Fight Aging! Newsletter, September 13th 2021

In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were only achieved via direct cell-cell contact between mDCs and mTEC1 cells. Furthermore, we observed that an intrathymic injection of the mDCs resulted in acute thymic atrophy and reduced thymocytes and TECs substantially in vivo. In sum, this demonstrated that circulating mDCs migrated into the thymus and induced the degeneration of the thymus. Overall, the findings of this study improve our understanding of the mechanisms underlying thymus degeneration. During infection, activated DCs are mature, and migrate into different lymph nodes through afferent lymphatic vessels. DCs, residing in tissues, can reach the periphery and carry antigens to secondary lymphoid organs through blood. A small number of circulating DCs, capturing pathogens, can migrate into thymus. Although the number of thymic homing DCs is relatively small, given numerous mild or severe infe...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Optimal nutrition is crucial for honey bee colony growth and robust immune systems. Honey bee nutrition is complex and depends on the floral composition of the landscape. Foraging behavior of honey bees depends on both colony environment and external environment. There are significant gaps in knowledge regarding honey bee nutrition, and hence no optimal diet is available for honey bees, as there is for other livestock. In this review, we discuss (1) foraging behavior of honey bees, (2) nutritional needs, (3) nutritional supplements used by beekeepers, (4) probiotics, and (5) supplemental forage and efforts integrating flor...
Source: Veterinary Clinics of North America: Food Animal Practice - Category: Veterinary Research Authors: Source Type: research
In this paper, a highly sensitive and low loss refractive index (RI) biosensor for high RI bio-analytes detection, such as for cholesterol, ...
Source: Journal of the Optical Society of America B - Category: Physics Authors: Source Type: research
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01910D, CommunicationAsaki Miyairi, Yoshihiro Oonishi, Yoshihiro Sato One-pot synthesis of fully substituted 2-aminofurans via a Au(I)-catalyzed cascade reaction of ynamides and propargylic alcohol was realized. Hydroalkoxylation of ynamide with propargylic alcohol, Saucy-Marbet rearrangement, and cyclization of the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Environ. Sci.: Processes Impacts, 2021, Accepted Manuscript DOI: 10.1039/D1EM00307K, PaperOluwadamilola Daramola, Amy A Rand The biotransformation of 6:2 fluorotelomer alcohol (6:2 FTOH) results in the production of bioactive and persistent metabolites, including perfluorinated carboxylic acids (PFCAs). While the products of 6:2 FTOH metabolism have... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Environ. Monit. latest articles - Category: Environmental Health Authors: Source Type: research
Researcher ‘staggered’ that institutes used newspaper photos to assess mask use and effect on Covid ratesFollow our Covid live blog for the latest updatesVic:hotspots;restrictions;vaccination rates by postcodeVaccine rollout tracker;cases and data trackerGet our free news app;get our morning email briefingA study relied on by the Victorian government to justify its strict mask mandate has been criticised by some doctors and epidemiologists as “low grade” evidence.While the experts emphasised that wearing masks indoors was important and that masks helped reduce transmission, they said the“world...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Victoria Medical research Health Australia news Coronavirus Source Type: news
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
AbstractActive hexose-correlated compound (AHCC) is a standardized extract from culturedLentinula edodes mycelia, used as a potent biological response modifier in cancer treatment. We evaluated the nutritional effect of AHCC, given during neoadjuvant therapy, to patients with pancreatic ductal adenocarcinoma (PDAC). Thirty patients with resectable or borderline-resectable PDAC received neoadjuvant therapy with gemcitabine plus S-1. We compared, retrospectively, the outcomes of 15 patients who received AHCC combined with neoadjuvant therapy with those of 15 patients who did not receive AHCC combined with neoadjuvant therapy...
Source: Surgery Today - Category: Surgery Source Type: research
AbstractPurposeRadical antegrade modular pancreatosplenectomy (RAMPS) has been reported to achieve high rates of a negative margin and resected metastatic lymph nodes. However, many studies have used historical controls and the results remain controversial. We conducted this study to compare the surgical and long-term outcomes of RAMPS vs. conventional distal pancreatectomy (DP).MethodsThe subjects of this multicenter retrospective study were 106 patients who underwent curative resection for left-sided pancreatic cancer between 2012 and 2017. Overall survival (OS) and recurrence-free survival (RFS) rates were compared usin...
Source: Surgery Today - Category: Surgery Source Type: research
AbstractPurposeTo assess the clinical indications for, and prognostic impact of surgery after, chemotherapy for type 4 gastric cancer.MethodsThe subjects of this retrospective study were 67 patients who received chemotherapy for type 4 gastric cancer. The patients were grouped into those with progressive disease (PD group) and those without PD (non-PD group), according to the tumor response to chemotherapy.ResultsDistant metastases developed in 58 patients. With regard to tumor response, there were 16 patients in the PD group and 51 patients in the non-PD group. The prognosis of the PD group patients was significantly poor...
Source: Surgery Today - Category: Surgery Source Type: research
AbstractAdvanced gastric cancers are responsible for overwhelming human suffering and death. Despite the development of combination chemotherapies, the survival rates of patients with gastric cancer remain unsatisfactory. Given the growing evidence of the benefits of immunotherapy as an alternative treatment for other cancers such as advanced melanoma, non-small cell lung cancer, renal cell carcinoma, and refractory Hodgkin ’s lymphoma, researchers have begun to explore its application in the treatment of gastric cancer. Three types of immunotherapy have shown promising effects against gastric cancer: immune checkpoi...
Source: Surgery Today - Category: Surgery Source Type: research
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