Early enteral feeding after intestinal anastomosis in children: a systematic review and meta-analysis of randomized controlled trials
AbstractPurposeDelayed enteral feeding (DEF) contributes to postoperative complications among children undergoing intestinal surgery. Various recent studies indicate the benefits of early enteral nutrition after intestinal surgery in adults. This systematic review and meta-analysis evaluates whether early enteral feeding (EEF) is beneficial in children who underwent intestinal anastomosis.MethodsMEDLINE, PubMed, the Cochrane Library, and Web of Science databases were searched for RCTs that addressed the effect of EEF in children (younger than 18  years old) undergoing intestinal anastomosis. EEF was defined as startin...
Source: Pediatric Surgery International - February 17, 2021 Category: Surgery Source Type: research

Post-operative enterocolitis in Hirschsprung ’s disease: response to a Letter to the Editor
(Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 16, 2021 Category: Surgery Source Type: research

Comparative analysis of reliability and clinical effects of the critical view of safety approach used in laparoscopic cholecystectomy in the pediatric population
ConclusionWe believe CVS is a reliable method to ensure safe cystic channel identification in the pediatric population. New studies are warranted on the effectiveness of CVS for safely performing laparoscopic cholecystectomy in children, as the procedure is being performed more frequently in the pediatric population. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 14, 2021 Category: Surgery Source Type: research

Lymphatic malformations: a 20-year single institution experience
ConclusionOur experience reiterates not only the wide variety of clinical presentations of lymphatic malformations, but also demonstrates the necessity of multiple subspecialties and their collaboration to achieve prompt and efficacious treatment. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 13, 2021 Category: Surgery Source Type: research

Doppler ultrasound assessment of splanchnic perfusion and heart rate for the detection of necrotizing enterocolitis
ConclusionsNEC is associated with intestinal hypo-perfusion at the periphery and flow in the SMA is reduced during the later stages of disease indicating the presence of intestinal epithelium damage. This study contributes to understanding NEC pathophysiology and illustrates the value of Doppler U/S in monitoring disease progression. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 12, 2021 Category: Surgery Source Type: research

Cell death induction (extrinsic versus intrinsic apoptotic pathway) by intestinal ischemia –reperfusion injury in rats is time-depended
ConclusionWhile cell apoptosis in IR-24 rats is regulated mainly by intrinsic apoptotic pathway, 48  h followed ischemia extrinsic apoptotic pathway is responsible for pro-apoptotic effects of IR injury. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 10, 2021 Category: Surgery Source Type: research

Administration of extracellular vesicles derived from human amniotic fluid stem cells: a new treatment for necrotizing enterocolitis
AbstractPurposeNecrotizing enterocolitis (NEC) is a devastating gastrointestinal disease. Amniotic fluid stem cells (AFSC) improve NEC injury but human translation remains difficult. We aimed to evaluate the use of extracellular vesicles (EV) derived from human AFSC.MethodsHuman AFSC (hAFSC) were cultured according to the protocol (Celprogen Inc., California, U.S.A.). Conditioned medium was obtained, ultra-centrifuged, and EV were suspended in phosphate-buffered saline (PBS). C57BL/6 pups were grouped into: (1) breast-fed (Control,n = 11); (2) NEC + placebo (NEC + PBS;n =&th...
Source: Pediatric Surgery International - February 10, 2021 Category: Surgery Source Type: research

Nasogastric decompression after intestinal surgery in children: a systematic review and meta-analysis
ConclusionRoutine postoperative nasogastric decompression can be omitted in children undergoing intestinal surgery due to no benefit in preventing postoperative complications while increasing patient discomfort. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 10, 2021 Category: Surgery Source Type: research

Remote ischemic conditioning avoids the development of intestinal damage after ischemia reperfusion by reducing intestinal inflammation and increasing intestinal regeneration
ConclusionsRemote ischemia conditioning avoids intestinal damage due to I/R injury. This beneficial effect is associated with decreased intestinal inflammation and enhanced intestinal regeneration. This study implicates that RIC is a novel non-invasive intervention to reduce the intestinal damage occurring in midgut volvulus. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 8, 2021 Category: Surgery Source Type: research

