Infectious spondylitis in a patient with chronic kidney disease: identification of Campylobacter fetus subsp. testudinum with 16S ribosomal RNA sequencing.
We report the first case in which spondylitis with bacteremia caused by Campylobacter fetus subsp. testudinum, which was identified by 16S ribosomal ribonucleic acid (rRNA) gene sequencing. An 81 year-old man presented with fever and general weakness. His medical history included end-stage renal disease, hypertension, and type 2 diabetes. Despite empirical antibiotic treatment, fever and back pain persisted. Magnetic resonance imaging with gadolinium enhancement showed a low-signal-intensity lesion in T1-weighted imaging and a high-signal-intensity lesion in T2-weighted imaging at the L3 vertebra body. Campylobacter fetus ...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Choi HS, Shin SU, Bae EH, Ma SK, Kim SW Tags: Jpn J Infect Dis Source Type: research

Ulcerative lesions with hemorrhage in a patient with severe fever with thrombocytopenia syndrome observed via upper gastrointestinal endoscopy.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a novel bunyavirus infection caused by SFTS virus (SFTSV, Family Bunyaviridae, Genus Phlebovirus) with high case fatality rate. A previously healthy man aged 72 showed symptoms of fever, general fatigue, and altered consciousness. He was hospitalized for treatment. On day 3, taking the day on which fever appeared first during the disease course as day 0, he experienced bloody vomit. An emergency upper gastrointestinal endoscopic examination revealed the presence of multiple ulcerative lesions with continuous oozing hemorrhage in the stomach. He died on...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Kaneyuki S, Yoshikawa T, Tani H, Fukushi S, Taniguchi S, Fukuma A, Shimojima M, Kurosu T, Morikawa S, Saijo M Tags: Jpn J Infect Dis Source Type: research

Strong Correlation between Annual Incidence of Male Amebiasis and that of Male Homosexual HIV.
PMID: 26743150 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak.
Abstract The first Korea Middle East respiratory syndrome coronavirus (MERS-CoV) was confirmed on 20 May 2015, with a subsequent outbreak in Korea. Five patients suspected of MERS-CoA infection were admitted to our hospital during this outbreak. One patient had no symptoms at admission pneumonia was identified on chest X-ray. Two patients required ventilator-assisted respiration because of rapid progression to acute respiratory failure. One patient needed extracorporeal membrane oxygenation due to refractory hypoxemia. One patient died of shock with multiorgan failure. All patients had fever, myalgia, leucopenia, ...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Rhee JY, Hong G, Ryu KM Tags: Jpn J Infect Dis Source Type: research

Distribution of Chlamydia trachomatis infection among pregnant women by nucleic acid amplification tests in Japan.
PMID: 26743152 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Suzuki S, Tanaka M, Sekizawa A, Kinoshita K Tags: Jpn J Infect Dis Source Type: research

Molecular epidemiological analyses of Monophasic Salmonella enterica serovar O7: -: 1, 5 isolates in Akita prefecture, Japan.
PMID: 26743153 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Konno T, Takahashi S, Kumagai Y Tags: Jpn J Infect Dis Source Type: research

Fatal outcome of coinfection of Crimean-Congo hemorrhagic fever and malaria.
Abstract Here, we report a case of a Bulgarian patient with imported falciparum malaria that manifested 6 days after his arrival in Bulgaria, which was complicated by bloody diarrhea 2 days later. Blood smear revealed high parasitemia, with annular forms and gametocytes of Plasmodium falciparum. In addition, RNA of the Crimean-Congo hemorrhagic fever (CCHF) virus was detected in the blood sample by real-time reverse transcription (RT)-PCR and nested RT-PCR. The obtained sequence was found to be clustered within the Europe 1 lineage close to the other Bulgarian strains. Notably, the two infectious diseases may appe...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Christova I, Petrov A, Papa A, Vutchev D, Kalvatchev N, Vatev N, Stoycheva M Tags: Jpn J Infect Dis Source Type: research

Rapid and sensitive identification of glycoprotein H genotypes in clinical human cytomegalovirus samples.
Abstract Human cytomegalovirus (HCMV) is a common pathogen that causes persistent infections in immune deficient patients and results in significant morbidity and mortality, particularly among transplant recipients and children. Different HCMV glycoprotein H (gH) genotypes may cause different diseases and affect the severity of these diseases. To develop a sensitive quantitative real-time PCR assay that could rapidly distinguish between two HCMV gH genotypes, primers were designed to target the conserved region of the gH gene. gH1 and gH2 probes were designed to target the two variable regions. Standard HCMV strai...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Li W, Tao R, Zhang X, Shu Q, Gao HH, Shang SQ, Peng ZY, Li HM Tags: Jpn J Infect Dis Source Type: research

