Co-infection HBV and malaria: a striking association.
CONCLUSION: Strategies to improve currently available diagnostic techniques, and studies dealing with vector control procedures and other operational tools and approaches are needed for better understanding of this health problem. PMID: 30882372 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Triple combination therapy with high-dose ampicillin/sulbactam, high-dose tigecycline and colistin in the treatment of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii: a case series study.
Authors: Assimakopoulos SF, Karamouzos V, Lefkaditi A, Sklavou C, Kolonitsiou F, Christofidou M, Fligou F, Gogos C, Marangos M Abstract Acinetobacter baumannii has evolved in recent decades as a major problem in carbapenem-resistant gram-negative nosocomial infections, associated with high mortality rates especially in intensive care units (ICUs). Recent reports highlight the increasing prevalence of resistance to colistin, a last resort therapeutic option for carbapenem-resistant A. baumannii. We retrospectively evaluated the potential efficacy, in terms of clinical and microbiological cure and mortality, of a com...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Trends in Klebsiella pneumoniae strains isolated from the bloodstream in a teaching hospital in southern Italy.
Authors: Del Prete R, Ronga L, Addati G, Magrone R, Abbasciano A, Decimo M, Mosca A, Miragliotta G Abstract Klebsiella pneumoniae is a common nosocomial pathogen involved in many infectious diseases such as bacteraemia, urinary and respiratory tract infections. It is responsible for the rise in morbidity and mortality rates since most clinical isolates exhibit resistance to several antibiotics. Moreover, the epidemiology of these nosocomial infections is variable across countries and regions. From January 2015 to December 2017 we retrospectively analysed the bloodstream infections caused by K. pneumoniae strains in...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Molecular characterization of multidrug and extensive drug-resistant Mycobacterium tuberculosis isolates from Iran.
This study provides information about molecular epidemiology of MDR-TB in Iran. The alarming increase in the incidence of MDR isolates, especially Beijing strains, raises concerns for TB control programs in Iran. PMID: 30882375 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Hepatitis C screening in the Emergency Department of a large hospital in southern Italy: results of a pilot study.
Authors: Gentile I, Pinchera B, Viceconte G, Crispo M, Simeone D, Scotto R, Zappulo E, Maraolo AE, Paladino F, Tortora R, Di Costanzo GG, Buonomo A, Borgia G Abstract Around 71 million people worldwide are chronically infected with hepatitis C. HCV prevalence among individuals born in the United States between 1945 and 1965 is estimated to be about 3%. In Italy, about 2% of the population is chronically infected with HCV. Since chronic HCV infection is often asymptomatic, many patients require access to medical care only in an advanced phase of the disease. The best strategy for bringing out hidden chronic HCV infe...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Risk of professional accidental exposure to biological agents in health care workers: a retrospective analysis carried out in a southern Italian tertiary hospital.
Authors: Bianco V, Spera AM, Maraolo AE, Parente S, Donno D, Schiano Moriello N, Tosone G Abstract Worldwide the needlestick injuries of health care workers (HCWs) still represent a major health problem. The authors aimed to evaluate the risk of HCW needlestick injuries in a tertiary university hospital in southern Italy in relation to some HCW characteristics (age, sex, professional profile, work department) and the source of infection. All HCWs of the University Hospital "Federico II" in Naples, Italy, attending the Infectious Diseases Unit after potential accidental contact to blood-borne viruses throu...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Alexithymia in HIV, HCV and coinfections.
This study aimed to assess alexithymia in patients suffering from HIV, HCV or HIV/HCV coinfection and observe major differences. We selected 153 subjects, excluding those with psychiatric diagnosis, cognitive impairment or opportunistic diseases, of whom 70 (46%) had HIV infection, 57 (37%) HCV infection and 26 (17%) HIV/HCV coinfection. For the evaluation of alexithymia, we used the Toronto Alexithymia Scale (TAS-20), a self-report questionnaire which allows the results to be assessed both on a dimensional level and on defined cutoff scores. Data analysis showed significant differences between monoinfected and coinfected ...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Prevalence and predictors of malignancies in HIV patients: results of a retrospective multicentric Italian cohort.
We report the sharp reduction in the incidence of AIDS defining cancers in a multicentric, retrospective study carried out since 1991 and involving six Infectious Diseases Units spread across Italy. However, due to the parallel increase in non-AIDS defining cancers, cancer incidence was not reduced. Focusing on predictors of death in HIV-positive patients with neoplastic disease, multivariate models revealed that males as well as drug abusers were independently associated with a poor clinical outcome. PMID: 30882379 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Efficacy of 5-nitroimidazole compounds for giardiasis in Cuban children: systematic review and meta-analysis.
