Isolation of a Capnophilic and an Extended-Spectrum- β-Lactamase-Producing Proteus mirabilis Isolate with Inability to Grow under pH-Indicator Dyes from the Urine of an Octogenarian Male-Patient with Acute Pyelonephritis.
Isolation of a Capnophilic and an Extended-Spectrum-β-Lactamase-Producing Proteus mirabilis Isolate with Inability to Grow under pH-Indicator Dyes from the Urine of an Octogenarian Male-Patient with Acute Pyelonephritis. Jpn J Infect Dis. 2018 Nov 30;: Authors: Soga E, Akiyama M, Ohsaki Y, Hayashi W, Matsumoto T, Oana K, Nagano N, Kawakami Y Abstract A capnophilic Gram-negative rod was recovered from the urine of an octogenarian male patient with acute pyelonephritis. The isolate also demonstrated to produce CTX-M-2-type- extended-spectrum-β-lactamase. Interestingly, the isolate failed to gr...
Source: Japanese Journal of Infectious Diseases - November 30, 2018 Category: Infectious Diseases Authors: Soga E, Akiyama M, Ohsaki Y, Hayashi W, Matsumoto T, Oana K, Nagano N, Kawakami Y Tags: Jpn J Infect Dis Source Type: research

Careful clinical surveillance is important for the identification of human parechovirus type A3-associated myalgia/myositis: a sporadic case found in a season with a low level of its activity in Yamagata, Japan in 2017.
PMID: 30504645 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 30, 2018 Category: Infectious Diseases Authors: Tanaka S, Sendo D, Ichikawa M, Toyota K, Furuyama M, Komabayashi K, Ikeda T, Mizuta K Tags: Jpn J Infect Dis Source Type: research

Study on Procedure for Lot Release of Vaccines in Japan.
Abstract Biological products, such as vaccines, blood products, antitoxin, and anti-venom, are released on the market following a lot release conducted by National Regulatory Authorities or National Control Laboratories, even if their manufacturing and marketing have been authorized. Independent lot release by regulatory authorities is not a unique procedure to Japan, but rather a common step worldwide. Previously Japan has carried out lot release mainly by laboratory tests, and the record of manufacturers' in-house tests was used as a reference, not involved in the decision of lot release. Conversely, the interna...
Source: Japanese Journal of Infectious Diseases - November 30, 2018 Category: Infectious Diseases Authors: Kato A, Fujita K, Ochiai M, Naito S, Konda T Tags: Jpn J Infect Dis Source Type: research

Predomination shift of different P44-expressing Anaplasma phagocytophilum in infected HL-60, THP-1, NB4, and RF/6A cell lines.
In this study, we performed RNA-seq to investigate P44 expression of A. phagocytophilum propagated in 4 different cell lines. In infected HL-60 cells, P44-2b transcript was predominantly detected in first RNA-seq analysis (HL-60.1), but P44-23 transcript became predominated in second RNA-seq analysis at 1 month after additional passages (HL-60.2). We further analyzed P44 expression of A. phagocytophilum cultured in THP-1, NB4, and RF/6A cells through consecutively-repeated passages with own cell line for 1 year after transfer of A. phagocytophilum from infected HL-60 to respective cell lines. In those long-term cultures, P...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Shimada M, Takamoto N, Su H, Sasahara H, Shimamura Y, Ando S, Ohashi N Tags: Jpn J Infect Dis Source Type: research

Loop-mediated isothermal amplification for rapid identification of Mycobacterium tuberculosis in comparison with immunochromatographic SD Bioline MPT64 Rapid ® in a high burden setting.
Loop-mediated isothermal amplification for rapid identification of Mycobacterium tuberculosis in comparison with immunochromatographic SD Bioline MPT64 Rapid® in a high burden setting. Jpn J Infect Dis. 2018 Oct 31;: Authors: Phetsuksiri B, Rudeeaneksin J, Srisungngam S, Bunchoo S, Klayut W, Sangkitporn S, Nakajima C, Hamada S, Suzuki Y Abstract Loop-mediated isothermal amplification (LAMP) was assessed for rapid identification of Mycobacterium tuberculosis complex (MTC) in comparison with an immunochromatographic test (ICT) using SD Bioline Ag MPT64 Rapid®. One hundred and fifty-one MGIT cult...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Phetsuksiri B, Rudeeaneksin J, Srisungngam S, Bunchoo S, Klayut W, Sangkitporn S, Nakajima C, Hamada S, Suzuki Y Tags: Jpn J Infect Dis Source Type: research

