Is Alzheimer's disease an individual-centered disease? Hypotheses from the atomic levels up to mathematical models for biological systems
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research

Assessment of focused ultrasound stimulation to induce peripheral nerve activity and potential damage in vivo
DiscussionPast reports on the ability of ultrasound to stimulate the peripheral nerve are controversial. After testing a wide range of FUS conditions, we conclude that it is not a reliable and safe method for stimulating the peripheral nerve. Special consideration should be taken, especially when low-frequency FUS is applied, as it may lead to nerve damage. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research

Stroke-associated pneumonia according to mCDC criteria: impact on prognosis and antibiotic therapy
The objective was to investigate the impact of SAP on stroke outcome depending on whether or not it conforms to mCDC criteria. Our secondary objective was to identify the responsible factors for antibiotic initiation in stroke patients.MethodsWe conducted a prospective, multicenter, observational study of ischemic stroke patients with moderate to severe stroke (NIHSS≥4) admitted within 24 h. For 7 days, mCDC criteria were assessed daily, and infections and antibiotics were recorded. Pneumonias were divided into those fulfilling mCDC criteria (mCDC-SAP) or not (other pneumonias, OPn). The effect of each type of pneumoni...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research

Evaluating circulating tumour cell enrichment techniques to establish an appropriate method for clinical application in glioblastomas
Brain tumours reduce life expectancy for an average of 20 years per patient, the highest of any cancer. A third of brain tumour patients visit their GP at least five times before diagnosis and many of those are diagnosed late through emergency departments. A possible solution to this challenge is to utilise a “liquid biopsy” blood test designed for circulating tumour cells (CTCs). Such a test could be applied at a primary healthcare centre, contributing to informed decision making for diagnostic imaging referrals. Furthermore, it could also be applied at secondary health care centres for the ongoing monitoring of dis...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research

Effect of concomitant usage of alteplase and mechanical thrombectomy for M1 middle cerebral artery occlusion on clinical outcome: a retrospective analysis of 457 patients from two centers
ConclusionUtilization of alteplase alongside EVT for MCA M1 occlusion did not result in excessive ICH occurrences or clinical deterioration. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research

Association between Sj ögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study
DiscussionOur findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 27, 2024 Category: Neurology Source Type: research

A systematic review of the effectiveness of epilepsy education programs on knowledge, attitudes, and skills among primary school learners
Epilepsy is a common neurological condition affecting primary school learners, often leading to misconceptions, stigma, and limited social inclusion. These misconceptions transpire because of a lack of knowledge regarding the condition and may lead to high school dropouts. This systematic review aimed to evaluate the effectiveness of epilepsy education programs on epilepsy-related knowledge and understanding, values and attitudes, and skills among primary school learners. A thorough search of electronic databases was conducted to identify relevant studies published between January 2000 and September 2023. Studies that sati...
Source: Frontiers in Neurology - February 27, 2024 Category: Neurology Source Type: research

Derivation and validation of a quantitative risk prediction model for weaning and extubation in neurocritical patients
ConclusionThese results suggest that the extubation risk prediction model constructed through quantitative scoring has good predictive accuracy and can provide a scientific basis for clinical practice, helping to assess and predict extubation risk, thereby improving the success rate of extubation and improving patient prognosis. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 27, 2024 Category: Neurology Source Type: research

Has collateral blood flow any effect on restenosis rate? Our experience
ConclusionsGood collateral circulation was significantly associated with restenosis in patients undergoing intracranial angioplasty, the residual stenosis rate tends to be 15.85% to reduce restenosis risk. Compared to patients with restenosis, those without restenosis have a low stroke risk during follow-up. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 27, 2024 Category: Neurology Source Type: research

Comparison of different rhythmic auditory stimuli on prefrontal cortex cortical activation during upper limb movement in patients with Parkinson ’s disease: a functional near-infrared spectroscopy study
ConclusionRAS may be a useful upper limb rehabilitation strategy for PD patients with upper limb dysfunction. At the same time, RAS with different rhythms also have different responses to PFC blood oxygen during upper limb movement in PD patients, so that we can design interventions for this kind of cortical mechanism. Identifying the neurophysiological mechanism of RAS on upper limb movement in PD patients may help clinicians customize rehabilitation methods for patients according to clues, so as to highly personalize upper limb training and optimize its effect. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 27, 2024 Category: Neurology Source Type: research

Predictors of non-primary auditory and vestibular symptom persistence following surgical repair of superior canal dehiscence syndrome
ConclusionsSurgical repair for SCDS offers meaningful reduction in the majority of auditory and vestibular symptoms. However, the persistence of certain, mostly non-primary, symptoms and the identification of potential associated factors including migraines, PTA thresholds, cVEMP threshold, bilateral SCD, and revision cases emphasize the importance of individualized patient counseling and management strategies. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 26, 2024 Category: Neurology Source Type: research

Spasticity-Plus syndrome in multiple sclerosis patients in a tertiary hospital in Spain
ConclusionSpasticity-Plus syndrome was present in all the study population of patients with different MS phenotypes, and treated with nabiximols. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 26, 2024 Category: Neurology Source Type: research

Acute histological reactions in the otolith organs to inner ear drug delivery through a cochlear implant
DiscussionA significant concern relates to the safety of cochlear implantation with regard to vestibular preservation and hearing. New advancements in electrode arrays, such as CI devices coupled with delivery pumps, pose a challenge in maintaining minimally traumatic surgical concept-based procedures without affecting the inner ear homeostasis. The implantation of this device may cause vestibular hydrops in the saccule, indicating that the longer the time of substance release, the greater the grade of hydrops evidenced at the saccular level. Apart from this finding, the risk of histological damage to the vestibule is low....
Source: Frontiers in Neurology - February 26, 2024 Category: Neurology Source Type: research

Curative effect analysis of robot-assisted drainage surgery in treatment of spontaneous hypertensive brainstem hemorrhage
ConclusionBased on the results of this study, robot-assisted minimally invasive drainage of brain stem hematoma may significantly reduce mortality and improve prognosis. Surgery should be conducted for selected patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 26, 2024 Category: Neurology Source Type: research

Clinical analysis of hyperbaric oxygen combined with subdural drilling and drainage in the management of subdural effusion type IV with intracranial infection in infant patients
ConclusionThe SDD is safe and effective for infant patients with intracranial infections through fluid replacement and intrathecal antibacterial. Hyperbaric oxygen is effective as an adjuvant therapy to promote brain re-expansion. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 26, 2024 Category: Neurology Source Type: research