Increase in Primary and Secondary Syphilis Notifications in Men in Tokyo, 2007-2013.
Abstract The number of notified syphilis cases in Tokyo has more than doubled in recent years. The number of reported primary and secondary syphilis cases increased from 108 cases (0.8 per 100,000 population) in 2007 to 245 cases in 2013 (1.9 per 100,000 population). During this period, the majority of cases was male (905/1,024), and the recent increase among primary and secondary syphilis cases was attributed to the increase among males (90/108 [83%] cases in 2007 to 218/245 [89%] cases in 2013); men aged 20-49 years contributed most to the increase, with those aged 30-34 years having the highest notification rat...
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Sugishita Y, Yamagishi T, Arima Y, Hori N, Seki N Tags: Jpn J Infect Dis Source Type: research

Molecular Characterization of Imipenem-Resistant, Meropenem-Susceptible Pseudomonas aeruginosa with blaVIM ₋₂ Phenotype: Potential for Dissemination.
Molecular Characterization of Imipenem-Resistant, Meropenem-Susceptible Pseudomonas aeruginosa with blaVIM₋₂ Phenotype: Potential for Dissemination. Jpn J Infect Dis. 2016;69(2):159-60 Authors: Pragasam AK, Raghanivedha M, Anandan S, Veeraraghavan B PMID: 26567829 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Pragasam AK, Raghanivedha M, Anandan S, Veeraraghavan B Tags: Jpn J Infect Dis Source Type: research

Distribution of Chlamydia trachomatis Infection Determined by Nucleic Acid Amplification Tests in Pregnant Women in Japan.
PMID: 26743152 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Suzuki S, Tanaka M, Sekizawa A, Kinoshita K Tags: Jpn J Infect Dis Source Type: research

Molecular Epidemiology of Monophasic Salmonella enterica serovar O7: -: 1, 5 Isolates in Akita Prefecture, Japan.
PMID: 26743153 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Konno T, Takahashi S, Kumagai Y Tags: Jpn J Infect Dis Source Type: research

The characteristics of extended-spectrum β-lactamases-producing Escherichia coli in hospital faecal carriage in Beijing Tongren Hospital.
The characteristics of extended-spectrum β-lactamases-producing Escherichia coli in hospital faecal carriage in Beijing Tongren Hospital. Jpn J Infect Dis. 2016 Oct 31; Authors: Xu M, Fan Y, Wang M, Lu X Abstract We aimed to investigate the prevalence of extended-spectrum β-lactamases (ESBL)-producing Escherichia coli (E. coli) in Beijing Tongren hospital and find the relationship between colonization and infection. The clinical data of 650 inpatients included between March 2012 and July 2012 were retrospectively reviewed. The prevalence of ESBL-producing E. coli among inpatients was 25.7% (...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Xu M, Fan Y, Wang M, Lu X Tags: Jpn J Infect Dis Source Type: research

Bloodstream infection due to CTX-M-15 and TEM-1 extended spectrum β-lactamase-producing Salmonella enterica serovar Virchow ST16.
Bloodstream infection due to CTX-M-15 and TEM-1 extended spectrum β-lactamase-producing Salmonella enterica serovar Virchow ST16. Jpn J Infect Dis. 2016 Oct 31; Authors: Hwang JH, Shin GW, Hwang JH, Lee CS Abstract A 57-year-old man presented with a high fever and diarrhea. A blood culture showed the presence of a Group C nontyphoidal Salmonella isolate. On Salmonella serotyping, the isolate was Salmonella enterica serovar Virchow. Its sequence type was determined to be ST16 by sequence analysis of seven different housekeeping genes. The blaCTX-M group 1 and blaTEM genes were amplified by multipl...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Hwang JH, Shin GW, Hwang JH, Lee CS Tags: Jpn J Infect Dis Source Type: research

Prevalence and determinants of HSV-2/syphilis co-infection and HSV-2 mono-infection among HIV-positive men who have sex with men: a cross-sectional study in Northeast China.
Abstract We aimed to assess the prevalence and determinants of herpes simplex virus type 2 (HSV-2) mono-infection and HSV-2/syphilis co-infection in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in China. A cross-sectional study was conducted on 545 HIV-positive MSM in Shenyang between February 2009 and October 2014. Participants received physical examinations and serological tests for HSV-2 and syphilis. A multinomial logistic regression was used to identify risk factors associated with HSV-2/syphilis co-infection and HSV-2 mono-infection. The HSV-2 mono-infection, syphilis mono-infe...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Hu QH, Xu JJ, Chu ZX, Zhang J, Yu YQ, Yu H, Ding HB, Jiang YJ, Geng WQ, Wang N, Shang H Tags: Jpn J Infect Dis Source Type: research

