Emerging antibiotic resistance: carbapenemase-producing enterobacteria. Bad new bugs, still no new drugs.
In conclusion, antimicrobial resistance is a global emergence and AMP is the most powerful tool actually available. Few limited options are available to treat infections due to Carbapenem Resistant Enterobacteria. Antimicrobial molecules with true novel mechanism of action are needed to win the fight against antimicrobial resistance. PMID: 31846984 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Clinical pharmacology of the single tablet regimen bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF).
Authors: Di Perri G Abstract The fourth HIV strand-transfer integrase inhibitor (INSTI) has been released into the market as part of a single-tablet-regimen (STR) consisting of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF). The newest component is thus BIC, a booster-free INSTI with pharmacological characteristics similar to those of dolutegravir (DTG), including high intrinsic antiretroviral potency. The BIC-containing STR underwent clinical development in both treatment-naive and virologically suppressed patients and was found non-inferior to DTG-based comparator arms. In the currently evolving th...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Bacterial resistance in cell phone cultures of medical students.
The objective of the study was to ascertain the presence of bacterial resistance type Extended-Spectrum Beta-Lactamase [ESBL] and its related factors in cultures isolated from cell phones of medical students. A quantitative, observational, analytical and transversal study was carried out in students of the Faculty of Medicine of the Universidad Nacional Hermilio Valdizán in Huánuco, Peru. The relationship was sought between the frequency of attendance at hospital practices, cell phone disinfection and hand washing after contact with patients with the presence of ESBL-type bacterial resistance. Of the total sa...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Risk factors for acute kidney injury in critically ill patients with bacteraemia by carbapenem non-susceptible Gram negative bacteria.
The objectives of the present study were to identify risk factors for development of acute kidney injury (AKI) during the treatment of bacteraemia due to carbapenem non-susceptible Gram-negative bacteria (CnS-GNB) and its role on mortality. Data of all patients with bacteraemia by CnS-GNB in the intensive care unit of a tertiary hospital from 2012 to 2016 were included. AKI was defined by AKIN criteria. Secondary outcomes were AKI development in patients treated with colistin and predictors of 14-day mortality. Among 285 episodes of bacteraemia due to CnS-GNB, 84 (29.5%) developed AKI. Multivariate analysis revealed that o...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Incidence of pertussis in the province of Pesaro-Urbino (Italy).
Authors: Brindicci G, Loconsole D, Carboni D, Genga R, Moschini E, Montorzi G, Viscogliosi F, Pompili M, Agostini M, Ripanti G Abstract Pertussis vaccination coverage in the Marche region is one of the lowest in Italy, with the province of Pesaro-Urbino remaining stable below 95% coverage since at least 2013. In this paper, we retrospectively analyzed all whooping cough notification cards arriving at the prevention department of the Area Vasta 1 Health Office in the Marche region and relating to the Pesaro-Urbino province (Italy). Between 2012 and 2017, there were 28 reported cases of pertussis with a peak in 2016 ...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Clinical spectrum and outcome of hospitalized patients with invasive fungal infections: a prospective study from a medical ward/intensive care unit of a teaching hospital in North India.
Authors: Sindhu D, Jorwal P, Gupta N, Xess I, Singh G, Soneja M, Nischal N, Sethi P, Ray A, Biswas A, Wig N Abstract The aim of the study was to determine the clinical spectrum and outcome of invasive fungal infections (IFIs) in hospitalized patients. A prospective study was conducted in a teaching hospital in North India between December 2016 and December 2018. Patients diagnosed with IFIs were enrolled. Their clinical and laboratory parameters were recorded using a pre-defined clinical report form. They were followed up till discharge or death and a 60-day outcome was recorded. A total of 110 IFI cases were ident...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

An outbreak of candidemia due to Candida parapsilosis in an adult intensive care unit.