Thoracoscopic oesophageal atresia/tracheo-oesophageal fistula (OA/TOF) repair is associated with a higher stricture rate: a single institution ’s experience
AbstractPurposeThoracoscopic OA/TOF repair was first described in 1999. Currently, less than 10% of surgeons routinely employ minimally access surgery. Our primary aim was to review our immediate-, early- and long-term outcomes with this technique compared with the open approach.MethodsA retrospective review of all patients undergoing primary OA/TOF (Type C) repair at our institution from 2009 was conducted. Outcome measures included length of surgery, conversion rate from thoracoscopy, early complications such as anastomotic leak and post-operative complications such as anastomotic strictures needing dilatations. Fisher &...
Source: Pediatric Surgery International - February 7, 2021 Category: Surgery Source Type: research

Hepatic oxidative injury: role of mitochondrial dysfunction in necrotizing enterocolitis
AbstractPurposeNecrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease that can cause damage to remote organs. Previous studies have shown that inflammatory and oxidative injury occur in the liver during NEC. Mitochondrial DNA (mtDNA) plays an important role in hepatic injuries of many other diseases. We aimed to investigate the mechanism of mitochondrial dysfunction in hepatic oxidative injury during NEC.MethodsNEC was induced in C57BL/6 mice (approval: 44032) by hypoxia, gavage feeding with hyperosmolar formula, and lipopolysaccharide administration from postnatal days 5 to 9 (n = 15)....
Source: Pediatric Surgery International - February 6, 2021 Category: Surgery Source Type: research

Risk factors of postoperative adhesive bowel obstruction in children with complicated appendicitis
ConclusionRisk factors for postoperative ABO should be taken seriously in children with complicated appendicitis. The scoring model is a novel but promising method to predict postoperative ABO and provide reference for clinical decision-making to relieve the obstruction. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 4, 2021 Category: Surgery Source Type: research

Congenital abdominal wall defects and cryptorchidism: a population-based study
ConclusionsCryptorchidism is more common among boys with an AWD than general population. Furthermore, omphalocele carries significantly higher risk of UDT and need for orchidopexy than gastroschisis. Due to high prevalence testicular maldescent, careful follow-up for UDT is recommended. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 31, 2021 Category: Surgery Source Type: research

Hepatic hemangioendothelioma of infancy: clinical features of a large cohort of patients and proposed management
AbstractPurposeThe management of hepatic hemangioendothelioma (HHE) may be challenging. We aimed to review a large cohort of children who presented to our centers with symptomatic HHE in the last 16  years.MethodsWe collected age at presentation, clinical features, histology, diagnostic process, management and outcome.ResultsTwenty seven patients (male/female 5/22), median age 13  days (1–1530) presented with hepatomegaly (24/27), cardiac failure (10/27), cutaneous hemangiomas (8/27), fever and anemia (6/27 each), vomiting (5/27), splenomegaly (4/27). The lesion was focal, multifocal, or diffuse in 9 patien...
Source: Pediatric Surgery International - January 29, 2021 Category: Surgery Source Type: research

Varied parameters and utility of the anal position index: a systematic review and meta-analysis
ConclusionThe anteriorly positioned anus has been associated with constipation. API been measured in various ethnic  populations with insignificant variations. The API is significantly (p
Source: Pediatric Surgery International - January 29, 2021 Category: Surgery Source Type: research

Three-dimensional visualization technique compared with magnetic resonance cholangiopancreatography for evaluation of anatomic variants of pediatric congenital choledochal cysts
ConclusionThe 3D visualization technique facilitated more precise morphological evaluation of congenital choledochal cysts and provided comprehensive spatial anatomic information for diagnosis. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 28, 2021 Category: Surgery Source Type: research

