Control and prevention of invasive pneumococcal disease in Taiwan: Current achievements and future challenges.
PMID: 30773273 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - February 15, 2019 Category: General Medicine Authors: Su WJ, Yang CH Tags: J Formos Med Assoc Source Type: research

Taiwan's Nationwide Cancer Registry System of 40 years: Past, present, and future.
PMID: 30773272 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - February 14, 2019 Category: General Medicine Authors: Chiang CJ, Wang YW, Lee WC Tags: J Formos Med Assoc Source Type: research

Cognitive impairment in patients with end-stage renal disease: Accelerated brain aging?
Abstract BACKGROUND: Chronic kidney disease exhibits a prominent premature aging phenotype in many different organ systems, including the brain. Nevertheless, a comprehensive characterization of brain aging in non-demented patients with end-stage renal disease (ESRD) is lacking and it remains unclear if the collective changes of cognitive functions and brain structures in ESRD is compatible with aging. METHODS: We compared 56 non-demented, independently living dialysis patients (mean age 59.4 ± 11.0 years; mean dialysis vintage of 5.9 years) and 60 non-dialysis controls on a battery of neurop...
Source: J Formos Med Assoc - February 7, 2019 Category: General Medicine Authors: Chiu YL, Tsai HH, Lai YJ, Tseng HY, Wu YW, Peng YS, Chiu CM, Chuang YF Tags: J Formos Med Assoc Source Type: research

Predisposing factors of necrotizing fasciitis with comparison to cellulitis in Taiwan: A nationwide population-based case-control study.
Abstract BACKGROUND: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with low incidence that requires prompt surgery. In the initial stage, it is difficult to distinguish NF and cellulitis, and limited population-based reports are available. METHODS: We queried inpatient data sets of National Health Institute Research Database in Taiwan from 2002 to 2011 for all patients with diagnoses of NF. Of them, only patients who underwent surgeries and had been admitted to intensive care units were included as the study group. Age and gender-matched patients with admission diagnoses of cellulitis...
Source: J Formos Med Assoc - February 6, 2019 Category: General Medicine Authors: Liu TJ, Tai HC, Chien KL, Cheng NC Tags: J Formos Med Assoc Source Type: research

Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.
This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. METHODS: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. RESULTS: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values 
Source: J Formos Med Assoc - February 5, 2019 Category: General Medicine Authors: Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Wu YC, Sun A Tags: J Formos Med Assoc Source Type: research

Emergency department utilization and resuscitation rate among patients receiving maintenance hemodialysis.
CONCLUSIONS: Patients receiving maintenance hemodialysis had higher ED utilization and a significantly higher risk of resuscitation during ED visits than those without hemodialysis. PMID: 30711255 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 31, 2019 Category: General Medicine Authors: Lin YC, Hsu HK, Lai TS, Chiang WC, Lin SL, Chen YM, Chen CC, Chu TS Tags: J Formos Med Assoc Source Type: research

Integration of imaging and molecular approaches in selective fetal reduction in twin pregnancies with one carrying a pathogenic genomic aberration.
CONCLUSIONS: We proposed a working scheme of integrating imaging and molecular techniques to correctly identify the affected co-twin before selective fetal reduction to ensure the accuracy of the identification. PMID: 30709693 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 29, 2019 Category: General Medicine Authors: Wu WJ, Yeh LT, Ma GC, Chang SP, Lee DJ, Chen M Tags: J Formos Med Assoc Source Type: research

Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy.
CONCLUSION: LED light irradiation during or after scaling and root planing assisted in the recovery of periodontium and can be used as an adjunct treatment during NSPT, specifically for sites with severe periodontal breakdown. PMID: 30709694 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 29, 2019 Category: General Medicine Authors: Chen YW, Hsieh O, Chen YA, Chiou LL, Chang PC Tags: J Formos Med Assoc Source Type: research