Detection of Uncommon Enteric Bacterial Pathogens from Acute Diarrheal Specimens using SYBR-Green Real Time PCR.
We examined SYBR-Green real-time PCR for the detection of ten uncommon bacterial pathogens using fecal specimens from acute diarrheal patients. In SYBR-Green real-time PCR, the products formed were identified based on melting point temperature (Tm) curve analysis and was validated with the respective reference strain. In a retrospective study, 1184 tested stool specimens by conventional culture methods were included. Enterotoxigenic Bacteriodes fragilis was detected more (6.7%) followed by enterotoxigenic Bacillus cereus (5.1%), Clostridium perfringens (3.9%) and Aeromonas hydrophila (3.8%). In the prospective study, A. hy...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Chowdhury G, Stine OC, Rajendran K, Mukhopadhyay AK, Okamoto K, Ramamurthy T Tags: Jpn J Infect Dis Source Type: research

Possible reintroduction of Taenia asiatica into the Kanto region of Japan.
PMID: 30381679 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Taniyama D, Inoue I, Kawano M, Arakawa C, Adachi T, Morishima Y, Yamasaki H, Sugiyama H Tags: Jpn J Infect Dis Source Type: research

Assessment of Bacteremia in a Large Tertiary Care Hospital in Northern Vietnam: A Single-center Retrospective Surveillance Study.
Abstract The clinical analysis of cases of Bacteremia would be valuable. However, thus far, limited data on bacteremia are available in Vietnam. A single-center, retrospective surveillance study was conducted in Bach Mai Hospital, Hanoi, Vietnam from 2009 to 2012. In total, 45,366 blood culture cases were analyzed. The number of blood cultures per 1,000 patient-days was 9.59 sets. The percentage of solitary blood culture sets was 49.6%. The rate of positive blood culture was 13.9%. The major pathogens isolated in adults were coagulase-negative Staphylococcus species (16.7%), followed by Escherichia coli (6.8%), St...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Takeshita N, Anh NQ, Phuong DM, Thanh DV, Thuy PP, Huong MTL, Takahashi M, Ohmagari N Tags: Jpn J Infect Dis Source Type: research

Species Identification of β-hemolytic Streptococci from Diseased Companion Animals and Their Antimicrobial Resistance Data in Japan (2017).
This study determined species identification and antimicrobial resistance (AMR) properties in β-hemolytic streptococci isolated from companion animals in Japan. Strains were isolated from clinical specimens of 131 companion animals with symptoms/signs in April-May, 2017. We identified strains by 16S rRNA sequencing and antimicrobial susceptibility was determined using the broth microdilution method. AMR genes (erm(A)-erm(B)-mef(A) and tet(M)-tet(O)-tet(K)-tet(L)-tet(S)) in all isolates were amplified by PCR. The 16S rRNA sequencing identified β-hemolytic streptococcal species as Streptococcus canis (n = 117, 89.3...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Fukushima Y, Tsuyuki Y, Goto M, Yoshida H, Takahashi T Tags: Jpn J Infect Dis Source Type: research

Neutralization potency of sera from Vietnamese patients with Japanese encephalitis (JE) against genotypes I and V JE viruses.
In this study, we investigated the neutralization ability of the sera collected from 22 Vietnamese JE patients who lived in northern Vietnam against GI and GV JEV strains. In most cases, the ratios of the titer against GV to that against GI (GV:GI) were equal to or less than 1:4. However, the titer against GV JEV was equivalent (1:1) to that against GI JEV in only a few cases, and no serum had a ratio higher than 1:1. Thus, our results did not show convincing evidence that GV JEV have been emerging in northern Vietnam in 2014. PMID: 30381682 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Nguyen TTT, Tajima S, Ikeda M, Nguyen TT, Le THT, Pham TTH, Pham DQ, Le TQM, Maeki T, Taniguchi S, Kato F, Moi ML, Morita K, Lim CK, Saijo M, Hasebe F Tags: Jpn J Infect Dis Source Type: research

Effects of a Public Subsidization Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan.
Abstract Nagoya City initiated a public subsidization program for mumps vaccination using either Torii- or Hoshino-strains in August 2010. To demonstrate the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rate and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported during this period by sentinel sites in a national database. The immunization rate in 1-year-old children increased fro...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Ozaki T, Goto Y, Nishimura N, Nakano T, Kumihashi H, Kano M, Ohfuji S Tags: Jpn J Infect Dis Source Type: research

The cost effective easy competitive ELISA (CEE-cELISA) available for monitoring protective immunity against the rabies virus in sera of humans and dogs.
Abstract The rabies vaccinations coverage has been reported as 70-80% of dogs in annual reports. However, there are still outbreaks of rabies in humans and dogs in Thailand, which indicate the necessity of ensuring seroprevalence in vaccinated dogs and efficacy of human immunization. The cost effective easy competitive ELISA (CEE-cELISA) was developed for monitoring protective immunity against the rabies virus in human and dog sera by using the monoclonal antibody clone 1-46-12, which recognized a conformation epitope of rabies G protein, with an ELISA plate coated with whole viral antigen of commercial vaccine. T...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Aronthippaitoon Y, Samer W, Atuntee T, Thananchai H, Thongkorn K, Pongsopawijit P, Inoue S, Noguchi A, Park ES, Kawai A, Petsophonsakul W Tags: Jpn J Infect Dis Source Type: research