Inpatient management of Hirschsprung ’s associated enterocolitis treatment: the benefits of standardized care (Svetanoff WJ et al., Pediatr Surg Int (2020) 26:1413–1421)
(Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 26, 2021 Category: Surgery Source Type: research

Therapeutic strategies for stricturing Crohn ’s disease in childhood: a systematic review
AbstractPurposeChildhood stricturing Crohn ’s disease (CD) has significant morbidity. Interventions including resection, stricturoplasty and endoscopic balloon dilatation (EBD) are often required. Optimal intervention modality and timing, and use of adjuvant medical therapies, remains unclear. We aim to review the therapies used in paediat ric stricturing CD.MethodsA systematic review in accordance with PRISMA was performed (PROSPERO: CRD42020164464). Demographics, stricture features, interventions and outcomes were extracted.ResultsFourteen studies were selected, including 177 patients (183 strictures). Strictures p...
Source: Pediatric Surgery International - January 25, 2021 Category: Surgery Source Type: research

Paediatric gastric organoids as a tool for disease modelling and clinical translation
ConclusionGastric organoids can be reliably generated from paediatric biopsies and are a representative in vitro model for studying gastric epithelium. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 25, 2021 Category: Surgery Source Type: research

Early definitive operation for patients with anorectal malformation was associated with a better long-term postoperative bowel function
AbstractPurposeIn general, patients with anorectal malformation (ARM) undergo surgical treatment at around 6  months of age in Japan. We aimed to clarify whether the timing of a definitive operation affects the long-term bowel function.MethodsPatient data were collected from 1984 to 2007. Fifty-two male patients with high- and intermediate-type ARM were enrolled. Patients were classified into two groups based on their operative period: the early group (EG) underwent anorectoplasty at  
Source: Pediatric Surgery International - January 25, 2021 Category: Surgery Source Type: research

Building sustainable and consequential research capacity within a global alliance of paediatric surgical centres
(Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 25, 2021 Category: Surgery Source Type: research

Therapeutic effectiveness of costal cartilage grafting into both anterior and posterior walls for laryngotracheal reconstruction in acquired subglottic stenosis
ConclusionSufficient dilatation of the subglottic space could not be achieved by costochondral grafting involving the anterior wall alone. The extubation rate was improved by dilatation of the posterior wall and the insertion of costal cartilage into both the anterior and posterior walls. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 24, 2021 Category: Surgery Source Type: research

Trends in gastrostomy tube placement with concomitant Nissen fundoplication for infants and young children at Pediatric Tertiary Centers
This study examines practice variation and longitudinal trends in NF at pediatric tertiary centers.MethodsPatients ≤ 2 years who underwent GT between 2008 and 2018 were identified in the Pediatric Health Information System database. Patient demographics and rates of NF were examined. Descriptive statistics were used to evaluate the variation in the proportion of GT with NF at each hospital, by volume and over time.Results40,348 patients were identified across 40 hospitals. Most patients were male (53.8%), non-Hispanic white (49.5%) and publicly-insured (60.4%). Rates of NF by hospital varied significantly from 4.2 to 75.2% (p 
Source: Pediatric Surgery International - January 24, 2021 Category: Surgery Source Type: research

Role of urodynamics in male patients of high-anorectal malformations: a prospective study
ConclusionUrodynamics can demonstrate occult neurovesical dysfunction in patients with HARM. This would help in early renal protective therapy and prevent the burden of long-term sequelae of neurovesical dysfunction in HARM patients. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 23, 2021 Category: Surgery Source Type: research

Differences in post-operative complications after reconstruction for congenital biliary dilatation in a single institution-Roux-en-Y hepaticojejunostomy versus hepaticoduodenostomy -
ConclusionHD is considered to be an acceptable reconstruction method compared to HJ, based on our results. There has been a suggestion that inadequate diversion in HD might increase the risk of cholangiocarcinoma. To date, in this series, that has not happened. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 22, 2021 Category: Surgery Source Type: research