Impaired thiol-disulphide balance in acute brucellosis.
The objective of this study was to examine a novel profile: thiol-disulphide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulphide profile tests were analysed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 ± 48.20 µmol/L in the acute brucellosis group and 461.13 ± 45.37 µmol/L in the healthy group, and total thiol levels were 298.58 ± 51.78 µmol/L in the acute brucellosis group and 504.83 ± 51.05 µmol/L in the healthy group (p
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Kolgelier S, Ergin M, Demir LS, Inkaya AC, Demir NA, Alisik M, Erel O Tags: Jpn J Infect Dis Source Type: research

Predictors of Hospitalization and Admission to Intensive Care Units of Influenza Patients in Serbia through Four Influenza Seasons from 2010/2011 to 2013/2014.
jićić SŠ Abstract Retrospective analysis of the surveillance of laboratory confirmed cases of influenza in four post pandemic seasons in Serbia, was performed to evaluate predictors of hospitalization and admission to intensive care units (ICU). The specimens, which combined nasal and throat swabs were tested for influenza. For statistical analysis univariate and multivariate logistic regression analyses were used. 777 confirmed influenza cases were analyzed. Age over 65 years, the presence of any co-morbidity or the presence of two or more comorbidities, infection with influenza A(H1)pdm09 and the interv...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Dimitrijević D, Ilić D, Adrović SR, Šuljagić V, Pelemiš M, Stevanović G, Milinković M, Grujićić SŠ Tags: Jpn J Infect Dis Source Type: research

Difference of the change of the hospitalization for pneumonia in children between Japanese secondary and tertiary medical facilities after the introduction of pneumococcal conjugate vaccine.
Abstract The aim of this study is to compare pneumonia hospitalization in children between secondary and tertiary medical facilities, hospitalizing many children without and with underlying diseases, respectively, after the introduction of pneumococcal conjugate vaccine (PCV). Our retrospective study was performed on the children who were admitted to the Department of Pediatrics at Kitakyushu General Hospital, a secondary medical facility, and at Hospital of the University of Occupational and Environment Health, Japan, a tertiary medical facility, from 2009 to 2013 for pneumonia. The variation of hospitalization r...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Haro K, Ogawa M, Hoshina T, Kojiro M, Kusuhara K Tags: Jpn J Infect Dis Source Type: research

Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution.
Abstract Population size dependency of measles, syphilis and amebiasis was expressed as P = kN(m), where P, N and m were respectively number of patients, population size and a constant (~2 for measles and 1.3~1.4 for syphilis and amebiases). The population size dependency emerged only when conditions other than the population size, such as, infant mortality, hygienic condition, vaccination practices, etc., were improved to the same level in all the prefectures in Japan. Formation of prefectures and municipalities was well simulated by the random coin toss assuming that people are attracted to a community with a pr...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Yoshikura H, Takeuchi F Tags: Jpn J Infect Dis Source Type: research

Dengue-associated acute encephalitis syndrome cases in Son La Province, Vietnam in 2014.
The objectives of this paper were to determine the proportion of encephalitic patients due to JEV during the 2014 outbreak in Son La Province in Vietnam and to find the association of DENV in non-JEV viral encephalitis cases. Out of 90 patients, 6 (6.7%) were positive for anti-JEV IgM, 5 (5.6%) were positive for anti-DENV IgM, 30 (33.3%) were positive for both anti-JEV and anti-DENV IgM and 56 (62.2%) were positive for flavi IgG. Five AES patients positive with anti-DENV IgM in at least one of paired serum samples were confirmed to have DENV by neutralization tests. The incidence of JEV infection rate was high. There is st...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Ngwe Tun MM, Muthugala RV, Thuy NT, Ly PH, Thu LT, Dinh DT, Hoang NV, Mai LT, Moi ML, Buerano CC, Morita K, Hasebe F Tags: Jpn J Infect Dis Source Type: research

An ecological survey of mosquitoes and the distribution of Japanese encephalitis virus in Ishikawa Prefecture, Japan between 2010 and 2014.
We report the seasonal dynamics of mosquitoes between 2010 and 2014 in Ishikawa Prefecture, Japan. We collected 39,308 female adult mosquitoes, 98.2% of which were classified as Culex tritaeniorhynchus Giles. We identified JEV genomic RNA belonging to genotype 1 among the homogenate of Cx. tritaeniorhynchus collected during our study using reverse transcription-polymerase chain reaction and nucleotide sequencing methods. Our results indicated that mosquito vectors for JEV are distributed not only in areas in Ishikawa but also throughout Japan and suggest that we must be careful regarding JEV outbreaks in Japan in the futur...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Murakami M, Hori K, Kitagawa Y, Oikawa Y, Kamimura K, Takagemi T Tags: Jpn J Infect Dis Source Type: research

