A simulation study of effects of host availability on the bite rate of Aedes albopictus (Skuse) (Diptera: Culicidae) and the risk of dengue outbreaks in non-endemic areas.
Abstract Aedes albopictus is an important vector of dengue fever and tends to ambush blood host in a single place. Thus, host contact frequency may affect the bite rate and risk of disease outbreak, although no studies have examined these parameters. The present study used a simple model to clarify the fundamental relationship between host availability, bite rate, and risk of dengue outbreaks in non-endemic areas. A hypothetical isolated mosquito population was divided into "ambush" and "resting" subpopulations, and human hosts were modeled as visiting mosquito population at constant intervals....
Source: Japanese Journal of Infectious Diseases - December 26, 2017 Category: Infectious Diseases Authors: Sunahara T Tags: Jpn J Infect Dis Source Type: research

Ten-year surveillance of measles virus from 2007-2016 in Osaka City, Japan.
In this study, long-term surveillance was performed in order to survey MV prevalence. A total of 417 patients diagnosed with or suspected of having measles were tested for MV between January 2007 and December 2016 in Osaka City, Japan. Reverse transcription-polymerase chain reaction (RT-PCR)-based testing of clinical specimens showed that 54 patients (12.9%) were MV-positive. An MV epidemic occurred in 2007, in which all detected MV strains were of genotype D5, an epidemic strain in Japan at that time. The detected wild-type MV strains in sporadic or outbreak-associated cases since 2011 included genotypes D4, D8, B3, and H...
Source: Japanese Journal of Infectious Diseases - December 26, 2017 Category: Infectious Diseases Authors: Kaida A, Iritani N, Kanbayashi D, Yamamoto SP, Hirai Y, Hakui N, Fujimori R, Mori H, Hirokawa H, Ogasawara J, Kubo H Tags: Jpn J Infect Dis Source Type: research

Epidemiology of respiratory pathogens in children with lower respiratory tract infections in Shanghai, China, from 2013 to 2015.
This study aimed to explore the epidemiology of pathogens in children who were hospitalized with lower respiratory tract infections (LRTIs) at the Children's Hospital of Fudan University, Shanghai, China. Children aged less than 18 years who were hospitalized with LRTIs were recruited from January 2013 to December 2015. Respiratory specimens were collected for the detection of common respiratory viruses, atypical bacteria and bacteria using current laboratory diagnostic tests. The epidemiological characteristics of the respiratory pathogens were analysed. Of the 10 123 specimens obtained from the patients, 5966 (58.7%) wer...
Source: Japanese Journal of Infectious Diseases - December 26, 2017 Category: Infectious Diseases Authors: Liu P, Xu M, He L, Su L, Wang A, Fu P, Lu L, Wang C, Xu J Tags: Jpn J Infect Dis Source Type: research

Prevalence and Genotype Distribution of Chlamydia trachomatis in Urine among Men Attending STD Clinics in Guangdong Province, China, 2016.
This study aimed to investigate the prevalence and molecular epidemiology of CT infection by examining urine samples among MSCs from different geographic areas of Guangdong province, China. A cross-sectional study was conducted among MSCs from ten HIV sentinel surveillance sites in Guangdong province. CT DNA in men urine samples were extracted and detected by using the Roche cobas® 4800 CT/NG. The ompA genes were amplified by nested polymerase chain reaction (PCR) and sequenced. The leukocyte esterase test was performed by routine urine analysis at local clinics. Of the 1903 samples, 163(8.6%, 95%CI3.8- 16.3%) were fou...
Source: Japanese Journal of Infectious Diseases - December 26, 2017 Category: Infectious Diseases Authors: Xue Y, Zheng H, Tang W, Mai Z, Huang J, Huang S, Qin X, Chen L, Zheng L Tags: Jpn J Infect Dis Source Type: research

Evaluation of the FilmArray Blood Culture Identification Panel in Detecting Pathogenic Microorganisms from Positive Blood Cultures: the First Clinical Report in Japan.
Abstract   The FilmArray (FA) is a multiplex polymerase chain reaction (PCR)-based desktop microbial detection system. The Blood Culture Identification (BCID) panel is an adaptable panel for the FA, which diagnoses sepsis or/and systemic infections by detecting 14 bacterial species, 4 bacterial genera, 1 bacterial family, 5 yeast species, and 3 antimicrobial resistance genes (mecA, KPC, and vanA/B) from positive blood cultures within 1 hour. We retrospectively evaluated the FA-BCID panel, using 54 positive blood cultures, from which 57 bacteria and 3 yeasts were identified through matrix-assisted laser d...
Source: Japanese Journal of Infectious Diseases - December 26, 2017 Category: Infectious Diseases Authors: Saito K, Endo S, Katsumi M, Ishizawa C, Fujikawa Y, Inomata S, Toyokawa M, Kaku M Tags: Jpn J Infect Dis Source Type: research