Analysis of HIV/AIDS epidemiology in Japan from 1985-2011-infection detection pattern for male homosexuals different from that for male heterosexuals but similar to that for females.
This article reviews Japanese HIV/AIDS surveillance data from 1985 to 2011. It revealed that heterosexual males are more prone to be detected as "AIDS cases," whereas male homosexuals and females are more prone to be detected as "HIV cases," irrespective of the gender, age, infection route, residential area, and nationality. The probability of being detected as an "AIDS case" increased with advanced age, irrespective of the gender and infection route. Interpretation of the data requires further information on the clinical latency of AIDS that could differ depending on differences in infection ...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Alcaligenes faecalis: an unusual cause of skin and soft tissue infection.
In conclusion, A. faecalis should be considered a potential pathogen of SSTI, particularly in patients with vascular diseases or after surgery. The history of contact with water or aqueous solutions should be investigated in all cases. The clinical outcome is usually good, but treatment can be difficult in some cases due to the high level of resistance to commonly used antibiotics. PMID: 25420652 [PubMed - indexed for MEDLINE] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Tena D, Fernández C, Lago MR Tags: Jpn J Infect Dis Source Type: research

Seroprevalence survey of zoonoses in Extremadura, southwestern Spain, 2002-2003.
os JM Abstract Our aims were to determine the seroprevalence rates for the most common types of zoonosis among the population of Extremadura (southwestern Spain) and to identify the associated risk factors. We conducted a seroepidemiological survey to collect information on family background and the habits of people residing in Extremadura between 2002 and 2003. Antibodies to Brucella were determined by Rose Bengal staining and a standard tube agglutination test; a titer of 1/80 was considered to be positive. Antibody titers for spotted fever, leishmaniasis, echinococcosis, and toxoplasmosis were determined by enz...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Asencio MA, Herraez O, Tenias JM, Garduño E, Huertas M, Carranza R, Ramos JM Tags: Jpn J Infect Dis Source Type: research

Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus.
Abstract An efficient cell culture and infection system for hepatitis C virus (HCV) facilitates analyses of the complete virus life cycle. Human hepatic Huh7.5.1 cells and an HCV-JFH1 strain have been widely employed in infection experiments. In the present study, cultured Huh7.5.1 cells exhibited heterogeneous phenotypes of HCV infection. Using single-cell cloning of Huh7.5.1 cells, we isolated a clone highly permissive to HCV (Huh7.5.1-8) and a CD81-defective clone nonpermissive to HCV (Huh7.5.1-5). Expression of CD81 in Huh7.5.1-5 cells restored permissiveness to HCV, indicating that CD81 is essential for HCV i...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Shirasago Y, Sekizuka T, Saito K, Suzuki T, Wakita T, Hanada K, Kuroda M, Abe R, Fukasawa M Tags: Jpn J Infect Dis Source Type: research

Detection of the human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata, Japan.
Abstract The available literature on human coronaviruses (HCoVs) in Japan is limited to epidemiological studies conducted over a maximum of 1 year. We conducted a 4-year study of HCoVs by analyzing 4,342 respiratory specimens obtained in Yamagata, Japan, between January 2010 and December 2013. A pan-coronavirus reverse transcription-PCR screening assay was performed, and all HCoV-positive specimens were subsequently confirmed by sequencing of the PCR products. We detected in 332 (7.6%) HCoV strains during the study period, comprising 133 (3.1%) HCoV-NL63, 83 (1.9%) HCoV-HKU1, 78 (1.8%) HCoV-OC43, and 38 (0.9%) HCo...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Matoba Y, Abiko C, Ikeda T, Aoki Y, Suzuki Y, Yahagi K, Matsuzaki Y, Itagaki T, Katsushima F, Katsushima Y, Mizuta K Tags: Jpn J Infect Dis Source Type: research