Detection of antibodies to Borna disease virus proteins in an autistic child and her mother.
PMID: 27795475 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, Tomonaga K Tags: Jpn J Infect Dis Source Type: research

A decennium of etiology and antimicrobial susceptibility patterns in patients with infective endocarditis at a university hospital, Thailand.
In conclusion, Group B streptococcus isolates increased in patients with infective endocarditis in Thailand. Streptococcus suis had the highest MIC90 and penicillin-nonsusceptible isolates. Rigorously restrict using of antimicrobial agents in animal feeds should more concern. PMID: 27795476 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Nakaranurack C, Puttilerpong C, Suwanpimolkul G Tags: Jpn J Infect Dis Source Type: research

First human case of Rickettsia sibirica mongolotimonae infection in Northern Greece in a teenager from Thrace.
We describe herein a male adolescent from Thrace, Northern Greece with clinical and serological evidence of infection due to this rickettsia species, who recovered uneventfully with appropriate therapy. The patient got infected in the island of Samothraki, the most northern island of the Aegean Sea, during a recent trip. Although R. sibirica mongolitimonae was neither cultivated nor was a PCR performed in a cutaneous specimen from the inoculation eschar, serological testing along with the typical clinical picture makes the diagnosis highly probable. Rickettsia sibirica mongolitimonae appears to be an emerging pathogen in b...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Chochlakis D, Mantadakis E, Thomaidis S, Tselentis Y, Chatzimichael A, Psaroulaki A Tags: Jpn J Infect Dis Source Type: research

High rates of contamination of poultry meat products with drug resistant Campylobacter in Metro Manila, Philippines.
Abstract A total of 265 chicken parts were collected from 15 wet markets and 15 supermarkets in Metro Manila, Philippines. Campylobacter spp. was isolated on modified charcoal cefoperazone deoxycholate agar plates and identified through biochemical tests and PCR amplification of genus and species specific genes. Antimicrobial resistance profiles were determined following Clinical and Laboratory Standards Institute protocols. Two hundred seven (78%) Campylobacter spp. were isolated. C. jejuni and C. coli were detected from 170 (64%) and 32 (12%) of the samples, respectively. Liver and skin samples had the greatest ...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Lim PW, Tiam-Lee DC, Paclibare PA, Subejano MS, Cabero-Palma JA, Penuliar GM Tags: Jpn J Infect Dis Source Type: research

Orbital Cellulitis with Endogenous Panophthalmitis caused by Methicillin-Sensitive Staphylococcus aureus in pregnancy.
Abstract Orbital cellulitis along with panophthalmitis is uncommon. The causes are usually trauma-related or endogenous. The prognosis in terms of globe salvage is very poor with most cases usually requiring enucleation or evisceration of the affected eye. Immunosuppression in some form is usually present, which accounts for the aggressive course of the infection. In this communication, we report a case of a 25-year-old female, in the second trimester of pregnancy, who developed orbital cellulitis and panophthalmitis caused by Methicillin sensitive Staphylococcus aureus (MSSA); with the primary source of infection...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Aulakh S, Nair AG, Gandhi R, Palkar AH, Trivedi MG, Potdar NA, Shinde CA Tags: Jpn J Infect Dis Source Type: research

Poliovirus study in the endgame of the polio eradication program.
Abstract Since the start of Global Polio Eradication Initiative in 1988, poliomyelitis cases caused by wild poliovirus (PV) were drastically reduced to only 74 cases in 2 endemic countries in 2015. With established vaccine campaign, current limited PV transmission suggested the endgame of the polio eradication program. In the endgame, we have emerging challenges specific to the endgame; tight budget, switching of the vaccines, and changes in the biorisk management. To overcome these challenges, several projects of PV study attract attention in the eradication program. Some of these emerging challenges/projects of ...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Arita M Tags: Jpn J Infect Dis Source Type: research

Biting Density and Distribution of Aedes albopictus during the September 2014 Outbreak of Dengue Fever in Yoyogi Park and the Vicinity of Tokyo Metropolis, Japan.
This study aimed to collect referential data to estimate the transmission threshold of dengue virus in terms of biting density of Ae. albopictus and determined high transmission risk areas of dengue virus in Yoyogi Park and its vicinity. The overall mean density of biting Ae. albopictus (7.13/man/8 min) was sufficiently high for successful transmission of dengue virus, and areas with biting densities higher than the overall mean density were classified as high risk areas for the transmission of dengue virus in Yoyogi Park. PMID: 25766613 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Tsuda Y, Maekawa Y, Ogawa K, Itokawa K, Komagata O, Sasaki T, Isawa H, Tomita T, Sawabe K Tags: Jpn J Infect Dis Source Type: research