Human parainfluenza virus type 3 infections in hematopoietic stem cell transplantation patients: The mode of nosocomial infections and the prognosis.
Abstract   There have been few prospective and comprehensive surveillance studies on the respiratory viral infections (RVI) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs in hospitalized HSCT patients was performed. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplexed PCR (MPCR). 2,747 OP swab samples were collected from 250 HSC...
Source: Japanese Journal of Infectious Diseases - December 26, 2017 Category: Infectious Diseases Authors: Kakiuchi S, Tsuji M, Nishimura H, Wang L, Takayama-Ito M, Kinoshita H, Lim CK, Taniguchi S, Oka A, Mizuguchi M, Saijo M Tags: Jpn J Infect Dis Source Type: research

Experiences of response measures against the 4 suspected cases of ebola virus disease from West Africa in the National Center for Global Health and Medicine, Tokyo, Japan.
Abstract In Japan, infectious diseases are classified into 4 types based on how contagious and severe the pathogens are, and Ebola virus disease (EVD) is categorized as a category 1 infectious disease. National Center for Global Health and Medicine in Tokyo, Japan, is designated as a specified hospital for category 1 infectious disease patients, and has experienced 4 probable cases of EVD from West Africa. Even after the end of the outbreak in West Africa, we should continue to pay attention for new EVD outbreaks. To increase the number of the infectious disease specialist with the proper knowledge of viral hemorr...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Kutsuna S, Yamamoto K, Takeshita N, Hayakawa K, Kato Y, Kanagawa S, Sugiki Y, Ohmagari N Tags: Jpn J Infect Dis Source Type: research

Seasonality and geographical distribution of Tsutsugamushi diseases in Japan: analysis of the trends since 1955 till 2014.
Abstract   Data concerning the seasonality and geographical location of tsutsugamushi disease (TD) in Japan from 1955 till 2014 were compiled. After disappearance of the "classical" TD in mid-1960, there was a long near vacuum. Then, in 1975, TD epidemic with October-December seasonality emerged in southern prefectures, and in 1979 that with May-June seasonality in northern prefectures. The current TD epidemic could be classified according to seasonality and geography into three types; a large October-December epidemic with negligibly small May-June epidemic in southern part of Japan, a large M...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Profile of mutations in the reverse transcriptase and overlapping surface genes of hepatitis B virus in treatment-na ïve Indonesian HBV carriers.
Profile of mutations in the reverse transcriptase and overlapping surface genes of hepatitis B virus in treatment-naïve Indonesian HBV carriers. Jpn J Infect Dis. 2017 Oct 31;: Authors: Yamani LN, Yano Y, Utsumi T, Wasityastuti W, Rinonce HT, Widasari DI, Juniastuti, Lusida MI, Soetjipto, Hayashi Y Abstract Mutations in the reverse transcriptase (RT) region of the hepatitis B virus (HBV) genome are an important factor in reduced therapeutic effectiveness. However, the prevalence of these mutations in HBV strains isolated previously from Indonesia has not been systematically examined. Therefore, t...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Yamani LN, Yano Y, Utsumi T, Wasityastuti W, Rinonce HT, Widasari DI, Juniastuti, Lusida MI, Soetjipto, Hayashi Y Tags: Jpn J Infect Dis Source Type: research

Infective endocarditis complicated by intraventricular abscesses, pericarditis, and mycotic aneurysm due to an emerging strain of serotype VI Streptococcus agalactiae.
We report a case of infective endocarditis complicated by intraventricular abscesses, pericarditis, and mycotic aneurysm due to S. agalactiae belonging to ST681 with a capsular serotype VI in a diabetic woman. The patient also had a myocardial infarction and was treated with percutaneous coronary intervention, pericardiocentesis, and 6 weeks of antibiotic treatment. Invasive infections due to serotype VI S. agalactiae are common in Asian countries such as Taiwan and Japan and continuous monitoring of invasive S. agalactiae strains is warranted. PMID: 29093314 [PubMed - as supplied by publisher] (Source: Japanese Journ...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Hirai N, Kasahara K, Uno K, Ogawa Y, Ogawa T, Yonekawa S, Nakano R, Yano H, Sakagami A, Uemura T, Okura H, Saito Y, Yoshikawa M, Mikasa K Tags: Jpn J Infect Dis Source Type: research

Detection and serotyping of dengue viruses from Aedes aegypti and Aedes albopictus (Diptera: Culicidae) collected in Surabaya, Indonesia 2008 - 2015.
PMID: 29093315 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Mulyatno KC, Kotaki T, Yotopranoto S, Rohmah EA, Churotin S, Sucipto TH, Amarullah IH, Wardhani P, Soegijanto S, Kameoka M Tags: Jpn J Infect Dis Source Type: research

