNA genes), and by multi-locus sequence typing. The F08/101-31 strain was originally identified as E. coli rather than the relatively new bacterial species E. albertii, which was first described in 2003, because it did not display any of the biochemical characteristics of E. albertii. This new classification will impact public health managemen...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Murakami K, Etoh Y, Tanaka E, Ichihara S, Horikawa K, Kawano K, Ooka T, Kawamura Y, Ito K Tags: Jpn J Infect Dis Source Type: research

Development of a Novel Dengue-1 Virus Replicon System Expressing Secretory Gaussia luciferase for Analysis of Viral Replication and Discovery of Antiviral Drugs.
Abstract Replicon systems have been used for high-throughput screening of anti-dengue virus (anti-DENV) inhibitors and for understanding mechanisms of viral replication. In the present study, we constructed novel DENV-1 replicons encoding Gaussia luciferase that was secreted into the culture medium. Two types of constructs were generated: RNA-based and DNA-based. Each type was translated in an internal ribosome entry site (IRES)-dependent or IRES-independent manner. Among these constructs, the DNA-based replicon employing IRES-dependent translation (DGL2) produced the highest titer. Luciferase levels in the cultur...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Kato F, Kobayashi T, Tajima S, Takasaki T, Miura T, Igarashi T, Hishiki T Tags: Jpn J Infect Dis Source Type: research

Acute encephalopathy associated with human metapneumovirus infection.
Abstract We encountered a 3.5-year-old girl with acute encephalopathy associated with human metapneumovirus (hMPV) infection. She had pyrexia and status epilepticus, followed by a coma. Cerebrospinal fluid analysis showed no pleocytosis or elevation of protein levels. hMPV RNA was detected in tracheal aspirate. Acute encephalopathy in the patient was probably related to the hMPV infection. Serum levels of interleukin-6 and matrix metalloproteinase-9 were elevated on admission, and these factors were presumed to be related to acute encephalopathy, associated with her viral infection, or due to status epilepticus. S...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Niizuma T, Okumura A, Kinoshita K, Shimizu T Tags: Jpn J Infect Dis Source Type: research

Longitudinal study on respiratory viral co-infections in the presence or absence of clinical manifestation in infants aged 0-2 years.
Abstract We conducted a long-term follow-up study between December 2005 and February 2007 on 4 immunocompetent infants, who repeatedly presented with respiratory symptoms, using PCR-based techniques targeting 14 viruses related to acute respiratory tract infection. Of 38 specimens, 30 were collected from symptomatic infants and 8 were collected when respiratory symptoms were absent. Overall, one or more respiratory viruses were detected in 94.7% (36/38) of the specimens. Of the 36 PCR-positive specimens, 77.8% (28/36) were positive for more than one virus. Most of these co-infections were double infections (55.6% ...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Kawabuchi-Kurata T, Misaki T, Suehiro Y, Komano AJ, Kase T, Takahashi K Tags: Jpn J Infect Dis Source Type: research

Outbreak of Cholera Caused by Vibrio cholerae O1 El Tor Variant Strain in Bihar, India.
Abstract An outbreak of cholera struck Bihar, an Indian state, in August 2008 following a massive flood. Here we report the phenotypic and genotypic characteristics of Vibrio cholerae strains isolated from patients with diarrhea. Rectal swabs were obtained from patients with diarrhea who were admitted to medical camps or the hospital, and the strains were biochemically and serologically characterized. V. cholerae was isolated from 21 (65.6%) of 32 rectal swabs. Serological studies revealed that all the 21 isolates belonged to V. cholerae O1 Ogawa. Mismatch amplification mutation assay (MAMA)-PCR showed that the is...
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Koley H, Ray N, Chowdhury G, Barman S, Mitra S, Ramamurthy T, Mukhopadhyay AK, Sarkar BL, Katyal R, Das P, Panda S, Ghosh S Tags: Jpn J Infect Dis Source Type: research

Phylogenetic analysis of dengue virus type 3 strains primarily isolated in 2013 from surabaya, indonesia.
PMID: 24858615 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Kotaki T, Yamanaka A, Mulyatno KC, Labiqah A, Sucipto TH, Churrotin S, Soegijanto S, Konishi E, Kameoka M Tags: Jpn J Infect Dis Source Type: research