Evaluation of Non-Viral Surrogate Markers as Predictive Indicators for Monitoring Progression of Human Immunodeficiency Virus Infection: An Eight-Year Analysis in a Regional Center.
Abstract Suitable methods for clinical monitoring of HIV-infected patients are crucial in resource-poor settings. Demographic data, clinical staging, and laboratory findings for 112 asymptomatic subjects positive for HIV were assessed at the first admission and the last visit from 2002 to 2010. Cox regression analysis showed hemoglobin (Hb) (HR = 0.643, P = 0.021) to be a predictive indicator for disease progression, while CD4, CD8, and platelet counts showed low HRs, despite having significant probability values. Hb and total lymphocyte count (TLC) rapidly declined from stage II to III (10.9 and 29.6%, respective...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Rafatpanah H, Essmailian L, Hedayati-Moghaddam MR, Vakili R, Norouzi M, Sarvghad MR, Hosseinpour AM, Sharebiani H, Rezaee SA Tags: Jpn J Infect Dis Source Type: research

Raltegravir and Abacavir/Lamivudine in Japanese Treatment-Na ïve and Treatment-Experienced Patients with HIV Infection: a 48-Week Retrospective Pilot Analysis.
Raltegravir and Abacavir/Lamivudine in Japanese Treatment-Naïve and Treatment-Experienced Patients with HIV Infection: a 48-Week Retrospective Pilot Analysis. Jpn J Infect Dis. 2016;69(1):33-8 Authors: Suzuki A, Uehara Y, Saita M, Inui A, Isonuma H, Naito T Abstract Abacavir/lamivudine (ABC/3TC) is a nucleoside reverse transcriptase inhibitor used for treating human immunodeficiency viral (HIV) infections. Hypersensitivity reactions such as skin eruptions caused by ABC are well-known, but rarely occur in Asians. Raltegravir (RAL) is an integrase strand transfer inhibitor, that is now increasingly...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Suzuki A, Uehara Y, Saita M, Inui A, Isonuma H, Naito T Tags: Jpn J Infect Dis Source Type: research

What We Have Learned from the Influenza A pH1N1 2009/10 Pandemic: High Clinical Impact of Human Metapneumovirus and Respiratory Syncytial Virus in Hospitalized Pediatric Patients.
Abstract The influenza pandemic in 2009/2010 shifted public awareness to respiratory tract infections caused by the influenza virus. A prospective study was conducted during the influenza pandemic from November 2009 through April 2010 to determine the causative pathogens and clinical symptoms present in all children and adolescents admitted to the University Children's Hospital, Duesseldorf, Germany, with signs and symptoms of respiratory tract infection. A total of 272 children and adolescents were admitted with symptoms of acute respiratory tract infection (ARI) or influenza-like illness. Viral pathogens were de...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Vogel M, Grund S, Pandey S, Mayatepek E, Schroten H, Tenenbaum T, Adams O Tags: Jpn J Infect Dis Source Type: research

The Economic Burden of Hepatitis A, B, and C in South Korea.
This study was performed in order to estimate the individual economic costs of the hepatitis A, B, and C viruses as well as to determine, using nationally representative data, the trends in South Korea with respect to these viruses during the 2008-2011 period. The study found that the prevalence of hepatitis A had decreased, but those of hepatitis B and C had increased overall. The mortality rate of hepatitis C was higher than that of the other two types. The mortality rate of hepatitis B had changed little, whereas that of hepatitis C had risen. The total cost of hepatitis A had decreased, from US $62.2 million to US $45....
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Shon C, Choi HY, Shim JJ, Park SY, Lee KS, Yoon SJ, Oh IH Tags: Jpn J Infect Dis Source Type: research

The First Report of Vibrio parahaemolyticus Strain O10:K60 in Japan, a New Combination of O and K Serotypes Isolated from a Patient with Gastroenteritis.
In this study, we examined V. parahaemolyticus isolated from a gastroenteritis patient's stool at a hospital in Saitama City, Japan in 2013. Serotyping of the O and K antigens identified the strain as O10:K60. To our knowledge, this is the first reported case of a V. parahaemolyticus strain with this antigen combination in Japan. Subsequently, we used PCR to assay for pathogenicity-associated genes, and found that it was positive for tdh, T3SS1, and T3SS2α genes. Antibiotic susceptibility tests showed that the strain was susceptible to all selected antibiotics except ampicillin. Moreover, we detected specific marker ...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Ueno H, Tomari K, Kikuchi K, Kobori S, Miyazaki M Tags: Jpn J Infect Dis Source Type: research