Authors: Haciseyitoğlu D, Çağ Y Abstract Candida spp. is one of the most common causes of nosocomial bloodstream infections, and Candida parapsilosis is an emerging pathogen that is associated with nosocomial outbreaks. We aimed to characterize an outbreak of candidemia due to C. parapsilosis in our hospital's adult intensive care unit to investigate the clonal relationship of isolates. This is a retrospective study designed to investigate an outbreak of C. parapsilosis bloodstream infections (BSIs) which developed during an 11-week period from July to October 2012. Thirteen outbreak isolates and five isol...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Single tablet regimen with abacavir/lamivudine/dolutegravir compared with two-drug regimen with lamivudine and dolutegravir as different strategies of simplification from a multicenter HIV cohort study.
Authors: Baldin G, Ciccullo A, Rusconi S, Madeddu G, Sterrantino G, Freedman A, Giacometti A, Celani L, Latini A, Rossetti B, Cossu MV, Giacomelli A, Lagi F, Capetti A, Di Giambenedetto S Abstract We investigated the effectiveness and safety of a dual therapy (DT) with lamivudine plus dolutegravir versus a single tablet regimen (STR) with abacavir/lamivudine/dolutegravir. We performed a retrospective analysis in a cohort of virologically suppressed HIV+ patients switching to lamivudine-dolutegravir or abacavir/lamivudine/dolutegravir. We evaluated the incidence of virological failure and treatment discontinuation, ...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

HIV rapid test in a community setting as a strategy to improve access to HIV testing: data from a multicentre experience in Italy.
Authors: Falanga C, Marotta C, Negri S, Di Gennaro F, Fiore Bavaro D, Poliseno M, Mazzucco W, Monno L, Saracino A, Lo Caputo S Abstract 4,000 new HIV diagnoses and approximately 800 AIDS cases are still reported annually in Italy. Improving public awareness and bringing out HIV-undiagnosed individuals are keystones to progress towards the control of the HIV epidemic. For this purpose, the Open HIV TEST project was organized and delivered by the Italian NGO Anlaids, together with local infectious diseases specialists, in order to provide free access to HIV testing outside the healthcare setting. Between October 2017...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Surgical treatment of liver echinococcosis and alveococcosis.
Authors: Panteleev V, Nartaylakov M, Mustafin A, Abdeyev R, Salimgareyev I, Samorodov A, Musharapov D Abstract Parasitic liver zoonoses are endemic to some regions of Russia as well as to Mediterranean countries, Australia, New Zealand, South America, and the Indian subcontinent. However, the available data on the surgical treatment of patients with parasitic liver diseases are often contradictory, and such treatments remain a difficult task today. The effectiveness of surgical treatment was analyzed in 628 patients with echinococcosis and 58 patients with liver alveococcosis managed at the Republican Clinical Hosp...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Necrotizing fasciitis and sepsis caused by Aeromonas hydrophila.
Authors: Tsujimoto Y, Kanzawa Y, Seto H, Nakajima T, Ishimaru N, Waki T, Kinami S Abstract Aeromonas hydrophila (A. hydrophila) occasionally causes necrotizing fasciitis (NF) and sepsis in immunocompromised hosts. NF is associated with high mortality. In cases of septic shock due to A. hydrophila, mortality is nearly 100%. Our 47-year-old male patient was diagnosed with NF and septic shock due to A. hydrophila. He had not been exposed to fresh or slightly salty water, which is where the bacterium is typically found, so its origin in this case is unclear. This is the first known case in which the patient was able to...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Isoniazid-induced Takayasu arteritis remission.
Authors: Agostinis P, Antonello RM, Orsaria M, Luzzati R, Di Bella S Abstract A 75-year-old man was admitted because of fever, unproductive cough, neck pain and upper limb claudication. The patient was febrile and hypotensive, and a cardiac systolic ejection murmur was heard. Blood tests showed normochromic anemia, elevated erythrocyte sedimentation rate, C-reactive protein, fibrinogen, and alpha-2 and beta-2 globulins. In order to investigate neck pain, an ultrasound examination of the carotid arteries was performed which showed a carotid intima-media thickness reaching the maximum value of 2.3 mm in both carotid ...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Do we care if you have a cat? Bartonella infection related glomerulonephritis with no endocarditis.
We report a case of RPGN with no endocarditis secondary to Bartonella infection. Good social history, high index of suspicion, diagnosis with polymerase chain reaction and treatment with antibiotics is the key for treatment. PMID: 31846996 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Iatrogenic Cushing syndrome due to drug interaction between inhaled fluticasone and cobicistat.