Venom and antivenom of redback spider (Latrodectus hasseltii) in Japan.
Abstract This is the first report of the large-scale experimentally production of an equine antivenom against redback spider (Latrodectus hasseltii) lived in Japan. We captured 10,000 redback spiders in Japan and prepared the toxoids of crude venom extract, mixed the toxoids with mineral oil adjuvant, and immunized repeatedly it to healthy horses over a period of several weeks. Then, we separated the horse plasma, and purified the γ-globulin fraction and stocked as a purified antivenom concentrate. Consequently, we manufactured approximately 6,500 vials of a single-dose freeze-dried test lot from a portion o...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Mori S, Horita A, Ginnaga A, Miyatsu Y, Sawabe K, Matsumura T, Ato M, Yamamoto A, Shibayama K, Arai S, Yamagishi T, Takahashi M, Taki H, Hifumi T Tags: Jpn J Infect Dis Source Type: research

Rapid and accurate diagnosis based on real-time PCR cycle threshold value for the identification of Campylobacter jejuni, astA gene-positive Escherichia coli, and eae gene-positive E. coli.
Abstract   We previously developed a multiplex real-time PCR assay (Rapid Foodborne Bacterial Screening 24 ver.5, RFBS24 ver.5) for simultaneous detection of 24 foodborne bacterial targets. Here, to overcome the discrepancy of the RFBS24 ver.5 and bacterial culture method (BC) results, we analyzed 246 human clinical samples from 49 gastroenteritis outbreaks by the RFBS24 ver.5 and evaluated the correlation between cycle threshold value (CT) of RFBS24 ver.5 and the BC results. The results showed that the RFBS24 ver.5 was more sensitive than BC for Campylobacter jejuni and Escherichia coli harboring astA o...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Kawase J, Asakura H, Kurosaki M, Oshiro H, Etoh Y, Ikeda T, Watahiki M, Kameyama M, Hayashi F, Kawakami Y, Murakami Y, Tsunomori Y Tags: Jpn J Infect Dis Source Type: research

The association between NFKBIA polymorphisms and the progression of chronic hepatitis B virus infection among the Chinese Han population.
Abstract Based on the involvement of NFKIBA (NF-κB Inhibitor Alpha) in the NF-κB pathway, which is closely related with host immunity, and this present study aimed to determine if NFKIBA polymorphisms are associated with the disease progression of chronic hepatitis B virus (HBV) infection. Our study collected blood samples from a total of 212 treatment-naïve patients with chronic HBV infection were included in present study, and the blood samples were collected. NFKBIA polymorphisms were determined by using Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry. Enzyme-linke...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Lin Y, Su C, Niu J, Guo Z, Lu Y Tags: Jpn J Infect Dis Source Type: research

Misidentification of Neisseria cinerea as Neisseria meningitidis in matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS).
PMID: 29093319 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Kawahara-Matsumizu M, Yamagishi Y, Mikamo H Tags: Jpn J Infect Dis Source Type: research

International comparison of causative bacteria and antimicrobial susceptibilities of urinary tract infections between Kobe, Japan and Surabaya, Indonesia.
Abstract The urinary tract infection (UTI)-causative bacteria have variation among countries partly owing to the difference of antibiotic uses. To compare their frequency and antibiotic susceptibilities between Kobe, Japan and Surabaya, Indonesia, we retrospectively analyzed 1,804 samples from UTI patients (1,251 from Kobe University Hospital, Kobe, and 544 from Dr. Soetomo Hospital, Surabaya) in 2014. Surabaya data were divided to adults and pediatrics because substantial number of pediatric-patients were collected. As the results, Escherichia coli was the most common uropathogen (24.1% in Kobe and 39.3% in Surab...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Kitagawa K, Shigemura K, Yamamichi F, Alimsardjono L, Rahardjo D, Kuntaman K, Shirakawa T, Fujisawa M Tags: Jpn J Infect Dis Source Type: research

Predominance of serogroup 19 CC320/271 among penicillin-non-susceptible Streptococcus pneumoniae isolates after the introduction of the PCV7 vaccine in several regions of Japan.
Abstract Multidrug-resistant Streptococcus pneumoniae serogroup 19, including serotypes 19A and 19F, associated with clonal complex 320/271 (CC320/271), was previously shown to be predominant in many countries after the introduction of a seven-valent pneumococcal conjugate vaccine (PCV7). However, in Japan there has been no epidemiological research focused on penicillin-non-susceptible isolates after this event. Thus, we aimed to characterize penicillin-non-susceptible S. pneumoniae (PNSSP; penicillin minimum inhibitory concentration (MIC) ≥ 4.0 µg/ml) after the introduction of PCV7 in Japan. From through...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Oodate M, Kimura K, Banno H, Yokoyama S, Jin W, Wachino JI, Hasegawa Y, Arakawa Y Tags: Jpn J Infect Dis Source Type: research