Adverse Drug Reactions in HIV/AIDS Patients at a Tertiary Care Hospital in Penang, Malaysia.
Abstract In the current study we explored the occurrence of adverse drug reactions (ADRs) to antiretroviral therapy among human immune-deficiency virus (HIV)/AIDS patients. We concluded an observational retrospective study in all patients who were diagnosed with HIV infection and were receiving highly active antiviral therapy from Jan. 2007 to Dec. 2012 at Hospital Pulau Pinang, Malaysia. Patient socio-demographic details along with clinical features and susceptible ADRs were observed during the study period. Out of 743 patients, 571 (76.9%) were men, and 172 (23.1%) were women. Overall 314 (42.2%) patients experi...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Khan K, Khan AH, Sulaiman SA, Soo CT, Akhtar A Tags: Jpn J Infect Dis Source Type: research

Relationship between MMP Expression and Virulence of Dengue Virus Type-2 in Infected Mosquito and Mammalian Cells.
Abstract Dengue virus infections are mostly asymptomatic but can produce a mild, self-limiting acute febrile illness, dengue fever, or a life threatening severe illness, dengue hemorrhagic fever. Dengue hemorrhagic fever is associated with increased vascular permeability partly as a result of elevated levels of matrix metalloproteinases (MMPs). We characterized MMP-2 and MMP-9 production in mosquito and mammalian cells after infection with three strains of dengue virus type-2 (D2-) ranging in virulence: 16681, the prototype New Guinea C (NGC), and PDK-53 vaccine strain. These strains were used to test variations i...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Leaungwutiwong P, Kelley JF, Sachair A, Jittmittraphap A, Luplertlop N Tags: Jpn J Infect Dis Source Type: research

Crimean-Congo Hemorrhagic Fever: Prognostic Factors and the Association of Leukocyte Counts with Mortality.
Abstract We aimed to determine the relationship between leukocyte counts and the survival of patients with Crimean-Congo hemorrhagic fever (CCHF), a life-threatening illness. This is the first study to do so. A total of 220 patients with CCHF were evaluated retrospectively. The mortality rate was 16.4%. Analysis of the relationship between leukocyte counts and mortality rates provided insight into the pathogenesis of CCHF. Receiving operating curve analysis revealed that leukocyte counts ≥2,950/mm(3) on the day of admission predicted mortality rate with 62.1% sensitivity. The mean hospitalization stay in patien...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Bastug A, Kayaaslan B, Kazancioglu S, Aslaner H, But A, Akinci E, Yetkin MA, Eren S, Bodur H Tags: Jpn J Infect Dis Source Type: research

Cleanliness of Linen and Clothing Items Professionally Laundered or Dry-Cleaned.
Abstract We asked 14 professional cleaners (laundry services) to clean various unused (new) linen and clothing items with a microbial contamination level of
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Oie S, Furukawa H, Kobayashi H, Okubo T Tags: Jpn J Infect Dis Source Type: research

Phage Display-Derived Cross-Reactive Neutralizing Antibody against Enterovirus 71 and Coxsackievirus A16.
Abstract Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are members of the Picornaviridae family and are considered the main causative agents of hand, foot and mouth disease (HFMD). In recent decades large HFMD outbreaks caused by EV71 and CVA16 have become significant public health concerns in the Asia-Pacific region. Vaccines and antiviral drugs are unavailable to prevent EV71 and CVA16 infection. In the current study, a chimeric antibody targeting a highly conserved peptide in the EV71 VP4 protein was isolated by using a phage display technique. The antibody showed cross-neutralizing capability against EV...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Zhang X, Sun C, Xiao X, Pang L, Shen S, Zhang J, Cen S, Yang BB, Huang Y, Sheng W, Zeng Y Tags: Jpn J Infect Dis Source Type: research

Serologic and Virologic Studies of an Imported Dengue Case Occurring in 2014 in Okinawa, Japan.
Abstract After returning from Bali, Indonesia, in February 2014, a 72-year-old man was hospitalized in Okinawa owing to a high fever and rash. Dengue was clinically suspected, and the patient tested positive for IgM against dengue using a commercial kit. Serologically, the patient showed secondary seroreactivity. Significant increases in neutralization titers (N-titers) against all 4 serotypes of dengue virus (DENV) and Japanese encephalitis virus (JEV) strains were recognized in convalescent-phase sera comparing to acute phase sera. The N-titer against DENV serotype 1 (DENV-1) was the highest among all DENV serot...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Saito M, Tamayose M, Miyagi K, Takaragawa H, Tateyama M, Tadano M, Fujita J Tags: Jpn J Infect Dis Source Type: research