Modulation of parietal cytokine and chemokine gene profiles by mesenchymal stem cell as a basis for neurotrauma recovery.
CONCLUSION: Our data suggest that modulation of parietal cytokines and chemokines gene profiles by MSC as a basis for neurotrauma recovery. PMID: 30709695 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 29, 2019 Category: General Medicine Authors: Lin CH, Lin W, Su YC, Cheng-Yo Hsuan Y, Chen YC, Chang CP, Chou W, Lin KC Tags: J Formos Med Assoc Source Type: research

Reply to: "The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease".
Reply to: "The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease". J Formos Med Assoc. 2019 Jan 28;: Authors: Lei WY, Chen CL PMID: 30704814 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 28, 2019 Category: General Medicine Authors: Lei WY, Chen CL Tags: J Formos Med Assoc Source Type: research

Successful management of type IV hypersensitivity reactions to human insulin analogue with injecting mixtures of biphasic insulin aspart and dexamethasone.
Abstract Although hypersensitivity reaction to insulin was supposed to be less-frequent with current insulin analogue, case reports with different types of allergic reactions to insulin analogue were still reported. The most common form is type I hypersensitivity reaction with IgE-mediated. Besides, type III (IgG and IgM-mediated) and type IV (T-cell mediated delayed reaction) hypersensitivity reactions were also reported. Here we presented a long-standing type 2 diabetes with insulin requirements with hypersensitivity reactions to insulin actrapid, insulin aspart, insulin glargine, insulin detemir, and biphasic i...
Source: J Formos Med Assoc - January 28, 2019 Category: General Medicine Authors: Wen WL, Tsai KB, Lin YH, Hwang SJ, Hsiao PJ, Shin SJ, Hung WW Tags: J Formos Med Assoc Source Type: research

The effectiveness of music therapy for individuals with Rett syndrome and their families.
CONCLUSION: The 24-week music therapy program was effective in improving social interaction, communication skills, eye contact, hand function, and reducing seizure frequency among RTT patients. Additionally, music therapy was effective in relieving parenting stress, which may help healthcare providers initiate early intervention strategies that can prevent parenting stress and reduce the risk of depression. PMID: 30670340 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 19, 2019 Category: General Medicine Authors: Chou MY, Chang NW, Chen C, Lee WT, Hsin YJ, Siu KK, Chen CJ, Wang LJ, Hung PL Tags: J Formos Med Assoc Source Type: research

The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease.
PMID: 30670341 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 19, 2019 Category: General Medicine Authors: Pellicano R Tags: J Formos Med Assoc Source Type: research

Early timing of single balloon enteroscopy is associated with increased diagnostic yield in patients with overt small bowel bleeding.
Abstract BACKGROUND/PURPOSE: Although performing balloon enteroscopy soon after the onset of small bowel bleeding appeared to enhance diagnostic rate, the optimal timing was unclear. METHODS: A retrospective cohort study in a single referral center. Patients with overt, suspected small bowel bleeding who underwent primary single-balloon enteroscopy (SBE) were evaluated to determine the association between procedure timing and diagnostic yield rates. RESULTS: A total of 220 patients were enrolled (47.7% males; mean age, 65.6 ± 18.1 years). They were stratified into four groups based on th...
Source: J Formos Med Assoc - January 17, 2019 Category: General Medicine Authors: Tu CH, Kao JY, Tseng PH, Lee YC, Chiang TH, Chen CC, Wang HP, Chiu HM, Wu MS Tags: J Formos Med Assoc Source Type: research

Microbiota and gastrointestinal cancer.
Abstract Gut microbiota plays important roles in many diseases, including cancer. It may promote carcinogenesis by inducing oxidative stress, genotoxicity, host immune response disturbance, and chronic inflammation. Colorectal cancer, hepatocellular carcinoma, and gastric cancer are the major gastrointestinal tract cancers in Taiwan. The microbiota detected in patients with tubular adenoma and villous/tubulovillous polyps is different from that in healthy controls and patients with hyperplastic polyps. Normalization of the microbiota is observed in patients after colorectal cancer treatment. Furthermore, the liver...
Source: J Formos Med Assoc - January 14, 2019 Category: General Medicine Authors: Weng MT, Chiu YT, Wei PY, Chiang CW, Fang HL, Wei SC Tags: J Formos Med Assoc Source Type: research