Burden of pertussis is underestimated in South Korea: a result from an active sentinel surveillance system.
PMID: 24858616 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Choe YJ, Kim JW, Park YJ, Jung C, Bae GR Tags: Jpn J Infect Dis Source Type: research

Intra-Abdominal Mycoplasma hominis Infection in a Liver Transplant Recipient: a Case Report.
PMID: 24858617 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 29, 2014 Category: Infectious Diseases Authors: Horiuchi K, Matsumoto T, Ohno Y, Kasuga E, Negishi T, Yaguchi T, Sugano M, Honda T Tags: Jpn J Infect Dis Source Type: research

A Comparison of Adult and Pediatric Measles Patients Admitted to Emergency Departments during the 2008-2011 Outbreak in the Midi-Pyrénées Region of France.
A Comparison of Adult and Pediatric Measles Patients Admitted to Emergency Departments during the 2008-2011 Outbreak in the Midi-Pyrénées Region of France. Jpn J Infect Dis. 2014;67(2):71-7 Authors: Ameline C, Raphaele H, Erick G, Bruno M, Isabelle C Abstract The present French and European measles outbreaks show a bimodal distribution: the two most affected populations are infants aged less than 1 year and adults older than 20 years. The purpose of this study was to determine wether there were differences in the clinical presentation and evolution of measles between adult and pediatric patie...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Ameline C, Raphaele H, Erick G, Bruno M, Isabelle C Tags: Jpn J Infect Dis Source Type: research

Prevalent Phenotypic and Genotypic Profile of Enterotoxigenic Escherichia coli among Iranian Children.
This study may lead to development of effective prophylactic measures. PMID: 24647248 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Nazarian S, Gargari SL, Rasooli I, Alerasol M, Bagheri S, Alipoor SD Tags: Jpn J Infect Dis Source Type: research

Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-α-Induced Permeability In Vitro.
Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-α-Induced Permeability In Vitro. Jpn J Infect Dis. 2014;67(2):86-94 Authors: Raekiansyah M, Espada-Murao LA, Okamoto K, Kubo T, Morita K Abstract The mechanisms of endothelial barrier dysfunction in dengue disease remain poorly understood. Endothelial cell (EC) death due to virus infection or in combination with an infection-induced cytokine storm is deemed as one of the major causes of plasma leakage. Using an in vitro model of human endothelia and several dengue virus (DENV) strains (including a clinical iso...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Raekiansyah M, Espada-Murao LA, Okamoto K, Kubo T, Morita K Tags: Jpn J Infect Dis Source Type: research

A case-control study to identify environmental risk factors for hand, foot, and mouth disease outbreaks in beijing.
Abstract A matched case-control study was conducted in Beijing to identify the relative importance of major environmental risk factors for outbreaks of hand, foot, and mouth disease (HFMD). A case was defined as a kindergarten class with at least 1 HFMD outbreak. As a control, a kindergarten class that did not experience an HFMD outbreak was used. To identify potential transmission factors, the control group was divided into 2 subgroups: a sporadic group and an HFMD-negative group. We collected data for 8 environmental factors and basic information of each class. The correlations between the suspected environmenta...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Xiaona W, Ying S, Changying L, Lei J, Qingrui W, Xinyu L, Quanyi W Tags: Jpn J Infect Dis Source Type: research

The (H1N1) 2009 Pandemic Influenza Pneumonia among Adult Patients in Japan.
Abstract The recent H1N1 influenza pandemic involved several cases of influenza pneumonia. Although influenza pneumonia may have occurred more frequently in fatal cases, the clinical characteristics of influenza pneumonia in Japan remain unclear. We conducted a retrospective cohort study of adult patients with influenza pneumonia, for which questionnaires were sent to respiratory physicians working in 2,491 hospitals across Japan. Questionnaires were returned by 994 physicians (39.9%), providing data on 346 influenza pneumonia cases. The case-fatality ratio was 8.2% (27 cases). Pure influenza viral pneumonia was o...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Fujikura Y, Kawano S, Kouzaki Y, Shinoda M, Hara Y, Shinkai M, Kanoh S, Kawana A Tags: Jpn J Infect Dis Source Type: research

