Fight Aging! Newsletter, December 18th 2017

In this study, we asked people in an open-ended way about their desire for longer life: Would you like to have more time? What age would you like to become? This was something more specific than asking about a preference for survival without reference to any length of time; about one's plans for the future; or whether people see the future as open or limited, as in studies of future time perspective. Our attempt was to discover whether there were preferred temporal spans with which older adults framed their futures and plans. The two-question series about extra years and desired age ("How old would you like to become?") was designed to generate talk about extended life. Free to answer the questions in their own way, participants could say any number of things about longer life during the interviews. Amid these responses, our analysis capitalized on a pattern that was strongly apparent. When it came to desired longevity, most people did in fact want to live longer, but few supplied a numerical answer that was not also conditional on the maintenance of continued good health. The majority preference was for longer life but "only if." The health stipulation was cited by three-quarters of the 57 cases who desired longer lives. This stance was a prominent pattern, and in the replies to our questions there were certain similarities: the conditional expressions (if, as long as, it depends), the anecdotes about others in poor health, and the reference...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 21 July 2018Source: Small Ruminant ResearchAuthor(s): Jeanette Olejnik, Natalka Suchowerska, Muren Herrid, Michael Jackson, Geoff Hinch, Jonathan HillAbstractMany alternatives to surgical castration have been explored to induce short or long term infertility in male animals. Comparatively few have been carefully evaluated in very young production animals. A comparison of four treatments known to deplete testicular cells in rodents (heating, cooling, chemotherapy, radiation) was undertaken using ram lambs.Neither testicular cooling (0 °C) nor heating (45 °C) affected ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Molecular BiologyAuthor(s): Michela Miani, Bernat Elvira, Esteban N. GurzovAbstractDiabetes is a metabolic disorder affecting more than 400 million individuals and their families worldwide. The major forms of diabetes (type 1 and 2) are characterized by pancreatic β-cell dysfunction and, in some cases, loss of β-cell mass causing hyperglycemia due to absolute or relative insulin deficiency. The BCL-2 homology 3 (BH3)-only protein BIM has a wide role in apoptosis induction in cells. In this review, we describe the apoptotic mechanisms mediated by BI...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
The objective was to characterize the pharmacological profile of 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-6′-ethoxycarbonyl-3,14-dihydroxyindolo [2′,3′-6,7]morphinan (TAN-452), a novel peripherally acting opioid receptor antagonist.Main methodsThe in vitro binding affinity for the μ-, δ-, and κ-opioid receptors (MOR, DOR, and KOR) and the inhibition of [35S]GTPγS binding were examined using membrane preparations from recombinant human (h) MOR, DOR, or KOR expressing cell. In vivo assays were performed to determine the inhibitory effect of TAN-452 on morphine-induced emesis ...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionThese results suggest that STAT3 and ReB constitute a minimal activator complex for positive regulation of MMP-1 in colon cancer
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 21 July 2018Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Karolina SapoĊ„, Teresa Janas, Aleksander F. Sikorski, Tadeusz JanasAbstractPolysialic acid (polySia) forms linear chains which are usually attached to the external surface of the plasma membrane mainly through the Neural Cell Adhesion Molecule (NCAM) protein. It is exposed on neural cells, several types of cancer cells, dendritic cells, and egg and sperm cells. There are several lipid raft-related phenomena in which polySia is involved; however the mechanisms of polySia action as well as determinants of its ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: August 2018Source: Journal of Environmental Chemical Engineering, Volume 6, Issue 4Author(s): Anwar Iqbal, S. Sabar, M.K. Mun-Yee, M.N. Nur Asshifa, A.R.M. Yahya, Farook AdamAbstractA novel biosorbent (RHA-PA) for the adsorption of methylene blue (MB) was developed by immobilizing deactivated Pseudomonas aeruginosa USM-AR2 (PA) cells on mesoporous rice husk ash silica (RHA-SiO2). The RHA-SiO2 was synthesized via sol-gel method with fructose as a water-soluble template. The highest Brunauer-Emmett-Teller (BET) surface area (601 m2 g−1) determined from N2 adsorption-desorption analysis w...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 20 July 2018Source: Journal of Electroanalytical ChemistryAuthor(s): Xiaoyu Zhao, Jianhua Ding, Wenlong Bai, Yanfei Wang, Yujia Yan, Yan Cheng, Juankun ZhangAbstractA PEDOT:PSS/AuNPs/CA modified screen-printed carbon based disposable electrochemical sensor for sensitive and selective determination of carmine was studied. Enhanced electrode conductivity was achieved via a 3-step process: (i) construction of a conductive polymer (PEDOT: PSS) on a disposable screen-printed carbon electrode (SPCE) (ii) electropolymerization with gold nanoparticles (AuNPs) and (iii) modification with positivel...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: 30 October 2018Source: Journal of Alloys and Compounds, Volume 767Author(s): Hang Zhang, Yujun Liang, Yingli Zhu, Shiqi Liu, Kai Li, Jian Yang, Wen LeiAbstractNovel single-phased and emission-tunable layered Bi4Ti3O12:Pr3+ nanosheets have been successfully synthesized via molten salt method. The as-prepared samples were characterized by X-ray diffraction and scanning electron microscopy to investigate their crystalline phases and morphologies. Furthermore, we explored the photoluminescence properties of the Bi4Ti3O12:Pr3+ phosphors, while the cross-relaxation processes between 1D2, 3P0 emitting states and...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: 30 October 2018Source: Journal of Alloys and Compounds, Volume 767Author(s): Rafaela S. Andre, Jessica C. Pereira, Luiza A. Mercante, Danilo Locilento, Luiz H.C. Mattoso, Daniel S. CorreaAbstractNanostructured metal oxide semiconductors (MOS) based chemoresistive sensors play an important role in designing handheld, portable and cost-effective sensing systems for the detection of various target analytes. Herein, one-dimensional ZnO-Co3O4 heterostructure nanofibers (NFZCo) were successfully fabricated via electrospinning technique followed by a high-temperature treatment. The heterostructured nanofibers we...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
In this study, the hollow structure of MOF-5 was synthesized. Its drug loading and drug release capacity were studied. The human ovarian cancer SK-OV-3 cell line was selected to study the drug loading system, cytotoxicity, and cellular uptake. We concluded that a hollow MOF with an excellent morphology was successfully fabricated in the experiment; it increased the drug loading capacity, achieved a more ideal sustained-release effect, improved the treatment efficiency of the hydrophobic Chinese medicine component, and provided a relatively efficient drug loading material.Graphical abstract
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
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