This study sought to compare the efficacy of any 5-NI with any other antigiardial drug for the treatment of Cuban children with giardiasis. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). We searched CUMED, EBSCOhost and PubMed databases. Two reviewers independently assessed trial eligibility, trial quality and extracted appropriate data. The primary outcome was the parasitological cure. The effect estimate was the pooled relative risk (RR) with 95% confidence intervals (CI). We included seven RCTs in the systematic review, involving a total of 1046 children. When the effect of 5-...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Human fascioliasis in nomads: A population-based serosurvey in southwest Iran.
Authors: Zoghi S, Emami M, Shahriarirad S, Vahedi R, Cheraghi MR, Zamiri B, Arefkhah N, Ghorbani F, Sarkari B Abstract Fascioliasis is a human and veterinary concern in Iran. This cross-sectional population-based study was conducted to determine the seroprevalence of human fascioliasis among nomadic people in Kohgiluyeh and Boyer-Ahmad province located in the southwest of Iran. Venous blood samples were collected from 933 nomads in the area. A predesigned questionnaire containing basic epidemiological information was filled out for each subject during the sampling. Sera were evaluated for anti-Fasciola antibodies, ...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Pseudomonas aeruginosa severe skin infection in a toddler with X-linked agammaglobulinemia due to a novel BTK mutation.
We report a case of invasive Pseudomonas aeruginosa severe skin and soft tissue infection treated with vacuum-assisted closure and antibiotics in a toddler with a previously unreported mutation of the Bruton tyrosin kinase gene. PMID: 30882382 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Primary non-typhoidal Salmonella infection presenting as a splenic abscess in a healthy adolescent male.
We present the clinical case of a patient who presented to our emergency room with a chief complaint of left shoulder and left upper quadrant abdominal pain. Abdominal imaging showed an intrasplenic collection suspicious for a hemorrhage or an abscess. Percutaneous drainage was successfully performed, followed by conservative management with intravenous antibiotics. The culture of the fluid drained from the spleen was positive for Salmonella Saintpaul. The patient improved and was discharged. A high degree of clinical suspicion is necessary for early identification of a splenic abscess. Splenectomy can be avoided with the ...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Rothia mucilaginosa bacteremia in end-stage renal disease and solid organ transplant: the need for raised awareness.
Authors: Bejjanki H, Koratala A Abstract Rothia mucilaginosa, previously known as Stomatococcus mucilaginosus, is a Gram-positive coccus that is a part of the oropharyngeal and upper respiratory tract microbiota. Although this organism is believed to be of low virulence, it is increasingly being recognized as an opportunistic pathogen mostly affecting immunocompromised hosts. In this article, we describe a case of Rothia mucilaginosa bacteremia in an immunocompromised heart transplant recipient with end-stage renal disease, who was getting maintenance hemodialysis via a tunneled catheter. To the best of our knowled...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Primary gastrointestinal aspergillosis: a case report and literature review.
Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

A case of Trichosporon asahii urinary tract infection in a frail elderly patient.
We report a case of Trichosporon asahii nosocomial UTI in an elderly patient. PMID: 30882386 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

HHV6-related mild encephalopathy with reversible splenial lesion (MERS) presenting with urinary and fecal retention in an Italian adolescent.
We report the case of an adolescent with an HHV6-related MERS presenting with hyponatremia and urinary and fecal retention. To our knowledge, urinary retention is not a constant aspect of the disease and has rarely been described, while fecal retention has never been reported before. Despite the self-limiting nature of the disease, it is mandatory to suspect it for a faster diagnosis and it might be useful to know its rare occurrences in order to better understand its etiopathogenetic mechanisms. PMID: 30882387 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Switch to rilpivirine improves diabetes in an elderly HIV-positive patient.
We describe a case in a 72-year-old Caucasian man with long-term HIV infection. We observed the development of unbalanced diabetes treated with insulin and metformin which improved when we replaced zidovudine with rilpivirine. This switch improved diabetes to such an extent that insulin suspension was required. In several countries zidovudine has long been used due to its low cost, although several side effects have been observed, especially in the long term. In this case, the switch to rilpivirine was shown to be able to improve the toxicity of zidovudine on glucose metabolism, representing a good option to be used. P...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Visceral leishmaniasis in a patient with systemic lupus erythematosus from Colombia, Latin America.