Terrestrial animal-derived rabies virus in a juvenile Indian flying fox in Sri Lanka.
Abstract Unlike the bats of New World, Old World bats are not considered to transmit rabies virus (RABV). Two RABV variants are circulating in Sri Lanka; one variant is circulating in dogs and other animals. The other variant has been identified in a wild civet. There is possibility that other variants are also circulating among the wild animals in Sri Lanka. Therefore we performed molecular characterization of the RABVs present in Sri Lankan wild animals. Samples from wild animals, dogs, cats and humans with suspected rabies submitted at the Department of Rabies Diagnosis and Research, Medical Research Institute ...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Matsumoto T, Nanayakkara S, Perera D, Ushijima S, Wimalaratne O, Nishizono A, Ahmed K Tags: Jpn J Infect Dis Source Type: research

Multiple-Locus Variable-Number Tandem-Repeat Analysis of Mycoplasma pneumoniae Isolates between 2004 and 2014 in Yamagata, Japan: Change of Molecular Characteristics during an 11-year Period.
Abstract Multiple-locus variable-number tandem-repeat analysis (MLVA) typing was performed of Mycoplasma pneumoniae strains isolated between 2004 and 2014 in Yamagata, Japan. The results were examined by combining P1 type and prevalence of macrolide resistance-associated mutations. Four-locus (Mpn13-16) MLVA classified 347 strains into nine MLVA types, including three major types: 3-5-6-2, 4-5-7-2, and 4-5-7-3. All type 3-5-6-2 strains (77 strains) were P1 type 2 variants (2a or 2c), while types 4-5-7-2 (181 strains) and 4-5-7-3 (75 strains) were P1 type 1. MLVA type 4-5-7-2 strains circulated dominantly until 201...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y Tags: Jpn J Infect Dis Source Type: research

Potential pathogenic Leptospira species isolated from waterfall in Thailand.
Abstract   We collected water and soil samples from a waterfall in Thailand in order to investigate the presence of potential pathogenic Leptospira. Isolation of Leptospira was completely accomplished from all 17 environmental samples. Based on 16S rRNA gene sequence analysis, a diverse group of Leptospira species was recovered from waterfall samples including two pathogenic species; L. alstonii (5/17, 29%) and L. kmetyi (1/17, 6%), one intermediate species; L. wolffii (9/17, 53%) and two non-pathogenic species; L. meyeri (1/17, 6%) and L. idonii (1/17, 6%). High prevalence of pathogenic and intermediate...
Source: Japanese Journal of Infectious Diseases - October 31, 2017 Category: Infectious Diseases Authors: Chaiwattanarungruengpaisan S, Suwanpakdee S, Sangkachai N, Chamsai T, Taruyanon K, Thongdee M Tags: Jpn J Infect Dis Source Type: research

Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother.
Abstract Volume 70, no 2, p.225-227, 2017. Page 226, Figure 1B and C should appear as shown below. PMID: 28943599 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 26, 2017 Category: Infectious Diseases Authors: Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, Tomonaga K Tags: Jpn J Infect Dis Source Type: research

Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years.
This study aimed to find risk factors in HIV-infected patients with early decline renal function or less than 90 ml/min/1.73m(2). The study was retrospective conducted at Chonprathan Hospital, Thailand. The inclusion criteria were HIV-infected adult patients who were treated at the hospital's HIV clinic and whose eGFR levels at the first visit had been evaluated. Eligible patients were categorized by eGFR level at 90 ml/min/1.73(2). Multivariate logistic analysis was performed to evaluate the association of the eGFR of less than 90 ml/min/1.73(2). There were 301 HIV-infected patients included in the study. Of those, 89 pat...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Limkunakul C, Srinithiwat P, Lochinda B, Sawanyawisuth K Tags: Jpn J Infect Dis Source Type: research

Spatial Clustering of Severe Hand-Foot-Mouth Disease Cases in Hainan Island, China.
This study explored spatial clusters of the incidence and proportion of severe HFMD cases in Hainan Island, Where the prevalence and mortality of HFMD were the highest in China in 2011. A spatial autocorrelation statistic (Anselin's Local Moran I) was calculated for the Empirical Bayesian (EB) smoothed dataset of severe HFMD cases. Significantly spatial clusters were detected for both incidence and the proportion of severe HFMD cases. Population density was higher in spatial clusters with a high proportion of severe HFMD cases among total HFMD cases. We speculate that a higher proportion of severe HFMD cases were diagnosed...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Chen SM, Qiu L, Du ZH, Jin YM, Du JW, Chen Y, Watanabe C, Umezaki M Tags: Jpn J Infect Dis Source Type: research

