Identification of co-expressed central genes and transcription factors in atherosclerosis-related intracranial aneurysm
ConclusionIntracranial aneurysms are correlated with atherosclerosis. We identified several hub genes for atherosclerosis-related intracranial aneurysms and explored the underlying pathogenesis. These discoveries may provide new insights for future experiments and clinical practice. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 2, 2023 Category: Neurology Source Type: research
Case report: Left gaze and facial nerve palsies after ventral intermediate thalamic nucleus deep brain stimulation implantation
Deep brain stimulation (DBS) to the ventral intermediate nucleus (VIM) of the thalamus has become a common procedure for some refractory, medication-resistant movement disorders like essential tremors. The most common adverse effects from this surgery include dysarthria and gait disturbances. This case report details a left gaze and ipsilateral facial nerve palsy following overshot cannula insertion into the pons during a VIM DBS procedure. Initial patient presentation after surgery revealed significant impairment of horizontal gaze to the left. This improved during follow-up visits and after the recession of the bilateral...
Source: Frontiers in Neurology - March 2, 2023 Category: Neurology Source Type: research
Nasal-temporal asymmetric changes in retinal peripheral refractive error in myopic adolescents induced by overnight orthokeratology lenses
ConclusionThis study demonstrated that after orthokeratology, relative peripheral hyperopia in the myopic patients turned into relative peripheral myopia, and the nasal-temporal asymmetry changed significantly after orthokeratology, which was correlated with the baseline refractive state. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 2, 2023 Category: Neurology Source Type: research
The effects of melatonin in the treatment of acute brachial plexus compression injury in rats
This study was conducted to evaluate the effects of melatonin in the treatment of acute brachial plexus compression injury in rats using histopathological, histomorphometric, immunohistochemical and electrophysiological methods. Forty-eight adult male Sprague Dawley rats were randomly allocated into three groups: sham, melatonin and vehicle groups. The brachial plexus compression injury model was performed by a vascular clamp. Melatonin group received intraperitoneal injection of melatonin at doses of 10 mg/kg for 21 days after crush injury. The conduction velocity and amplitude of compound muscle action potential (CAMP) i...
Source: Frontiers in Neurology - March 1, 2023 Category: Neurology Source Type: research
Neurochemical and microstructural alterations in bipolar and depressive disorders: A multimodal magnetic resonance imaging study
ConclusionThe findings demonstrated that both patients with UD and BD have abnormal microstructure and metabolic alterations, and the changes are not completely consistent in the prefrontal lobe region. Elevated Glu, Cho, and GluCEST% in the ACC and VPFWM of patients with UD and BD may help in differentiating between these two disorders. Our findings support the significance for the microstructural integrity and brain metabolic changes of the prefrontal lobe region in BD and UD. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 1, 2023 Category: Neurology Source Type: research
Supplementing transcranial direct current stimulation to local infiltration series for refractory neuropathic craniocephalic pain: A randomized controlled pilot trial
DiscussionThis pilot trial does not support series of anodal tDCS as neuro-modulatory treatment to enhance pain alleviation of local anesthetic infiltration series. Notably, results may indicate placebo effects of tDCS settings. Feasibility of studies in this population was limited due to relevant drop-out rates. Anodal tDCS warrants further confirmation as neuro-modulatory pain treatment option. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 1, 2023 Category: Neurology Source Type: research
Case report: Saccadic ping-pong gaze in progressive supranuclear palsy with predominant postural instability
We report a 63-year-old female patient with progressive supranuclear palsy (PSP). She presented predominant postural instability and “saccadic ping-pong gaze” (SPPG). She had unprovoked falls recurrently within a year from the onset of gait disturbance. She tended to fall backward with eye closure but had no freezing of gait on examination. She showed no signs of nuchal dystonia, limb tremor, rigidity, spasticity, or ataxia. The dopaminergic response was negative. On the initial examination, her vertical eye movements were normal, but frequent macro square wave jerks and SPPG were observed. SPPG consisted of short-cycl...
Source: Frontiers in Neurology - March 1, 2023 Category: Neurology Source Type: research
Can non-swallowing function assessment predict nasogastric tube removal in patients with poststroke dysphagia? A clinical study
ConclusionWe established a predictive model in patients with PSD using a non-swallowing assessment, which enabled us to predict swallowing recovery based on the non-swallowing function. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 1, 2023 Category: Neurology Source Type: research
Editorial: The role of gene mutations in the neuropathology of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) – Progress and challenges
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
Role of LDL-C level alteration in increased mortality risks in spontaneous intracerebral hemorrhage patients: Systematic review and meta-analysis
ConclusionsThis meta-analysis suggests a higher LDL-C level may decrease the mortality risk in sICH patients. LDL-C level increase is inversely associated with the 3-month mortality risks in these patients but not significantly correlated with the in-hospital mortality risks. Further well-designed prospective studies with extended follow-up periods are needed to confirm these findings and explore underlying cross-talks.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022318318, identifier: PROSPERO 2022 CRD42022318318. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
Ethiopians' knowledge of and attitudes toward epilepsy: A systematic review and meta-analysis
ConclusionIn the current review, we found out that there is a huge knowledge gap and an unfavorable level of attitudes towardepilepsy, which demand immediate public health action as well as a targeted policy intervention. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease
Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD) is a spectrum of diseases, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis, and cerebral cortical encephalitis. In addition to distinct clinical, radiological, and immunological features, the infectious prodrome is more commonly reported in MOGAD (37–70%) than NMOSD (15–35%). Interestingly, pediatric MOGAD is not more aggressive than adult-onset MOGAD, unlike in multiple sclerosis (MS), where annualized relapse rates are three times higher in pediatric-onset MS. MOGAD pathophysiology is driven by acute attacks during which ...
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
Pipeline embolization devices for the treatment of nonsaccular aneurysms in pediatric patients
ConclusionsThe use of PEDs to treat pediatric nonsaccular aneurysms is feasible, with a high rate of complete occlusion of the aneurysm and favorable follow-up outcomes. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
The need for a tailored national dementia plan in Ethiopia: A call for action
Globally, a rapid demographic transition is occurring with a significant increment in the proportion of older individuals. For the first time in history, individuals aged 65 and above outnumber that of children under 5 years of age. In Ethiopia, the life expectancy has shown dramatic improvements in the past few decades and is expected to reach 74 years by mid-century. Older age is considered the most important non-modifiable risk factor for dementia. Likewise, other modifiable diseases such as infectious diseases, non-communicable diseases, particularly cardiovascular diseases, and traumatic brain injuries are associated ...
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
Gait and turning characteristics from daily life increase ability to predict future falls in people with Parkinson's disease
ConclusionsThese findings highlight the importance of considering precise digital measures, captured via sensors strategically placed on the feet and low back, to quantify several different aspects of gait (walking and turning) during daily life to improve the classification of future fallers in PD. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2023 Category: Neurology Source Type: research
