Communist China building nearly 100 more biolabs similar to the Wuhan Institute of Virology
(Natural News) The Communist Chinese Party’s (CCP) Ministry of Science and Technology has announced that the dictatorship is planning to build three more level-4 biosafety labs throughout the country, along with 88 more level-3 biosafety labs. The Wuhan Institute of Virology (WIV), currently one of China’s two level-4 biosafety labs, is widely believed to be... (Source: NaturalNews.com)
Source: NaturalNews.com - April 20, 2021 Category: Consumer Health News Source Type: news

Post-vaccine variants: India discovers new "double mutant" Wuhan coronavirus strain
(Natural News) Indian scientists have discovered a “double mutant strain” of the Wuhan coronavirus (COVID-19) in their country. An Indian virologist stated that the variant has raised alarm bells because it could bypass the immune system and become more infectious. The variant features two mutations coming together in the same virus. Speaking to the BBC, Ashoka University virologist Dr. Shahid Jameel... (Source: NaturalNews.com)
Source: NaturalNews.com - April 19, 2021 Category: Consumer Health News Source Type: news

Coronavirus: China knew Wuhan market was a disease risk for years before Covid, scientist says
Professor Eddie Holmes, a virologist at the University of Sydney, revealed infectious disease experts in Wuhan took him to the market in 2014, and he said: 'It felt like a disease incubator.' (Source: the Mail online | Health)
Source: the Mail online | Health - April 19, 2021 Category: Consumer Health News Source Type: news

Dr. Sanjay Gupta now embraces the coronavirus lab origin theory – will CNN fire him now?
(Natural News) CNN’s Dr. Sanjay Gupta is now embracing the coronavirus lab origin theory. In a recent interview, Gupta supported Dr. Robert Redfield’s analysis, which postulates that SARS-CoV-2 likely originated from the Wuhan Institute of Virology. This is the controversial Chinese lab where coronavirus gain-of-function research was being conducted in order to develop new vaccines.... (Source: NaturalNews.com)
Source: NaturalNews.com - April 16, 2021 Category: Consumer Health News Source Type: news

Virginia Tech and UVA virologists develop broadly protective coronavirus vaccines
(Virginia Tech) A candidate vaccine that could provide protection against the COVID-19 virus and other coronaviruses has shown promising results in early animal testing. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 16, 2021 Category: Infectious Diseases Source Type: news

You're close enough to catch Covid from someone else if you can smell their breath, expert says
Dr Julian Tang, a virologist at the University of Leicester, said Britons could tell they were standing close enough to someone for the virus to transmit if they could smell their breath. (Source: the Mail online | Health)
Source: the Mail online | Health - April 15, 2021 Category: Consumer Health News Source Type: news

One year of SARS-CoV-2 evolution
(Microbiology Society) Today, researchers published an in-depth look at the SARS-CoV-2 mutations that have taken place during the past year in the Journal of General Virology. The review discusses the findings of over 180 research articles and follows the changes that have taken place in the SARS-CoV-2 genome, and the variants that have occurred as a result. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2021 Category: International Medicine & Public Health Source Type: news

Will Covid vaccines protect us against new variants? | Julian Tang
New strains such as the South African variant that ’s emerged in south London will require constant vigilance as lockdown easesAll viruses mutate. They do this to adapt and survive better in their specific host. The virus that causes Covid-19 is no different: it has moved from the animal realm, where it most likelyoriginated in bats, to the human world. Since then, scientists have been locked in a battle between the spread of the virus and the ability to immunise against it. We now have the vaccines to protect us against Covid-19 – but what happens when this virus mutates further, as it likely will?As lockdown ...
Source: Guardian Unlimited Science - April 14, 2021 Category: Science Authors: Julian Tang Tags: Coronavirus Infectious diseases Medical research Microbiology Science Vaccines and immunisation Society Pfizer AstraZeneca Pharmaceuticals industry World news UK news Source Type: news