Impact of human adenovirus serotype 7 in hospitalized children with severe fatal pneumonia in the Philippines.
This study demonstrated the significance of HAdV7 as an etiological agent of severe pediatric pneumonia with a high fatality rate. Hence, continuous monitoring is required to define the clinical and public health significance of HAdV7 infection. PMID: 24647252 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Yamamoto D, Okamoto M, Lupisan S, Suzuki A, Saito M, Tamaki R, Tandoc Iii A, Mercado E, Sombrero L, Olveda R, Oshitani H Tags: Jpn J Infect Dis Source Type: research

Detection of Anaplasma phagocytophilum and Anaplasma bovis in Small Wild Mammals from Taichung and Kinmen Island, Taiwan.
Abstract A total of 138 animals from 7 species (Apodemus agrarius, Bandicota indica, Crocidura suaveolens, Mus caroli, Mus formosanus, Rattus losea, and Suncus murinus) captured in Taichung, located in central Taiwan, and Kinmen Island, an island off the shore of China, were examined for the presence of Anaplasma phagocytophilum. The presence of the bacteria, which causes human granulocytic anaplasmosis, was examined by nested PCR targeting the16S rDNA. Twelve animals (8.7%) from M. caroli and R. losea, and 25 (18.1%) from A. agrarius, B. indica, M. caroli, and R. losea were infected with A. phagocytophilum and An...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Masuzawa T, Uchishima Y, Fukui T, Okamoto Y, Pan MJ, Kadosaka T, Takada N Tags: Jpn J Infect Dis Source Type: research

A case report of scrub typhus-associated hemophagocytic syndrome and a review of literature.
Abstract A 34-year-old woman presented with septic shock, disseminated intravascular coagulation (DIC), and multiorgan dysfunction with a 1-week history of fever, abdominal pain in the right upper quadrant, and dull pain in the right flank. Physical and laboratory data showed cytopenia (thrombocytopenia and anemia), splenomegaly, hyperferritinemia, hypofibrinogenemia, and an elevated level of interleukin-2 receptor (soluble CD25). Bone marrow examinations disclosed hypercellular marrow with increased infiltration of histiocytes with hemophagocytosis. This diagnosis was confirmed by positive Weil-Felix test results...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Lin YH, Lin YH, Shi ZY Tags: Jpn J Infect Dis Source Type: research

Appropriate Sampling Sites for the Surveillance of Multidrug-Resistant Pseudomonas aeruginosa Colonization.
This study aimed at evaluating the effectiveness of testing multiple samples (urine, stool, and pharyngeal swabs) for accurate screening of multidrug-resistant (MDR) Pseudomonas aeruginosa. Of a total of 641 patients, 16 (2.5%) were confirmed for MDR P. aeruginosa carriage at any site (urine and/or stool and/or pharyngeal swab). Notably, of the 3 sample sites, urine culture had the highest rate of positive surveillance for MDR P. aeruginosa. Seven (43.8%) of the 16 cases of MDR P. aeruginosa were detected by urine culture alone. Eleven (91.7%) of the 12 MDR P. aeruginosa carriers detected by urine culture had an indwelling...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Araoka H, Kimura M, Abe M, Takahashi N, Yoneyama A Tags: Jpn J Infect Dis Source Type: research

Isolation of OXA-48 Carbapenemase-Producing Klebsiella pneumoniae ST101 from an Overseas Traveler Returning to Japan.
Abstract OXA-48 carbapenemase-producing organisms have emerged rapidly worldwide and may be transmitted through patients who receive medical care abroad. To our knowledge, this is the second case of OXA-48-producing Klebsiella pneumoniae isolated from a patient who had returned to Japan after receiving treatment abroad. PMID: 24647256 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Hashimoto A, Nagamatsu M, Ohmagari N, Hayakawa K, Kato Y, Kirikae T Tags: Jpn J Infect Dis Source Type: research