Seasonal influenza prevention and control in Taiwan-Strategies revisited.
Abstract Influenza remains a serious public health threat in Taiwan. During 2017-18, Taiwan experienced two seasonal influenza epidemics caused by A/H3N2 and B, respectively. In addition to national influenza vaccination campaign, Taiwan Centers for Diseases Control and Infectious Disease Control Advisory Committee has multi-faceted strategies for seasonal influenza prevention and control to mitigate the risk of disease transmission among vulnerable groups and decrease influenza-related morbidity and mortality. In this article, we reviewed the key elements of the prevention and control strategies-enhanced influenz...
Source: J Formos Med Assoc - January 12, 2019 Category: General Medicine Authors: Su CP, Tsou TP, Chen CH, Lin TY, Chang SC, Influenza Control Group, Infectious Disease Control Advisory Committee Tags: J Formos Med Assoc Source Type: research

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy.
CONCLUSION: This study provides indirect evidences of etiology-disease relationship of anti-PLA2R antibody in IMN patients. The role of C5a, a predictor of remission, in the disease course of MN and the influences on inflammatory cells in MN patients is worth to be clarified. PMID: 30639075 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 10, 2019 Category: General Medicine Authors: Chi JN, Lai TS, Wu CF, Fu TY, Chou YH, Chiu YL, Lin WC, Chiang WC, Chen YM, Wu MS Tags: J Formos Med Assoc Source Type: research

Tuberculosis case finding: Supplement intensified case finding among acute lower respiratory infection (ALRI) hospitalized patients in Sa Kaeo province, Thailand.
CONCLUSION: Supplementary-ICF among ALRI hospitalizations would be expected to result in improved active TB case detection compared to the current policy of PIP. The supplementary-ICF also enhanced early case detection and showed lower prevalence of secondary infection. PMID: 30638734 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 9, 2019 Category: General Medicine Authors: Naowarat S, Rojanaworarit C, Surinsak W, Umain K, Ruadreaw D, Yuenprakone S, Pisutaporn A, Meeyai AC Tags: J Formos Med Assoc Source Type: research

Does one-man method better than two-man method for colonoscopy insertion in children.
CONCLUSIONS: One-man method colonoscopy is safe and has higher CIR and TI intubation rate than two-man method colonoscopy in children, even performed by second-year GI fellows. PMID: 30638735 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 8, 2019 Category: General Medicine Authors: Chen HS, Wu JF, Chen HL, Ni YH Tags: J Formos Med Assoc Source Type: research

Etiologies and clinical characteristics of non-obstructive dysphagia in a Taiwanese population: A prospective study based on high-resolution impedance manometry.
Abstract BACKGROUND: Esophageal motility disorders are the major cause of non-obstructive dysphagia (NOD), but may be underdiagnosed. In this high-resolution impedance manometry (HRIM)-based study, we aimed to clarify the etiologies and clinical characteristics of patients presenting with NOD in a Taiwanese population. METHODS: From October 2014 to July 2017, consecutive patients with the chief complaint of dysphagia were prospectively enrolled in the study at a tertiary medical center. All subjects underwent a comprehensive diagnostic work-up, which included validated symptom questionnaires, esophagogastrodu...
Source: J Formos Med Assoc - January 8, 2019 Category: General Medicine Authors: Yeh CC, Chen CC, Wu JF, Lee HC, Lee YC, Liu KL, Wang HP, Wu MS, Tseng PH Tags: J Formos Med Assoc Source Type: research