Authors: Monge E, Colombo V, Giacomelli A Abstract In this paper we report a case of iatrogenic Cushing syndrome due to a pharmacological interaction between fluticasone and cobicistat. Inhaled corticosteroids were previously thought to be safe, but increasing numbers of cases of iatrogenic Cushing syndrome are being reported, especially in patients taking cytochrome P450 inhibitors, including cobicistat. Although the drug interaction between cobicistat and fluticasone has been described elsewhere, to our knowledge we present one of the first descriptions of iatrogenic Cushing syndrome due to this pharmacological i...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Herpes zoster after vaccination with one dose varicella vaccine to a 4-year-old child.
We present the case of a four-year-old immunocompetent girl who developed herpes zoster after she had received one dose of varicella-zoster virus live attenuated vaccine at the age of 15 months. Continued surveillance for herpes zoster among vaccinated persons is important to evaluate the varicella vaccination program and to detect any changes in the epidemiology of herpes zoster. Vaccinated children appear to have a lower risk of herpes zoster than people who were infected naturally with varicella zoster virus (chickenpox). PMID: 31846998 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Use of miltefosine in a patient with mucosal leishmaniasis and HIV-coinfection: a challenge in long-term management.
We describe a case of mucosal leishmaniasis in an HIV-coinfected patient treated with miltefosine due to a severe allergic reaction to liposomal amphotericin B. PMID: 31846999 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Pelvic echinococcosis presenting as a mass in the gluteal region: a case report.
We present one such case of pelvic echinococcosis in a 62-year-old male who presented with the chief complaints of pain and swelling in the left gluteal region for the past twelve years. The patient was planned for and underwent en-bloc excision of the lesion. Albendazole was used pre- and post-operatively to reduce parasitic load. At the last follow-up, the patient was disease-free and able to carry out his daily activities without much difficulty. We would conclude that, although uncommon, echinococcosis should always be ruled out, especially when dealing with other indolent pathologies of the hip joint. PMID: 318470...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Thessaly and medicine from ancient Greek mythology to contemporary times: a perpetual relationship.
Authors: Papagiannis D, Rachiotis G Abstract The aim of this narrative review is to provide an overview of the connection between Thessaly and the development of medicine from ancient Greek mythology to contemporary times. From Chiron to Asclepius, from Asclepius to Hippocrates, and from Hippocrates to the true Hippocratic epidemiologist Dimitrios Trichopoulos, a plethora of myths and facts indicate the strong and perpetual alignment between Thessaly and the science of medicine. PMID: 31847001 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

The health of Italian troops and prisoners during World War I.
Authors: Sabbatani S, Fiorino S, Manfredi R Abstract During the Great War, which involved Italy from May 1915 until November 1918, the Italian Army paid an extremely high price in terms of suffering; around 600,000 soldiers died. About 100,000 of these deaths were caused by diseases, mainly infectious ones. The casualties accounted for over one million cases. Epidemics of cholera and petechial typhus were recorded as well as an increase in morbidity due to tuberculosis and malaria, which had shown some minor epidemiological reduction in several regions of Italy during the years preceding the Great War. A large numb...
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Sanitary alert: acute gastroenteritis associated with house-fly infestation after heavy rainfall in Karachi, Pakistan.
Authors: Baloch M, Tarar S, Taimur S Abstract Not available. PMID: 31847003 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

ERRATUM Drug-drug interactions in anti-HCV therapy: a comparison among options available in Italy.
Authors: Di Perri G, Cariti G Abstract Erratum Following publication of the original article (Le Infezioni in Medicina, 2019, vol:27 (4):pp:239-250) we became aware of the following errors : In table 3a, pag 245, the interaction between GLE/PIB and Omeprazole does not require dosage adjustments and the correct recommendation is A (allowed) instead of NR (not recommended). The original explanation in the text is correct. PMID: 31847004 [PubMed] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - December 19, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Diabetic calcaneal osteomyelitis.