An alarmingly high proportion of anti-retroviral drugs resistant HIV-1 infection among high risk groups in central Vietnam: A sub-study of the national sentinel survey.
Abstract We investigated the prevalence of HIV drug resistance among high risk groups such as injecting drug user (IDU), female sex worker (FSW) and men having sex with men (MSM) in central Vietnam. We used HIV positive samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays and the positive samples were further tested for HIV viral load and drug resistant mutations by in-house assays. Drug resistant mutations (DRMs) were determined using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. ...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Do HT, Nguyen DT, Nguyen LAT, Do DH, Le HX, Trinh XMT, Ton HVN, Sawada I, Kitamura N, Le NM, Yoshihara K, Phan THT, Bui CT, Ariyoshi K, Yoshida LM Tags: Jpn J Infect Dis Source Type: research

A case of community-acquired pneumonia due to Legionella pneumophila serogroup 9 in which initial treatment with single-dose oral azithromycin appeared useful.
Abstract Legionella species are important causative pathogens for severe community-acquired pneumonia (CAP). Most cases of Legionella pneumonia are due to Legionella pneumophila serogroup 1, and CAP due to Legionella pneumophila serogroup 9 is rare. A fourth case of CAP due to Legionella pneumophila serogroup 9 is reported, and initial treatment using single-dose oral azithromycin appeared useful. Azithromycin injection or fluoroquinolone injection is usually recommended for the treatment of Legionella pneumonia, and no previous reports have shown the effectiveness of single-dose oral azithromycin. This case repor...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Ito A, Ishida T, Tachibana H, Ito Y, Takaiwa T, Fujii H, Hashimoto T, Nakajima H, Amemura-Maekawa J Tags: Jpn J Infect Dis Source Type: research

Sepsis due to Chryseobacterium gleum in a diabetic patient with COPD - case report and mini review.
PMID: 28890506 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Singhal L, Gupta V, Mehta V, Singla N, Janmeja AK, Chander J Tags: Jpn J Infect Dis Source Type: research

Surveillance of adenovirus respiratory infections in children in Osaka, Japan.
Abstract Human adenovirus (HAdV) strains isolated from respiratory specimens of 139 children between 2008 and 2015 were analyzed with the intent of evaluating the endemic situation of HAdV infections in Osaka, Japan. The cases increased in spring and winter, and the infections were confirmed mainly in children aged ≤ 5 years, comprising 91.9% of the total population examined. Molecular typing of the isolates revealed that the most common types belonged to HAdV-B and HAdV-C, and a case of co-infection with HAdV-C1 and HAdV-C2 was confirmed. The median age of HAdV-E cases were higher than that of HAdV-B and -C ca...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Hiroi S, Morikawa S, Nakata K, Kase T Tags: Jpn J Infect Dis Source Type: research

Does Helicobacter pylori infection play a role in susceptibility to Brucellosis?
This study aimed to determine the relationship between brucellosis and Helicobacter pylori. In this case-control study, 100 patients with brucellosis as ceases and 200 participants without brucellosis as controls were evaluated. To compare the prevalence of Helicobacter pylori in the two groups, odds ratio and confidence intervals for every variable were analyzed through using logistic regression model after adjustment for confounding factors. The results obtained in patients with brucellosis showed that fever, sweating and joint pain were the most prevalent clinical symptoms among the studied patients; in addition, compar...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Afrasiabian S, Mohsenpour B, Ghaderi E, Nadri S, Hajibagheri K Tags: Jpn J Infect Dis Source Type: research

Proposed pharmacokinetic-pharmacodynamic breakpoint of garenoxacin and other quinolones.
Abstract The pharmacokinetic-pharmacodynamic (PK-PD) breakpoints (BPs) of garenoxacin (GRNX) and other oral quinolones were calculated using the Monte Carlo simulation (MCS) based on the distribution of changes in their plasma concentrations. PK-PD BPs of 400 mg once a day (QD) of GRNX for the free area under the curve/minimum inhibitory concentration (fAUC/MIC) for 30 of Streptococcus pneumoniae and 100 of Gram-negative bacteria: (G (-)) were 0.5 and 0.125 μg/mL, respectively. PK-PD BPs of other quinolones for S. pneumoniae/G(-) were 1/0.25 μg/mL for levofloxacin (LVFX) 500 mg QD, 0.5/0.125 μg/mL for mox...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Yamagishi Y, Shibata T, Nakagawa S, Nomura N, Mitsuyama J, Mikamo H Tags: Jpn J Infect Dis Source Type: research