$1.9 million award could keep Zika virus at bay
(University of California - Riverside) A UC Riverside virologist has won a $1.9 million award to investigate how Zika virus uses a protein, NS5, to beat the human immune system. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 14, 2021 Category: International Medicine & Public Health Source Type: news

Double mutation found in 61% of 361 COVID-19 samples: Expert
"I am told that out of 361 COVID-19 samples tested by the National Institute of Virology in Pune, 61 per cent had the double mutation. However, this sample size is too small to conclude as Maharashtra has been conducting nearly two lakh tests per day," a senior genome sequencing expert told . (Source: The Economic Times)
Source: The Economic Times - April 14, 2021 Category: Consumer Health News Source Type: news

W.H.O. and Critics Look at What's Next to Investigate Virus Origins
A scientific mission to China proposed further study for a number of topics. Critics and the director of the W.H.O. have weighed in as well. (Source: NYT Health)
Source: NYT Health - April 7, 2021 Category: Consumer Health News Authors: James Gorman Tags: Coronavirus (2019-nCoV) Animals Bats Minks (Animals) Wuhan Institute of Virology (China) World Health Organization Wuhan (China) EcoHealth Alliance Southeast Asia Source Type: news

Committee with no domain expertise approved indigenously manufactured Covaxin: Health experts
“The committee is Delhi centric and dominated by disciplines not connected to vaccines and clinical research. Like in the US such important committees should be multidisciplinary with virologist, persons having a background in cellular and molecular biology, biochemistry, public health and experie nce of conducting clinical research,” former health secretary Sujatha Rao said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 6, 2021 Category: Pharmaceuticals Source Type: news

Committee with no domain expertise approved indigenously manufactured Covaxin, say health experts
“The committee is Delhi centric and dominated by disciplines not connected to vaccines and clinical research. Like in the US such important committees should be multidisciplinary with virologist, persons having a background in cellular and molecular biology, biochemistry, public health and experie nce of conducting clinical research,” former health secretary Sujatha Rao said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 6, 2021 Category: Pharmaceuticals Source Type: news

Roberto Burioni on Conquering COVID and Charming the Skeptics Roberto Burioni on Conquering COVID and Charming the Skeptics
Virologist-author Roberto Burioni talks about the relevance of variants, why vaccines are our ticket out of this nightmare, and how best to deal with science and vaccine skeptics.Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 2, 2021 Category: Consumer Health News Tags: Internal Medicine Expert Interview Source Type: news

Communist China loves to play "god" with Frankenstein-style virus experiments
(Natural News) A top scientist has accused communist China of being the world’s dumping ground for “Frankenstein-style” experiments that threaten to unleash even more genetically modified (GMO) viruses into the wild. Since we now know that the Wuhan coronavirus (Covid-19) was more than likely cooked up by scientists at the Wuhan Institute of Virology (WIV)... (Source: NaturalNews.com)
Source: NaturalNews.com - April 2, 2021 Category: Consumer Health News Source Type: news

Cadila Healthcare Working on Needle-free, 2-Dose Vaccine
The drug company is conducting phase-3 trials with over 20,000 participants to test whether its three-dose vaccine ZyCoV-D prevents virologically confirmed symptomatic Covid-19 cases compared to the placebo. The vaccine candidate is administered on day 1, day 28 and day 54. (Source: The Economic Times)
Source: The Economic Times - April 2, 2021 Category: Consumer Health News Source Type: news

Leaders of Covid-hit German states call for national lockdown
Leading virologist says country is in ‘serious and complicated’ stage of pandemicCoronavirus – latest updatesSee all our coronavirus coverageRegional leaders of two German states badly hit by a third wave of coronavirus have urged the rest of the country to reimpose a tough lockdown to flatten infection rates, as a leading virologist said Germany was in a “serious and complicated” stage of the pandemic.In a joint letter reported on by S üddeutsche Zeitung newspaper, Bavaria’s conservative premier, Markus Söder, and the Green head of Baden-Württemberg, Winfried Kretschmann,...
Source: Guardian Unlimited Science - March 31, 2021 Category: Science Authors: Philip Oltermann in Berlin Tags: Coronavirus Germany Vaccines and immunisation Europe AstraZeneca Science World news Source Type: news