Rat bite injuries in children: description of a novel classification
ConclusionWe suggest that treatment of rat bites should be based on the wound type. Most patients do not require hospital admission or antibiotic treatment. Treatment should be mostly conservative wound care management. Surgery is only indicated for drainage of pus, debridement, skin graft or rarely reconstruction. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 21, 2021 Category: Surgery Source Type: research

A review of adopted colorectal patients: a parent ’s perspective
ConclusionWe strongly recommend putting support systems in place, obtaining as much medical information as possible, preparing for possible lifelong management, and consulting with a specialized colorectal team before adoption. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 21, 2021 Category: Surgery Source Type: research

Diagnostic and management strategies for congenital H-type tracheoesophageal fistula: a systematic review
ConclusionThis study shows that paediatric surgeons record low volume activity with H type tracheoesophageal fistula. Variation(s) in clinical practice are widely evident. Laryngeal nerve injury and its subsequent management warrant special consideration. Care pathways may offset attendant morbidity and define 'best practice.' (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 20, 2021 Category: Surgery Source Type: research

The incidence of infantile hypertrophic pyloric stenosis nearly halved from 2005 to 2017: analysis of German administrative data
AbstractPurposeSome paediatric surgical diseases showed a declining incidence in recent years, among which hypertrophic pyloric stenosis has been particularly striking shortly in the years after the millennium. We aimed to assess whether this development continued over the following decade, as it might offer the chance to better understand the underlying reasons.MethodsWe analysed data files obtained from the German federal statistics office for principal diagnosis of hypertrophic pyloric stenosis and pyloromyotomies from 2005 to 2017. Changes over time were assessed via linear regression for incidences per 1000 live birth...
Source: Pediatric Surgery International - January 20, 2021 Category: Surgery Source Type: research

Venous thromboembolism prophylaxis after pediatric trauma
AbstractIn recent years, there has been an increased focus on developing and validating venous thromboprophylaxis guidelines in the pediatric trauma population. We review the current literature regarding the incidence of and risk factors for venous thromboembolism (VTE) and the use of prophylaxis in the pediatric trauma population. Risk factors such as age, injury severity, central venous catheters, mental status, injury type, surgery, and comorbidities can lead to a higher incidence of VTE. Risk stratification tools have been developed to determine whether mechanical and/or pharmacologic prophylaxis should be implemented ...
Source: Pediatric Surgery International - January 19, 2021 Category: Surgery Source Type: research

The 33rd international symposium on pediatric surgical research
(Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 19, 2021 Category: Surgery Source Type: research

Trends and outcomes following intentional injuries in pediatric patients in a resource-limited setting
AbstractIntroductionIntentional injuries pose a significant, yet underreported threat to children in sub-Saharan Africa. We sought to evaluate intentional injuries trends and compare outcomes between unintentional and intentional injuries in pediatric patients presenting to a tertiary care facility in Malawi.MethodsWe performed a review of pediatric ( ≤15 years old) trauma patients presenting to Kamuzu Central Hospital, Lilongwe, Malawi, from 2009 to 2018. Patient characteristics and outcomes were compared based on the injury intent, using bivariate and multivariate regression analysis.ResultsWe included 42,600 ped...
Source: Pediatric Surgery International - January 18, 2021 Category: Surgery Source Type: research

Testis-sparing surgery for testicular tumors in children: a 20  year single center experience and systematic review of the literature
This study herein reports a 20  year single center experience applying testicular sparing surgery (TSS) as a primary operative strategy in pediatric patients. A systematic literature review summarizes the utility and outcomes of TSS in appropriately selected patients.MethodsPediatric patients with TT who underwent TSS between 1997 and 2018 were studied. TSS was indicated if patients presented evidence of adequately spared healthy testicular parenchyma on preoperative ultrasound and negative serum tumor markers.  A systematic review of the literature was also performed.Results12 cases met full inclusion criteria w...
Source: Pediatric Surgery International - January 17, 2021 Category: Surgery Source Type: research