Post-transplantation lymphoproliferative disease in pediatric liver recipients in Taiwan.
In this study, the disease characteristics, outcomes, and prognostic factors of PTLD were investigated. METHODS: A retrospective, observational study was conducted on 16 pediatric liver transplant (LT) recipients who developed PTLD between February 2001 and December 2013 at a tertiary referral center in Taiwan. The disease characteristics and treatment outcomes of the patients were analyzed. RESULTS: The median time from liver transplantation to the development of PTLD was 8 months. Early onset (
Source: J Formos Med Assoc - January 8, 2019 Category: General Medicine Authors: Hsu CT, Chang MH, Ho MC, Chang HH, Lu MY, Jou ST, Ni YH, Chen HL, Hsu HY, Wu JF Tags: J Formos Med Assoc Source Type: research

Outcomes research and quality improvement for the global Asian populations: Opportunity for Taiwan.
PMID: 30630699 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 7, 2019 Category: General Medicine Authors: Hsu YT, Hung YC, Chang DC Tags: J Formos Med Assoc Source Type: research

Blood loss and operative time associated with orthognathic surgery utilizing a novel navigation system in cleft lip and palate patients.
This study included 53 skeletal Class III nongrowing patients with unilateral CLP who underwent bimaxillary OGS using either the CASNOS protocol (n = 30) or the traditional two-dimensional (2D) method (n = 23). The skeletal parameters of jaw-bone components, the levels of hemoglobin (Hb) and hematocrit (Hct) were measured before and after surgery. The estimated blood loss and actual blood loss (ABL) were also calculated. RESULTS: The two groups did not differ significantly with regard to the demographic parameters (age, gender, and body mass index), the preoperative skeletal parameters and surgical...
Source: J Formos Med Assoc - January 7, 2019 Category: General Medicine Authors: Tsai CY, Chang YJ, Wu TJ, Lai JP, Chen TY, Lin SS Tags: J Formos Med Assoc Source Type: research

Traumatic dislocation of the mandibular condyle into the middle cranial fossa treated by an intraoral approach.
Abstract Dislocation of the mandibular condyle is one of several consequences of facial trauma that can be anticipated. The condylar neck is inherently weak and likely to fracture at the time of impact before dislocating into the middle cranial fossa. A review of the literature revealed that most cases of dislocation of the mandibular condyle into the middle cranial fossa are treated by open reduction and internal fixation via an extraoral approach or are treated conservatively with closed reduction. An intraoral approach is rare. Here we present a patient with traumatic dislocation of the mandibular condyle into ...
Source: J Formos Med Assoc - January 7, 2019 Category: General Medicine Authors: Chen I, Chang CM, Yuan-Chien Chen M, Chen KJ Tags: J Formos Med Assoc Source Type: research

Resident burnout in Taiwan Hospitals-and its relation to physician felt trust from patients.
CONCLUSIONS: The prevalence of burnout among residents in Taiwan was high, especially personal burnout. The validity of the PFTFP scale is satisfactory. Strategies in improving wellbeing of residents shall not overlook the importance of positive social capital such as resident's feeling of patient trust. PMID: 30626545 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 7, 2019 Category: General Medicine Authors: Huang EC, Pu C, Huang N, Chou YJ Tags: J Formos Med Assoc Source Type: research

Transient elastography correlated with diffusion-weighted magnetic resonance imaging and cholestatic complications.
CONCLUSIONS: TE and DW-MRI findings showed a similar ability to predict liver fibrosis in cholestatic children. The LSMs measured by TE are predictive of the occurrence of cholestatic complications in 6 months in children with cholestatic liver diseases. PMID: 30621960 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 6, 2019 Category: General Medicine Authors: Lee CZ, Peng SS, Lee CS, Chen HL, Ni YH, Chang MH, Wu JF Tags: J Formos Med Assoc Source Type: research

