Association between systemic immune-inflammation index and post-stroke depression: a cross-sectional study of the national health and nutrition examination survey 2005 –2020
ConclusionThe results of our research support the existence of a significant positive correlation between SII levels and PSD. Further prospective trials are required to comprehend SII, which is for the PSD thoroughly. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 15, 2024 Category: Neurology Source Type: research
Risk of intracranial hemorrhage in patients using anticoagulant therapy for atrial fibrillation after cerebral microbleeds combined with acute ischemic stroke: a meta-analysis
ConclusionAnticoagulant therapy for ischemic stroke patients with non-valvular AF and CMBs increases future ICH risk. Discontinuing anticoagulation due to ICH risk should be avoided. NOACs are safe and effective for patients with CMBs and IS. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 15, 2024 Category: Neurology Source Type: research
Rethinking the effects of adjuvant beam radiation therapy on overall survival in atypical meningioma patients: age considerations
ConclusionOur study found that ABRT enhanced OS in younger primary single intracranial AM patients. But we also revealed a negative correlation between OS and ABRT in older patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 15, 2024 Category: Neurology Source Type: research
Suppression head impulse test in children —experiences in a tertiary paediatric vestibular centre
This study is a retrospective case note audit over a period of 2 months in a tertiary pediatric vestibular center in the United Kingdom to investigate whether SHIMP is safe/robust to be used in children conforming to existing standards/norms in normal children and whether it yields any meaningful inferences in pediatric vestibular hypofunction. This is the largest pediatric SHIMP study to date. A total of 44 referred children (6–18 years, female children>male children) with a range of complaints from dizziness, imbalance, motor incoordination, postural instability, and hearing loss were included, and their SHIMP p...
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
Peripheral T cell immune repertoire is associated with the outcomes of acute spontaneous intracerebral hemorrhage
This study reveals the occurrence of peripheral T-cell diminishment and activation in response to acute hematoma. ICH lesion also alters the T cell receptor (TCR) immune repertoire, which is associated with patient prognosis. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
POLR3-related leukodystrophy caused by biallelic POLR3A and 1C pathogenic variants: a single-center experience
ConclusionThe phenotypic diversity of POLR3-HLD associated with pathogenic variants ranges from mild to very severe for neurological and non-neurological symptoms. Most patients presented symptoms in the first 2 years of life. The c.1771-6C>G or c.1771-7C>G variant is the most frequent mutation site in POLR3A in Chinese individuals. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
Editorial: Methodological development and applications of nonlinear dynamic analysis for neuroimaging
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
Association between social determinants of health and pediatric traumatic brain injury outcomes
DiscussionPatients from minority backgrounds had more severe injuries, many resulting from pedestrian vs. motor vehicle accidents. Additionally, patients from minority backgrounds experience more social vulnerability and lower opportunity. Despite these discrepancies, we did not observe differences on rates of mortality or functional outcomes in either racial or ethnic groups. SDH were not found to impact outcomes. Further research is needed to determine how these complex social and environmental variables impact health outcomes. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
Myelin oligodendrocyte glycoprotein antibody titers by fixed cell-based assay: positive predictive value and impact of sample collection timing
ConclusionOverall PPV of anti-MOG testing by fixed CBA was reasonably high. The PPV of low-positive anti-MOG was significantly lower than clear-positive anti-MOG. This was driven by the significantly lower PPV of low-positive anti-MOG in adults, possibly reflecting the lower prevalence of MOG antibody-associated disease among adults tested. Timing of sample collection relative to administration of immunotherapy and symptom onset may substantially impact titers, indicating that testing should ideally be performed prior to immunotherapy and close to time of attack. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
Exploring brain network oscillations during seizures in drug-na ïve patients with juvenile absence epilepsy
ConclusionThe present study supported the idea that the changes in the EEG brain networks in JAE patients are characterized by decreased global and local efficiency and clustering coefficient in the alpha band. Moreover, the onset of seizures is accompanied by excessively enhanced network efficiency. JAE patients with different ictal discharge patterns may have different functional network oscillations. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 14, 2024 Category: Neurology Source Type: research
Risk factors and outcomes after interruption of sedation in subarachnoid hemorrhage (ROUTINE-SAH) —a retrospective cohort study
ConclusionIn aSAH, complications during the definite withdrawal of sedation are frequent but can potentially be predicted using clinical parameters available at the bedside. Prospective multicenter studies are essential to validate these results and further investigate the impact of IS complications. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 13, 2024 Category: Neurology Source Type: research
Hyperbaric oxygen therapy for thalamic pain syndrome: case report
Thalamic pain syndrome is a distressing type of central post-stroke pain (CPSP) that occurs in up to 10% of cases following a cerebrovascular accident, typically with a delayed onset of signs and symptoms, and is often chronic or even life-long. Thalamic pain syndrome, as is the case for other CPSPs, is difficult to treat, and the response is typically moderate at best. Central pain also occurs after vascular insults in parts of the CNS other than the thalamus. Only a few patients present with the classic “Dejerine and Roussy syndrome,” so the term CPSP is preferred for describing neuropathic pain after stroke. There a...
Source: Frontiers in Neurology - March 13, 2024 Category: Neurology Source Type: research
A clinical-radiomics combined model based on carotid atherosclerotic plaque for prediction of ischemic stroke
ConclusionCompared with other models, the radiomics_T1CE model based on HR-VWMRI combined clinical characteristics, which is a combined_T1CE model, can accurately predict the risk of ischemic stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 13, 2024 Category: Neurology Source Type: research
Do people with ME/CFS and joint hypermobility represent a disease subgroup? An analysis using registry data
ConclusionME/CFS patients with joint hypermobility, particularly those with EDS, demonstrate distinct clinical characteristics, including more severe symptomatology and reduced HRQOL. These findings highlight the need for comprehensive clinical assessments of ME/CFS patients with joint hypermobility. Understanding these relationships could aid in subgroup identification, improving diagnosis, and informing targeted therapeutic approaches. Further research is warranted to explore these associations and their implications for clinical practice. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 13, 2024 Category: Neurology Source Type: research
Overlapping and distinct phenotypic profiles in Alzheimer ’s disease and late onset epilepsy: a biologically-based approach
We describe the neurobiological decline occurring at different spatial in AD and LOE patients, which may explain why their phenotypes overlap and differ. We provide suggestions for clinical recognition of dual presentation and novel approaches for behavioral testing that reflect an “inside-out,” or biologically-based approach to testing memory. New memory and language assessments could detect—and treat—memory impairment in AD and LOE at an earlier, actionable stage. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 13, 2024 Category: Neurology Source Type: research
