Fight Aging! Newsletter, August 15th 2016

In conclusion, our results demonstrate that circulating GDF11 levels are reduced in our mouse model of premature aging, which shares most of the symptoms that occur in normal aging. However, GDF11 protein administration is not sufficient to extend longevity in these progeroid mice. Although accelerated-aging mouse models can serve as powerful tools to test and develop anti-aging therapies common to both physiological and pathological aging, the existence of certain differences between the two processes implies that further investigation is still required to determine whether long-term GDF11 administration has a pro-survival effect on normal aged animals. Latest Headlines from Fight Aging! Recent Research on Mechanisms of Limb Regeneration https://www.fightaging.org/archives/2016/08/recent-research-on-mechanisms-of-limb-regeneration/ A number of research groups are engaging in mapping the biochemistry of limb and organ regeneration in species capable of such regrowth, such as salamanders and zebrafish. The hope is that the underlying systems of regeneration are merely inactive in mammals, not missing entirely, and therefore somewhere in all of this lies the basis for a therapy to provoke regrowth of missing tissues in adult humans. Whether or not this is the case is yet to be determined, though some of the evidence is promising: scarless healing of minor wounds present in MRL mice; the same outcome induced via inhibition of Cxcr4; the ability to selectiv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 28 January 2020Source: Urology Case ReportsAuthor(s): Shinro Hata, Satoki AbeAbstractIn the Checkmate-025 trial, nivolumab treatment prolonged overall survival among patients with previously treated advanced renal cell carcinoma (RCC) compared with treatment with everolimus. Although effective, nivolumab is associated with immune-related adverse events (irAEs). However, the occurrence of hematological irAEs is rare. Some studies have reported on nivolumab-induced thrombocytopenia. Nivolumab associated thrombocytopenia in almost all patients improved with administration of various drugs. H...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
We present the case of pre-operative pelvic lymph node sampling with the use of MRI/TRUS fusion-guided biopsy at the time of prostate biopsy. Lymph node pathology revealed metastatic, poorly differentiated prostate cancer, concurrent with Gleason 4+5 disease showing perineural invasion. The use of MRI fusion guided biopsy for nodal sampling may be an effective method pre-operative staging and treatment planning for prostate adenocarcinoma.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionsThese voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse. However, diagnostic and treatment decisions should always be individualised based on patient-specific factors, such as disease extent and location, prior lines of therapy, comorbidities, and treatment preferences, together with current and emerging clinical evidence and logistic and economic constraints. Clinical trial enrolment for men with advanced prostate cancer should be strongly encouraged. Importantly, APCCC 2019...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Beginning in 2018, the Trump administration launched an aggressive effort to persuade states to pursue experiments under Section 1115 waivers, which allow states flexibility in the way they serve Medicaid beneficiaries. Many states have used these waivers to launch work-requirement programs that withhold coverage from most working-age, poor adults who fail to fulfill “community engagement” obligations. These obligations include documentation of nearly year-round work or other allowed activities, such as job training or volunteering for at least 20 hours per week. Some people may qualify for an exemption if they...
Source: The Commonwealth Fund: Blog - Category: International Medicine & Public Health Authors: Source Type: blogs
ConclusionsThis study showed that natalizumab dominated fingolimod with lower costs and higher QALYs in patients with high-activity RRMS. These results are consistent with previous published international literature.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 28 January 2020Source: Preventive MedicineAuthor(s): Elizabeth A. Sarma, Katharine A. Rendle, Sarah C. KobrinAbstractSymptom awareness may improve cancer outcomes by prompting timely help-seeking and diagnosis. Research in the UK has shown lower symptom awareness among sociodemographic groups at higher risk of poor cancer outcomes; however, no population-based surveys in the US have assessed whether cancer symptom awareness varies across sociodemographic groups. We therefore examined associations between sociodemographic factors and recognition of 11 cancer symptoms using a novel populati...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 27 January 2020Source: Preventive MedicineAuthor(s): Louis Jacob, Lee Smith, Sarah E. Jackson, Jae Il Shin, Josep Maria Haro, Davy Vancampfort, Brendon Stubbs, Ai KoyanagiAbstractData on the association between informal caregiving and physical activity (PA) levels are scarce, especially from low- and middle-income countries (LMICs). Furthermore, previous research has yielded conflicting results. Thus, we investigated this association in adults from 38 LMICs. Data from the World Health Survey (WHS), a cross-sectional, predominantly nationally representative survey conducted in 2002–2...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 27 January 2020Source: Preventive MedicineAuthor(s): Nilofer S. Azad, Ira L. Leeds, Waruguru Wanjau, Eun J. Shin, William V. PadulaAbstractThe incidence of colorectal cancer (CRC) is increasing in patients under the age of 50. The purpose of this study was to assess the cost-utility of available screening modalities starting at 40 years in the general population compared to standard screening at 50 years old. A decision tree modeling average-risk of the CRC in the United States population was constructed for the cost per quality-adjusted life year (QALY) of the five most common and ef...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Individuals with chronic pain are at an elevated risk of suicide, yet psychosocial factors that might be involved in increasing or decreasing vulnerability for suicidal ideation and behaviour have received little attention. Extant literature on the topic o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
OBJECTIVES: To determine the efficacy of fall intervention programs in nursing homes (NHs) and the generalizability of these interventions to people living with cognitive impairment and dementia. DESIGN: Systematic review and meta-analysis. SETTING...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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