Why SARS-CoV-2 replicates better in the upper respiratory tract
(University of Bern) A team of researchers from the Institute for Infectious Diseases (IFIK) at the University of Bern and the Federal Institute of Virology and Immunology (IVI) have assessed virus growth and activation of the cellular defense mechanisms in the respiratory tract. They have shown that natural temperature differences that exist in the upper and lower respiratory tract have a profound influence on SARS-CoV-2 replication and subsequent innate immune activation in human cells. The findings can help to develop antiviral drugs and preventive measures. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 31, 2021 Category: Infectious Diseases Source Type: news

What We Know About the W.H.O.'s Inquiry on the Origin of Covid
Did Covid-19 come from animal markets? It ’s unclear. Did it emerge from a lab? Also unclear. Here’s what a new W.H.O. report says — including questions that the agency’s own chief raised about the findings. (Source: NYT Health)
Source: NYT Health - March 30, 2021 Category: Consumer Health News Authors: Javier C. Hern ández Tags: Coronavirus (2019-nCoV) World Health Organization Wuhan Institute of Virology (China) Wuhan (China) Source Type: news

Vaccines may need regular updates as coronavirus evolves, say scientists
In the research, virologists from Charite -- Universitatsmedizin Berlin in Germany studied the genetic evolution of the four currently known 'common cold' coronaviruses, particularly the two longest-known viruses, 229E and OC43. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 27, 2021 Category: Pharmaceuticals Source Type: news

Targeting the SARS-CoV-2 main protease
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Vinson, V. Tags: Microbiology, Virology twis Source Type: news

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. The main protease (Mpro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing Mpro inhibitors derived from either boceprevir or telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 Mpro activity in vitro, with 50% inhibitory concentration values ranging from 7.6 to 748.5 nM. The cocrystal structure of Mpro in complex with MI-23, one of the most potent compounds, revealed its in...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Qiao, J., Li, Y.-S., Zeng, R., Liu, F.-L., Luo, R.-H., Huang, C., Wang, Y.-F., Zhang, J., Quan, B., Shen, C., Mao, X., Liu, X., Sun, W., Yang, W., Ni, X., Wang, K., Xu, L., Duan, Z.-L., Zou, Q.-C., Zhang, H.-L., Qu, W., Long, Y.-H.-P., Li, M.-H., Yang, R. Tags: Microbiology, Virology reports Source Type: news

Potential COVID-19 treatment identified in UCLA-led lab study
This study identified a new potential therapy that could help the global fight against COVID-19 and support populations that have been disproportionately affected by this deadly disease.”Drugs are categorized as small molecules when their individual molecules are tiny enough that they can penetrate to where they are needed. The researchers screened 430 drugs from among the approximately 200,000 compounds in CNSI ’sMolecular Screening Shared Resource libraries. They identified 34  that demonstrated at least some ability to halt the coronavirus, and eight that did so at relatively lower doses, before zeroing...
Source: UCLA Newsroom: Health Sciences - March 24, 2021 Category: Universities & Medical Training Source Type: news

Gilead's virology drug head named CEO of East Coast biotech AlloVir
Dr. Diana Brainard, a 10-year veteran of Gilead Sciences Inc. who currently heads up the company's broad virology drug pipeline, will take over as CEO of a young cell therapy company backed by her soon-to-be former employer. Starting May 17, Brainard will lead AlloVir Inc. (NASDAQ: ALVR), a Cambridge, Massachusetts, company working on off-the-shelf, virus-specific T cell therapy candidates, including the coronavirus that causes Covid-19. She will leave Foster City-based-based Gilead (NASDAQ: GILD)… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - March 23, 2021 Category: Health Management Authors: Ron Leuty Source Type: news