Circulating genotypes of Dengue-1 virus in South West India, 2014-2015.
Abstract Dengue is found to be the most prevalent arboviral disease affecting humans. Tropical and subtropical regions are at high risk of dengue virus infections. The clinical manifestations often range from mild fever to fever with hemorrhagic manifestations and shock. Since 2010, India is witnessing a marked increase in the number of Dengue Virus Serotype 1(DENV-1) apart from Dengue Virus 2 (DENV-2) and Dengue Virus 3 (DENV-3) Serotypes. The present study was undertaken to understand the circulating genotypes of DENV-1 in South West India by sequencing the envelope gene of DENV-1 samples representative of the t...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Pooja S, Sabeena S, Revti B, Sanjay R, Anjali A, Rajendra K, Aswathyraj S, Giselle D, Hindol M, Arunkumar G Tags: Jpn J Infect Dis Source Type: research

The antibacterial effects of antimicrobial peptides OP-145 against clinically isolated multi-resistant strains.
Abstract OP-145 is a synthetic antimicrobial peptide developed from the human cathelicidin LL-37. The purpose of this investigation was to evaluate the effect of the antimicrobial peptide OP-145 against clinically isolated drug resistant strains. Ten Methicillin-resistant Staphylococcus aureus (MRSA) strains were obtained from our hospital's clinical inspection center and the activity of OP-145 on growth and biofilm formation on these strains was evaluated by colony counts and scanning electron microscopy. The antimicrobial peptide OP-145 showed significant antibacterial activity against 9 MRSA strains. For the bi...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Ming L, Huang JA Tags: Jpn J Infect Dis Source Type: research

Update on the structure of oxazolidinone analogues and comparing their in vitro and intracellular efficacy with linezolid against clinically relevant bacterial species.
Abstract  Oxazolidinones comprise a novel class of antimicrobials as inhibitors of bacterial ribosomal protein synthesis. In the present study, we identified 15 novel oxazolidinone analogues with potent antituberculosis activities. Compounds sy124 and sy125 displayed the best antituberculosis activity in vitro, against various clinically relevant bacterial species, including most Gram positive bacteria, Mycobacterium and Helicobacter pylori, which are better than that of the linezolid. Cell based assay indicated that these compounds showed strong ability to kill the intracellular pathogens. Our results indicate ...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Tang Q, Zhao Y, Xu B, Gong P, Wang D Tags: Jpn J Infect Dis Source Type: research

Leptospirosis Cases in the Tokyo Metropolitan Area, Japan.
Abstract In Japan, 20-50 cases of leptospirosis are reported annually, typically involving farmers or returnees from tropical areas. Here, we report five indigenous leptospirosis cases that occurred in the Tokyo urban area. All cases were male (mean age 65.8 ± 4.7 years) and presented with clinical features including high fever, acute kidney injury, and jaundice. Three cases presented with pulmonary infiltration and ground glass opacity on admission. Two of the five patients were intubated and underwent continuous hemodiafiltration. The mean length of hospitalization was 38 ± 17.0 days, and all patie...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Mutoh Y, Koizumi N, Morino E, Hayakawa K, Kato Y, Ohmagari N Tags: Jpn J Infect Dis Source Type: research

Attack rates of norovirus and Campylobacter food poisonings that cannot be represented by numeric constant but by plotting attack rate against number of patients per incident in Cartesian coordinates.
Abstract  In norovirus and Campylobacter food poisonings, the frequencies of the number of patients per incident and that of the number of eaters per incident followed lognormal distribution, and their respective medians were 12~27 and 23~48 for norovirus food poisoning and 5~8 and 9~21 for Campylobacter food poisoning. The lognormal frequency distribution of eaters could be simulated by assuming that people are attracted more to a dish that has already attracted many. The number of patients per incident and that of eaters per incident were not necessarily inter-correlated; the frequencies of the attack rates ...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Yoshikura H, Takeuchi F Tags: Jpn J Infect Dis Source Type: research

High prevalence of Campylobacter in broiler flocks is a crucial factor for food poisoning frequency in humans.
PMID: 28890515 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Yamazaki W, Sabike II, Sekiguchi S Tags: Jpn J Infect Dis Source Type: research

Molecular characterization of non-carbapenemase-producing Escherichia coli clinical isolates with reduced carbapenem susceptibility from a Thai university hospital.
Abstract Twelve non-replicate carbapenemase-negative ertapenem-non-susceptible (CNENS) Escherichia coli isolates from a Thai university hospital between 2010 and 2014 were characterized and compared with two carbapenemase-producing E. coli isolates from the same hospital. Eight unique PFGE patterns were obtained. All produced CTX-M-15 β-lactamase and two isolates co-expressed either CMY-2 cephalosporinase or increased efflux pump. Amino acid sequence analysis revealed that OmpF defect (seven isolates) due to mutations generating premature proteins or an IS1 insertion was more prevalent than in OmpC (no trunca...
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Nuramrum S, Chanawong A, Lunha K, Lulitanond A, Sangka A, Wilailuckana C, Angkititrakul S, Charoensri N, Wonglakorn L, Chaimanee P, Chetchotisakd P Tags: Jpn J Infect Dis Source Type: research