A case of recalcitrant pediatric Vogt-Koyanagi-Harada disease successfully controlled with adalimumab.
Abstract Vogt-Koyanagi-Harada (VKH) disease is uncommon in the pediatric population and can have an aggressive course with serious visual sequelae. A 12-year-old Han Chinese American female, who presented with mild headaches and panuveitis with diffuse serous retinal detachments, was diagnosed with VKH. Despite treatment with a combination of high-dose systemic corticosteroids, intravitreal triamcinolone injection, and mycophenolate mofetil, ocular inflammation was inadequately controlled. Addition of adalimumab allowed for inflammation remission, improvement of vision, and tapering of systemic corticosteroids. Es...
Source: J Formos Med Assoc - January 5, 2019 Category: General Medicine Authors: Su E, Oza VS, Latkany P Tags: J Formos Med Assoc Source Type: research

Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies.
CONCLUSION: Elevated systolic BP, proteinuria, and anemia are independently associated with CKD progression in pediatric patients with non-GN etiologies. PMID: 30616992 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 4, 2019 Category: General Medicine Authors: Chen CC, Chou HH, Chiou YY Tags: J Formos Med Assoc Source Type: research

Prenatal diagnosis of paternal uniparental disomy for chromosome 14 using a single-nucleotide-polymorphism-based microarray analysis: A case report.
We report a case of a fetus with abnormal ultrasound features at 18 weeks of gestation and normal karyotype result. Subsequent Single nucleotide polymorphism (SNP)-based Affymetrix 750K Microarray analysis revealed the complete loss of heterozygosity for chromosome 14, identifying a case of uniparental disomy. Postmortem examination of the aborted fetus at 21 weeks, coupled with further Affymetrix 750K microarray analysis on the parents, confirmed the diagnosis of parental uniparental disomy for chromosome 14. PMID: 30616993 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 4, 2019 Category: General Medicine Authors: Chen CL, Lee CN, Lin MW, Hsu WW, Tai YY, Lin SY Tags: J Formos Med Assoc Source Type: research

Noisy breathing sounds - A life-threatening cause of an infant with a vallecular cyst.
PMID: 30616994 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 4, 2019 Category: General Medicine Authors: Cheng FY, Yen TA, Wu ET, Wang CC Tags: J Formos Med Assoc Source Type: research

Survival analysis of extracorporeal membrane oxygenation in neonatal and pediatric patients - A nationwide cohort study.
This study reported the survival rate for pediatric patients from Taiwan's national cohort. METHODS: Patients under the age of 18 who received ECMO from January 1, 2002 to December 31, 2012 were identified from the Taiwan National Health Insurance Research Database. The underlying etiology for ECMO use was categorized into post-operative (n = 410), cardiac (245), pulmonary (146) groups, and others (120). A Cox regression model was used to determine hazard ratios and to compare 30-day and 1-year survival rates using post-operative group as a reference. RESULTS: The average age of all 921 patients was 4.8...
Source: J Formos Med Assoc - January 4, 2019 Category: General Medicine Authors: Hsu J, Chang CH, Chiang LT, Caffrey JL, Lin JW, Chen YS Tags: J Formos Med Assoc Source Type: research

Roles of Epstein-Barr virus viral load monitoring in the prediction of posttransplant lymphoproliferative disorder in pediatric liver transplantation.
CONCLUSIONS: Close monitoring of EBV viral load within 3 months after LT is helpful to predict a high risk of PTLD. Tapering of immunosuppressants is suggested if the EBV viral load is>4100 copies/μg PBMC DNA in LT children. PMID: 30612881 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 3, 2019 Category: General Medicine Authors: Chen HS, Ho MC, Hu RH, Wu JF, Chen HL, Ni YH, Hsu HY, Jeng YM, Chang MH Tags: J Formos Med Assoc Source Type: research