Authors: Waibel FWA, Uçkay I, Sairanen K, Waibel L, Berli MC, Böni T, Gariani K, Lipsky BA Abstract Diabetic foot infection (DFI), a multi-facetted disease requiring a multidisciplinary approach for successful treatment, mostly affects the forefoot. Calcaneal osteomyelitis (CO) is an uncommon presentation of DFI with a somewhat different epidemiology, clinical features, and approach to management. These patients, compared to those with non-calcaneal DFI, more often require special surgical techniques and off-loading approaches. In this narrative review targeted to non-surgical clinicians, we explore how...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Drug-drug interactions in anti-HCV therapy: a comparison among options available in Italy.
Authors: Di Perri G, Cariti G Abstract After a long period of interferon-and ribavirin-based therapy (IFN/RBV), a very fast evolution in the development of directly acting antivirals (DAAs) has now established a totally new paradigm for the treatment chronic HCV infection. An efficacy rate within the 95-100% interval, safer and more tolerable drugs, much shorter treatment duration and a quicker establishment of the sustained virological response (SVR) are among the most relevant properties of new DAAs as compared to former IFN/RBV therapies. The last wave of DAAs is also characterized by a lesser tendency to genera...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Educational ICU Antimicrobial Stewardship model: the daily activities of the AMS team over a 10-month period.
We describe a 10-month persuasive ASP intervention model used in a referral ICU with daily rounds. The aim of the study was to improve medication appropriateness through educational action and reduce the consumption of carbapenems and echinocandins by conducting post-prescription reviews, prescribing reviews and holding daily discussions with the ICU team. We analyzed the prescribing appropriateness of the ICU team in accordance with the decisions made by the Antimicrobial Stewardship (AMS) team to improve the quality of antibiotic prescribing during the first five months and the last five months of the surveillance period...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Risk factors for central venous catheter-related bloodstream infections.
Authors: Bekçibaşi M, Dayan S, Aslan E, Kortak MZ, Hoşoğlu S Abstract Our study aimed to identify the risk factors playing a role in central venous catheter-related bloodstream infections (CR-BSI) in a tertiary large volume university hospital. The current prospective clinical trial was conducted in a university hospital with 1400 beds. All demographic data, length of hospital stay, coexisting diseases, features of catheters used, invasive diagnostic and therapeutic procedures and all antibiotics used in patients with CVCs were recorded. A total of 356 CVCs inserted in 281 patients were followed up for 56...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Trends in the antibiotic resistance of S. aureus clinical isolates: a 4 years retrospective study in a teaching hospital in South Italy.
Authors: Ronga L, Abbasciano A, Calia C, Mosca A, Battista M, Sparapano E, De Carlo C, Miragliotta G, Del Prete R Abstract Staphylococcus aureus is responsible for life-threatening conditions, while in the meantime it has rapidly acquired resistance to several antibiotic classes. In the context of an effective empirical antibiotic therapy, an accurate evaluation of the resistance rates of S. aureus may be critical. The aim of this study was to determine the resistance rates of S. aureus in the years 2015-2018 and to assess the impact of specimen stratification on the resistance rates. We have retrospectively analys...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Cognitive impairment and cardiovascular disease related to alexithymia in a well-controlled HIV-infected population.
In conclusion, in the context of a well-controlled HIV infection, we found a low prevalence of alexithymia comparable to healthy controls. Alexithymia was linked to higher risk of CV disease in the HIV-positive population, but with a rate similar to that previously estimated in the HIV-negative alexithymic. Finally, alexithymia was clearly associated to cognitive impairment only in the psychomotor speed domain, suggesting a common fronto-striatal system dysregulation. PMID: 31545771 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Microbiology of Elizabethkingia spp. isolates in hospitalized patients.
Authors: Bazzi AM, Rabaan AA, Al-Tawfiq J Abstract An increasing number of infections due to Elisabethkingia spp. have been observed and reported in recent years. Here we report the microbiological aspects of 13 cases with positive cultures for Elizabethkingia spp. from 1998 to 2017. Elizabethkingia isolates were identified using the Vitek 2 Compact 60 (AES software) Gram-Negative Identification test (GNI) card (bioMerieux. Marcy-l'Etoile, France). The MICs were determined using Vitek 2 and interpreted according to CLSI guidelines based on the interpretive MIC breakpoints for Acinetobacter spp. Vitek 2 susceptibili...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Evaluation of the possible involvement of Ad-36-induced adipogenesis and coronary artery disease development in mediastinal adipose tissue samples.