An outbreak of rhinovirus species C infection in a welfare facility in Fukuoka Prefecture, Japan.
PMID: 30381685 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Ashizuka Y, Nakamura A, Yoshitomi H, Kobayashi T, Kajiwara J, Katsuki S, Kuroda M Tags: Jpn J Infect Dis Source Type: research

Infectious keratitis: microbiological review of 297 cases.
raetorius A Abstract Infectious keratitis is a serious ocular infection that can lead to loss of vision. The aim of the study was to investigate the microbiological characteristics of this infection at the University Hospital of Guadalajara (Spain). We retrospectively reviewed all cases diagnosed between January 2010 and December 2016. During the 7-year study period, 297 corneal scrapes corresponding to 298 patients were performed. Antibiotic treatment previous to the culture occurred in 59 cases (19.5%). Contact lens wear was the most common risk factor (33.2%). Bacterial keratitis accounted for 64.6% of cases, v...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Tena D, Rodríguez N, Toribio L, González-Praetorius A Tags: Jpn J Infect Dis Source Type: research

A novel recombinant norovirus GII.4 Sydney 2012 strain detected from a food poisoning outbreak in the 2017-2018 season, Japan.
PMID: 30381687 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Inasaki N, Aoyagi Y, Morioka S, Hasegawa S, Yoneda T, Saga Y, Itamochi M, Obuchi M Tags: Jpn J Infect Dis Source Type: research

Does quick Sepsis-related Organ Failure Assessment (qSOFA) suggest the use of initial empirical carbapenem therapy in bacteremia caused by extended-spectrum β-lactamase-producing bacteria? A multicenter case-control study.
Does quick Sepsis-related Organ Failure Assessment (qSOFA) suggest the use of initial empirical carbapenem therapy in bacteremia caused by extended-spectrum β-lactamase-producing bacteria? A multicenter case-control study. Jpn J Infect Dis. 2018 Oct 31;: Authors: Mitsuboshi S, Tsuruma N, Watanabe K, Takahashi S, Nakashita M, Ito A, Kobayashi K, Tsugita M Abstract We hypothesized that quick Sequential Organ Failure Assessment (qSOFA) would be associated with 30-day mortality in bacteremia caused by extended-spectrum β-lactamase (ESBL)-producing bacteria and might be a selection criterion for ...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Mitsuboshi S, Tsuruma N, Watanabe K, Takahashi S, Nakashita M, Ito A, Kobayashi K, Tsugita M Tags: Jpn J Infect Dis Source Type: research

Indication of Minimum Inhibitory Concentration of β-Lactam Antimicrobials for the Primary Extraction of IMP-Producing Enterobacteriaceae.
Indication of Minimum Inhibitory Concentration of β-Lactam Antimicrobials for the Primary Extraction of IMP-Producing Enterobacteriaceae. Jpn J Infect Dis. 2018 Oct 31;: Authors: Saito K, Nakamura K, Harada R, Nakano R, Yano H, Kanemitsu K PMID: 30381689 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Saito K, Nakamura K, Harada R, Nakano R, Yano H, Kanemitsu K Tags: Jpn J Infect Dis Source Type: research

Persistence of antibodies against diphtheria, tetanus, pertussis, and poliovirus types I, II, and III following immunization with DTaP combined with inactivated wild-type polio vaccine (DTaP-wIPV).
Abstract A follow-up serological study was conducted involving 47 subjects who received four doses of diphtheria and tetanus toxoids combined with acellular pertussis vaccine (DTaP) together with Salk-type inactivated polio vaccine (DTaP-wIPV) until 6 years of age. All antibody levels declined more rapidly than expected within 3 years after the completion of the primary vaccination with 4th booster dose and titers persisted until 6 years of age. The positive rate of the IgG antibody against pertussis toxin (PT) was 31.9% (15/47) at 4 years of age, 41.0% (16/39) at 5 years of age, and 40.5% (15/37) at 6 years of ag...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Nakayama T, Suga S, Okada K, Okabe N Tags: Jpn J Infect Dis Source Type: research

Comparison of established PCR assays for accurate identification of Campylobacter jejuni and Campylobacter coli.
This study examined the sensitivity and specificity of 12 PCR assays targeting 23S rRNA, ceuE, lpxA, hipO, mapA, ask, and cdt genes of C. jejuni and C. coli. The PCR assays had sensitivity of 85.2-100%, and 97-100%, and specificity of 90.5-100%, and 94.3-100% for the tested C. jejuni (n = 61) and C. coli (n = 33) strains, respectively. Two PCR assays, targeting cdtC and hipO genes, were found to be 100% sensitive and/or specific for all C. jejuni strains, while, three assays, targeting cdtB, cdtA, and ask genes, were 100% sensitive and/or specific for C. coli strains. However, PCR assays for hipO and ask genes are problema...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Kabir SML, Chowdhury N, Asakura M, Shiramaru S, Kikuchi K, Hinenoya A, Neogi SB, Yamasaki S Tags: Jpn J Infect Dis Source Type: research