Authors: Villamil-Gómez WE, Calderón-Gomezcaseres Á, Rodriguez-Morales AJ Abstract Not available. PMID: 30882389 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Emergence of a highly resistant typhoid strain: a new global health challenge.
Authors: Fatima K, Shabbir O, Ochani RK Abstract Not available. PMID: 30882390 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Piero Sepulcri (1899-1980) and malaria eradication in Veneto.
Authors: Lazzarini L, Giordani MT, Manfrin V Abstract Piero Sepulcri may be considered the antimalaria pioneer in the Italian region of Veneto during the 20th century. Through his activity with the Regional Antimalarial Institute he made a major contribution to one of the most important successes of medicine in the 20th century: malaria eradication in Italy. His writings on the activity of the Antimalarial Institute display the phases of eradication. In the first period antimalarial drugs were used to cure infected patients and as prophylaxis against infection. In the second period, eradication of vectors permitted...
Source: Infezioni in Medicina - March 20, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Burkholderia cepacia complex outbreaks among non-cystic fibrosis patients in the intensive care units: A review of adult and pediatric literature.
Authors: Abdallah M, Abdallah HA, Memish ZA Abstract Burkholderia cepacia complex (Bcc) is a Gram-negative bacterium commonly found in moist environments and soil. Bcc species are associated with many outbreaks in intensive care units (ICUs). In this review, we describe the sources of Bcc outbreaks among non-cystic fibrosis (CF) patients in various ICUs that include neonatal intensive care units, pediatric intensive care units and adult ICUs. Also we summarize the risk factors and outcome predictors of Bcc infection or colonization in non-CF critically ill patients. Finally, we describe the infection control measur...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

A multicenter-based study on epidemiology, antibiotic susceptibility and risk factors of toxigenic Clostridium difficile in hospitalized patients in southwestern Iran.
Authors: Sedigh Ebrahim-Saraie H, Heidari H, Amanati A, Bazargani A, Alireza Taghavi S, Nikokar I, Kalantar K, Motamedifar M Abstract Clostridium difficile (recently Clostridioides difficile) is a leading cause of hospital- and antimicrobial-associated diarrhea (AAD). The present study was carried out to investigate the prevalence of toxigenic C. difficile, antibiotic resistance and its associated risk factors in Iranian hospitalized patients. This cross-sectional study was conducted from October 2017 to June 2018 in three teaching hospitals in southwestern Iran. During this period, a total of 215 non duplicated no...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Investigation of Salmonella enteritidis outbreak in four kindergartens.
Authors: Pavlova M, Velev V, Karageorgiev M, Aleksandrova E, Ivanov IN, Kamenov G, Halova B, Popov M, Pentchev D, Dinkova M, Mangarov A, Kantardjiev T Abstract In June 2018, in the city of Sofia, Bulgaria, 40 children from four different kindergartens suffered from salmonellosis caused by S. enteritidis. They were reported to have consumed food prepared and delivered by a private catering service. The patients had fever, diarrhea, and some had vomiting and abdominal pain. Sixteen of them were treated in hospital, and the other 24 received home treatment. Some of the outpatients received antibiotic treatment despite...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Molecular epidemiology and genetic characterization of Shigella in pediatric patients in Iran.
This study showed the high prevalence of multidrug resistant S. sonnei and S. flexneri. Furthermore, it highlighted the increasing integrons (intI and intII) and ESBL genes, especially blaCTX-M15, in Shigella isolates. PMID: 30555135 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

The diversity of class B and class D carbapenemases in clinical Acinetobacter baumannii isolates.
In this study, we report the distribution of carbapenemase genes in A. baumannii isolated from hospitalized patients. The study was conducted on 110 non-repetitive A. baumannii isolates collected from hospitalized patients, over a nine-month period. Clinical isolates were examined by conventional susceptibility testing, using the disk-diffusion method and multiplex polymerase chain reaction to detect acquired carbapenemase genes. All of the isolates were completely resistant to TOB, SXT, IPM, MEM, CTX, CRO, FEP, CAZ, CIP, PTZ, PIP and were susceptible to colistin, but moderately susceptible TET (2.72%), AK (4.54%) and GEN ...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice.