Authors: Ergin S, Turan N, Gode S, Yilmaz H, Saribas S, Dinc O, Cizmecigil U, Bakir I, Keskin M, Sirekbasan S, Atalik K, Yeniterzi M, Demirci M, Gurcan M, Erdogan S, Gareayaghi N, Kocazeybek BS Abstract Mediastinal fat has been suggested to be associated with cardiovascular diseases such as carotid stiffness, atherosclerosis and coronary artery calcification. We investigated the possible role of Ad-36-induced obesity in the pathogenesis of the coronary artery disease (CAD). Ad-36 DNA was investigated in the anterior mediastinal fat tissue samples of obese adults with CAD. Seventy-five obese adults with left main co...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Overuse of prophylaxis in HBsAg and/or anti-HBc positive patients after increasing awareness to prevent reactivation in patients receiving immunosuppressive therapies: How rational are our prophylaxis decisions according to the literature?
Authors: Yenilmez E, Cetinkaya RA Abstract Screening prior to initiation of immunosuppressive therapy, and decision making between the initiation of hepatitis B virus (HBV) prophylaxis and monitoring with the intent of on-demand anti-HBV therapy initiation are the key determinants to prevent reactivation of HBV. Patients over 18 years of age with HBsAg and/or anti-HBc positivity, who received HBV prophylaxis due to immunosuppressive treatments between 2013 and 2019, enrolled in this retrospective descriptive study. We tried to create awareness about the reactivation of hepatitis among clinicians in our hospital fro...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Epidemiological trends in patients living with human immunodeficiency virus: a 13-year experience from a tertiary care center in India.
Authors: Gupta N, Niyas VKM, Nischal N, Soneja M, Vinod KS, Ranjan S, Sethi P, Jorwal P, Biswas A, Wig N, Sood R Abstract With significant advancement in the tools and strategies available for diagnosis and management, there is an expected change in the epidemiological profile of patients living with HIV/AIDS (Human immunodeficiency syndrome/Acquired immunedeficiency syndrome). We retrospectively analyzed the changing epidemiological pattern of HIV infection over a period of 13 years in the anti-retroviral (ART) center of a tertiary care hospital in India. The study included a total of 9419 patients (8811 adults an...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

HBsAg, anti-HCV and anti-HIV seroprevalence among blood donors in Southeastern Anatolia, Turkey, 2011-2015.
Authors: Dayan S, Özekinci T, Bekçibaşi M, Deveci Ö Abstract Transmission of infections through blood and blood product transfusion is a serious healthcare problem. There are insufficient up-to-date data about seroprevalence of HBsAg, anti-HCV and anti-HIV ½ among healthy blood donors in Turkey. We aimed to investigate the seroprevalence of HBsAg, anti-HCV and anti-HIV ½ in Southeastern Anatolia, Turkey. HBsAg, anti-HCV, and anti-HIV ½ analysis results among blood donors who applied to Dicle University Faculty of Medicine, Diyarbakir District Blood Centre, between January 1, 2...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Low prevalence of Toxoplasma gondii infection among children in a rural community in Fars province, Southern Iran.
Authors: Arefkhah N, Goodarzi R, Rezaei Z, Layegh Gigloo A, Sarkari B Abstract The current study aimed to determine the seroprevalence of Toxoplasma gondii infection and associated risk factors in children in a rural community in Fars province in southern Iran. Blood samples were collected from 671 children living in three rural areas, and sera and buffy coats were isolated from each sample. Anti-T. gondii antibodies were detected by ELISA, using a commercial kit. Also, buffy coats of seropositive children were examined by a PCR method, targeting a 529 bp gene of T. gondii. Of 671 children participating in the stud...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Acquisition of FKS2 mutation after echinocandin treatment of infective endocarditis by Candida glabrata.