Invasive fungal infection caused by Geotrichum clavatum in an acute leukemia child: first documented case from mainland China.
Abstract Invasive fungal infections (IFIs) are one of the vital complications for acute leukemia patients undergoing induction chemotherapy. Among them, Geotrichum clavatum fungal infections present extremely rare with atypical clinical symptoms which make it difficult to diagnosis. In this paper, we report a case of infection caused by Geotrichum clavatum in a 10-year old acute leukemia child, which is the first documented case from mainland China. With childhood leukemia as the basic disease, the child suffered from repeated bacterial and fungal infection, and even underwent abdominal surgery during the treatmen...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Liu X, Zhou W, Jiang Y, Kuang L Tags: Jpn J Infect Dis Source Type: research

Development and evaluation of new real-time RT-PCR assays for identifying the influenza A virus Cluster IV H3N2 variant.
Abstract From 2005 to July 6, 2018, a total of 435 swine-origin influenza A H3N2 variant virus (H3N2v) human infections were reported in the USA. The largest H3N2v outbreak in the USA occurred in 2011-2012. This virus obtained the HA gene from human seasonal H3N2 influenza A viruses (seasonal H3N2) via human-to-swine transmission in the mid-1990s and was classified as Cluster IV H3N2v. For early detection of public health threats associated with Cluster IV H3N2v in distinction from seasonal H3N2, we developed highly specific and sensitive one-step real-time RT-PCR assays directly targeting the HA genes of Cluster ...
Source: Japanese Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Authors: Saito S, Nakauchi M, Takayama I, Nagata S, Odagiri T, Kageyama T Tags: Jpn J Infect Dis Source Type: research

Molecular Investigation of Dengue virus serotype 2 Circulation in Kassala State, Sudan.
This study urges the need for a wider investigation of the DENV serotypes composition and estimating their contribution to the ongoing transmission. PMID: 30270247 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 28, 2018 Category: Infectious Diseases Authors: Hamid Z, Hamid T, Alsedig K, Abdallah T, Elaagip A, Ahmed A, Khalid F, Abdel Hamid M Tags: Jpn J Infect Dis Source Type: research

Selective detection of DNA of viable   Mycobacterium tuberculosis complex strains using EMA-PCR method.
In this study, the ability to discriminate viable cells from dead cells of Mycobacterium tuberculosis complex (MTC) using the viable bacteria selection kit for PCR (Gram Positive) (TaKaRa Bio, Inc., Japan), an Ethidium monoazide (EMA) treatment kit was examined. The range of bacterial concentrations in which the detection of dead bacteria was determined as 1.5 × 107-3.0 × 107 CFU/mL, which equivalent to McFarland No. 0.05-0.10. There was a significant difference between results of viable and dead bacteria, and the sensitivity and specificity of this method for culture-negative samples from patients were 83% and...
Source: Japanese Journal of Infectious Diseases - September 28, 2018 Category: Infectious Diseases Authors: Fukuzawa S, Shiho H, Fujita T Tags: Jpn J Infect Dis Source Type: research

Prevalence of Salmonella enterica subspecies enterica in red-eared sliders Trachemys scripta elegans retailed in pet shops in Japan.
Abstract We investigated the prevalence of Salmonella in 227 small red-eared sliders (Trachemys scripta elegans) from 2006 to 2008. One hundred thirty turtles (57.3%) were positive for S. enterica subsp. enterica. Twenty-two serotypes including S. Montevideo, S. Newport, S. Pomona, S. Braenderup, S. Sandiego, and S. Litchfield were identified. Salmonella strains with closely related PFGE patterns were isolated from several shops located in different areas over 2006 to 2008. Antimicrobial resistance was detected among strains of S. Montevideo, S. Newport, S. Braenderup, S. Sandiego, and S. Litchfield. The relatedne...
Source: Japanese Journal of Infectious Diseases - September 28, 2018 Category: Infectious Diseases Authors: Kuroki T, Ishihara T, Nakajima N, Furukawa I, Une Y Tags: Jpn J Infect Dis Source Type: research

