Fight Aging! Newsletter, September 12th 2022

Discussion of Present Drug Development to Target Senescent Cells Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome Arguing for an Expansion of the Hallmarks of Aging https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/ The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. This is not the same thing as a list of causes of aging. A few of the hallmarks mostly likely are or include deeper causes of aging, or close to causes of aging. The hallmarks do overlap with the SENS description of aging as a set of root causes, forms of molecular damage that result from the normal operation of a youthful metabolism. Since the hallmarks of aging are not, and are not intended to be a list of causes of aging, it is always possible to argue for an expansion, particularly since the hallmarks as they stand omit a number of line items that are not as well studied, but still probably important. Equally, once started on an expansion of the hallmarks, where does one stop? We might ask ourselves: what use is a taxonomy of aging? To my eyes, the best thing that a taxonomy can achieve is to focus research and development efforts in directions that ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs