Japanese Journal of Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dysregulated leukotriene metabolism in covid-19 patients
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.211. Online ahead of print.ABSTRACTThe aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Halef Okan Do ğan Mahir Budak K übra Doğan G özde Ertürk Zararsız Serra İlayda Yerlitaş Serkan Bolat Onur Şenol Seyit Ali B üyüktuna Ergun P ınarbaşı Ra ğıp Sarıismailoğlu Hayrettin Yavuz Source Type: research

Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2022.571. Online ahead of print.ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were included in the analysis from April 2016 to April 2022. Multivariable logistic regression analysis showed that pancreatic injury (OR...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Mengke Yang Yang Yang Aiping Zhang Mingyue Ni Manman Liang Bin Quan Wenzheng Han Jianghua Yang Source Type: research

Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins
Jpn J Infect Dis. 2023 Dec 28. doi: 10.7883/yoken.JJID.2023.400. Online ahead of print.ABSTRACTSome lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutra...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Yusuke Inoue Yoshihiro Kaku Michiko Harada Keita Ishijima Yudai Kuroda Kango Tatemoto Milagros Virhuez-Mendoza Ayano Nishino Tsukasa Yamamoto Satoshi Inoue Aya Matsuu Ken Maeda Source Type: research

Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017-2022
In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Ja...
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Kazuya Shirato Reiko Suwa Naganori Nao Miyuki Kawase Satoko Sugimoto Yohei Kume Mina Chishiki Takashi Ono Hisao Okabe Sakurako Norito Masatoki Sato Hiroko Sakuma Shigeo Suzuki Mitsuaki Hosoya Makoto Takeda Koichi Hashimoto Source Type: research

First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan
This report is the first to detect JMTV in the Kanto region. Further studies are required to elucidate the potential risk of infection by this tick-borne virus in Japan. In particular, the prevalence of JMTV in wild animals should be examined to clarify its geographical distribution, host range, and transmission cycle in nature.PMID:38171848 | DOI:10.7883/yoken.JJID.2023.347 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 3, 2024 Category: Infectious Diseases Authors: Ryo Matsumura Daisuke Kobayashi Kyo Itoyama Haruhiko Isawa Source Type: research

Cleavage activation of respiratory viruses - Half a century of history from Sendai virus to SARS-CoV-2
Jpn J Infect Dis. 2023 Nov 30. doi: 10.7883/yoken.JJID.2023.353. Online ahead of print.ABSTRACTFor many viruses, cleavage activation of membrane fusion protein by host proteases is required for infection. This knowledge is based on the historical studies on Sendai virus in the 1970s. From the 1970s to the 1990s, the avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and host proteases' cleavage activation of viral membrane fusion proteins (hemagglutinin and fusion proteins). In these viruses, the cleavage of viral membrane fusion proteins by furin is the basis for their h...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Makoto Takeda Source Type: research

Development of Molecular-based Screening Test for Hepatitis B Virus in Human Plasma Samples
This study developed a rapid, sensitive, and portable system-integrative LAMP assay to detect Hepatitis B DNA in plasma samples. The final optimized assay was achieved with an amplification time of less than 45 minutes at 62°C. As a result of testing 77 HBV-positive plasma samples with known Cq values, the LAMP assay showed 100% specificity, 92, 20% sensitivity, and a detection limit of 10 copies/µL. Our results showed that the colorimetric LAMP assay is a sensitive, efficient, and highly reliable assay for the rapid detection of HBV and has the potential to be used as a screening test in areas where poor laboratory faci...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Kevser Hanne Alt ın Esra Agel Source Type: research

A case of Legionella pneumophila serogroup 13 pneumonia based on the detection of serogroup-specific genes in culture-negative sputum
Jpn J Infect Dis. 2023 Nov 30. doi: 10.7883/yoken.JJID.2023.302. Online ahead of print.ABSTRACTLegionella pneumophila serogroup (SG) 1, the main cause of Legionnaires' disease, can be diagnosed with urinary antigen testing kits; however, lower respiratory tract specimen culture is necessary to identify L. pneumophila SG 2-15. We attempted to detect L. pneumophila SG-specific genes in a culture-negative sputum specimen from a patient with pneumonia suspected to have Legionnaires' disease. Two multiplex PCR methods targeting L. pneumophila were modified and amplicons considered to be SG13 specific were detected. Direct seque...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Junji Seto Jun Takahashi Mika Sampei Tatsuya Ikeda Katsumi Mizuta Source Type: research

Difficulty in Serologic Screening for Subclinical Rubella During Pregnancy
This study showed that the single combination of rubella HI and rubella-specific IgM measurements alone did not detect subclinical rubella. Creating awareness among pregnant women by informing them that almost all rubella-specific IgM-positive individuals without symptoms are not acutely infected could decrease their anxiety and prevent unnecessary termination of pregnancies.PMID:38030270 | DOI:10.7883/yoken.JJID.2023.222 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Kazuya Hiiragi Ryosuke Shindo Satoru Shinoda Mika Okuda Keiko Tanaka-Taya Kentaro Kurasawa Etsuko Miyagi Shigeru Aoki Source Type: research

Establishment of reference reagents for single-radial-immunodiffusion assay on the 2022/23 seasonal influenza vaccine in Japan and their quality validation
Jpn J Infect Dis. 2023 Nov 30. doi: 10.7883/yoken.JJID.2023.218. Online ahead of print.ABSTRACTPotency test of influenza vaccine is currently performed using a single-radial-immunodiffusion (SRID) assay, which requires a reference antigen and anti-hemagglutinin (HA) serum as reference reagents. The reagents must be newly prepared each time the strain used for vaccine production is changed. Establishing reference reagents with consistent quality is, therefore, crucial to accurately and precisely conduct vaccine potency tests. Here, we established the reference reagents for the SRID assay to conduct lot release tests of quad...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Noriko Shimasaki Tomoko Kuwahara Haruna Nishijima Kazuya Nakamura Kayoko Sato Keiko Murano Shigeyuki Itamura Yukiko Akahori Emi Takashita Noriko Kishida Tomoko Arita Mina Nakauchi Makoto Takeda Hideki Hasegawa Akihide Ryo Yuichi Harada Source Type: research

High prevalence of carbapenem-resistant Enterobacterales producing OXA-48 among carbapenem-resistant isolates in a regional hospital in central Taiwan
In conclusion, our study highlights high carbapenemase prevalence in CRE, primarily OXA-48. Multiple carbapenemases within strains were common, and PFGE showed diverse patterns in these carbapenem-resistant isolates.PMID:38030272 | DOI:10.7883/yoken.JJID.2023.213 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Lii-Tzu Wu Hong-Thuy Vy Nguyen Se-Chin Ke Yi-Pei Lin Yi-Chun Pang Ming-Kai Guo Chih-Ming Chen Source Type: research

Bacterial Infections Versus Viral Infections Preference of ABO Blood Group Phenotype Patient
This study aimed to evaluate a correlation between the blood group type and the susceptibility to infection. 558 patients were enrolled in this study who attended at the Althawra Hospital, Ibb city, from March to August 2018. A blood sample was analyzed for complete blood count (CBC) and blood group. High frequency of infections affecting the digestive system (26.4%), while the less affected system is the urogenital system 5.9%. Patients with A blood group have increased probability to be infected by viruses than bacteria(Odds Ratio =1.430; 95% Confidence Interval =1.005 to 2.035; p= 0.05) and (OR=0.098; 95% CI=0.064 to 0....
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Jamil Mohammed Abduh Saeed Obaid Fadhl Ahmed Saeed Al-Gashaa Source Type: research