HIV/AIDS in Japan: route and age of infection that shaped the epidemics in 1987- 2016.
Abstract In Japan, HIV infection is classified as "HIV" or "AIDS" depending upon whether the infection was detected before or after development of AIDS. For male homosexuals, in the plot of the number of "AIDS" versus the number of "HIV", the plots fell on a straight line with a slope close to 1. When the number of "HIV" stopped increasing, that of "AIDS" stopped increasing. The number of "HIV" in one region or in one age group was correlated with that of other regions or that of other age groups, respectively. No such correlation was detected f...
Source: Japanese Journal of Infectious Diseases - September 28, 2018 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Age distribution of people dying of HIV/AIDS that shifted towards older ages by ten years in the past twenty odd years.
Abstract The frequency of the ages of the HIV/AIDS deaths and that of the patients detected before or after the development of AIDS followed normal distribution. The median of HIV/AIDS deaths was 40-44 years in 1995-1998 and 50-54 years in 2014-2016, while the median of detection of the infection as "HIV" or as "AIDS" was constantly 25-29 years; it implied that the survival time of the HIV/AIDS patients became longer by 10 years in the past twenty odd years. The lengthening of the survival time could have been attributable to introduction of HIV/AIDS therapy, such as HAART. Importantly, however...
Source: Japanese Journal of Infectious Diseases - September 28, 2018 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

A case of hepatitis A infection presumed to be related to asari clams and investigation on spread of viral contamination from asari clams.
Abstract In a case of hepatitis A infection that occurred in 2017 in Nagano Prefecture, hepatitis A virus (HAV) was detected in asari clams (reference food) and the patients' fecal samples. Initially, the asari clams were suspected to be the infection source. However, as a patient who had not consumed a asari clam dish also developed the disease, the exact infection route remained unknown. Suspecting a secondary infection originating from the asari clams, we investigated the presence of HAV genomes in water used for washing and soaking the frozen asari clams and detected HAV in the "Soaking Water." These...
Source: Japanese Journal of Infectious Diseases - September 28, 2018 Category: Infectious Diseases Authors: Tsukada R, Ono S, Kobayashi H, Wada Y, Nishizawa K, Fujii M, Takeuchi M, Kuroiwa K, Kobayashi Y, Ishii K, Nakazawa H Tags: Jpn J Infect Dis Source Type: research

Streptococcus mitis/oralis Causing Blood Stream Infections in Pediatric Patients.
Abstract Viridans streptococci are still under investigation concerning epidemiology, pathogenesis and clinical presentations. We aimed to investigate the clinical presentations and outcomes of the pediatric patients infected with Streptococcus mitis/oralis. Based on accumulation of blood stream infections (BSI) caused by S. mitis /oralis in four patients in Hematology and Bone Marrow Transplantation Department in a particular time, review of medical and microbiological records of pediatric patients with positive blood cultures for S. mitis/oralis in whole hospital was performed. In addition, a retrospective case ...
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Basaranoglu ST, Ozsurekci Y, Aykac K, Aycan AE, Bıcakcigil A, Altun B, Sancak B, Cengiz AB, Kara A, Ceyhan M Tags: Jpn J Infect Dis Source Type: research

Detection of Subgenotype IA and IIIA Hepatitis A Viruses   in Rivers Flowing through Metro Manila, the Philippines.
Detection of Subgenotype IA and IIIA Hepatitis A Viruses  in Rivers Flowing through Metro Manila, the Philippines. Jpn J Infect Dis. 2018 Aug 31;: Authors: Bai H, Shiota T, Yoshizaki S, Saito-Obata M, Malbas FF, Lupisan SP, Oshitani H, Takeda N, Muramatsu M, Wakita T, Ishii K, Li TC Abstract Hepatitis A virus (HAV) is a common infectious etiology of acute hepatitis worldwide. The Philippines remains highly endemic for hepatitis A, but there is still lack of information about HAV in the Philippines. To understand the contamination of environment water with HAV in the Philippines, we performed dete...
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Bai H, Shiota T, Yoshizaki S, Saito-Obata M, Malbas FF, Lupisan SP, Oshitani H, Takeda N, Muramatsu M, Wakita T, Ishii K, Li TC Tags: Jpn J Infect Dis Source Type: research

The research of the tetanus seropositivity levels in registered family physicians in Ankara province, Turkey, 2017.
Abstract The aim of this research is to determine the seropositivity levels of tetanus vaccine according to age groups in Ankara province, to identify possible factors that could affect the immune status, and to make recommendations especially in people aged 50 years and older. This cross-sectional epidemiological study covers people over three years of age registered in the Family Medicine Information System. We received blood samples from 992 people and 968 of them were surveyed. Protective tetanus antibody levels were 80.5% in the age group of 3-5 years; 92.0% in the age group of 6-12 years; 94.3% in the age gr...
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Sahan S, Demirbilek Y, Sonmez C, Temel F, Sencan I Tags: Jpn J Infect Dis Source Type: research