Laboratory and epidemiology communications.
PMID: 28890517 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Tanaka S, Matoba Y, Unno M, Ikeda T, Itagaki T, Mizuta K Tags: Jpn J Infect Dis Source Type: research

A case of imported dengue fever from Burkina Faso to Japan in October 2016.
We present a case of imported dengue fever from Burkina Faso to Japan, where an outbreak of dengue was reported on October 18, 2016. The phylogenetic analysis revealed that the isolate from our patient belonged to a distinct of sylvatic dengue viruses, suggesting that dengue viruses have been maintained in the mosquitoes and human cycles in Burkina Faso for more than 30 years. PMID: 28890518 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Hashimoto T, Kutsuna S, Maeki T, Tajima S, Takaya S, Katanami Y, Yamamoto K, Takeshita N, Hayakawa K, Kato Y, Kanagawa S, Ohmagari N Tags: Jpn J Infect Dis Source Type: research

Two rare cases of wound infections caused by trueperella bernardiae.
We report two cases of wound infections in two patients that underwent different surgical procedures, although in the second case the microorganism was isolated in mixed culture. Culture of wound secretion resulted on T. bernardiae isolation. Treatment was performed and resolution of these infections were documented. PMID: 28890519 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2017 Category: Infectious Diseases Authors: Cobo F, Rodríguez-Granger J, Sampedro A, Gutiérrez-Fernández J, Navarro-Marí JM Tags: Jpn J Infect Dis Source Type: research

Phylogenetic Characteristics of Mycobacterium tuberculosis Clinical Isolates in Akita Prefecture, Japan, on the Basis of the Preliminary Detection of Beijing Family Strains.
PMID: 28740030 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 28, 2017 Category: Infectious Diseases Authors: Konno T, Takahashi S, Suzuki S, Kashio H, Kumagai Y Tags: Jpn J Infect Dis Source Type: research

Distribution of Rotavirus Genotypes from the 2008/2009 to 2015/2016 Season in Nara Prefecture, Japan.
This study was conducted to investigate the distribution of rotavirus genotypes in Nara Prefecture, Japan before and after introduction of vaccination in 2011. Since the 2011/2012 season, DS-1-like G1P[8] strains have been detected in Nara Prefecture, accounting for about half of all strains in the 2014/2015 season. During the 2015/2016 season, no DS-1-like G1P[8] strain was detected. G2P[4] was the predominant genotype. Group A rotavirus (RVA), a major cause of severe gastroenteritis in infants and young children, poses an important public health issue in Japan. Molecular surveillance of RVA infections has been conducted ...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Sugimoto D, Nakano M, Inada M, Fujitani M, Chiba S, Sakai T Tags: Jpn J Infect Dis Source Type: research

Molecular epidemiology of Microsporum canis isolated in Japan based on multilocus microsatellite typing fragment analysis.
Abstract Intraspecies polymorphisms of Microsporum canis strains isolated from human lesions and domesticated cats in Japan were examined by multilocus microsatellite (MS) analysis. Using nine MS markers, 70 strains were classified into 20 genotypes (genotypes A to T). Of the nine MS markers, five were useful for genotyping, whereas the other four were not. The combination of MS2, MS4 and MS7 has the highest resolution power for inter-strain differentiation. Genotype A, present in 15 strains (21.4%), was the most frequent, followed by genotypes H (10 strains, 14.3%), P (eight strains, 11.4%), I (six strains, 8.6%)...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Watanabe J, Anzawa K, Mochizuki T Tags: Jpn J Infect Dis Source Type: research

Molecular Subtyping of Salmonella enterica Serovar Typhi by Pulsed-Field Gel Electrophoresis and Multiple-Locus Variable-Number Tandem-Repeat Analysis in India: Their Association with Antimicrobial Resistance Profiles.
Abstract Molecular subtyping, and recently DNA sequencing based methods, which are commonly used for discriminating Salmonella enterica serovar Typhi (S. Typhi) isolates, leads to improved molecular epidemiological investigations for prevention and control of typhoid fever. We included S. Typhi blood isolates (n=66) from India during 2007-14 for molecular subtyping by pulsed-field gel electrophoresis (PFGE) and multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) in association with antibiotic resistance profiles. Genotypic diversity was observed more in MLVA (Simpson's index of diversity, D value 0...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Das S, Samajpati S, Roy I, Sankar S, Gaind R, Deb M, Kulkarni R, Kumar Paul D, Dutta S Tags: Jpn J Infect Dis Source Type: research