Authors: Ciccullo A, D'Avino A, Lassandro AP, Baldin G, Borghetti A, Dusina A, Emiliozzi A, Gagliardini R, Moschese D, Belmonti S, Lombardi F, Di Giambenedetto S Abstract Bone toxicity is a well-known side effect of several antiviral agents. In a cohort of virologically suppressed HIV-infected patients, we investigated the effects of a lamivudine/dolutegravir dual therapy on bone mineral density (BMD). We observed a significant improvement in lumbar spine BMD as well as T-score after 12 months of observation with concomitant bisphosphonate therapy independently predicting a greater improvement. These preliminary da...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Effects of platelet function on the haemorrhagic manifestations and mortality in Crimean-Congo haemorrhagic fever.
Authors: Duygu F, Sari T, Celik H Abstract Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease which can lead to life-threatening with haemorrhagic manifestations. We aimed here in this study was to evaluate the effect of the platelet count and volume-related indices, such as the mean platelet volume (MPV), platelet distribution width (PDW) which is a measure of platelet anisocytosis and plateletcrit, in the haemorrhagic manifestations and mortality seen in CCHF cases. We retrospectively examined data derived from 173 patients. The age, gender, alanine transaminase (ALT), aspartate transaminase (AST...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Prevalence of parasitic infections in migrants: do official symptom-driven guidelines apply to the current situation?
Authors: Mazzitelli M, Torti C, Greco G, Strazzulla A, Costa C, Pisani V, Sorace C, Giancotti A, Lamberti A, Barreca GS, Quirino A, Liberto MC, Focà A, Matera G Abstract In recent years, migration has become a significant challenge in Western countries. Migrant populations, coming from hyper-endemic areas, may present parasitic infections that remain latent and asymptomatic even for years, eventually leading to severe complications. Italian guidelines have been established to perform screening guided by the presence of symptoms and/or hypereosinophilia. Parasitological screening was conducted in a migrant po...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Erysipelothrix rhusiopathiae septicaemia in systemic lupus erythematosus.
We report a case of invasive infection caused by Erysipelothrix rhusiopathiae without skin or endocardium involvement in a patient with systemic lupus erythematosus (SLE). To our knowledge, this is the first report of an isolated bacteraemia due to this pathogen in a patient with SLE without skin or endocardium involvement. PMID: 30555140 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

A case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus.
We report a case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus. PMID: 30555141 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature.
Authors: Özcan N, Saat N, Yildirim Baylan M, Akpolat N, Atmaca S, Gül K Abstract New identification techniques such as gene sequencing and mass spectrometry have increased the incidence of novel agents such as Kerstersia gyiorum. As a new member of the Alcaligenaceae family, K. gyiorum was isolated from wounds, respiratory tract, urine specimens and most frequently from chronic suppurative otitis media (CSOM). We isolated three K. gyiorum strains from three CSOM cases over a one-year period. The strains were analyzed by mass spectrometry and identified by Bruker Biotyper 3.1 (Bruker Daltonics, USA). The c...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

A clinical case of sepsis due to Staphylococcus pettenkoferi.
Authors: Vecchia M, Lombardi A, Zuccaro V, Mariani B, Morea A, Asperges E, Grecchi C, Sacchi P, Bruno R Abstract Coagulase-negative staphylococci are part of the human skin flora but are frequently responsible for bloodstream infection, especially in the presence of intravascular devices or immunosuppressive conditions. Antibiotic resistance in such bacteria is common, with more than 80% of isolates resistant to methicillin. Among this genus Staphylococcus pettenkoferi is a recently identified organism, reported to be responsible for a growing number of infections. Here we describe a case of sepsis due to methicill...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Ralstonia mannitolilytica bacteraemia: a case report and literature review.
We report the first case of R. mannitolilytica bacteraemia in a kidney transplant recipient. Identification of R. mannitolilytica was finally performed by 16S rRNA gene sequencing. All cases of R. mannitolilytica bacteraemia reported in the English language literature over the past 20 years are reviewed to alert clinicians to the epidemiological, clinical, diagnostic, prognostic and microbiologic features of this emerging pathogen. PMID: 30555144 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Treatment of refractory paediatric giardiasis using secnidazole plus albendazole: a case series.
