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Difficulty in Serologic Screening for Subclinical Rubella During Pregnancy
This study showed that the single combination of rubella HI and rubella-specific IgM measurements alone did not detect subclinical rubella. Creating awareness among pregnant women by informing them that almost all rubella-specific IgM-positive individuals without symptoms are not acutely infected could decrease their anxiety and prevent unnecessary termination of pregnancies.PMID:38030270 | DOI:10.7883/yoken.JJID.2023.222 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Kazuya Hiiragi Ryosuke Shindo Satoru Shinoda Mika Okuda Keiko Tanaka-Taya Kentaro Kurasawa Etsuko Miyagi Shigeru Aoki Source Type: research

Establishment of reference reagents for single-radial-immunodiffusion assay on the 2022/23 seasonal influenza vaccine in Japan and their quality validation
Jpn J Infect Dis. 2023 Nov 30. doi: 10.7883/yoken.JJID.2023.218. Online ahead of print.ABSTRACTPotency test of influenza vaccine is currently performed using a single-radial-immunodiffusion (SRID) assay, which requires a reference antigen and anti-hemagglutinin (HA) serum as reference reagents. The reagents must be newly prepared each time the strain used for vaccine production is changed. Establishing reference reagents with consistent quality is, therefore, crucial to accurately and precisely conduct vaccine potency tests. Here, we established the reference reagents for the SRID assay to conduct lot release tests of quad...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Noriko Shimasaki Tomoko Kuwahara Haruna Nishijima Kazuya Nakamura Kayoko Sato Keiko Murano Shigeyuki Itamura Yukiko Akahori Emi Takashita Noriko Kishida Tomoko Arita Mina Nakauchi Makoto Takeda Hideki Hasegawa Akihide Ryo Yuichi Harada Source Type: research

High prevalence of carbapenem-resistant Enterobacterales producing OXA-48 among carbapenem-resistant isolates in a regional hospital in central Taiwan
In conclusion, our study highlights high carbapenemase prevalence in CRE, primarily OXA-48. Multiple carbapenemases within strains were common, and PFGE showed diverse patterns in these carbapenem-resistant isolates.PMID:38030272 | DOI:10.7883/yoken.JJID.2023.213 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Lii-Tzu Wu Hong-Thuy Vy Nguyen Se-Chin Ke Yi-Pei Lin Yi-Chun Pang Ming-Kai Guo Chih-Ming Chen Source Type: research

Bacterial Infections Versus Viral Infections Preference of ABO Blood Group Phenotype Patient
This study aimed to evaluate a correlation between the blood group type and the susceptibility to infection. 558 patients were enrolled in this study who attended at the Althawra Hospital, Ibb city, from March to August 2018. A blood sample was analyzed for complete blood count (CBC) and blood group. High frequency of infections affecting the digestive system (26.4%), while the less affected system is the urogenital system 5.9%. Patients with A blood group have increased probability to be infected by viruses than bacteria(Odds Ratio =1.430; 95% Confidence Interval =1.005 to 2.035; p= 0.05) and (OR=0.098; 95% CI=0.064 to 0....
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Jamil Mohammed Abduh Saeed Obaid Fadhl Ahmed Saeed Al-Gashaa Source Type: research

Cleavage activation of respiratory viruses - Half a century of history from Sendai virus to SARS-CoV-2
Jpn J Infect Dis. 2023 Nov 30. doi: 10.7883/yoken.JJID.2023.353. Online ahead of print.ABSTRACTFor many viruses, cleavage activation of membrane fusion protein by host proteases is required for infection. This knowledge is based on the historical studies on Sendai virus in the 1970s. From the 1970s to the 1990s, the avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and host proteases' cleavage activation of viral membrane fusion proteins (hemagglutinin and fusion proteins). In these viruses, the cleavage of viral membrane fusion proteins by furin is the basis for their h...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Makoto Takeda Source Type: research