A registry of acromegaly patients and one year following up in Taiwan.
CONCLUSION: This study described the profiles of acromegaly in Taiwan. It is important to enhance early diagnosis and timely commencement of treatment to prevent serious complications of acromegaly. PMID: 30612883 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 3, 2019 Category: General Medicine Authors: Tseng FY, Huang TS, Lin JD, Chen ST, Wang PW, Chen JF, Huey-Herng Sheu W, Chang TC, Acromegaly Registry Study Group Tags: J Formos Med Assoc Source Type: research

Advanced physical examination training course improves medical students' confidence in physical examination.
Abstract BACKGROUND: Physical examination (PE) is a basic diagnostic tool in clinical settings. It is important to enhance medical students' skills and confidence in PE. SUBJECTS AND METHODS: Our medical students begin learning PE in the fourth medical year (M4). They undergo hands-on clinical training in the fifth medical year (M5). To improve the teaching of PE, we implemented an advanced PE training course (APETC) for M5 students. In APETC, PE skills for chest (CH), cardiovascular system (CV), and abdomen (GI) domains were demonstrated by senior specialists. Under tutors' supervision, students performed PE...
Source: J Formos Med Assoc - January 3, 2019 Category: General Medicine Authors: Tseng FY, Chang YT, Yu CJ, Chang SC Tags: J Formos Med Assoc Source Type: research

Effectiveness and appropriateness in the application of office hysteroscopy.
This article reviews the literature to find the best available evidence on the effectiveness of office hysteroscopy in comparison with other clinical diagnostic tools, as well as the current opinions on such controversies in its application. PMID: 30611636 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 2, 2019 Category: General Medicine Authors: Yen CF, Chou HH, Wu HM, Lee CL, Chang TC Tags: J Formos Med Assoc Source Type: research

Taiwanese depression questionnaire revisit: Factor structure and measurement invariance across genders.
CONCLUSION: The 15-item TDQ with a 3-factor structure reflects the manifestations of depression of Taiwanese general population well. Although the results of measurement invariance suggest no gender difference in factor structure, the partial strict invariance suggests that there is gender difference in the amount of variance captured by TDQ. Hence, examining gender differences in the predictive value of different factors regarding health behaviors or medical conditions may bring fruitful results. PMID: 30600133 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 29, 2018 Category: General Medicine Authors: Sun YC, Chen CL, Wen SH Tags: J Formos Med Assoc Source Type: research

Application of high-fidelity simulation in critical care residency training as an effective learning, assessment, and prediction tool for clinical performance.
This study was conducted to assess: 1) the impact of the HFS curriculum on residents' knowledge and skills, and 2) the correlation between learning outcomes and the clinical performance. METHODS: An HFS-based curriculum was implemented for junior residents prior to their ICU rotations. Residents completed written tests before (pre-test) and after (post-test) the curriculum and were assessed on their performance during the simulation sessions. Clinical performance was evaluated using global rating for knowledge, clinical skills, and leadership and decision-making skills. RESULTS: Complete data on pre-, post-test, ...
Source: J Formos Med Assoc - December 21, 2018 Category: General Medicine Authors: Yang CW, Ku SC, Ma MH, Chu TS, Chang SC Tags: J Formos Med Assoc Source Type: research

2019 Taiwan Society of Lipids and Atherosclerosis expert consensus statement on statin intolerance.
Abstract Statin reduces low-density lipoprotein cholesterol and improves clinical outcomes in high risk patients. In general, statin is a safe and well-tolerated medication. However, varieties of adverse effects are reported in some patients and may interfere long-term drug compliance. Statin-associated muscle events and liver function change account for most of these adverse effects. Patients are regarded as statin intolerance if they need to discontinue statin therapy due to these adverse effects. To date, there is no universal standard definition of statin intolerance. But a pragmatic definition of statin intol...
Source: J Formos Med Assoc - December 21, 2018 Category: General Medicine Authors: Chien SC, Chen PS, Huang YH, Tang SC, Li YH, Yeh HI Tags: J Formos Med Assoc Source Type: research

Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease.
Abstract BACKGROUND: Patients with gastroesophageal reflux disease (GERD) frequently report symptoms like dyspepsia or/and irritable bowel syndrome (IBS). The aim of the study was to investigate the impact of symptom overlap on GERD symptom burden. We also investigate whether GERD overlapping dyspepsia or/and IBS would have different clinical and psychological features as compared with GERD alone. METHODS: A total of 2752 subjects were screened from a health check-up population. We compared the clinical and psychological factors among subjects with GERD alone and with overlap of two or all three diseases. All...
Source: J Formos Med Assoc - December 21, 2018 Category: General Medicine Authors: Lei WY, Chang WC, Wen SH, Wong MW, Hung JS, Yi CH, Liu TT, Hsu CS, Orr WC, Vaezi MF, Pace F, Hsieh TC, Chen CL Tags: J Formos Med Assoc Source Type: research

Timely eradication of HCV viremia by PegIFN/RBV is crucial in prevention of post RFA recurrence in CHC-HCC patients.
CONCLUSIONS: Timely treatment with SVR achievement has the lowest tumor recurrence rate in CHC-HCC patients. Secondary prevention might be even more important than tertiary prevention in CHC patients, especially regarding prevention of post RFA HCC recurrence. PMID: 30581103 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 20, 2018 Category: General Medicine Authors: Chen YC, Teng W, Hsieh YC, Chen WT, Jeng WJ, Huang CH, Lin CC, Chen YC, Lin SM, Lin CY, Sheen IS Tags: J Formos Med Assoc Source Type: research

Factors affecting serum concentration of  dabigatran in Asian patients with non-valvular atrial fibrillation.
CONCLUSIONS: Dabigatran monitoring may be considered for patients at risk of overexposure, especially those with low body weight and renal insufficiency, and also for detecting those with extremely low drug concentration. PMID: 30581104 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 20, 2018 Category: General Medicine Authors: Lin SY, Tang SC, Kuo CH, Tsai LK, Yeh SJ, Shen LJ, Jeng JS Tags: J Formos Med Assoc Source Type: research

Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients.
CONCLUSIONS: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA-AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients. PMID: 30581105 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 20, 2018 Category: General Medicine Authors: Chiang CP, Chang JY, Wang YP, Wu YH, Wu YC, Sun A Tags: J Formos Med Assoc Source Type: research

Correlation between visual association memory test and structural changes in patients with Alzheimer's disease and amnestic mild cognitive impairment.
This study aimed to investigate the correlation of the VAMT performance with amyloid plaque burden and hippocampal atrophy. METHODS: Fourteen patients with AD, 29 with amnestic mild cognitive impairment (aMCI), and 11 normal cognition (NC) subjects were recruited. Brain magnetic resonance imaging (MRI) and [18F]AV-45 positron emission tomography (PET) were performed to evaluate hippocampal atrophy and amyloid plaque burden. RESULTS: The VAMT median score and interquartile range of the NC, aMCI and AD groups were 6 (6-6), 2 (0-4), and 0 (0-1), respectively (p 
Source: J Formos Med Assoc - December 19, 2018 Category: General Medicine Authors: Huang KL, Hsiao IT, Kuo HC, Hsieh CJ, Hsieh YC, Wu YM, Wey SP, Yen TC, Lin KJ, Huang CC Tags: J Formos Med Assoc Source Type: research

Developing a novel cholesterol-based nanocarrier with high transfection efficiency and serum compatibility for gene therapy.
CONCLUSION: With high transfection efficiency and serum compatibility, this novel biocompatible cholesterol-based nanocarrier provides an ideal platform especially for RNAi-based gene manipulation. It also opens a wide range of biomedical applications for in vivo cell tracking and gene therapeutics for clinical usage. PMID: 30579664 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 19, 2018 Category: General Medicine Authors: Chang K, Chang FH, Chen MH Tags: J Formos Med Assoc Source Type: research

