Bioinformatic identification of potential biomarkers and therapeutic targets in carotid atherosclerosis and vascular dementia
BackgroundVascular disease is the second most common cause of dementia. The prevalence of vascular dementia (VaD) has increased over the past decade. However, there are no licensed treatments for this disease. Carotid atherosclerosis (CAS) is highly prevalent and is the main cause of ischemic stroke and VaD. We studied co-expressed genes to understand the relationships between CAS and VaD and further reveal the potential biomarkers and therapeutic targets of CAS and VaD.MethodsCAS and VaD differentially expressed genes (DEGs) were identified through bioinformatic analysis Gene Expression Omnibus (GEO) datasets GSE43292 and...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Rescue stenting after the failure of mechanical thrombectomy to treat acute intracranial atherosclerotic occlusion
ConclusionsRescue stenting after MT failure might be a feasible rescue modality for treating acute intracranial atherosclerotic occlusion. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Systemic inflammation response index as a prognostic predictor in patients with acute ischemic stroke: A propensity score matching analysis
ConclusionA higher SIRI (≥4.57) was associated with a higher risk of 90-day, 30-day, and 1-year mortality and was an independent risk factor of mortality in patients with acute ischemic stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Image-to-image generative adversarial networks for synthesizing perfusion parameter maps from DSC-MR images in cerebrovascular disease
Stroke is a major cause of death or disability. As imaging-based patient stratification improves acute stroke therapy, dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is of major interest in image brain perfusion. However, expert-level perfusion maps require a manual or semi-manual post-processing by a medical expert making the procedure time-consuming and less-standardized. Modern machine learning methods such as generative adversarial networks (GANs) have the potential to automate the perfusion map generation on an expert level without manual validation. We propose a modified pix2pix GAN with a tempo...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Case report: KPTN gene-related syndrome associated with a spectrum of neurodevelopmental anomalies including severe epilepsy
Biallelic variants in the kaptin gene KPTN were identified recently in individuals with a novel syndrome referred to as autosomal recessive intellectual developmental disorder 41 (MRT41). MRT41 is characterized by developmental delay, predominantly in language development, behavioral abnormalities, and epilepsy. Only about 15 affected individuals have been described in the literature, all with primary or secondary macrocephaly. Using exome sequencing, we identified three different biallelic variants in KPTN in five affected individuals from three unrelated families. In total, two KPTN variants were already reported as a lo...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Admission neutrophil-to-lymphocyte ratio to predict 30-day mortality in severe spontaneous basal ganglia hemorrhage
ConclusionsThe NLR is expected to be a potential biomarker for predicting the prognosis of patients with severe basal ganglia hemorrhage. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Pediatric dumbbell-shaped orbital schwannoma with extension to the cranial cavity: A case report and literature review
Orbital schwannomas are rare in children, especially those with intracranial extension. Herein, our report refers to a 12-year-old boy who had a cranial-orbital mass with a dumbbell-like appearance. The total neoplasms was successfully removed via a transcranial approach, and the pathological diagnostic result was schwannoma. Neither radiotherapy nor chemotherapy was performed after surgery, and no recurrences were observed for 3 months. Our report suggests that orbital schwannomas should be differentiated from other types of orbital tumors with sufficient evidence and that complete surgical resection remains the first cho...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden
ConclusionADAMTS-13 activity is inversely correlated with the number of vascular risk factors across different stroke etiologies. Further study is warranted to establish ADAMTS-13 as a mediator of cerebrovascular risk. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Risk factors and complications associated with intra-operative or post-operative identification of a PFO in cardiac surgery patients: A cohort study
ConclusionPatent foramen ovale finding incidence in peri-operative cardiac surgery care was rare (2%) but post-operative finding of PFO was associated with a increased risk of ischemic strokes, worsened respiratory outcomes, and prolonged hospitalization. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

EMG biofeedback combined with rehabilitation training may be the best physical therapy for improving upper limb motor function and relieving pain in patients with the post-stroke shoulder-hand syndrome: A Bayesian network meta-analysis
ConclusionEMG biofeedback combined with rehabilitation training may be the best physical therapy for improving upper limb motor function and relieving pain in patients with post-stroke SHS according to our Bayesian network meta-analysis results. However, the above conclusions need further analysis and validation by more high-quality RCTs.Systematic review registrationwww.crd.york.ac.uk/prospero/, identifier: CRD42022348743. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Dimorphic glioblastoma with glial and epithelioid phenotypes: Clonal evolution and immune selection
ConclusionEpithelioid glioblastoma may be genomically more unstable and oncogenically more advanced, harboring an increased number of mutations and karyotype abnormalities, compared to typical glioblastomas. The tumor immune microenvironment is also different. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Case report: Utilization and efficacy of large-bore catheters in mechanical thrombectomies
This report focuses on the Zoom 0.088” large-bore catheter, which has the potential to be navigated into a large vessel for thrombus removal via aspiration, and weigh the risks and benefits of its utilization in thrombectomy patients. In this case, we discuss the use of this device for thrombectomy of a left M1 middle cerebral artery occlusion that resulted in a distal left MCA dissection and eventual loss of access to the site of the thrombus. Ultimately, the patient died from a large stroke in the left MCA territory. In light of this occurrence, we seek to explore the utility and feasibility of large-bore catheters and...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Unilateral biportal endoscopic lumbar interbody fusion enhanced the recovery of patients with the lumbar degenerative disease compared with the conventional posterior procedures: A systematic review and meta-analysis
ConclusionCompared with conventional MI-TLIF and PLIF, ULIF was associated with reduced EBL, shorter LOS, and comparable fusion rate as well as complication management. Compared with MI-TLIF, a better short-term improvement in VAS-BP and ODI was achieved by ULIF; compared with open PLIF, additional enhanced short-term improvement in VAS-LP and long-term improvement in ODI were observed in ULIF. ULIF could enhance the recovery of patients with LDD compared with conventional posterior procedures.Systematic trial registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230695, CRD42021230695. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Impact of polycyclic aromatic hydrocarbon exposure on cognitive function and neurodegeneration in humans: A systematic review and meta-analysis
This article documents an emerging body of evidence concerning the neurological effect of polycyclic aromatic hydrocarbon (PAH) exposure with regard to cognitive function and increased risk of neurodegeneration.MethodsTwo electronic databases, PubMed and Web of Science, were systematically searched.ResultsThe 37/428 studies selected included outcomes measuring cognitive function, neurobehavioral symptoms of impaired cognition, and pathologies associated with neurodegeneration from pre-natal (21/37 studies), childhood (14/37 studies), and adult (8/37 studies) PAH exposure. Sufficient evidence was found surrounding pre-natal...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Case report: Paralysis after epidural analgesia due to a hemorrhage of pure epidural venous hemangioma
ConclusionsBefore administering epidural analgesia to relieve undetermined pain, it is prudent to carefully weigh potential benefits against potential risks to patient health to minimize the likelihood of complications. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research