Nasopharyngeal Carriage Prevalence, Serotype Distribution and Antimicrobial Resistance of Streptococcus Pneumoniae Among Children with Chronic Diseases.
akır M Abstract The aim of this study is to evaluate the nasopharyngeal (NP) carriage prevalence, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae (SP) in children with chronic diseases that predispose them to invasive pneumococcal disease (IPD) in comparison with healthy children.A cross sectional prevalence study was performed between February 2015 and February 2016 in Istanbul, Turkey. We enrolled 1024 children with chronic diseases and 394 healthy children aged 0-18 years.Overall prevalence of SPNP carriage was 9.8%. The prevalence of SPNP carriage among the healthy children was ...
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Pekuz S, Soysal A, Akkoc G, Atıcı S, Yakut N, Gelmez GA, Kadayifci EK, Güneser D, Demir SO, Söyletir G, Bakır M Tags: Jpn J Infect Dis Source Type: research

Molecular Epidemiological Analysis of the Spreading Conditions of Trichophyton   in the Long-term Care Facilities in Japan.
This study proved that T. mentagrophytes strain of the same type had spread in the long-term care facilities. We suggested the importance of cleaning in the long-term care facility as a countermeasure for the spread of Trichophyton. PMID: 30175735 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Suzuki S, Mano Y, Furuya N, Fujitani K Tags: Jpn J Infect Dis Source Type: research

Low incidence of macrolide-resistant Mycoplasma  pneumoniae between April 2016 and March 2017 in Akita Prefecture, Japan.
Low incidence of macrolide-resistant Mycoplasma pneumoniae between April 2016 and March 2017 in Akita Prefecture, Japan. Jpn J Infect Dis. 2018 Aug 31;: Authors: Suzuki S, Konno T, Shibata C, Saito H PMID: 30175736 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Suzuki S, Konno T, Shibata C, Saito H Tags: Jpn J Infect Dis Source Type: research

Fatal amoebic meningoencephalitis caused by Balamuthia mandrillaris in a sarcoidosis patient.
PMID: 30175737 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Tarai B, Agarwal P, Krishnamoorthi S, Mewara A, Khurana S Tags: Jpn J Infect Dis Source Type: research

First Practical Major Step toward Appropriate Antimicrobial Use by the Government of Japan.
Abstract Antimicrobial resistance (AMR) is one of the top public health agendas in Japan. Since Japan published the national action plan (NAP) on AMR in 2016, the NAP implementation has been a major focus in Japan Ministry of Health, Labour and Welfare (MHLW). Japan MHLW recently published the 1st edition of "Manual of Antimicrobial Stewardship" (including English version), a narrative review with particular focus on outpatient setting of primary care and two common infectious disease conditions. This is one of very few occasions where MHLW proactively set a clinical guidance for health care delivery at ...
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Saito H, Noda H, Takakura S, Jindai K, Takahashi McLellan R, Asanuma K Tags: Jpn J Infect Dis Source Type: research

Poliovirus detection and genetic characteristic from sewage in Heilongjiang province from 2013 to 2016.
In this study, we collected 139 sewage samples from eight regions in Heilongjiang Province. Poliovirus was identified from 72 samples and the positive rate was 51%. 263 strains of poliovirus were isolated, including 22 type1, 104 type2 and 137 type3 polioviruses. As results of intratypic differentiation (ITD), using real time PCR and nucleotide sequencing, three type 1 pre-VDPV, one type 2 VDPV and two type 3 pre-VDPV strains were isolated, respectively. Interestingly, one type 1 strain with 5 nucleotide deletion and one type 3 recombinant on VP1 were isolated. By monitoring the poliovirus in the environment continually, w...
Source: Japanese Journal of Infectious Diseases - July 31, 2018 Category: Infectious Diseases Authors: Ma Y, Wang X, Zhou X, Lv P, Wang H, Song J, Song C, Sun Z Tags: Jpn J Infect Dis Source Type: research

An outbreak of enterohemorrhagic   Escherichia coli  O157:H7 infection associated with minced meat cutlets in Kanagawa, Japan.
An outbreak of enterohemorrhagic  Escherichia coli  O157:H7 infection associated with minced meat cutlets in Kanagawa, Japan. Jpn J Infect Dis. 2018 Jul 31;: Authors: Furukawa I, Suzuki M, Masaoka T, Nakajima N, Mitani E, Tasaka M, Teranishi H, Matsumoto Y, Koizumi M, Ogawa A, Oota Y, Homma S, Sasaki K, Satoh H, Sato K, Muto S, Anan Y, Kuroki T Abstract An outbreak of enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection occurred in October 2016 in Kanagawa, Japan. A total of 61 patients and 17 asymptomatic cases were confirmed to be infected with EHEC O157:H7 by laboratory testing. Am...
Source: Japanese Journal of Infectious Diseases - July 31, 2018 Category: Infectious Diseases Authors: Furukawa I, Suzuki M, Masaoka T, Nakajima N, Mitani E, Tasaka M, Teranishi H, Matsumoto Y, Koizumi M, Ogawa A, Oota Y, Homma S, Sasaki K, Satoh H, Sato K, Muto S, Anan Y, Kuroki T Tags: Jpn J Infect Dis Source Type: research