PI3K inhibitor provides durable response in metastatic metaplastic carcinoma of the breast: A hidden gem in the BELLE-4 study.
CONCLUSION: Buparlisib plus weekly paclitaxel might be a new treatment option for patients with metastatic MCB harboring a PIK3CA mutation. Additional prospective studies for investigating the efficacy of the proposed combination are warranted. PMID: 30577988 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 18, 2018 Category: General Medicine Authors: Yang MH, Chen IC, Lu YS Tags: J Formos Med Assoc Source Type: research

IL-1 ╬▓-induced ICAM-1 and IL-8 expression/secretion of dental pulp cells is differentially regulated by IRAK and p38.
CONCLUSION: The Results reveal the important role of IL-1β in pulpal inflammatory responses via stimulation of IL-8 and ICAM-1 expression and secretion. Moreover, IL-1β-induced effects on IL-8 and ICAM-1 are differentially regulated by IRAK1/4 and p38 signaling in dental pulp cells. Blocking of IRAKs and p38 signaling may have potential to control inflammation of dental pulp in the future. PMID: 30558829 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 14, 2018 Category: General Medicine Authors: Chang MC, Lin SI, Pan YH, Lin LD, Wang YL, Yeung SY, Chang HH, Jeng JH Tags: J Formos Med Assoc Source Type: research

Prognostic factors on outcomes of follicular thyroid cancer.
CONCLUSIONS: Dynamic distant metastases and locoregional recurrences were the most dominant risk factors influencing FTC-specific hazard and cumulative incidence for FTC death by accounting for non-FTC death as a competing risk for FTC patients. PMID: 30541677 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 10, 2018 Category: General Medicine Authors: Su DH, Chang TC, Chang SH Tags: J Formos Med Assoc Source Type: research

Taiwan consensus statement on the management of chronic hepatitis B.
Abstract The experts of Taiwan Association for the Study of Liver (TASL) have actively participated and led the guidelines on hepatitis B virus (HBV) management by Asian Pacific Association for the Study of Liver (APASL) which is the first international association for the study of liver to publish the statement on HBV management before. However, there are more and more new data on the natural history and treatment of HBV infection in the past decade. These include new application of an old biomarker (quantitative HBsAg), clinical significance of HBV genotype and naturally occurring mutations, the role of non-inva...
Source: J Formos Med Assoc - December 5, 2018 Category: General Medicine Authors: Chien RN, Kao JH, Peng CY, Chen CH, Liu CJ, Huang YH, Hu TH, Yang HI, Lu SN, Ni YH, Chuang WL, Lee CM, Wu JC, Chen PJ, Liaw YF Tags: J Formos Med Assoc Source Type: research

Trends, demographics, and conditions of emergency dental visits in Taiwan 1997-2013: A nationwide population-based retrospective study.
CONCLUSION: Taken together, these demographic data could serve as a reference for the authorities concerned to improve the current situation of ED in Taiwan. PMID: 30527437 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 5, 2018 Category: General Medicine Authors: Huang SM, Huang JY, Yu HC, Su NY, Chang YC Tags: J Formos Med Assoc Source Type: research

Clinical characteristics and prognosis of HCC occurrence after antiviral therapy for HCV patients between sustained and non-sustained responders.
CONCLUSIONS: Liver cirrhosis plays a key role in HCC occurrence after antiviral therapies. SVR patients may have lower HCC recurrence and longer survival rates than non-SVR patients. Only APRI was associated with HCC recurrence; and post-IFN AFP and HCC recurrence were predictive of subsequent mortality independently. PMID: 30527565 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 4, 2018 Category: General Medicine Authors: Sou FM, Wu CK, Chang KC, Lu SN, Wang JH, Hung CH, Chen CH, Kee KM, Yen YH, Lin MT, Tsai MC, Hu TH Tags: J Formos Med Assoc Source Type: research