We report our experience with 11 paediatric patients with drug-refractory giardiasis, for whom therapy with a combination of secnidazole (SNZ) (30 mg/kg/day, divided into 2 doses, for 3 days) and albendazole (ABZ) (400 mg daily for 5 days) resulted in cure for 9 of the 11 (82%) patients. This combination of drugs was well tolerated; only mild, transient, and self-limited side effects were reported and these did not require discontinuation of treatment. These results support the use of SNZ plus ABZ as an alternative treatment for paediatric patients with giardiasis who have failed conventional treatments. Further research i...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Oral and cutaneous myiasis in a five-year-old child from Karachi, Pakistan.
Authors: Khan BA, Nazir MB, Perveen B, Bin M Abstract Myiasis is a pathological condition in which there is a pestilence of fly larvae feeding on living or dead tissues. This disease is common in the tropics and subtropics of Africa and America and rarely affects humans. Our case report describes a five-year-old boy from Karachi, Pakistan with a history of extraction sockets and incisional biopsy of the left parotid lymph node. Lack of proper wound maintenance led to infestation of maggots both over the overlying skin of the left parotid region and the posterior oral cavity. The plan was wound debridement both outs...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Poliovirus: a long-due battle for Pakistan.
Authors: Asad A, Ochani RK, Shaikh A, Batra S Abstract Not available. PMID: 30555147 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Caelius Aurelianus (5th century AD) study on worms.
This study is the most complete and comprehensive analysis of this special infection of the Greek and Roman antiquity. In this chapter, the physician examined in great detail the semiology, differential diagnosis and treatment of such an infection. In addition, there are saved the views of many other ancient Greek physicians whose original text now are lost. Although the study of Caelius Aurelianus was based on the original Greek text of Soranus of Ephesus it should not be denied that Caelius Aurelianus made his own additions and arranged the text in a more accurate and organized manner. PMID: 30555148 [PubMed - in pro...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Paleoparasitology in Iran: A Review.
Authors: Khodkar I, Feizhadad MH, Tavalla M Abstract Paleoparasitology was created to trace and recover the natural development of parasites as well as the origin of infectious diseases. Paleoparasitology is defined as the study of parasites in ancient material and their interactions with hosts and vectors. Advances in the field have helped to open up new prospects for anthropologists, archaeologists, biologists and medical scientists. In recent years, Iranian parasitologists and biologists have developed immense interest in this field. One of the first human settlements on earth was established in Iran and there i...
Source: Infezioni in Medicina - December 19, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

What is new in infectious diseases: Nipah virus, MERS-CoV and the Blueprint List of the World Health Organization.
Authors: Rizzardini G, Saporito T, Visconti A Abstract Not available. PMID: 30246760 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Can a non-invasive urine-based test become the next-generation diagnostic tool for malaria?
Authors: Pradhan N, Hazra RK Abstract This mini review summarises the non-invasive urine-based diagnostic approaches that have been used to diagnose malaria. Amongst all urine-based diagnosis methods, commercially available Rapid Diagnostic kit/strip is most likely to be suitable for malaria detection in a cost-effective, time-consuming and user-friendly manner. With further improvement in sensitivity, specificity and accuracy, this technique may become a useful next-generation gold standard malaria diagnostic tool in resource-limited regions and in areas where invasive blood tests are restricted. PMID: 3024676...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

A three-year study entailing molecular characterization and epidemiology of Clostridium difficile in an Italian tertiary care hospital.
Authors: Mancini A, La Vigna G, Puciarelli S, Lombardi FE, Barocci S Abstract In Italy, there are limited studies on the molecular epidemiology of Clostridium difficile, possibly due to insufficient laboratory diagnostic capacity, low awareness and lack of high-quality surveillance systems. The aim of this study was to evaluate the diffusion of C. difficile in a tertiary care hospital and to genotype all the collected strains in order for hospital staff to take corrective action. All specimens were subjected to a CDI diagnostic algorithm. This included highly specific toxin PCRs and multilocus sequence typing (MLST...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

A new strategy to control the proliferation of microorganisms in solid hospital waste and the diffusion of nosocomial infections.
In this study, solid hospital waste was considered a potential source of contamination, and a strategy to reduce the potential risk of pathogen contamination was tested. This paper describes a novel technique for waste management in healthcare settings with a view to facilitating infection prevention and control. We explored the innovative use of sodium dichloroisocyanurate (NaDCC) by investigating the microbicidal activity of chlorine, which derives from the hydrolysis of NaDCC mediated by humidity, and by testing its effect on the inhibition of microorganism growth. NaDCC was inserted in a solid hospital waste bin contai...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Metallo-beta-Lactamase-producing Pseudomonas aeruginosa in Iran: a systematic review and meta-analysis.