Genetic characterization of rarely reported GI.Pc_GI.5 norovirus strain detected from a foodborne suspected outbreak in Japan.
PMID: 30068887 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 31, 2018 Category: Infectious Diseases Authors: Kobayashi T, Yoshitomi H, Nakamura A, Ashizuka Y, Kajiwara J, Noda M Tags: Jpn J Infect Dis Source Type: research

Single amino acid mutation in dengue virus NS4B protein has opposing effects on viral proliferation in mammalian and mosquito cells.
Abstract Dengue virus (DENV) has a considerable impact on global health and causes morbidity and mortality each year. Through the passages of a DENV2 in BHK-21 cells, we have isolated a mutant clone of DENV2 which reveals cytopathic effects (CPE) rapidly compared to the parent strain in BHK-21 cells. To investigate the relationship between amino acid mutations and proliferation activity of the isolated DENV2 clone, we performed full genome sequencing and identified three amino acid mutations in its coding region, the Envelope (Env) T120K, NS4A M85T and NS4B G124A, compared to that of the parent strain. Genetically...
Source: Japanese Journal of Infectious Diseases - July 31, 2018 Category: Infectious Diseases Authors: Fujiki J, Nobori H, Sato A, Sasaki M, Carr M, Hall WW, Orba Y, Sawa H Tags: Jpn J Infect Dis Source Type: research

Molecular typing of   Escherichia coli O157 isolates from Romanian human cases.
This study should be a catalyst for improved laboratory-based surveillance of autochthonous VTEC. PMID: 30068889 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 31, 2018 Category: Infectious Diseases Authors: Oprea M, Ciontea AS, Militaru M, Dinu S, Cristea D, Usein CR Tags: Jpn J Infect Dis Source Type: research

Cocirculation of Influenza C Viruses with Distinct Internal Genome Constellations in Iwate Prefecture, Japan, in 2016.
PMID: 30068890 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 31, 2018 Category: Infectious Diseases Authors: Takahashi M, Obara T, Matsuzaki Y, Maisawa SI, Sasaki Y, Yoshino N, Shirasawa A, Iwabuchi K, Takahashi T, Kajita H, Ono Y, Ryo A, Kimura H, Muraki Y Tags: Jpn J Infect Dis Source Type: research

SAFETY AND IMMUNOGENICITY STUDY OF A SINGLE DOSE OF A MENINGOCOCCAL (GROUPS A, C, W, and Y) POLYSACCHARIDE DIPHTHERIA TOXOID CONJUGATE VACCINE (MEN-ACWY-D) IN HEALTHY JAPANESE PARTICIPANTS.
Abstract Meningococcal disease can cause significant disability and mortality. The quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine (Men-ACWY-D) protects against invasive meningococcal disease caused by serogroups A, C, W, and Y. This phase III, open-label, single-arm, multicenter study evaluated the safety and immunogenicity of a single vaccine dose in healthy Japanese adults. The study enrolled 200 participants 2-55 years of age. Immunogenicity was assessed by quantifying seroprotection rates (the proportion of participants with antibody titers ≥1:128 against capsular polysacchari...
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Fukushima S, Kikuchi H, Miyazu M, Hamada A, Ouchi K, Takagi H, Mihara H, Sasaki T, Oka H, Bosch-Castells V, Oster P Tags: Jpn J Infect Dis Source Type: research

A case of conjunctival ulcer and uveitis caused by   Acrophialophora  sp. in an immunocompromised patient; a case report and literature review.
We report the first case of invasive ophthalmologic infection by Acrophialophora sp. that was successfully treated using voriconazole (VRCZ). Acrophialophora spp., which has been reported to be an opportunistic pathogen, is rare thermotolerant soil fungus, but its pathogenicity remains unclear. A 77-year-old man had neutropenia and prostate carcinoma, and was receiving hemodialysis. His right eye had been infected for 2 days. His conjunctiva was congested and partially formed an abscess. Liposomal amphotericin B (L-AMB) was administered following systemic itraconazole. However, treatment was changed from L-AMB to systemic ...
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Watanabe Y, Kobayashi T, Nakamura I, Fujita H, Shimoinaba M, Fukushima S, Miyazaki Y, Matsumoto T Tags: Jpn J Infect Dis Source Type: research

Bartonella henselae   neuroretinitis in patients without cat scratch.
In conclusion, even though there may be a lack of systemic signs and symptoms of CSD in a patient with neuroretinitis, B henselae infection should be considered. PMID: 29962482 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Celiker H, Kazokoglu H, Eraslan M, Cerman E, Karabas L Tags: Jpn J Infect Dis Source Type: research