Meta-analyses in paediatric surgery are often fragile: implications and consequences
ConclusionPaediatric surgical meta-analyses are often fragile. In almost 60% of results, the statistical significance depends on less than 1% of the included population. However, as the fragility index is just a transformation of theP value, it basically conveys the same information in a different format. It therefore should be avoided. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 16, 2021 Category: Surgery Source Type: research

Comparison of physical functions and psychosocial conditions between adolescents with pectus excavatum, pectus carinatum and healthy controls
This study included 180 adolescents (aged 10 –18 years) with pectus deformity [PE (n = 90) and PC (n = 90)] and 90 age-matched HC. The following parameters were evaluated for each participant: clinical parameters, perceived appearance of the chest area (PAC), physical functions (grip strength, flexibility, muscle strength, endurance, physical activity), posture, psychosocial conditions, and qu ality of life (QOL).ResultsPatients with PE and PC had a lower body weight, a worse, a poorer posture, lower scores for physical functions compared to the HC group (p 
Source: Pediatric Surgery International - January 16, 2021 Category: Surgery Source Type: research

Delayed presentation of anorectal malformations in a tertiary care hospital in India
ConclusionDelayed presentation of ARMs is not uncommon and is more common in females. Management is almost similar to those who present early. Those who present with chronic constipation and megarectum require staged repair. Complications were more frequent with delayed presentation. Hence, every newborn should have careful examination of perineum and screened for ARM to avoid possible morbidity and mortality. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 15, 2021 Category: Surgery Source Type: research

Laparoscopic ligation of ectopic ureter in pediatric patients: a safe surgical option for the management of urinary incontinence due to ectopic ureters
ConclusionLaparoscopic ureteric clipping of the ectopic ureter appears to be a valid alternative to extirpative or reconstructive procedures. Follow-up shows an increase in hydronephrosis without any consequence for the patients. Further studies are necessary to reinforce these observations. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 15, 2021 Category: Surgery Source Type: research

Neovagina stricture complicated by high-grade dysplasia in a patient with history of cloaca and ulcerative colitis: a case report and review of the literature
We present a case of an adolescent female with history of cloaca, ulcerative colitis, and high-grade dysplasia of the sigmoid neovagina. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 12, 2021 Category: Surgery Source Type: research

Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children
AbstractPurposePrescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients.MethodsPatients  
Source: Pediatric Surgery International - January 12, 2021 Category: Surgery Source Type: research

Fetal surgery for spina bifida in Zurich: results from 150 cases
ConclusionA majority of patients benefitted from prenatal intervention, in that the shunt rate was lower and the rates of continent and walking patients were higher than reported with postnatal care. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 12, 2021 Category: Surgery Source Type: research

Current practice of rectal biopsies for the diagnosis of Hirschsprung ’s disease in Latin America: an international online survey
ConclusionsIn Latin –America, the accessibility for RSB is limited only 18 out of 149 surgeons have access to rectal suction tool. There is no consensus regarding sample number, site of proximal biopsy, and antibiotics use. The complications associated with the procedure seems to be less than reported with RSB. There fore, we should standardize this common surgical practice and establish universal guidelines for rectal biopsy procedure (RBP). (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 12, 2021 Category: Surgery Source Type: research

Epithelial and ganglionic distribution at the distal rectal end in anorectal malformations: could it play a role in anastomotic adaptation?
ConclusionEpithelial and ganglionic distribution was similar in the distal rectal end of ARMs and in a normal anal canal. The ATZ is the epithelial boundary between the rectum and skin in a normal anal canal. ATZ preservation could reproduce anal canal structure in ARM reconstruction. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 11, 2021 Category: Surgery Source Type: research

