Editorial: Immune-mediated disorders of the spinal cord: Diagnosis, treatment strategies, and outcomes in the 21st century
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

New onset headache during delivery and postpartum: Clinical characteristics of a case series
DiscussionThe onset of a headache attack during labor in women who usually do not experience headache suggests other pathogenic mechanisms underlying the attack and merits further study. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

Functional improvement in individuals with chronic spinal cord injury treated with 4-aminopyridine: A systematic review
ConclusionsThis review confirms the efficacy of 4-AP in improving several conditions resulting from SCI but further research on this topic is warranted. Additional randomized clinical trials with 4-AP involving larger sample sizes are needed, as are consistent outcome measures in order to obtain adequate data for analysis with a view to enhance treatment benefits.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=334835, PROSPERO CRD42022334835. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

Case report: Varicella-zoster virus infection triggering progressive encephalomyelitis with rigidity and myoclonus
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare neurological disease of unknown etiology, and most patients with PERM are positive for anti-glycine receptor (GlyR) antibody. In this case study, we report a clinical case of a varicella-zoster virus-infected patient who developed anti-GlyR antibody-positive PERM. He initially suffered from herpes zoster and gradually developed symptoms of impaired brainstem functions including hoarse voice and dysphagia, accompanied by paroxysmal sympathetic hyperactivity. The patient also suffered from severe spasms, which were easily triggered by external stimuli...
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

The diagnostic value of the ocular tilt reaction plus head tilt subjective visual vertical ( ±45°) in patients with acute central vascular vertigo
ConclusionsThe evaluation of OTR plus head tilt SVV (±45°) in vertigo patients is helpful for identifying and diagnosing ACVV, especially when SD is ≥ 3° or the E-effect is symmetrically increased. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

Shifts in the clinical epidemiology of severe malaria after scaling up control strategies in Mali
A decrease in malaria incidence following implementation of control strategies such as use of artemisinin-based combination therapies, insecticide-impregnated nets, intermittent preventive treatment during pregnancy and seasonal malaria chemoprevention (SMC) has been observed in many parts of Africa. We hypothesized that changes in malaria incidence is accompanied by a change in the predominant clinical phenotypes of severe malaria. To test our hypothesis, we used data from a severe malaria case-control study that lasted from 2014–2019 to describe clinical phenotypes of severe forms experienced by participants enrolled i...
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

Leptospira infection complicated by demyelinating disease: A case report
Leptospirosis is a zoonotic disease, found worldwide, that is caused by bacteria of the genus Leptospira. People can be infected with Leptospira if they come in direct contact with the urine of an infected animal. Leptospirosis may be associated with demyelinating lesions of the central nervous system. This case report describes a 66-year-old female patient who presented with fever and generalized aches and progressed to unconsciousness within a few hours of admission. Laboratory tests showed Leptospira infection, and brain magnetic resonance imaging revealed acute demyelinating lesions. The patient responded well to penic...
Source: Frontiers in Neurology - November 29, 2022 Category: Neurology Source Type: research

Diagnosis and treatment of brain injury complicated by hypernatremia
Hypernatremia is a common electrolyte disorder in patients with brain injury. The mortality of brain injury patients with severe hypernatremia may be as high as 86.8%. The efficacy of conventional treatment for hypernatremia is limited. Continuous renal replacement therapy (CRRT) can slowly, controllably, and continuously reduce the blood sodium concentration and gradually become an important treatment for severe hypernatremia patients. This review aims to provide important information for clinicians and clinical researchers by describing the etiology, diagnosis, hazards, conventional treatment, and CRRT treatment of hyper...
Source: Frontiers in Neurology - November 28, 2022 Category: Neurology Source Type: research

Different assessment tools to detect sarcopenia in patients with Parkinson's disease
ConclusionSarcopenia prevalence in patients with PD in Tirol, Austria is higher with EWGSOP-1 criteria compared to EWGSOP-2 criteria. The sensitivity and specificity of the SARC-F scale to detect sarcopenia in this population are poor. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 28, 2022 Category: Neurology Source Type: research

The correlation between serum Cyclophilin A level and severity, prognosis of craniocerebral injury
ConclusionSerum Cyp A has a certain predictive value for the prognosis of patients with different severity of craniocerebral injury. Among them, patients with severe craniocerebral injury have the highest predictive value and mild craniocerebral injury patients have the least. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 28, 2022 Category: Neurology Source Type: research

Data-driven clustering of combined Functional Motor Disorders based on the Italian registry
ConclusionUsing a data-driven approach of clinical data from the Italian registry, we differentiated clinical subtypes among combined FMDs to be validated by prospective studies. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 28, 2022 Category: Neurology Source Type: research

Memory decline in young stroke survivors during a 9-year follow-up: A cohort study
ConclusionYoung stroke survivors might be at risk of memory decline over the decade following the stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 25, 2022 Category: Neurology Source Type: research

Repetitive bout of controlled soccer heading does not alter heart rate variability metrics: A preliminary investigation
ConclusionWhereas, symptoms as measured by the SCAT3 were induced following an acute bout of controlled soccer heading, these preliminary findings indicate they were not accompanied by alterations to autonomic function. Ultimately, this demonstrates further research is needed to understand the physiological underpinnings of alterations in brain function occurring immediately after a bout of soccer heading and how these may, over time, contribute to long-term neurological impairments. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 25, 2022 Category: Neurology Source Type: research

Regional brain dysfunction in insomnia after ischemic stroke: A resting-state fMRI study
ConclusionPatients with PSI have abnormal local activities in multiple brain regions, including the visual processing-related cortex, sensorimotor cortex, and some default-mode network (DMN) regions. Over-arousal of the DMN and over-sensitivity of the audiovisual stimuli in patients with PSI may be the main mechanisms of insomnia and can lead to a decline in cognitive function and abnormalities in emotion regulation simultaneously. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 25, 2022 Category: Neurology Source Type: research

Prenatal exposure to antibiotics and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis
ConclusionPrenatal antibiotic exposure during pregnancy is linked to a higher incidence of ADHD and epilepsy in the offspring. Further prospective studies that compare prenatal antibiotic use and are adjusted for various confounders are needed to further assess the association of prenatal antibiotic exposure and neurological disorders in offspring.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022306248. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 25, 2022 Category: Neurology Source Type: research