Implication of three distinct groups of Anopheles lindesayi in Japan by morphological and genetic analyses.
In this study, we re-evaluated the taxonomic status of An. l. japonicus in Japan and another subspecies, An. l. pleccau distributed in Taiwan, by comparative morphological and molecular analyses based on gene sequences of mitochondrial DNA cytochrome oxidase I (COI) and ribosomal DNA internal transcribed spacer 2 (ITS2). Nucleotide sequence divergence was calculated using the Kimura-two-parameter (K2P) distance model. Phylogenetic trees based on the COI and ITS2 sequences showed three distinct clades: Eastern Japan, Western Japan and, Ryukyus. The sequences of Ryukyus were located the same clade as the sequences of Taiwan....
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Imanishi N, Higa Y, Teng HJ, Sunahara T, Minakawa N Tags: Jpn J Infect Dis Source Type: research

International travel and exotic dengue fever of South Korea in the last decade.
Abstract We undertook analysis of reported dengue fever (DF) cases and DF-relevant characteristics in South Korea from 2006 to 2015. A total of 1,260 DF notifications occurred in the study period were presumedly introduced from endemic foreign countries. The nationwide cumulative incidence rate (CIR) of DF was 0.25 per 100,000 populations; the cumulative incidence rate of DF among overseas travelers was 0.93. CIRs of overseas male and female travelers were 1.13 and 0.87, respectively. CIR of overseas travelers of 20 to 39 years old was highest. Men (61.9%) were more infected with DF than women were (38.1%, P
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Cho KH, Park SY, Lee WC, Lee MJ, Lee JB Tags: Jpn J Infect Dis Source Type: research

Epidemiological outbreaks of measles virus in Kazakhstan during 2015.
This study was addressed to epidemiological surveillance of measles virus (MV) in the territory of Republic of Kazakhstan during 2015 - 2016 years. In our study we have detected D8 genotype of MV occurred in outbreak season of measles disease. Totally 2341 cases were registered and 19 of them were identified by genotyping. As a result, 16 samples attributed to subgroup A of D8 genotype, and 3 import cases were represented by B3 and H1 genotype of MV. Vaccination coverage analysis showed that large group of infected people were not vaccinated and did not have a reliable report on vaccination status. This issue might increas...
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Abeev A, Zhylkibayev A, Kamalova D, Kusheva N, Nusupbaeva G, Tleumbetova N, Smagul M, Beissenova S, Aubakirova S, Kassenova Z, Demessinova B, Amanbayev A, Ramankulov Y, Shevtsov A Tags: Jpn J Infect Dis Source Type: research

Cutaneous Findings of Crimean-Congo Haemorrhagic Fever: A Study of 269 Cases.
Abstract Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease. We aimed here in this study to investigate the cutaneous manifestations of CCHF and reveal their associations with fatality. Two hundred and sixty-nine patients diagnosed with CCHF were recorded. Skin findings were seen in 170 (63.1%) patients. A facial rash was most common cutaneous finding (82 (30.4%)). In the severe cases, haemorrhagic cutaneous manifestations (petechiae and ecchymoses) were recognised. A statistically significant correlation was obtained between the cutaneous manifestations and fatality, and it was determined that th...
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Duygu F, Sari T, Gunal O, Barut S, Atay A, Aytekin F Tags: Jpn J Infect Dis Source Type: research

Epidemiology characteristics of human coxsackievirus A16 and enterovirus 71 circulating from 2009 to 2017 in Linyi, China.
Abstract In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 and HFMD has become an important issue for China. There are more than 20 types of enterovirus causing HFMD, of which Coxsackievirus A16 (CA16) and enterovirus 71 (EV71) are the most common. To analyze the epidemiological characteristics of HFMD caused by EV71 and CA16 in Linyi, Shandong province, China from 2009 to 2017. 5324 stool specimens or throat samples were collected from 5324 HFMD cases for nucleic acid detection of enterovirus. 4040 HFMD cases caused by viral pathogens contained 1706 EV71 positiv...
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Yin DQ, Wang CB, Xiao-Zhou, Ji SX Tags: Jpn J Infect Dis Source Type: research

The largest measles outbreak, including 38 modified measles and 22 typical measles cases, Yamagata, Japan, 2017 in its elimination era.
Abstract Modified measles (M-Me), characterized by milder symptoms than typical measles (T-Me), has been increasing in Japan, but M-Me dominated outbreak has not been investigated sufficiently worldwide. During March-April 2017, there was the largest importation-related outbreak of measles with genotype D8 in Yamagata, Japan, after Japan had achieved measles elimination in 2015. We confirmed 60 cases by detecting measles virus (MeV) genome, among whom 38 M-Me and 22 T-Me cases were identified. Thirty-nine cases (65.0%) were between 20-39 years of age. Three out of seven primary cases produced 50 transmissions, in ...
Source: Japanese Journal of Infectious Diseases - June 29, 2018 Category: Infectious Diseases Authors: Komabayashi K, Seto J, Tanaka S, Suzuki Y, Ikeda T, Onuki N, Yamada K, Ahiko T, Ishikawa H, Mizuta K Tags: Jpn J Infect Dis Source Type: research