Development of a diagnostic system for novel influenza A(H7N9) virus using a real-time RT-PCR assay in Japan.
In this study, a one-step real-time RT-PCR assay was developed for detecting the novel A(H7N9) virus. This assay was shown to have high specificity, good linearity, and high sensitivity to a broad range of Eurasian H7 viruses. The assay is useful both for diagnostic purposes in cases of suspected human infection with the influenza A(H7N9) virus and in the surveillance of both avian and human influenza viruses. A diagnostic system using this assay was prepared at 74 prefectural and municipal public health institutes and 16 quarantine stations in Japan early into the human H7N9 infection outbreaks, enabling potential diagnos...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Takayama I, Takahashi H, Nakauchi M, Nagata S, Tashiro M, Kageyama T Tags: Jpn J Infect Dis Source Type: research

Kudoa septempunctata-induced gastroenteritis in humans after flounder consumption in Japan: a case-controlled study.
Abstract Raw fish consumption is increasing worldwide. Since around the year 2000, western regions of Japan have reported a foodborne disease of unknown cause that occurred after the consumption of flounder. In October 2010, a particularly large outbreak was reported in these regions among individuals who consumed flounder fish that had been raised in aquaculture systems. The median incubation period was 5 h (range, 4-19 h), and the most frequently reported symptom was diarrhea (80%). The risk estimate of the consumption of flounder was significantly higher than that of the development of symptoms (odds ratio=9.50...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Yahata Y, Sugita-Konishi Y, Ohnishi T, Toyokawa T, Nakamura N, Taniguchi K, Okabe N Tags: Jpn J Infect Dis Source Type: research

Establishment of a rabbit model of spinal tuberculosis using Mycobacterium tuberculosis strain H37Rv.
This study aimed to establish a spinal tuberculosis model by implanting Mycobacterium tuberculosis strain H37Rv into the lumbar vertebral body of New Zealand white rabbits. A hole was first drilled into the top of the 6th lumbar vertebra of each rabbit, which was then filled with a gelatin sponge to adsorb 0.2 ml of M. tuberculosis suspension (10(7) CFU /ml) for the infection group or normal saline for the control group. The holes were then closed with sutures. CT findings demonstrated that 5 and 10 rabbits developed spinal tuberculosis at 4 and 8 weeks, respectively, after this procedure. MRI examinations revealed that 7 ...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Liu X, Jia W, Wang H, Wang Y, Ma J, Wang H, Zhou X, Li G Tags: Jpn J Infect Dis Source Type: research

Laboratory-confirmed dengue fever and chikungunya fever cases at the Narita Airport Quarantine Station in 2013.
Abstract Fourteen patients were laboratory-confirmed cases of imported infectious diseases at the Narita Airport Quarantine Station in 2013. Blood tests were performed on 283 subjects suspected of having imported infectious diseases. Of these, 11 were diagnosed as having dengue fever (dengue) and 3 as having chikungunya fever (chikungunya) using real-time RT-PCR. The possible countries from which dengue virus infections were contracted were Thailand, Laos, Sri Lanka, and some other countries in Southeast Asia and South Asia. The 3 chikungunya cases were also diagnosed in individuals that returned from Southeast As...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Furuichi M, Makie T, Honma Y, Isoda T, Miyake S Tags: Jpn J Infect Dis Source Type: research

Epidemiological characteristics of rubella and congenital rubella syndrome in the 2012-2013 epidemics in Tokyo, Japan.
Abstract A large rubella outbreak has been observed since June 2012 in Tokyo, Japan, and a rapid increase in the number of congenital rubella syndrome (CRS) cases have also been reported in Japan since October 2012. All the clinically diagnosed and laboratory-confirmed rubella cases reported in Tokyo from January 2012 to December 2013 and all the laboratory-confirmed CRS cases from January 2012 to March 2014 were analyzed. In total, 4,116 rubella cases were reported in Tokyo. Of these, 77.2% (n=3,176) were male; the highest number of cases occurred in males aged 35-39 years and in females aged 20-24 years. Complic...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Sugishita Y, Shimatani N, Katow S, Takahashi T, Hori N Tags: Jpn J Infect Dis Source Type: research

Description of hospitalized cases of influenza A(H1N1)pdm09 infection on the basis of the national hospitalized-case surveillance, 2009-2010, Japan.
This study reports the epidemiological characteristics of hospitalized cases of influenza A(H1N1)pdm09 infection analyzed on the basis of surveillance data collected from July 24, 2009, the date on which the hospital-based surveillance of influenza cases was implemented in Japan, to September 5, 2010. During the study period, 13,581 confirmed cases were reported. Among those cases with information regarding the reason for hospitalization, 39% were admitted to hospitals for non-therapeutic purposes such as medical observation and laboratory testing. The overall hospitalization rate was 5.8 cases per 100,000 population when ...
Source: Japanese Journal of Infectious Diseases - December 18, 2015 Category: Infectious Diseases Authors: Shimada T, Sunagawa T, Taniguchi K, Yahata Y, Kamiya H, Yamamoto KU, Yasui Y, Okabe N Tags: Jpn J Infect Dis Source Type: research