Antibiotic Resistance of Campylobacter jejuni and C. coli Isolated from Children with Diarrhea in Thailand and Japan.
Abstract A total of 29 Campylobacter jejuni and C. coli strains were isolated from Thai and Japanese children with diarrhea using the Loop-mediated Isothermal Amplification method. The samples were evaluated for mutations in gyrA and 23S rRNA in order to assess resistance against fluoroquinolones and macrolides, respectively. Among the isolated strains, 9 (8 C. jejuni and 1 C. coli) were from Thai children, and the other 20 (C. jejuni) were isolated from Japanese children. High fluoroquinolone resistance rates were observed in Thai (66.7%) and Japanese (90%) children. Macrolide resistance was not observed in Japan...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Pham NT, Thongprachum A, Tran DN, Nishimura S, Shimizu-Onda Y, Trinh QD, Khamrin P, Ukarapol N, Kongsricharoern T, Komine-Aizawa S, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H Tags: Jpn J Infect Dis Source Type: research

The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan.
Abstract We previously reported that progression of liver cirrhosis is quicker and survival is dismal in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection, especially when acquired in childhood through contaminated blood products. Recently, we performed the first deceased donor liver transplantation (DDLT) for an HIV/HCV-coinfected hemophilic patient in Japan. A 40-year-old man was referred to our hospital for liver transplantation. Regular DDLT was performed using the piggyback technique with a full-sized liver graft. Cold ischemia time was 465 min, and the graft liver weigh...
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Eguchi S, Takatsuki M, Soyama A, Hidaka M, Kugiyama T, Natsuda K, Adachi T, Kitasato A, Fujita F, Kuroki T Tags: Jpn J Infect Dis Source Type: research

Characterization of an A (H1N1)pdm09 Virus Imported from India in March 2015.
PMID: 26567835 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 20, 2016 Category: Infectious Diseases Authors: Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Ohmiya S, Sato K, Ito H, Chiba F, Nishimura H, Shindo S, Watanabe S, Odagiri T, Influenza Virus Surveillance Group of Japan Tags: Jpn J Infect Dis Source Type: research

The Phantom Menace for the Patients with Hepatobiliary Diseases: Shewanella haliotis, often Misidentified as Shewanella algae by Biochemical Tests and MALDI-TOF.
Abstract Although Shewanella algae has been known for weak pathogenicity, case reports have been steadily increased. Shewanella algae and Shewanella haliotis are not easy to distinguish by conventional phenotypical methods. We reviewed microbiological and clinical features of S. algae and S. haliotis infections in our institute. Bacterial culture and identification reports from patient samples from 2010 to 2014 were reviewed to screen the cases of Shewanella infections. In addition to conventional biochemical tests, 16S rRNA gene sequence analysis and MALDI-TOF were performed with 19 bacterial isolates stored. Med...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Byun JH, Park H, Kim S Tags: Jpn J Infect Dis Source Type: research

Rapid detection and typing of carbapenemase-producing genes from carbapenem-resistant Enterobacteriaceae isolates collected in a Japanese hospital using the Xpert(TM) Carba-R assay.
PMID: 27580570 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Uwamino Y, Sugita K, Hasegawa N, Nishimura T, Fujiwara H, Iwata S Tags: Jpn J Infect Dis Source Type: research

Prospective epidemiological evaluation of seasonal influenza in all elementary schoolchildren in Matsumoto City, Japan, in 2014/2015.
Abstract Seasonal influenza is known to spread within and among educational organizations. Detailed understanding of the pattern of infection requires prospective epidemiological studies among all schools in a community. This prospective survey evaluated 13,217 schoolchildren attending all 29 public elementary schools in Matsumoto City, Japan, in 2014/2015. Questionnaires were distributed to school nurses to obtain information about onset date and suspected route of transmission of influenza of all schoolchildren diagnosed at medical institutions. Responses were obtained regarding 2,548 infected individuals, repre...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Uchida M, Kaneko M, Hidaka Y, Yamamoto H, Honda T, Takeuchi S, Saito M, Kawa S Tags: Jpn J Infect Dis Source Type: research

Antimicrobial susceptibility and molecular epidemiology of multidrug-resistant Klebsiella pneumoniae in Central China.
This study investigated the epidemiology and resistance profiles of K. pneumoniae strains isolated in Central China between 2009 and 2014. Antimicrobial susceptibility tests and polymerase chain reaction were used to investigate the prevalence and resistance of ESBLs and carbapenemases produced by K. pneumoniae, and the prevalence of KPC-producing K. pneumoniae was investigated by multilocus sequence typing. Carbapenem resistance has emerged as the main concern in K. pneumoniae infections, with phenotype tests detecting carbapenemases in nearly 20% of isolates. KPC-producing isolates were clonally related in a local epidem...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Guo X, Cao Z, Dai Z, Li Y, He X, Hu X, Tian F, Ren Y Tags: Jpn J Infect Dis Source Type: research