Cambridge biotech taps Gilead's virology drug chief as its next CEO
Diana Brainard's new cell therapy company is working on off-the-shelf virus-specific T cell drug therapy candidates targeting 12 viruses, including the coronavirus that causes Covid-19. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 23, 2021 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

Reputation of AstraZeneca's COVID vaccine marred by missteps
"The way they handled their data early on, AstraZeneca basically shot themselves in the foot," Julian Tang, a virologist at the University of Leicester, said even before the latest issue arose. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 23, 2021 Category: Pharmaceuticals Source Type: news

Gilead's virology drug head to take East Coast biotech's CEO post
Diana Brainard's new cell therapy company is working on off-the-shelf virus-specific T cell drug therapy candidates targeting 12 viruses, including the coronavirus that causes Covid-19. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 22, 2021 Category: Biotechnology Authors: Ron Leuty Source Type: news

Gilead's virology drug head to take East Coast biotech's CEO post
Diana Brainard's new cell therapy company is working on off-the-shelf virus-specific T cell drug therapy candidates targeting 12 viruses, including the coronavirus that causes Covid-19. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - March 22, 2021 Category: Health Management Authors: Ron Leuty Source Type: news

COVID-19: Scientists, doctors launch virtual town halls to address vaccine concerns
(University of Virginia Health System) More than 50 scientific experts from across the United States, including virologists, infectious disease specialists and medical doctors, are launching a series of virtual town halls to answer the public's questions about the COVID-19 vaccines. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 22, 2021 Category: Infectious Diseases Source Type: news

US organization with ties to Wuhan lab failed to disclose taxpayer funding
(Natural News) An American non-profit organization closely tied to the Wuhan Institute of Virology (WIV) is being sued for its alleged failure to disclose that taxpayer funds supported its work. In its lawsuit, filed March 15, the White Coat Waste Project (WCWP) alleges that the EcoHealth Alliance (EHA)’s omission of taxpayer funding in its declarations violated a... (Source: NaturalNews.com)
Source: NaturalNews.com - March 21, 2021 Category: Consumer Health News Source Type: news

WHO investigator on CCP payroll still pushing debunked coronavirus lies
(Natural News) A top Wuhan coronavirus (COVID-19) investigator at the World Health Organization (WHO) is doubling down on the long-debunked lie that the Chinese virus originated spontaneously in bats at a Wuhan wet market rather than intentionally at the Wuhan Institute of Virology (WIV) under the direction of the Chinese Communist Party (CCP) and Anthony... (Source: NaturalNews.com)
Source: NaturalNews.com - March 18, 2021 Category: Consumer Health News Source Type: news

Former State Department investigator concludes coronavirus escaped from a Wuhan bioweapons lab
(Natural News) Did the Wuhan coronavirus (Covid-19) escape from communist China’s only level-four biosafety laboratory at the Wuhan Institute of Virology (WIV)? According to David Asher, the former State Department lead investigator for the Chinese virus, the answer is yes. Asher, who is now a senior fellow at the Hudson Institute, told Fox News during... (Source: NaturalNews.com)
Source: NaturalNews.com - March 18, 2021 Category: Consumer Health News Source Type: news

Studies chase clues to immune syndrome in kids
(Source: ScienceNOW)
Source: ScienceNOW - March 18, 2021 Category: Science Authors: Couzin-Frankel, J. Tags: Epidemiology, Medicine, Diseases, Virology In Depth Source Type: news

Medicine's longest year
(Source: ScienceNOW)
Source: ScienceNOW - March 18, 2021 Category: Science Authors: Servick, K., Couzin-Frankel, J., Matacic, C. Tags: Epidemiology, Medicine, Diseases, Scientific Community, Virology Feature Source Type: news