Molecular Characterization of imipenem resistant meropenem susceptible Pseudomonas aeruginosa with blaVIM-2 phenotype - potential for dissemination.
PMID: 26567829 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Pragasam AK, M R, Anandan S, Veeraraghavan B Tags: Jpn J Infect Dis Source Type: research

A Handy Field Portable ELISA-system for Rapid Onsite Diagnosis of Infectious Diseases.
In this study, we demonstrate the efficiency (90% less in time and volume consumption compared to 96-well ELISA), detection capacity and ease in operation of a field portable battery operated ELISA-system, about the size of a cellular phone (12 × 6 × 5.5 cm) in the serological diagnosis of Measles and Rubella virus with potential for onsite testing such as during disease outbreaks. PMID: 26567830 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Singh H, Morioka K, Shimojima M, Van An L, Nakajima H, Hemmi A, Uchiyama K, Loong SK, AbuBakar S, Yang M, Sugamata M Tags: Jpn J Infect Dis Source Type: research

Shedding of Rubella Virus in Congenital Rubella Syndrome: Study of Affected Infants Born in Tokyo, Japan, 2013-2014.
Abstract Rubella is usually a mild illness with febrile rash being its main symptom. However, serious consequences of rubella can result from an infection during the early stages of pregnancy. After a rubella outbreak in Japan observed from June 2012 to 2013, 45 infants were reportedly born with Congenital Rubella Syndrome (CRS). We followed up the 15 CRS cases reported in Tokyo to determine the virus shedding periods by utilizing nested RT-PCR to detect rubella virus genes. Out of the 15 cases, 4 cases became unavailable for follow-ups and were excluded from analysis. During the estimated virus shedding periods, ...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Sugishita Y, Akiba T, Sumitomo M, Hayata N, Hasegawa M, Tsunoda T, Okazaki T, Murauchi K, Hayashi Y, Kai A, Seki N, Kayebeta A, Iwashita Y, Kurita M, Tahara N Tags: Jpn J Infect Dis Source Type: research

Pneumonia in Vietnamese Children Aged 1 to 15 years Due to Atypical Pneumonia Causative Bacteria: Hospital-Based Microbiological and Epidemiological Characteristics.
Abstract Pneumonia caused by Mycoplasma pneumoniae (M), Chlamydophila (Chlamydia) pneumoniae (C) and Legionella pneumophila (L) (these three bacteria are referred as the MCL, hereafter) is not well-documented in Vietnam, which may limit effectiveness of treatment. We investigated epidemiological & microbiological characteristics of MCL-caused pneumonia in hospitalized children aged 1-15 years.Multiplex PCR and specific IgM determination were used to detect the target bacteria. Of 722 community-acquired pneumonia (CAP) children, the MCL were the most frequently found pathogens (215 children, 29.78%). M. pneumon...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Huong PL, Hien PT, Lan NT, Binh TQ, Tuan DM, Anh DD Tags: Jpn J Infect Dis Source Type: research

Rapid identification of Echinococcus granulosus and E. canadensis using high-resolution melting (HRM) analysis by focusing on single nucleotide polymorphism.
Abstract High-resolution melting (HRM) is reliable and sensitive scanning method to detect variation in DNA sequencing, understand the epidemiology, and transmission of Echinococcus granulosus. HRM method to discriminate E. granulosus and E. canadensis genotypes were tested. One hundred forty-one hydatid cysts were collected from slaughtered animals in different parts of Isfahan-Iran during 2013. After DNA extraction, the mitochondrial cytochrome c oxidase subunit 1 gene (cox1) was amplified using polymerase chain reaction (PCR) coupled with HRM curve. The result of HRM analysis using partial sequences of cox1 gen...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Safa AH, Harandi MF, Tajaddini M, Rostami-Nejad M, Mohtashami-Pour M, Pestehchian N Tags: Jpn J Infect Dis Source Type: research