Shiga Toxin Subtypes and Virulence Genes Distributed among Escherichia coli Isolated from Cattle.
Abstract Subtypes of stx1 and stx2 carried in 45 Shiga toxin-producing Escherichia coli (STEC) strains isolated from cattle were investigated using PCR. Only subtype stx1a was detected among all the stx1-positive strains. The major stx2 subtype was stx2a, and followed by stx2d, stx2c, stx2b and stx2g in decreasing order. stx2c was found in the strains of O157 and O174. stx2d was found in 11 strains; they were confirmed using DNA sequencing to carry both the activatable tail and the END motif, all of which were eae-negative and three contained stx2d as the only stx. stx2g was found in two strains in association wit...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Akiyama Y, Futai H, Saito E, Ogita K, Sakae H, Fukunaga M, Tsuji H, Chikahira M, Iguchi A Tags: Jpn J Infect Dis Source Type: research

Synergistic effect of TNF- α and dengue virus infection on adhesion molecule reorganization in human endothelial cells.
In conclusion, the synergistic effect of TNF-α and DENV induced permeability changes in endothelial cells. These results will improve better understanding of the mechanisms of enhanced vascular permeability in DENV infection. PMID: 27580574 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Inyoo S, Suttitheptumrong A, Pattanakitsakul SN Tags: Jpn J Infect Dis Source Type: research

Clinical and diagnostic aspects of brucellosis and antimicrobial susceptibility of Brucella isolates in Hamedan, Iran.
Abstract Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resistance pattern of Brucella melitensis clinical isolates by E-test method in Hamadan, west of Iran. In a 15-month period, all patients with suspected brucellosis were enrolled. Blood Specimens were collected for diagnosis of brucellosis by BACTEC system and serological tests. Antimicrobial susceptibility of clinic...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Asadi FT, Hashemi SH, Alikhani MY, Moghimbeigi A, Naseri Z Tags: Jpn J Infect Dis Source Type: research

A comparative evaluation of the serological and molecular methods for the diagnosis of scrub typhus in Indian settings.
Abstract The major brunt of Scrub typhus is borne by the developing countries like India but the disease still remains neglected. The rapid progression to fatal complications and associated mortality calls for improved diagnostic services. IgM Immunofluorescence assay (IFA) with all its limitations is still the gold standard. Out of 218 suspected cases enrolled in the 2 year study period, 30 cases of scrub typhus were detected by IgM IFA at 1:64 dilution. The sensitivity of IgM Enzyme linked immunosorbant assay (ELISA), IgM Rapid Flow assay (RFA) and IgG RFA was found to be 97%, 87% and 77% respectively. Their res...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Gupta N, Chaudhry R, K Kabra S, Lodha R, R Mirdha B, K Das B, Dey AB, Sreenivas V Tags: Jpn J Infect Dis Source Type: research

Prevalence and characteristics of Salmonella and Campylobacter in retail poultry meat in Japan.
This study was undertaken to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Salmonella enterica subsp. enterica and Campylobacter spp. in poultry meat, and to analyze the association of genetic types of these bacteria with their geographical distribution and antimicrobial resistance profiles. Fifty-four and 71 of 100 samples were found to be contaminated with Salmonella and Campylobacter, respectively. Nine Salmonella serotypes were found, including S. enterica subsp. enterica serovar Infantis (33%), Schwarzengrund (12%), Manhattan (9%), and others. Campylobacter jejuni and C. coli were ...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Furukawa I, Ishihara T, Teranishi H, Saito S, Yatsuyanagi J, Wada E, Kumagai Y, Takahashi S, Konno T, Kashio H, Kobayashi A, Kato N, Hayashi KI, Fukushima K, Ishikawa K, Horikawa K, Oishi A, Izumiya H, Ohnishi T, Konishi Y, Kuroki T Tags: Jpn J Infect Dis Source Type: research

Third-generation cephalosporin-resistant non-typhoidal Salmonella isolated from human feces in Japan.
Abstract Detection and characterization of β-lactamase genes in a total of ten non-typhoidal Salmonella (NTS) clinical isolates exhibiting resistance to the third-generation cephalosporins collected during 2012 -2014 in Japan were conducted. Among five strains with cefotaxime MIC (minimum inhibitory concentration) ≥64 μg/ml and positive results of clavulanic acid inhibition effect, blaCTX-M-2 was detected in three strains (serotypes Stanley and Muenchen), and each of blaTEM-52 (serotype Manhattan) and blaSHV-12 (serotype Infantis) was found in one strain. The blaCMY-2 was detected in all of the remainin...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Saito S, Koori Y, Ohsaki Y, Osaka S, Oana K, Nagano Y, Arakawa Y, Nagano N Tags: Jpn J Infect Dis Source Type: research

