Association of aquaporin-4 antibody-seropositive optic neuritis with vision-related quality of life and depression
ConclusionAQP4-positive optic neuritis is associated with a decline in vision-related quality of life as well as an increased likelihood of experiencing depression. It is crucial for clinicians to assess both vision-related QoL and depression in patients with AQP4-positive optic neuritis to provide patient-centered care. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Neuroendoscopy surgery for hypertensive intracerebral hemorrhage with concurrent brain herniation: a retrospective study of comparison with craniotomy
ConclusionNeuroendoscopy can safely and effectively remove the intracranial hematoma in patients with hypertensive intracerebral hemorrhage and cerebral hernia, significantly shorten the operation time, reduce the amount of intraoperative hemorrhage, shorten the ICU stay. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
A case report of neurosyphilis coexisting with a positive MOG antibody manifested as optic neuritis
ConclusionNeurosyphilis could be a potential triggering factor for MOGAD. In patients with neurosyphilis, it is strongly recommended to perform testing for MOG antibody along with other brain disease antibodies. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Diagnosing multiple system atrophy: current clinical guidance and emerging molecular biomarkers
Multiple system atrophy (MSA) is a rare and progressive neurodegenerative disorder characterized by motor and autonomic dysfunction. Accurate and early diagnosis of MSA is challenging due to its clinical similarity with other neurodegenerative disorders, such as Parkinson’s disease and atypical parkinsonian disorders. Currently, MSA diagnosis is based on clinical criteria drawing from the patient’s symptoms, lack of response to levodopa therapy, neuroimaging studies, and exclusion of other diseases. However, these methods have limitations in sensitivity and specificity. Recent advances in molecular biomarker research, ...
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Case report: A novel CACNA1S mutation associated with hypokalemic periodic paralysis
ConclusionNovel CACNA1S mutation, associated with HypoKPP was identified. Monte-Carlo energy minimization of the CaV1.1 model supported the association of this mutation with this disease. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
CRISPR deletion of a SINE-VNTR-Alu (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the MAPT locus
In this study, we provide data highlighting the SVA-specific effect on differential gene expression. We demonstrate that the hemizygous deletion of the endogenous SVA_67 in CRISPR edited cell lines was associated with differential expression of several genes at the MAPT locus associated with neurodegenerative diseases including KANSL1, MAPT and LRRC37A.DiscussionThis data is consistent with our previous bioinformatic work of differential gene expression analysis using transcriptomic data from the Parkinson’s Progression Markers Initiative (PPMI) cohort. As SVAs have regulatory influences on gene expression, and insertion...
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Functional MRI evaluation of hyperbaric oxygen therapy effect on hand motor recovery in a chronic post-stroke patient: a case report and physiological discussion
ConclusionThis study provides additional insights into HBOT-induced brain plasticity and functional improvement in chronic post-stroke patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Clinical outcome and outcome prediction of octogenarians with acute basilar artery occlusion and endovascular stroke treatment compared to younger patients
ConclusionOctogenarians with acute BAO eligible for EST are as likely to achieve a favorable outcome as YPs, and the rate of death or severe disability is comparable. The admission NIHSS is an independent predictor for favorable and unfavorable outcomes in YP and for favorable outcomes in octogenarians. In this study cohort, pre-stroke mRS predicted favorable outcomes in octogenarians while age predicted an unfavorable outcome in YPs. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Case report: Giant atypical granular cell tumor of the median nerve
Granular cell tumors are extremely uncommon soft tissue neoplasms that mostly occur in the head and neck regions. Granular cell tumors are generally benign, asymptomatic, and rarely involve the median nerve. Due to the lack of awareness about granular cell tumors, they are easily misdiagnosed and mistreated in primary hospitals. Here, we report a giant atypical granular cell tumor located on the median nerve, approximately 12 cm in size, with unusual symptoms of median nerve damage. Magnetic resonance imaging revealed a fusiform mass that was hyperintense on T2-weighted images and iso-hypointense on T1-weighted images. The...
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Current role of portable MRI in diagnosis of acute neurological conditions
This article reviews pMRI technologies and their clinical implications in acute neurological conditions. Benefits of pMRI include timely and accurate detection of major acute neurological pathologies such as stroke and intracranial hemorrhage. Additionally, pMRI can be potentially used to monitor the progression of neurological complications by facilitating serial measurements at the bedside. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Computer-assisted cognitive rehabilitation in neurological patients: state-of-art and future perspectives
ConclusionAccording to our results, CCT entails the possibility to continue cognitive training also in different settings, such as home, which is a significant breakthrough for the improvement of community care. Other possible areas of use should be the increase in the amount of cognitive therapy in the free time during the hospital stay. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Net water uptake within the ischemic penumbra predicts the presence of the midline shift in patients with acute ischemic stroke
ConclusionNet water uptake measured acutely within the ischemic penumbra could predict severe cerebral edema at 24–48 h. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 29, 2023 Category: Neurology Source Type: research
Stroke-induced damage on the blood –brain barrier
The blood–brain barrier (BBB) is a functional phenotype exhibited by the neurovascular unit (NVU). It is maintained and regulated by the interaction between cellular and non-cellular matrix components of the NVU. The BBB plays a vital role in maintaining the dynamic stability of the intracerebral microenvironment as a barrier layer at the critical interface between the blood and neural tissues. The large contact area (approximately 20 m2/1.3 kg brain) and short diffusion distance between neurons and capillaries allow endothelial cells to dominate the regulatory role. The NVU is a structural component of the BBB. Individu...
Source: Frontiers in Neurology - September 28, 2023 Category: Neurology Source Type: research
Editorial: MOGAD, current knowledge and future trends
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 28, 2023 Category: Neurology Source Type: research
Outcome of early rehabilitation of patients with traumatic brain injury during COVID-19 pandemic in The Republic of Srpska, Bosnia and Herzegovina
ConclusionThe COVID-19 pandemic had a significant effect on the epidemiological data but not on the clinical outcome of patients with TBI. Early rehabilitation proved to be effective and to contribute to positive treatment outcome. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 28, 2023 Category: Neurology Source Type: research