Cytomegalovirus Retinitis in Three Pediatric Cases with Acute Lymphoblastic Leukemia: Case Series and Review of the Literature.
A, Bakir M, Soysal A Abstract Cytomegalovirus (CMV) retinitis is typically diagnosed in acquired immunodeficiency syndrome (AIDS) patients and allogeneic hematopoietic cell transplant recipients. However, it may develop in patients with acute lymphoblastic leukemia (ALL) not receiving hematopoietic cell transplantation. In order to increase awareness of CMV retinitis in this group herein, we describe three cases aged 3,9,12 years with ALL who developed CMV retinitis. The diagnosis of CMV retinitis was made on the basis of ophthalmological findings suggesting typical retinal lesions. In two cases, CMV DNAemia was ...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Öcal Demir S, Çeliker H, Karaaslan A, Kepenekli Kadayifci E, Akkoç G, Atici S, Yakut N, Şenay E, Kazokoğlu H, Koç A, Bakir M, Soysal A Tags: Jpn J Infect Dis Source Type: research

Characterization of an A(H1N1)pdm09 virus imported from India, March 2015.
PMID: 26567835 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Ohmiya S, Sato K, Ito H, Chiba F, Nishimura H, Shindo S, Watanabe S, Odagiri T, Influenza Virus Surveillance Group of Japan Tags: Jpn J Infect Dis Source Type: research

Measles and Rubella - Scale Free Distribution of Local Infection Clusters.
This article examines the size distribution of "local infection clusters" ("clusters" in short; see text for the definition) of measles and rubella from 2008 to 2013 in Japan. When the logarithm of cluster sizes were plotted on the x-axis and the logarithm of their frequencies in the y-axis, the plots fell on a rightward descending straight line. The size distribution was found to follow power law. As the size distribution of the clusters could be equated with that of local secondary infections initiated by one patient, the size distribution of the clusters was in fact that of the "effective reprod...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Yoshikura H, Takeuchi F Tags: Jpn J Infect Dis Source Type: research

Survey of Francisella tularensis in Wild Animals in the Endemic Areas in Japan.
Abstract Samples taken from 428 wild animals and 126 ticks collected from tularemia endemic area in Japan between 2005 and 2013 were analyzed for the presence of Francisella tularensis. F. tularensis was isolated from a Japanese hare carcass whereas the samples from live animals and ticks were negative by real-time PCR. Our results suggest F. tularensis is still present in Japan although its prevalence is considerably low even in the endemic area. PMID: 26567837 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Hotta A, Tanabayashi K, Fujita O, Shindo J, Park CH, Kudo N, Hatai H, Oyamada T, Yamamoto Y, Takano A, Kawabata H, Sharma N, Uda A, Yamada A, Morikawa S Tags: Jpn J Infect Dis Source Type: research

Pathogenic description of Streptococcus pyogenes among invasive and non-invasive diseases in Aichi, Japan.
Abstract We determined the presence of hypervirulent S. pyogenes in 27 and 420 isolates from patients with invasive and non-invasive diseases, respectively, in Aichi Prefecture, Japan between 2003 and 2012 to determine why the prevalence of streptococcal toxic shock syndrome (STSS) suddenly increased in this location during 2011. The hypervirulent strain is defined by the emm1 genotype, a mutation of covR/S genes that regulates many other genes, encoding virulence determinants and results in the absence of proteinase, streptococcal exotoxin B (SpeB) and the production of virulence factors such as superantigen, str...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Matsumoto M, Yamada K, Suzuki M, Adachi H, Kobayashi S, Yamashita T, Minagawa H, Tatsuno I, Hasegawa T Tags: Jpn J Infect Dis Source Type: research

Prevalence and phylogenetic characterization of enterovirus d68 in pediatric patients with acute respiratory tract infection in thailand.
PREVALENCE AND PHYLOGENETIC CHARACTERIZATION OF ENTEROVIRUS D68 IN PEDIATRIC PATIENTS WITH ACUTE RESPIRATORY TRACT INFECTION IN THAILAND. Jpn J Infect Dis. 2015 Nov 13; Authors: Thongpan I, Wanlapakorn N, Vongpunsawad S, Linsuwanon P, Theamboonlers A, Payungporn S, Poovorawan Y Abstract Enterovirus D68 (EV-D68) was associated with severe lower respiratory tract infection and neurological abnormalities including acute myelitis and cranial nerve dysfunction. To determine whether the increased incidence of EV-D68 also occurs in Southeast Asia, we retrospectively tested specimens collected from Thai pedia...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Thongpan I, Wanlapakorn N, Vongpunsawad S, Linsuwanon P, Theamboonlers A, Payungporn S, Poovorawan Y Tags: Jpn J Infect Dis Source Type: research