Expert virologist urges WHO to halt mass vaccination for coronavirus, warns about deadly "viral immune escape"
(Natural News) One of the world’s leading virologists and a strong proponent of vaccines is sounding the alarm about how Wuhan coronavirus (Covid-19) injections are going to trigger a global catastrophe of epic proportions. Dr. Geert Vanden Bossche, PhD, DVM, who has worked for GlaxoSmithKline (GSK), Novartis, the Bill & Melinda Gates Foundation, and the... (Source: NaturalNews.com)
Source: NaturalNews.com - March 16, 2021 Category: Consumer Health News Source Type: news

Another HIV Tivicay Birth Outcome: Better Infant Survival Another HIV Tivicay Birth Outcome: Better Infant Survival
Nearly 1 year after delivery, women living with HIV who were taking dolutegravir and TAF-containing regimens were less likely to experience virologic failure compared to those taking efavirenz.Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - March 15, 2021 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

New book details Dr. Fauci's involvement in Wuhan and the Chinese military's dangerous gain-of-function coronavirus research
(Natural News) Washington Post journalist Josh Rogin published a new book titled: “Chaos Under Heaven: Trump, Xi, and the Battle for the Twenty-First Century.” The new book provides valuable intel on the origins of SARS CoV-2. China’s Wuhan Institute of Virology (WIV) is home to the world’s most unethical gain-of-function research on virus infectivity. Scientists... (Source: NaturalNews.com)
Source: NaturalNews.com - March 14, 2021 Category: Consumer Health News Source Type: news

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human populations. The descendants of these viruses have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses. In the spike glycoprotein, we found that recurrent deletions overcome this slow substitution rate. Deletion variants arise in diverse genetic and geographic backgrounds, transmit efficiently, and are present in novel lineages, including those of current global conc...
Source: ScienceNOW - March 11, 2021 Category: Science Authors: McCarthy, K. R., Rennick, L. J., Nambulli, S., Robinson-McCarthy, L. R., Bain, W. G., Haidar, G., Duprex, W. P. Tags: Virology reports Source Type: news

Eluding detection
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Ash, C. Tags: Virology twis Source Type: news

Nigeria: Nigeria At Sixes and Sevens On Covid-19 Vaccine Rollout
[The Conversation Africa] Nigeria has started to vaccinate people after receiving its first batch of COVID-19 vaccines. Virologist and senior research fellow Dr Solomon Bakarey provides some insights on how the country should go about the rollout plan. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 10, 2021 Category: African Health Source Type: news

NHS COVID-19 app: privacy information, DHSC (updated 10th March 2021)
Privacy notice and data protection impact assessment for the NHS COVID-19 mobile app. 10 March 2021 Added link to frequently asked questions under'Right of access and requests for information'. 26 February 2021 Updated data protection impact assessment to reflect recent changes to the app and digital contact tracing functionality (provided by Apple and Google). Includes updates on virology testing, design objectives, coronavirus testing at scale, self-isolation countdown (isolate) and data dictionary. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 10, 2021 Category: Consumer Health News Source Type: news

Janssen Announces 96-week Results of Phase 3b Study Demonstrating the Continued Safety and Efficacy of Long-acting HIV Treatment of Rilpivirine and Cabotegravir
CORK, IRELAND, March 6, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today presented positive long-term data from the global Phase 3b trial of the first complete, long-acting (LA), two-drug injectable regimen (consisting of Janssen’s rilpivirine and ViiV Healthcare’s cabotegravir) for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults. The 96-week findings of the Antiretroviral Therapy as Long-Acting Suppression Every 2 Months (ATLAS-2M) trial confirmed the primary endpoint, met at Week 48, and met the secondary endpoint, showing efficacy of both month...
Source: Johnson and Johnson - March 6, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Coronavirus vaccine update: Second shot should cause fewer side effects - Dr Chris
THE VACCINE rollout continues at pace and a clear picture of the side effects is emerging. Virologist Dr Chris Smith weighed in on whether one can expect side effects from the second dose of vaccines. (Source: Daily Express - Health)
Source: Daily Express - Health - March 1, 2021 Category: Consumer Health News Source Type: news

