Zika Virus Potentiates the Development of Neurological Defects and Microcephaly: Challenges and Control Strategies

Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and dysregulate hNPCs. During pregnancy in mice, ZIKV inoculation resulted in stunted heads, restricted intrauterine growth, and ocular anomalies. Despite this, still, the information about its epidemiology, pathology and mechanism is not clear. Therefore, further studies are needed toward advance research and vaccine development for ZIKV treatment and prevention. Author Contributions RS conceived and wrote the manuscript. YL and WS edited the manuscript. GN critically reviewed and edited the manuscript. MX and SK revised, supervised, and funded the study. Funding This research was funded by the National Natural Science Foundation of China (grants no: 81471174, 81520108011, and 81870942), National Key Research and Development Program of China (grant no: 2018YFC1312200), and Innovation Scientists and Technicians Troop Constructions Projects of Henan Province...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

Related Links:

Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Surendra Gulla, Dakshayani Lomada, Vadali V.S.S. Srikanth, Muthukonda Venkatakrishnan Shankar, Kakarla Raghava Reddy, Sarvesh Soni, Madhava C. ReddyAbstractNanoparticles' based cancer therapeutics are greatly dependent on the development of science and engineering of nanoparticles. In this article, important strategies based on nanoparticles used for cancer treatment are discussed. The inspiration to write this article is not only to review the existing strategies based on nanoparticles but also to highlight the pertinent and possible solutions ther...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Kakarla Raghava Reddy, Pattubala Adinaraya Reddy, Chandragiri Venkata Reddy, Nagaraj P. Shetti, Bhatula Babu, Koutavarapu Ravindranadh, Muthukonda Venkatakrishnan Shankar, Madhava C. Reddy, Sarvesh Soni, Shivalingegowda NaveenAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most extensively used functional nanomaterials as antibacterial agents, and for other biomedical applications due to their unique physical, chemical, magnetic and biocompatibility properties. However, due to their small size, particles tend to aggregate by dipo...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Hemraj ChhipaAbstractExcess use of chemical fertilizers and pesticides has shown negative impacts on soil health and environment. Chemical residues destroy the soil ecosystem by affecting the non-targeted organisms and decrease soil fertility simultaneously. To prevent such adversity in soil and environment, researchers have applied nanotechnology in agriculture. Nanotechnology is the rising technology of the current decade, which has shown promising results in controlling excess agri-inputs and maintaining environmental balance. The characteristics...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Aaron Elbourne, Vi Khanh Truong, Samuel Cheeseman, Piumie Rajapaksha, Sheeana Gangadoo, James Chapman, Russell J. CrawfordAbstractAntimicrobial resistance (AMR) has been identified as one of the greatest threats to human health (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). Unfortunately, the current rise in AMR has made biofilm-related infections a primary health-care concern, since these biofilms can no longer be effectively treated using conventional antibiotic metho...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
ConclusionNo significant difference was found in the clinical manifestations, mortality, and complication between children and adults but children tended to have lesser chance of using alternative antibiotics, methylprednisolone and inhaled NO. The chance of associated cytomegalovirus (CMV) disease was also significantly lower in children.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Publication date: Available online 21 May 2019Source: Comptes Rendus PhysiqueAuthor(s): Guy LavalAbstractAt their very beginning, the researches on the magnetic confinement fusion had to face up plasma instabilities. Macroscopic plasma instabilities were the first ones to be identified and they were found to be very harmful for plasma confinement. During the first years after the Atoms for Peace Meeting in 1958, the main goals of experimental and theoretical researches dealt with their suppression or control. During this period, two special types of instabilities, the localized interchange modes and the tearing modes, were...
Source: Comptes Rendus Physique - Category: Physics Source Type: research
Publication date: Available online 21 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lamia Abou El-Kassem, Usama W. Hawas, Sahar El-Souda, Eman F. Ahmed, Wail El-Khateeb, Walid FayadAbstractForty-eight endophytic fungal strains were isolated and purified from ten Egyptian medicinal plants and their culture broth extracts were explored for HCV protease inhibitory activity and cytotoxicity. The ethyl acetate extracts of Alternaria alternata PGL-3, Cochlibolus lunatus PML-17, Nigrospora sphaerica EPS-38, followed by Emerecilla nidulans RPL-21 showed the most potent inhibition of HCV NS3/4A protease with...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
PMID: 31109490 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
CONCLUSION: Increasing on-time percent does not improve efficiency under torsional long-pulse US. There is no significant change in chatter with increasing on-time percent. Increasing power increases efficiency despite chatter increase. Long-pulse US does not appear to influence torsional action in a clinically meaningful way. PMID: 31109482 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract OBJECTIVE: To determine the use of home care services in those with and without visual impairment in Canada. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Participants came from the baseline examination of the Canadian Longitudinal Study on Aging Comprehensive Cohort. Inclusion criteria included age between 45 and 85 years, community dwelling, and living near one of the 11 data collection sites across 7 Canadian provinces. People were excluded if they were in an institution, were living on a First Nations reserve, were full-time members of the Canadian Armed Forces, did not speak...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
More News: Academia | Academies | African Health | AIDS Vaccine | Amniocentesis | Antimicrobial Resistance | Arthritis | Autoimmune Disease | Azithromycin | Babies | Blood Transusion | Brain | Brain Cancers | Brazil Health | Breast Conservation Surgery | Cabo Verde Health | Cambodia Health | Cancer | Cancer & Oncology | Cancer Vaccines | Cervical Cancer Vaccine | Chemistry | Chikungunya | Child Development | Children | China Health | Clinical Trials | Cold Sores | Colombia Health | CT Scan | Cytomegalovirus | Dengue Fever | Disability | Emergency Medicine | Encephalitis | Environmental Health | Epidemics | Epidemiology | Epithelial Cancer | Flu Pandemic | France Health | Gastroenterology | Genetics | Genital Herpes | Genital Warts | Grants | Group A Streptococcus | Guillain-Barr Syndrome | Haiti Health | Health Management | Hepatitis | Hepatitis A | Hepatitis B | Hepatitis Vaccine | Herpes | HIV AIDS | HPV Testing | Human Papillomavirus (HPV) | Hydrocephalus | Influenza | Influenza Vaccine | International Medicine & Public Health | Italy Health | Japan Health | Jordan Health | Laboratory Medicine | Malaria | Malaria Vaccine | Measles | Measles Vaccine | Men | Micronesia Health | Middle East Health | Milk | Miscarriage | MRI Scan | Nanotechnology | Neurology | Neuroscience | Nutrition | Outbreaks | Pandemics | Parvovirus | Pathology | Pediatrics | Perinatology & Neonatology | Physiology | Pregnancy | Recession | Reproduction Medicine | Rheumatology | Rubella | Rubella Vaccine | Samoa Health | Science | Skin | Slovenia Health | Spinal Cord Injury | Statistics | STDs | Stem Cell Therapy | Stem Cells | Study | Syphilis | Tickborne Diseases | Toxicology | Truvada | Uganda Health | Ultrasound | Unemployment | USA Health | Vaccines | Veterinary Vaccinations | Viread | Virology | West Nile Virus | WHO | Women | Yellow Fever | Yellow Fever Vaccination | Zika Virus | Zithromax