Authors: Vaez H, Khademi F, Salehi-Abargouei A, Sahebkar A Abstract Metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa is considered to be a serious threat to human health worldwide. Limited information is available concerning the prevalence of MBL-producing P. aeruginosa in Iran. The aim of the present study was to investigate the prevalence of MBL-producing P. aeruginosa in different parts of Iran. We searched major electronic databases including PubMed, ISI Web of Science, Scopus and Google Scholar as well as two Iranian search engines using appropriate keywords. After applying inclusion and exclusion...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Integron types, antimicrobial resistance genes, virulence gene profile, alginate production and biofilm formation in Iranian cystic fibrosis Pseudomonas aeruginosa isolates.
This study aimed to determine the integron types, gene cassettes, virulence determinants, β-lactam resistance genes, biofilm formation and alginate production in P. aeruginosa isolated from Iranian CF patients. A total of 143 P. aeruginosa isolates were obtained from CF patients. Susceptibility of isolates to different antimicrobials was evaluated by disc diffusion method. ESBL, MBL and KPC production was assessed. Congo red agar and tissue culture plates were used for evaluation of biofilm formation. Alginate production was determined using the Carbazole assay. Integrase genes, resistance determinants (ESBLs, MBLs an...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Prevalence of occult hepatitis C virus infection in patients who achieved sustained virologic response to direct-acting antiviral agents.
Authors: Yousif MM, Elsadek Fakhr A, Morad EA, Kelani H, Hamed EF, Elsadek HM, Zahran MH, Fahmy Afify A, Ismail WA, Elagrody AI, Ibrahim NF, Amer FA, Zaki AM, Sadek AMEM, Shendi AM, Emad G, Farrag HA Abstract The reappearance of HCV infection months or years after sustained virologic response (SVR) may be due to the persistence of HCV in tissue cells in spite of being undetected in serum. This situation is known as occult hepatitis C infection (OCI). We aimed to assess the prevalence of OCI in Egyptian patients with chronic hepatitis C (CHC) who achieved SVR after treatment with direct-acting antiviral agents (DAA)...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis.
Authors: Zampino R, Macera M, Cirillo G, Pafundi C, Rinaldi L, Coppola N, Pisaturo M, Adinolfi LE, Miraglia Del Giudice E, Ingrosso D, Capasso R Abstract PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms ...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Redox alteration in patients infected by different HCV genotypes.
Authors: Limongi D, Baldelli S, Santi F, D'Agostini C, Palamara AT, Nencioni L, Ciotti M Abstract Chronic hepatitis C virus (HCV) infection plays a pivotal role in hepatocarcinogenesis and has been associated with oxidative DNA damage. Few data have been reported on the general redox state in patients infected with different HCV genotypes. Total antioxidant capacity (TAC) and hydrogen peroxide levels as well as oxidative stress index were measured in serum of hepatitis C chronic patients in relation to genotype, viral load, transaminases level and degree of fibrosis. Serum was obtained from two-hundred-fifty-two HC...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Relationship between malaria epidemiology and the human development index in Colombia and Latin America.
Authors: Franco-Herrera D, González-Ocampo D, Restrepo-Montoya V, Gómez-Guevara JE, Alvear-Villacorte N, Rodríguez-Morales AJ Abstract Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal tuberculosis is a medical emergency: it is the most severe, lethal and disabling form of tuberculosis. Early diagnosis and treatment can be lifesaving. Even, in developed countries the ...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Brevibacterium casei bacteraemia in a port-a-cath carrier patient: a case report.
We present a case of a port-a-cath-related bacteraemia caused by Brevibacterium casei in a woman with a prior history of bilateral breast cancer. The clinical outcome was favourable. PMID: 30246770 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research

Liver abscess with Citrobacter koseri bacteremia.
We report a rare case of C. koseri liver abscess with C. koseri bacteremia in an elderly male with chronic kidney disease. He presented vomiting and weakness without any other signs. He was diagnosed with liver abscess by ultrasound, and blood culture showed C. koseri growth. The patient was treated effectively with a course of antibiotics and drainage. When C. koseri is isolated in patients with comorbidity, such as chronic kidney disease, we should consider the possibility of abscess including liver abscess and utilize a combined treatment of drainage and course of antibiotics for mixed infection. PMID: 30246771 [Pub...
Source: Infezioni in Medicina - September 26, 2018 Category: Infectious Diseases Tags: Infez Med Source Type: research