We report the case of a 65-year-old woman who developed candidemia and endocarditis by C. glabrata with a newly acquired FKS mutation 24 months after successful treatment of infective endocarditis by C. glabrata with a double dosage of anidulafungin (200 mg daily) followed by oral voriconazole. Driven by high echinocandin MICs the strain taken by intraoperative cultures was further analyzed in a referral microbiology laboratory, confirming the new onset of point mutation S633P of the FKS2 gene. PMID: 31545778 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Norwegian scabies presenting as erythroderma in HIV: A case report.
We describe the case of a 55-year-old patient with a history of HIV infection and injection drug use. The patient was not on any antiretroviral therapy during the previous year, was malnourished and was living in unsanitary conditions. He had extensive, generalized, thick, hyperkeratotic, crusting, papular lesions, which had evolved over the previous month. Hyperkeratotic areas were fissured and linear excoriations were noted diffusely. The rash was distributed on the entire body from the scalp to the toes, with mild itching. Microscopic examination of the scale revealed numerous scabies mites and eggs. The patient was tre...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Giardiasis: report of a case refractory to treatment.
We describe the follow-up of a patient with recurrent giardiasis refractory to nitroimidazoles. Despite the different therapies received, the symptomatology and parasitic forms of G. lamblia persisted in the patient. There is no standard treatment regimen for giardiasis refractory to nitroimidazoles. When treatment failure is confirmed, it is necessary to switch to second-line regimens. PMID: 31545780 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Myiasis from Sarcophaga spp in a patient with cutaneous lymphoma.
This report describes a case of myiasis of a wound caused by Sarcophaga spp. Suffering from cutaneous lymphoma, the patient showed, at the level of his scalp lesions, the presence of larvae that were removed during curettage surgery; they were subsequently identified as belonging to the genus Sarcophaga. Preservation of these larvae in 10% formalin did not allow identification at the species level using molecular methods. PMID: 31545781 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Cutaneous leishmaniasis associated with Systemic Lupus Erythematosus (SLE).
Authors: Asgari Q, Gholizadeh F, Nohtani M, Mirzaeipour M, Zare M, Bahreini MS Abstract Cutaneous Leishmaniasis (CL) is a protozoan disease caused by Leishmania spp. and is endemic in the Americas, the Mediterranean basin, Middle East, and Central Asia. There are reports regarding the co-infection of CL with other diseases, especially immune system disorders. Herein, we presented a patient with several leishmania lesions who suffered from Systemic Lupus Erythematosus (SLE). He was a 22-year-old man from Fars province, southern Iran who was treated with corticosteroid drugs to control the manifestations of SLE. The ...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

De morbo gallico omnia quae extant apud omnes medicos cuiuscunque nationis: the sixteenth-century collection of Luigi Luigini.
Authors: Martini M, Gazzaniga V, Barberis I, Bragazzi NL, Parodi A, Armocida E Abstract In recent decades, a rising rate of syphilis infection, often in association with HIV, has been recorded in Europe. In the first years following their appearance, syphilis and HIV shared the character of "new", challenging and serious diseases. The prime example of a "new disease", syphilis appeared between the end of the Middle Ages and the beginning of the Renaissance period, a time in which medicine was changing from a dogmatic to an experimental discipline. Luigi Luigini's collection of all the works on s...
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Philippines hit by deadly Measles outbreak - a wakeup call?
Authors: Ochani RK, Yasmin F, Tariq A, Shaikh A Abstract Not available. PMID: 31545784 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - September 25, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Nipah virus - the rising epidemic: a review.
Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Is there a role for procalcitonin determination in avoiding unnecessary exposure to antibiotics in a non-intensive care setting?
Authors: Giacomelli A, van den Bogaart L, Corbellino M, Oreni L, Dolci A, Panteghini M, Rizzardini G, Galli M, Antinori S Abstract The use of procalcitonin (PCT) as a tool to assist clinicians in using antibiotics in intensive care patients has been postulated. Here we evaluate the efficacy of procalcitonin determination in helping clinicians in the decision to start or discontinue an antibiotic treatment in patients admitted to infectious disease wards. A retrospective observational single centre study was conducted in two infectious disease wards. Descriptive and inferential statistical analysis was carried out a...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Variability in the community consumption of antibiotics: a problem in Europe, Spain and Asturias.