First detection of Escherichia coli harboring mcr-1 gene from retail domestic chicken meat in Japan.
We report here the first detection of mcr-1 from retail chicken meats. A total of 70 ESBL-producing E. coli isolates recovered from retail chicken meats collected between August 2015 and June 2016 were screened for mcr-1, which resulted in positive for one isolate of CTX-M-1 producing E. coli belonging to ST1684, phylogroup A. The mcr-1 was not located in an IncI1 plasmid encoding a blaCTX-M-1. However, whole plasmid sequencing revealed that mcr-1 was located on an IncI2 plasmid. Sequences of nikB-mcr-1-pap2-ydfA-topB region were mostly identical to those of previously described IncI2 plasmid pECJS-61-63 harbored by E. col...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Ohsaki Y, Hayashi W, Saito S, Osaka S, Taniguchi Y, Koide S, Kawamura K, Nagano Y, Arakawa Y, Nagano N Tags: Jpn J Infect Dis Source Type: research

Candida tropicalis Biofilm Formation and Efficacy of Liposomal Amphotericin B using time-lapse images.
This study was conducted to investigate the process of biofilm formation by C. tropicalis and the antifungal activity of liposomal amphotericin B (LAB) against both forming-biofilms and developed-biofilms using time-lapse imaging. We found that C. tropicalis has high ability of hyphae growth and gas generation due to high metabolic activity. Thus, we visually observed that C. tropicalis formed aggressive biofilms which are fast-growing type. Also, LAB acts immediately and completely inhibits against forming-biofilms. Furthermore, we demonstrated that LAB was effective against developed-biofilms of C. tropicalis by reducing...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Kawai A, Yamagishi Y, Mikamo H Tags: Jpn J Infect Dis Source Type: research

Genomic characterization of travel-associated dengue viruses isolated at entry-exit ports in Fujian province, China, 2013-2015.
In this study, a total of three DENV-2 and two DENV-4 strains were isolated from suspected febrile travelers at two ports-of-entry in Fujian during 2013-2015. Complete viral genome sequences of these new isolates were obtained with Sanger chemistry. Genomic sequence analysis revealed that these strains belonged to genotypes of 2-Cosmopolitan and 4-II. In consistence with the patients' travel information, phylogenetic analyses of complete coding regions also indicated that most of the new isolates were genetically close to the circulating strains in Southeast Asia, rather than previous Chinese strains available. Therefore, ...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Gao B, Zhang J, Wang Y, Chen F, Zheng C, Xie L Tags: Jpn J Infect Dis Source Type: research

Vibrio cholerae O1 Ogawa strains carrying the ctxB7 allele caused large cholera outbreak during 2014 in the tribal areas of Odisha, India.
Abstract The large outbreak of cholera reported during July to Sept, 2014 in Narla block of Kalahandi district was investigated to find out the causative organism. The rectal swabs collected from diarrhoea patients and environmental water samples were sub-cultured following standard techniques. The causative organism was V.cholerae O1 Ogawa biotype El Tor while DMAMA-PCR assay confirmed that all strains were ctxB7 of Haitian variants V.cholerae O1. The water samples were negative for V. cholerae .The V.cholerae O1 strains were sensitive to tetracycline, ciprofloxacin, norfloxacin, ofloxacin, doxycycline, azithromy...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Bhusan Pal B, Kumar Khuntia H, Ranjan Nayak S, Mohanty A, Biswal B Tags: Jpn J Infect Dis Source Type: research

Cerebral syphilitic gumma: case presentation of a brainstem mass lesion and a brief review of the literature.
PMID: 28674317 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Shi F, Jiang H, Shi Z, Liu H, Zhang Q Tags: Jpn J Infect Dis Source Type: research

A case of type 54 human mastadenovirus keratoconjunctivitis causing severe broad epithelial defect ten years after LASIK surgery.
PMID: 28674318 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Suzuki S, Kawamura T, Saeki Y, Okubo M, Konagaya M, Hanaoka N, Arashiro T, Fujimoto T, Uchio E Tags: Jpn J Infect Dis Source Type: research

Comparative study on lot release systems for vaccines as of 2016.
Abstract Many countries have established their own vaccine lot release system, which fits each country's situation, while the World Health Organization is promoting convergence in regulatory systems for vaccines so that vaccines of assured quality are provided globally. We conducted questionnaire-based investigation of the lot release systems for vaccines in seven countries and two regions. It was found that a review of the summary protocol by National Regulatory Authorities was commonly applied for independent lot release of vaccines, whereas there was diversity, especially in the testing policy. Some countries a...
Source: Japanese Journal of Infectious Diseases - July 1, 2017 Category: Infectious Diseases Authors: Fujita K, Naito S, Ochiai M, Konda T, Kato A Tags: Jpn J Infect Dis Source Type: research