HBV multidrug resistant sW172* truncated variant possibly involve in the ER stress pathway during hepatocarcinogenesis.
Abstract We investigated the biological effect of HBV rtA181T/sW172* point mutation on HBsAg secretion and the potential mechanisms involved in hepatocarcinogenesis. Plasmids expressed full-long HBV wildtype and HBV rtA181T/sW172* were transfected into HepG2 HCC cell lines or were injected to C57BL / 6 mice. The HBsAg and HBeAg expressions of extracellular and intracellular proteins, mice serum and liver tissues were detected by ELISA. The localization of truncate protein was characterized in vitro. The expression of ER stress gene GRP78 mRNA was determined. Significant high levels of HBsAg was observed in superna...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Zheng J, Jiang S, Lu F Tags: Jpn J Infect Dis Source Type: research

Multiple Renal and Splenic Lesions in a Child with Cat Scratch Disease.
Abstract Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae. Atypical clinical presentations of CSD include prolonged fever and multiple hepatosplenic lesions, although these are rare. Furthermore, multiple renal lesions are extremely rare in CSD. The patient was an 11-year-old Japanese girl who had a prolonged fever of unknown cause after being scratched and bitten by a kitten. Abdominal computed tomography (CT) revealed multiple small, round hypodense lesions in both kidneys and in the spleen. Based on her history and the results of CT, a diagnosis of CSD was made; the diagnosis was...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Wakiguchi H, Okamoto Y, Matsunaga M, Kodama Y, Miyazono A, Seki S, Ikeda N, Kawano Y Tags: Jpn J Infect Dis Source Type: research

Time-series analysis comparing the prevalence of antibodies against nine viral species found in umbilical cord blood in Japan.
In this study, we investigated the prevalence of antibodies against nine viral species found in umbilical cord blood obtained from 561 neonates in 2013. Serum IgG antibodies against the following viruses were measured: herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), measles virus (MV), rubella virus (RV), mumps virus (MuV), and human parvovirus B19 (HPV B19). A survey questionnaire for past history and maternal immunization status was simultaneously administered for the vaccine-preventable diseases of varicella, measles, rubella, and mu...
Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Takemoto K, Nishimura N, Kozawa K, Hibino H, Kawaguchi M, Takeuchi S, Fujishiro N, Arai S, Gotoh K, Hosono H, Ozaki T Tags: Jpn J Infect Dis Source Type: research

Isolation of Saffold Virus Type 2 from Children with Acute Respiratory Infections by Using the RD-18S-Niigata Cell Line.
PMID: 26399926 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 26, 2015 Category: Infectious Diseases Authors: Aoki Y, Matoba Y, Tanaka S, Yahagi K, Hirokawa C, Tamura T, Itagaki T, Matsuzaki Y, Mizuta K Tags: Jpn J Infect Dis Source Type: research

An Outbreak of Human Coronavirus OC43 during the 2014-2015 Influenza Season in Yamagata, Japan.
PMID: 26399927 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 26, 2015 Category: Infectious Diseases Authors: Matoba Y, Aoki Y, Tanaka S, Yahagi K, Shimotai Y, Matsuzaki Y, Itagaki T, Mizuta K Tags: Jpn J Infect Dis Source Type: research

Infectious Disease, Population Size/Density, and Tax Income of Prefectures.
PMID: 26399928 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 26, 2015 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Import-Associated Measles Outbreak Including Hospital- and Clinic-Based Transmission in the Non-Endemic Hokkaido District, Japan, 2014.
PMID: 26399929 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 26, 2015 Category: Infectious Diseases Authors: Miyoshi M, Komagome R, Ishida S, Ohnishi A, Furudate T, Mizushima Y, Narabayashi H, Miyata J, Nagano H, Okano M Tags: Jpn J Infect Dis Source Type: research

Paragonimiasis due to the consumption of wild boar meat in Japan: Contamination levels of lung fluke larvae in muscle samples of wild boars caught in the Kagoshima Prefecture.
PMID: 26370424 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Sugiyama H, Shibata K, Kawakami Y, Arakawa K, Morishima Y, Yamasaki H, Gokuden M, Iwakiri T, Fukumori J Tags: Jpn J Infect Dis Source Type: research