Isolation and characterization of an Escherichia albertii producing three different toxins from a child with diarrhea.
Abstract Here, we show that a bacterium isolated as a sole pathogen from a child with diarrhea harbor eae and 2 different cytolethal distending toxin genes (cdt) homologous to Escherichia coli cdt-I and cdt-II genes, respectively. The bacterium was originally identified as atypical E. coli by conventional biochemical tests. However, this bacterium was finally identified as E. albertii by multilocus sequence analysis, which is an only method being able to clearly differentiate E. coli from E. albertii. Shiga toxin 2f (stx2f) genes were also detected in the strain. Production of the 3 toxins was confirmed by cytotox...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Hinenoya A, Yasuda N, Hibino T, Shima A, Nagita A, Tsukamoto T, Yamasaki S Tags: Jpn J Infect Dis Source Type: research

Gonococcal Antimicrobial Susceptibility and Prevalence of blaTEM-1, blaTEM-135 Genes in Thailand.
Abstract We studied antimicrobial susceptibility and the current rates of blaTEM-1 and blaTEM-135. Neisseria gonorrhoeae 370 isolates were tested by using disk diffusion method and found 100% susceptible to cefixime, ceftriaxone, cefotaxime, ceftazidime, cefepime, spectinomycin and azithromycin. They were resistant to penicillin (85.7%), ciprofloxacin (88.0%), ofloxacin (97.4%), and tetracycline (89.1%). Penicillinase-producing N. gonorrhoeae (PPNG) was 83.8% which 70.0% was further identified as PPNG plus tetracycline resistant N. gonorrhoeae, with 13.8% being PPNG alone. Penicillin, tetracycline and ciprofloxaci...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Tribuddharat C, Pongpech P, Charoenwatanachokchai A, Lokpichart S, Srifuengfung S, Sonprasert S Tags: Jpn J Infect Dis Source Type: research

Presence of Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Non-endemic Areas, China.
According to this study, we suggested that health education should be enhanced to increase residents (especially the older ones and tea pluckers) awareness in order to protect them against SFTS viral infection. PMID: 27580581 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Huang X, Zhang Z, Jin G, Wang X, Tan C, Yin H, Wang S Tags: Jpn J Infect Dis Source Type: research

Prevalence and characteristics of pediatric healthcare workers without immunity to varicella zoster virus.
This study aimed to determine the proportion of varicella non-immune pediatric healthcare workers (HCWs) of Pediatrics Department, King Chulalongkorn Memorial Hospital and to determine cost effective strategies to identify non-immune personnel. A cross-sectional study, using a self-administered questionnaire to determine history of chickenpox or 2-dose varicella vaccination was conducted. From a total of 699 HCWs, 653 HCWs (93%) including 145 physicians (22%), 297 nurses (46%) and 211 administrative staff (32%) responded to questionnaires. There were 475 HCWs (73%) who had a history of chickenpox, 58(9%) who had completed ...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Anugulruengkitt S, Puthanakit T, Siengboon S, Paitoonpong L, Kowitdamrong E, Pancharoen C, Pichitchok Y Tags: Jpn J Infect Dis Source Type: research

Large-scale one-year survey of Trichinella spp. infection in wild boar (Sus scrofa) in Japan.
This study presents the results of a large-scale one-year survey of Trichinella spp. in Japanese wild boar (Sus scrofa). We analyzed the tongues of 1168 wild boars captured by hunters in 30 prefectures of Japan, most of which were boar habitats, from October 2014 to January 2015. The samples were digested, and the Trichinella spp. muscle larvae prevalences were examined. Pooled samples from 10 individuals (15 g per head) and 117 randomly selected samples (10% of the total samples) that were processed individually showed no larval infection. Thus, most Japanese wild boar do not play a major role in the sylvatic cycle of Tri...
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Hatta T, Imamura K, Yamamoto T, Matsubayashi M, Tsuji N, Tsutsui T Tags: Jpn J Infect Dis Source Type: research

No evidence of rat hepatitis E virus excretion into urine of rats.
Abstract To investigate whether rat hepatitis E virus (rat HEV) is excreted into the urine of rats, we infected three Wistar and six nude rats with rat HEV and examined the rat HEV RNA in serum, fecal and urine samples. We detected rat HEV RNA in the serum and fecal samples of all rats but not in the urine. Our results suggest that in rats, rat HEV is not transmitted via urine. PMID: 27580584 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2016 Category: Infectious Diseases Authors: Li TC, Yoshizaki S, Ami Y, Suzaki Y, Johne R, Wakita T Tags: Jpn J Infect Dis Source Type: research