Discrepancy between the survival rate and neuropsychological development in postsurgical extremely low-birth-weight infants: a retrospective study over two decades at a single institution
AbstractPurposeNecrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI) are major diseases that cause gastrointestinal disorders in extremely low-birth-weight infants (ELBWIs). We conducted a review to compare the postoperative outcomes of ELBWIs with these diseases in our neonatal intensive-care unit.MethodsA retrospective chart review of ELBWIs surgically treated for NEC (n = 31), FIP (n = 35), and MRI (n = 16) in 2001–2018 was undertaken. This period was divided into early (2001–2005), middle (2006–2010), and late (2...
Source: Pediatric Surgery International - January 11, 2021 Category: Surgery Source Type: research

Functional outcome after cord detethering in fecally incontinent patients with anorectal malformations
This study aimed to examine whether cord detethering could improve fecal and urinary incontinence in these patients.MethodsThis was a retrospective study of TC patients (>3 years old) with fecal incontinence and ARMs, who underwent detethering surgery between 2016 and 2020 and were followed up for at least 6  months.ResultsOf the 27 included patients, 55% had sacral ratios between 0.4 and 0.7, and in 37% it was  
Source: Pediatric Surgery International - January 11, 2021 Category: Surgery Source Type: research

Optimal Rex shunt procedures as a treatment for pediatric extrahepatic portal hypertension
AbstractPurposeTo assess the long-term results after Rex bypass (RB) shunt and Rex transposition (RT) shunt and determine the optimal approach.MethodsBetween 2010 and 2019, traditional RB shunt was performed in 24 patients, and modified RT shunt was performed in 23 children with extrahepatic portal hypertension (pHTN). A retrospective study was conducted based on comparative symptoms, platelet counts, color Doppler ultrasonography and computed tomographic portography of the portal system, and gastroscopic gastroesophageal varices postoperatively. The portal venous pressure was evaluated intraoperatively.ResultsThe operatio...
Source: Pediatric Surgery International - January 10, 2021 Category: Surgery Source Type: research

Lung surgery in children and their post-operative risk of respiratory infection
ConclusionIn the general pediatric population, the risk of admission for respiratory illness is 3 –21%. At this institution, overall risk of respiratory infection after lung resection appears comparable to baseline community risk. Our findings could aid counseling pediatric patients and their families regarding the 1-year risk of infection after lung resection. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 10, 2021 Category: Surgery Source Type: research

Analysis of patients ’ and caregivers’ psychosocial functioning in colorectal conditions: comparison of diagnosis, gender, and developmental functioning
ConclusionKey findings suggest that level of parental stress and behavioral concerns were significantly influenced by diagnoses, and partly by gender and presence of developmental delay. Thus, psychosocial support may need to be tailored based on these findings to provide optimum quality of care for patients and families. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 9, 2021 Category: Surgery Source Type: research

The impact of early and successful orchidopexy on hormonal follow-up for 208 boys with bilateral non-syndromic cryptorchidism
ConclusionOrchidopexy, especially before 1  year of age, improves the fertility potential in bilateral cryptorchidism. At follow-up, 26% (54/208) had a risk of infertility based on inhibin-B. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 9, 2021 Category: Surgery Source Type: research

An overview of opioid usage and regional anesthesia for patients undergoing repair of anorectal malformation
ConclusionsRegional anesthesia is a useful modality for pain control for PSARP/PSARVUP with laparotomy, decreasing the opioid usage, but it is unnecessary for the already low opioid requirements, in patients younger than 5  years of age, without laparotomy. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 7, 2021 Category: Surgery Source Type: research

Eosinophilic colitis in children: a new and elusive enemy?
ConclusionThis study focus attention on EC as a new challenging pathology. Multicentric randomized clinical trials are needed to understand physiopathological mechanisms to validate a possible endoscopic score and related histological threshold, and to standardize therapy according to clinical features and instrumental findings. The high prevalence of EC in ASD need further specific research. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 7, 2021 Category: Surgery Source Type: research