Possible Rickettsia massiliae infection in Greece: an imported case.
Abstract Tick-borne rickettsioses are endemic in Greece, however until recently only Rickettsia typhi and R. conorii were routinely tested in human samples arriving at the National Reference Centre. During the last years, the identification of different rickettsia species in ticks led to the introduction of other spotted fever group rickettsiae in the routine analysis. Under the new scheme, R. massiliae is now routinely tested in human samples, hence the description of the current human case. PMID: 26370425 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Chochlakis D, Bongiorni C, Partalis N, Tselentis Y, Psaroulaki A Tags: Jpn J Infect Dis Source Type: research

Proteomic Profiling of the Respiratory Syncytial Virus-Infected Rat Pneumonia Model.
Abstract Respiratory syncytial virus (RSV) is a major cause of pediatric lower respiratory tract disease. Our goal was to obtain a detailed understanding of the molecular pathogenesis of RSV infections by studying the protein expression profiles in rats with pneumonia. First, we successfully established the pneumonia rat model by intranasal injection with RSV. The differentially expressed proteins of lung tissues of RSV-infected rats compared with those of the controls were analyzed by using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) and MALDI-TOF/TOF MS. A total of 41 differentially exp...
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Wang XF, Zhang XY, Gao X, Liu XX, Wang YH Tags: Jpn J Infect Dis Source Type: research

Rotavirus infection in children with diarrhoea at korle-bu teaching hospital in ghana.
ROTAVIRUS INFECTION IN CHILDREN WITH DIARRHOEA AT KORLE-BU TEACHING HOSPITAL IN GHANA. Jpn J Infect Dis. 2015 Sep 11; Authors: Damanka S, Adiku TK, Armah GE, Rodrigues O, Donkor ES, Nortey D, Asmah R Abstract Human rotavirus infection was studied over a 12-month period (January 2004 to January 2005) in children
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Damanka S, Adiku TK, Armah GE, Rodrigues O, Donkor ES, Nortey D, Asmah R Tags: Jpn J Infect Dis Source Type: research

Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014.
In this study, we constructed an autoregressive integrated moving average (ARIMA) model for monthly HFRS incidence in Zibo from 2004 to 2013, the ARIMA (3, 1, 1)×(2, 1, 1)12 model is reliable with a high validity, which can be used to predict the next one year's HFRS incidence in Zibo. The forecast results suggest that the HFRS incidence in Zibo will experience a slight growth in the next one year. PMID: 26370428 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Wang T, Zhou Y, Wang L, Huang Z, Cui F, Zhai S Tags: Jpn J Infect Dis Source Type: research

A case of human infection by Rickettsia slovaca in Greece.
Abstract Although tick-borne rickettsiosis is endemic in Greece, until recently only Rickettsia typhi and R. conorii were routinely tested in human samples arriving at the National Reference Centre under the suspicion of rickettsial infection. However, the identification of more than these two rickettsia species in ticks, urged towards the change of the so far followed protocol in 2010; up until that year all human samples received by the laboratory were tested for antibodies against R. conorii and R. typhi only. Since then, R. slovaca, R. felis, R. mongolotimonae were added into the routine analysis. Under the ne...
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Kostopoulou V, Chochlakis D, Kanta C, Katsanou A, Rossiou K, Rammos A, Papadopoulos SF, Katsarou T, Tselentis Y, Psaroulaki A, Boukas C Tags: Jpn J Infect Dis Source Type: research

Prevalence of Providencia strains among patients with diarrhea and retail meats in Thailand.
In conclusion, retail meats were substantially contaminated with Providencia, especially P. alcalifaciens and might be source of infection of Providencia to human. PMID: 26370430 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Shima A, Hinenoya A, Samosornsuk W, Samosornsuk S, Mungkornkaew N, Yamasaki S Tags: Jpn J Infect Dis Source Type: research

High prevalence of G12 human rotaviruses in children with gastroenteritis in Myanmar.
Abstract A total of human rotaviruses from 54 children with acute gastroenteritis in Myanmar in 2011 were subjected to reverse transcription-PCR to determine their G and P types. On G typing, G2 (24/54: 44.4 %) was the most prevalent, followed by G12 (17/54: 31.5%) and G1 (1/54: 1.9%). Mixed cases with G2 and G12 were found in 12 of 54 (22.2%). On P typing, P[4] was the most predominant (29/54: 53.7%), followed by P[8] (17/54: 31.5%) and P[6] (4/54:7.4%). Mixed cases with P[4] and P[8] were detected in 4 of 54 (7.4%). Thus, the detection of G2 and unusual G12 in high proportions was characteristic of human rotavir...
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Ide T, Higo-Moriguchi K, Komoto S, Htun KW, Myint YY, Myat TW, Thant KZ, Thu HM, Win MM, Oo HN, Htut T, Rahman S, Nguyen SV, Umeda K, Oguma K, Tsuji T, Taniguchi K Tags: Jpn J Infect Dis Source Type: research

