Fight Aging! Newsletter, June 14th 2021

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: Contents There is No One Universal Pro-Longevity Gut Microbiome Aducanumab Approved by FDA to Treat Alzheimer's Disease Inflammaging and Disruption of Coagulation as Contributions to High COVID-19 Mortality in the Old Trends in Human Healthspan versus Lifespan Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity Glial Cell Senescence in the Aging Brainstem Reduced Oxygen Supply to the Brain as a Cause of Early Memory Symptoms in Alzheimer's Disease A Treatment to Rebuild Tooth Enamel A Mechanism by which Amyloid-β can Reduce Capillary Density in the Alzheimer's Brain A Less Well Explored Cdkn1a Transcript is a Marker of Aging and Cellular Senescence Distinctive Macrophage Signaling is Vital to Axolotl Limb and Organ Regenera...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Ecarin is a metalloproteinase found in snake venom (SVMP) with an important role in coagulation and control of hemostasis. It can specifically produce active-thrombin from prethrombin-2 and does not differentiate between normal and abnormal prothrombin. It is used in diagnostic tests and to evaluate the treatment process of many diseases. There are many drawbacks associated with separating these compounds from snake venom. Therefore, in this study, full-length recombinant Ecarin (r-Ecarin) was cloned, expressed, and purified in eukaryotic host cells. To determine the most effective form of the enzyme, r-Ecarin was compared...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: In our sample, percentages of variation in PLR and PD were found to be directly representative of TBI patients’ fentanyl blood concentration. Considering information about blood drug concentration is generally not available at bedside, PLR could be used as a proxy to assess analgesia requirements before a nociceptive procedure in critically ill sedated TBI patients who are vulnerable to stress.
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Articles Source Type: research
CONCLUSION: Unmet needs identified by SSs and CGs were used to extend NTCM specific to the stroke population and to develop the Recommendations and Exemplars for Stroke Specific Comprehensive Transitional Care Delivery (see Supplementary Digital Content, available at Researchers and practitioners can use the findings to develop and deliver more comprehensive TC to SSs and CGs.
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Articles Source Type: research
CONCLUSION: According to the results, the proportion of patients with high medication adherence was low. Patients' concerns about the possible side effects of their prescribed medications and beliefs about the overuse of medications negatively affected their medication adherence. It is recommended that nurses evaluate patients' medication adherence and beliefs about medications during hospitalization, discharge, or home visits. Structured nurse-led intervention programs are needed to enhance patients' medication adherence and beliefs about their medications.
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Articles Source Type: research
This study used data from 2 cross-sectional studies conducted in the neurology departments of 3 hospitals in Guangzhou, China. In total, 110 hypertensive stroke patients were recruited in stage I (2008-2009), and 119 hypertensive stroke patients were recruited in stage II (2018-2019). Patients' stroke knowledge was measured by the Stroke Knowledge Questionnaire. Patients' prestroke health behavior was measured by the Health Behavior Scale for Stroke Patients. RESULTS: The total score of prestroke health behaviors significantly increased over the decade (P
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Articles Source Type: research
Journal of Human Hypertension, Published online: 16 January 2022; doi:10.1038/s41371-021-00649-7Masked hypertension and neonatal outcome in high-risk pregnancies
Source: Journal of Human Hypertension - Category: Cardiology Authors: Source Type: research
ConclusionsPatient experiences related toH. pylori management are predominantly negative. Increasing providers ’ awareness about patients’ values, beliefs, anxieties, and expectations surroundingH. pylori diagnosis/treatment may improve provider-patient communication and, ideally, related outcomes.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Oncogene, Published online: 16 January 2022; doi:10.1038/s41388-021-02151-3The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research
Cases seem to be subsiding in states with high vaccination rates, but observers are reluctant to make firm predictionsIn February 2021, Dr Craig Spencer wrote in a Mediumpost that he was as “eager as anyone to see the end of this pandemic. Thankfully, that may be in sight”.“Covid cases and hospitalizations are dropping,” wrote Spencer, director of Global Health in Emergency Medicine at New York-Presbyterian/Columbia University Medical Center. “Vaccines are getting into arms. So, what happens next?”Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Omicron variant Coronavirus Science New York US news North Carolina Source Type: news
Here's how this reaction may be different from an immediate skin reaction.
Source: Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation Science /science business pharma Source Type: news
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