South Africa: How Does the J & J Vaccine Compare?
[The Conversation Africa] The U.S. Food and Drug Administration has authorized the use of the Johnson& Johnson coronavirus vaccine in adults. Maureen Ferran, a virologist at the Rochester Institute of Technology, explains how this third authorized vaccine works and explores the differences between it and the Moderna and Pfizer-BioNTech vaccines that are already in use. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 28, 2021 Category: African Health Source Type: news

Covid vaccine side effects: The side effects to expect from the second jab - Dr Chris
THE VACCINE rollout continues at pace and a clear picture of the side effects is emerging. Virologist Dr Chris Smith weighed in on whether one can expect side effects from the second dose of vaccines. (Source: Daily Express - Health)
Source: Daily Express - Health - February 27, 2021 Category: Consumer Health News Source Type: news

SARS-CoV-2 mutations in competition
(University of Bern) How dangerous are new mutations of the SARS-CoV-2 virus? An international team involving researchers from the Institute of Virology and Immunology (IVI) of the Federal Food Safety and Veterinary Office BLV and the University of Bern (Switzerland), the Centers for Disease Control and Prevention (USA), and the Friedrich-Loeffler Institute (Germany), has developed an approach that can accurately assess the transmissibility of new virus mutants. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Human infection with avian influenza A (H5N8) – the Russian Federation
On 18 February 2021, the National IHR Focal Point for the Russian Federation notified WHO of detection of avian influenza A(H5N8) in seven human clinical specimens. These are the first reported detection of avian influenza A(H5N8) in humans. Positive clinical specimens were collected from poultry farm workers who participated in a response operation to contain an avian influenza A(H5N8) outbreak detected in a poultry farm in Astrakhan Oblast in the Russian Federation. The laboratory confirmation of the seven specimens were performed by the State Research Centre for Virology and Biotechnology VECTOR (WHO H5 Reference Labora...
Source: WHO Disease Outbreaks - February 26, 2021 Category: Infectious Diseases Tags: news Source Type: news

We ’ll Probably Never Eliminate COVID-19 from the U.S. It’s Still Worth Trying
2021 got off to a grim pandemic start in the U.S. A huge surge in COVID-19 cases followed the holiday season, peaking at around 300,000 new cases on Jan. 8, 2020. More than 20,000 Americans lost their lives to the virus in a single week in January alone and over 146,00 in total have died since the start of the year. But six weeks later, the picture looks more promising. New daily cases have fallen sharply, daily deaths have fallen to levels not seen since Thanksgiving, and the pace of vaccine roll-out is speeding up. These positive trends mean that we can now begin to ask what the endgame might look like. Would we be happy...
Source: TIME: Health - February 25, 2021 Category: Consumer Health News Authors: William Hanage and Gavin Yamey Tags: Uncategorized COVID-19 Source Type: news

Hurting the virus by targeting the host
(Source: ScienceNOW)
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Vinson, V. Tags: Medicine, Diseases, Virology twis Source Type: news

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with the eukaryotic translation machinery, and inhibitors of translation have potent antiviral effects. We found that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (90% inhibitory concentration = 0.88 nM) that is more potent than remdesivir against SARS-CoV-2 in vitro by a factor of 27.5, with limited toxicity in cell culture. Through the use of a drug-resistant mutant, we show that the antiviral activity of plitidepsin against SARS-CoV-2 is mediated through inhibition of the known target...
Source: ScienceNOW - February 25, 2021 Category: Science Authors: White, K. M., Rosales, R., Yildiz, S., Kehrer, T., Miorin, L., Moreno, E., Jangra, S., Uccellini, M. B., Rathnasinghe, R., Coughlan, L., Martinez-Romero, C., Batra, J., Rojc, A., Bouhaddou, M., Fabius, J. M., Obernier, K., Dejosez, M., Guillen, M. J., Los Tags: Medicine, Diseases, Virology r-articles Source Type: news