A Case Series of Possibly Recrudescent Orientia tsutsugamushi Infection Presenting as Pneumonia.
Abstract Orientia tsutsugamushi remains latent in humans after scrub typhus. Pneumonia occurs as a complication of scrub typhus in the late-phase disease. However, pneumonia may also occur as a presenting manifestation of O. tsutsugamushi infection. We reviewed the cases of 3 patients with atypical pneumonia who presented at our hospital and were later confirmed to have O. tsutsugamushi infection by serology, nested polymerase chain reaction (PCR), and cell culture. All patients were young adults with no history of scrub typhus, and none claimed to have recently been exposed to areas where scrub typhus is endemic....
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Im JH, Baek JH, Lee JS, Chung MH, Lee SM, Kang JS Tags: Jpn J Infect Dis Source Type: research

Phylogenetic analysis and seroprevalence of influenza C virus in mie prefecture, Japan in 2012.
Abstract Reverse transcription polymerase chain reaction (RT-PCR) and real-time RT-PCR were used to detect 14 (6.6%) influenza C virus (InfC) among 213 clinical samples collected from children with respiratory symptoms in Mie Prefecture, Japan, between January 2012 and December 2012. Virus isolation using Madin-Darby canine kidney cells and/or embryonated chicken eggs was also successful for 3 of the 14 PCR-positive samples. Eleven patients (78.6%) were aged
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Yano T, Maeda C, Akachi S, Matsuno Y, Yamadera M, Kobayashi T, Nagai Y, Iwade Y, Kusuhara H, Katayama M, Fukuta M, Nakagawa Y, Naraya S, Takahashi H, Hiraoka M, Yamauchi A, Nishinaka T, Amano H, Yamaguchi T, Ochiai H, Ihara T, Matsuzaki Y Tags: Jpn J Infect Dis Source Type: research

Sequence variation of dengue type 2 virus isolated from clinical cases in Thailand.
In this study, the sequence diversity of the envelope gene of 8 DENV-2 clinical isolates from primary/secondary infections was analyzed. DENV-2 from primary infections were highly heterogeneous in individual patients, whereas those from secondary infections were homogeneous. Phylogenetic analysis demonstrated that the heterogeneous population of DENV-2 from primary infections was composed of closely related quasispecies. Homogenous DENV-2 could be derived from selection of a particular viral population in secondary infections. The degree of sequence diversity of DENV-2 varied, and thus quasispecies may be involved in the p...
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Kurosu T, Chaichana P, Phanthanawiboon S, Khamlert C, Yamashita A, A-Nuegoonpipat A, Ikuta K, Anantapreecha S Tags: Jpn J Infect Dis Source Type: research

Vaccine-associated paralytic poliomyelitis: a case report.
PMID: 24647260 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Ilic MD, Obradovic SD Tags: Jpn J Infect Dis Source Type: research

Potential sexual transmission of crimean-congo hemorrhagic Fever infection.
PMID: 24647261 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Ergonul O, Battal I Tags: Jpn J Infect Dis Source Type: research

Identification of Escherichia albertii as a Causative Agent of a Food-Borne Outbreak Occurred in 2003.
PMID: 24647262 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Asoshima N, Matsuda M, Shigemura K, Honda M, Yoshida H, Hiwaki H, Ogata K, Oda T Tags: Jpn J Infect Dis Source Type: research

Phylogenetic analysis of sapovirus detected from an outbreak of acute gastroenteritis on ishigaki island (okinawa prefecture, Japan) in 2012.
PMID: 24647263 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Nidaira M, Taira K, Kato T, Arakaki E, Kyan H, Takara T, Okano S, Kuba Y, Kudaka J, Noda M Tags: Jpn J Infect Dis Source Type: research

A cross-sectional survey of severe Fever with thrombocytopenia syndrome virus infection of domestic animals in laizhou city, shandong province, china.
Abstract A serosurvey of severe fever with thrombocytopenia syndrome virus (SFTSV) infection in domestic animals was conducted in the rural areas of Laizhou City, Shandong Province, China to determine strategies for control and prevention of SFTS. Serum samples were collected from cattle, goats, dogs, pigs, and chickens and antibodies against SFTSV were detected by double-antigen sandwich enzyme-linked immunosorbent assay (ELISA). Of 641 serum samples, the SFTSV seropositive rate was 41.8% (268/641): 74.8%, 57.1%, 52.1%, 35.9%, and 0%, for goats, cattle, dogs, chickens, and pigs, respectively. We also found that t...
Source: Japanese Journal of Infectious Diseases - January 25, 2014 Category: Infectious Diseases Authors: Ding S, Yin H, Xu X, Liu G, Jiang S, Wang W, Han X, Liu J, Niu G, Zhang X, Yu XJ, Wang X Tags: Jpn J Infect Dis Source Type: research