Age group-based monitoring of progress of measles and rubella elimination - search for a population size/density independent parameter.
PMID: 26370432 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Yoshikura H Tags: Jpn J Infect Dis Source Type: research

Increase in primary and secondary syphilis notifications in men in Tokyo, 2007-2013.
Abstract The number of notified syphilis cases in Tokyo has more than doubled in recent years. The number of reported primary and secondary syphilis cases increased from 108 cases (0.8 per 100,000 population) in 2007 to 245 cases in 2013 (1.9 per 100,000 population). During this period, the majority of cases was male (905/1,024), and the recent increase among primary and secondary syphilis cases was attributed to the increase among males (90/108 [83%] cases in 2007 to 218/245 [89%] cases in 2013); men aged 20-49 years contributed most to the increase, with those aged 30-34 years having the highest rate in 2013. Ma...
Source: Japanese Journal of Infectious Diseases - September 11, 2015 Category: Infectious Diseases Authors: Sugishita Y, Yamagishi T, Arima Y, Hori N, Seki N Tags: Jpn J Infect Dis Source Type: research

Genotyping Giardia intestinalis Using DNA Extracted from Long-Term-Preserved Human Specimens Stained with Chlorasol Black E.
Abstract Giardia intestinalis is a parasitic protozoan that causes diarrhea and abdominal pain in humans. Studies on the Giardia genotypes are thought to be important for understanding their infection routes and prevalence. However, there are few reports on genotyping of the pathogen in human giardiasis in Japan. We genotyped G. intestinalis using DNA extracted from chlorasol black E stained fecal smears from patients. The triosephosphate isomerase gene was amplified from 21 (91.3%) of 23 human fecal samples. Twelve (52.2%) of the pathogens detected were of genotype A, and nine (39.1%) of genotype B. A restriction...
Source: Japanese Journal of Infectious Diseases - August 7, 2015 Category: Infectious Diseases Authors: Nishida Y, Morimoto N, Korenaga M, Komatsu Y, Takeuchi H, Matsumura Y, Sugiura T Tags: Jpn J Infect Dis Source Type: research

The effect of Olyset(®) Net on mosquito larvae and their Heteroptera predators in water jars in southern Vietnam.
The effect of Olyset(®) Net on mosquito larvae and their Heteroptera predators in water jars in southern Vietnam. Jpn J Infect Dis. 2015 Aug 7; Authors: Ohba SY, Huynh TT, Kawada H, Le LL, Ngoc HT, Hoang SL, Takagi M Abstract Residents of Vietnam living in areas with water shortages collect and store tap water when available in containers such as jars, for their daily activities. Although these water jars are important breeding sites of the mosquito, the use of chemical larvicides in such containers is legally prohibited in Vietnam. The effect of Olyset(®) Net on the abundance of mosquito larv...
Source: Japanese Journal of Infectious Diseases - August 7, 2015 Category: Infectious Diseases Authors: Ohba SY, Huynh TT, Kawada H, Le LL, Ngoc HT, Hoang SL, Takagi M Tags: Jpn J Infect Dis Source Type: research

Effects of sulfamethoxazole-trimethoprim on airway colonization with Pneumocystis jirovecii.
Abstract Reactivation of latent infection is considered to be the main mechanism underlying the development of Pneumocystis pneumonia in immunosuppressed patients. We retrospectively assessed the effects of the prophylactic administration of sulfamethoxazole-trimethoprim on the development of Pneumocystis pneumonia and airway colonization with Pneumocystis jirovecii in patients undergoing examinations to diagnose or rule out Pneumocystis pneumonia. Polymerase chain reaction was performed to detect Pneumocystis jirovecii using bronchoalveolar lavage fluid or sputum of 60 consecutive patients between 2004 and 2012. ...
Source: Japanese Journal of Infectious Diseases - August 7, 2015 Category: Infectious Diseases Authors: Kushima H, Ishii H, Tokimatsu I, Umeki K, Sato T, Kadota JI Tags: Jpn J Infect Dis Source Type: research