Authors: Sanchez ML, Vallina-Victorero MJ, Bachiller MR, Arbizu R, Llaneza E, Rozada S, Eiros JM Abstract Increasing bacterial resistance is strictly correlated to the increasing use of antibiotics, currently constituting a public health problem. The aim of this study was to describe the consumption of antibiotics in Asturias, an autonomous community in northwestern Spain, and compare the results obtained with data from elsewhere in Spain and other European countries. A descriptive study was carried out on the use of antibacterial drugs for systemic use, ATC code J01 in Asturias in 2011-2015. Data were obtained fro...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Diagnostic accuracy of a commercial multiplex PCR for the diagnosis of meningitis and encephalitis in an Italian general hospital.
Authors: Leli C, Di Matteo L, Gotta F, Vay D, Calcagno L, Callegari T, Cassinari M, Cattana E, Ciriello MM, Copponi V, Sacchi MC, Zambon D, Guaschino R, Rocchetti A Abstract Infectious meningitis and encephalitis are potentially life-threatening conditions caused mostly by bacterial and viral agents. Rapid diagnosis and prompt treatment are associated with a more favorable outcome. In recent years nucleic acid amplification tests have been developed to speed detection and identification of pathogens directly from cerebrospinal fluid (CSF). The aim of this study was to compare the diagnostic accuracy of a commercial...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

The effectiveness of antibacterial curtains in comparison with standard privacy curtains against transmission of microorganisms in a hospital setting.
In this study, we examined the difference in bacterial colonization of different curtains. We experimentally contaminated antibacterial Fantex protective curtains and compared the bacterial counts to natural contamination of privacy curtains. There was a significant reduction in the CFU/cm2 on antibacterial Fantex protective privacy curtains after 24 hours of experimental contamination with Pseudomonas aeruginosa, Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum-producing organisms (Escherichia coli or Klebsiella pneumoniae), compared to standard privacy curtains. Levels of e...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Comparison of the effectiveness of caspofungin and liposomal amphotericin-B for the treatment of C. tropicalis-induced peritonitis in mice.
Authors: Demirci M, Tünger Ö, Çetin ÇB, Senol Ş Abstract In order to compare the effectiveness of liposomal amphotericin B (LAB) and caspofungin monotherapy in Candida tropicalis-induced peritonitis in an experimental mice model 56 healthy male BALB/c mice (10-12 weeks; 20-25 g) were divided into groups and C. tropicalis strains were intraperitoneally (IP) inoculated into mice groups except the control group. After the injection, three doses of LAB (0.5, 1.0, 2.0 mg/kg/day) and caspofungin (1.0, 2.0, 5.0 mg/kg/day) were administered to groups for five consecutive days, starting 48-h post-in...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Evaluation of Candida colonization and use of the Candida Colonization Index in a paediatric Intensive Care Unit: a prospective observational study.
This study was performed in a medical PICU with patients prone to contracting invasive candidiasis, to determine the usefulness of the Candida colonization index in forecasting invasive candidiasis in children. This prospective study including 87 patients (children 1 month to 16 years old with several illnesses and requiring ICU care) was conducted in a 22-bed medical PICU, Health Science University of Kayseri Training and Research Hospital, between January 2015 and September 2016. Those patients not on antifungal therapy, who were expected to stay more than seven days in PICU and had no history of a PICU stay within the p...
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Opportunistic intestinal parasites in immunocompromised patients from a tertiary hospital in Monterrey, Mexico.
In conclusion, microsporidia and coccidia are major parasitic agents causing diarrhea in immunocompromised patients, particularly HIV-infected patients. PMID: 31205040 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure.
We report a case of Bifidobacterium spp bacteremia in a child with heart disease, undergoing probiotic supplementation to prevent antibiotic-associated diarrhea. PMID: 31205041 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research

The first Italian case report of leg ulcer and sepsis caused by Shewanella algae in a immunocompetent patient.
We describe the first Italian case of Shewanella algae septicemia in an immunocompetent patient with chronic leg ulcers. The patient had been exposed to seawater before the onset of symptoms. Despite the absence of severe underlying diseases, the primary soft tissue infection of the leg was complicated by hematogenous dissemination. PMID: 31205042 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - June 18, 2019 Category: Infectious Diseases Tags: Infez Med Source Type: research