Device-associated nosocomial infection rates and distribution of antimicrobial resistance in a medical-surgical intensive care unit in Turkey.
Abstract The aim of this study was to explore the rate of device-associated nosocomial infections (DANIs) and the distributions of causative agents and patterns of antibiotic resistance in the medical-surgical intensive care unit (ICU) over a 3-year period and to compare these rates with those reported by National Nosocomial Infections Surveillance System and International Nosocomial Infection Control Consortium. A total of 1,798 patients were hospitalized in our ICU for 13,942 days, of which 309 patients had DANIs, indicating an overall infection rate of 22.1 per 1,000 ICU-days. The central line-associated bloods...
Source: Japanese Journal of Infectious Diseases - January 25, 2014 Category: Infectious Diseases Authors: Tigen ET, Dogru A, Koltka EN, Unlu C, Gura M Tags: Jpn J Infect Dis Source Type: research

Mutant murine hepatitis virus-induced apoptosis in the hippocampus.
Abstract The mutant virus Mu-3 was isolated from the soluble receptor-resistant mutant 7 virus (srr7), which is a neuropathogenic strain of the mouse hepatitis virus JHMV, and cloned as a soluble receptor-resistant mutant from the highly neuropathogenic JHMV strain cl-2 virus (cl-2). In order to identify specific characteristcs of Mu-3, the pathology of Mu-3-infected mice was compared with that of srr7- and cl-2-infected mice. The neuropathology after Mu-3 infection exhibited a mixed pattern comparable to that induced by srr7 and cl-2 infections. In addition, Mu-3 infection caused marked apoptotic lesions in the h...
Source: Japanese Journal of Infectious Diseases - January 25, 2014 Category: Infectious Diseases Authors: Kakizaki M, Kashiwazaki H, Watanabe R Tags: Jpn J Infect Dis Source Type: research

An Epidemiological Study of Mycoplasma genitalium Infections among Males Attending a Sexually Transmitted Disease Clinic in Guangxi, China.
The objective of this study was to determine the prevalence of urethral Mycoplasma genitalium infections among male patients attending a sexually transmitted disease (STD) clinic in China and identify risk factors associated with this disease. A total of 423 patients were recruited in Hezhou City, Guangxi Province, China, and each was requested to complete a questionnaire regarding sociological and sexual behaviors. First-void urine samples were collected for M. genitalium analysis by polymerase chain reaction. Of the 406 urine samples collected, 114 were M. genitalium-positive, giving a prevalence rate of 28.1%. Univariat...
Source: Japanese Journal of Infectious Diseases - January 25, 2014 Category: Infectious Diseases Authors: Zheng BJ, Yin YP, Xiang Z, Han Y, Shi MQ, Jiang N, Yu RX, Chen XS Tags: Jpn J Infect Dis Source Type: research

Plasma oxidative stress and total thiol levels in crimean-congo hemorrhagic Fever.
In this study, we investigated the pro- and antioxidant status of patients with a pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) in terms of their role in its pathogenesis. During the study period, 34 children and 41 adults were diagnosed with CCHF. The control group consisted of healthy age- and gender-matched children and adults. Serum levels of the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and plasma total thiol (TTL) were evaluated and compared between groups. The difference in mean TAC values between CCHF patients and healthy controls was not statistically sign...
Source: Japanese Journal of Infectious Diseases - January 25, 2014 Category: Infectious Diseases Authors: Karadag-Oncel E, Erel O, Ozsurekci Y, Caglayik DY, Kaya A, Gozel MG, Icagasioglu FD, Engin A, Korukluoglu G, Uyar Y, Elaldi N, Ceyhan M Tags: Jpn J Infect Dis Source Type: research