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Reduced, Compressed Chemotherapy Fails in Pediatric Germ Cell Tumors
Event-free survival was not maintained in children and adolescents with intermediate-risk malignant germ cell tumors when cisplatin-based chemotherapy was reduced from four to three cycles and compressed from 5 to 3 days per cycles. (Source: CancerNetwork)
Source: CancerNetwork - March 11, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Genitourinary Cancers Gynecologic Cancers News Ovarian Cancer Pediatric Cancers Testicular Cancer Source Type: news

Single-Cycle of BEP Shows Promise Against Testicular Cancer Recurrence
A single cycle of adjuvant bleomycin, etoposide, and cisplatin (BEP) chemotherapy might reduce recurrence rates for nonseminomatous or combined germ cell tumors of the testis. (Source: CancerNetwork)
Source: CancerNetwork - February 18, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: ASCO Genitourinary Cancers Symposium News Testicular Cancer Source Type: news

High-Dose Chemo Plus Stem Cells for Relapsed Metastatic Germ Cell Cancer High-Dose Chemo Plus Stem Cells for Relapsed Metastatic Germ Cell Cancer
High-dose chemotherapy (HDCT) and autologous peripheral-blood stem-cell transplantation (PBSCT) may be able to cure men with relapsed metastatic testicular and other germ cell tumors, even when the approach is used as third-line or later therapy, new research suggests.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - November 29, 2016 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Surveillance an Option for Early-Stage Ovarian Germ Cell Tumors
The use of surveillance did not affect survival among women with stage I malignant ovarian germ cell tumors, according to a new retrospective analysis. (Source: CancerNetwork)
Source: CancerNetwork - November 11, 2016 Category: Cancer & Oncology Authors: Dave Levitan Tags: Gynecologic Cancers News Ovarian Cancer Source Type: news

Researchers Identify Promising MicroRNA Biomarker for Germ Cell Tumors Researchers Identify Promising MicroRNA Biomarker for Germ Cell Tumors
The microRNA miR-371a-3p is a new and promising serum marker for germ cell tumors, researchers from Germany report.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 18, 2016 Category: Pathology Tags: Pathology & Lab Medicine News Source Type: news

What is Immature Tertatoma and How is it Treated?
What kind of malignant germ cell tumor are immature teratomas, how are they treated and how is prognosis determined? (Source: About.com Ovarian Cancer)
Source: About.com Ovarian Cancer - February 23, 2016 Category: Cancer & Oncology Authors: ovariancancer.guide at about.com Tags: health Source Type: news

Chemotherapy for Germ Cell Tumor May Spur CMLChemotherapy for Germ Cell Tumor May Spur CML
Findings raise the question of a causal link between etoposide and/or platinum-containing chemotherapy and the development of chronic myelogenous leukemia (CML). Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 4, 2015 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

New test to predict relapse of testicular cancers
Scientists have developed a new test to identify patients who are at risk of suffering a relapse from testicular cancer. Assessing just three features of a common kind of testicular cancer -- called non-seminomatous germ cell tumor -- can identify those at most at risk of relapse even where there is no evidence of tumor spread. The researchers believe the test could be used in the clinic to make decisions about which patients should be given chemotherapy. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 15, 2015 Category: Science Source Type: news

New test to predict relapse of testicular cancers
(Institute of Cancer Research) Scientists have developed a new test to identify patients who are at risk of suffering a relapse from testicular cancer. Assessing just three features of a common kind of testicular cancer -- called non-seminomatous germ cell tumor -- can identify those at most at risk of relapse even where there is no evidence of tumor spread. The researchers believe the test could be used in the clinic to make decisions about which patients should be given chemotherapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 15, 2015 Category: Global & Universal Source Type: news

What are the More Rare Types of Ovarian Cancers?
Rare ovarian cancers include the sex cord stromal tumors and ovarian germ cell tumors. These make up just 5 to 6% of malignant ovarian cancers. (Source: About.com Ovarian Cancer)
Source: About.com Ovarian Cancer - September 3, 2015 Category: Cancer & Oncology Tags: health Source Type: news

A mother’s intuition—and a fall down the stairs—save a little girl’s life
Photo: Kate Ackermann Photography Liz Beaulieu is likely the only person in the world who can say she saved her child by falling down the stairs. Her daughter, Arielle, was just 4 days old. Liz was carrying her downstairs when she slipped. Not sure whether Arielle had hit her head, she whisked her to her local ER. “She seemed fine, and they said that she looked fine,” Liz says. Still concerned, though, Liz kept a close eye on Arielle over the next couple of days. That’s when she noticed something. “I noticed the slightest flicker of her eyes,” Liz recalls, “and decided that I wanted to g...
Source: Thrive, Children's Hospital Boston - July 8, 2015 Category: Pediatrics Authors: Tom Ulrich Tags: Diseases & conditions Our patients’ stories Brain tumor congenital intracranial teratoma CT scan Dana-Farber/Boston Children's Cancer and Blood Disorders Center Liliana Goumnerova Mark Kieran Source Type: news

UCLA study finds cells that become sperm or eggs in humans are vulnerable during pregnancy
UCLA scientists examining causes of human infertility have found that the cells that create eggs or sperm during the prenatal stage of development are vulnerable to damage, according to new research published today. The study by Amander Clark, of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, was published in the journal Cell. Clark said that the findings advance the understanding of human germ cells, which are responsible for carrying parents’ genes to a child. Abnormalities in the germ cells can cause infertility as well as diseases such as germ cell tumors in young boys and p...
Source: UCLA Newsroom: Health Sciences - May 22, 2015 Category: Universities & Medical Training Source Type: news

MiR-371 Promising New Marker in Testicular Germ Cell TumorsMiR-371 Promising New Marker in Testicular Germ Cell Tumors
MiR-371-3p appears to be a sensitive and specific biomarker in testicular germ cell cancers, and could potentially outperform standard markers. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 2, 2015 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

MD Anderson's David M. Gershenson, MD, Receives IGCS's Award for Excellence in Gynecologic Oncology
For his myriad clinical, organizational and scientific accomplishments in the field of gynecologic oncology and the health and well-being of women, David M. Gershenson, M.D. has been recognized with the International Gynecology Cancer Society's (IGCS) Award of Excellence. Gershenson, professor and past chair of the Department of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center, received the award at the IGCS's 15th Biennial Meeting in Melbourne, Australia. William J. Hoskins, MD., of Memorial Sloan Kettering, also was honored with the distinction.The IGCS is a not-for-prof...
Source: M. D. Anderson Cancer Center - News Releases - November 10, 2014 Category: Cancer & Oncology Source Type: news

Testicular Cancer Increasing in Young Hispanic AmericansTesticular Cancer Increasing in Young Hispanic Americans
The incidence of testicular germ cell tumors has risen substantially in Hispanic adolescents and young adults in recent years in the United States. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 15, 2014 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

IVC Replacement in a Man With Horseshoe Kidney and NSGCTIVC Replacement in a Man With Horseshoe Kidney and NSGCT
A patient with horseshoe kidney and metastatic non-seminomatous germ cell tumor requires an inferior vena cava prosthetic replacement, as described in this rare case. BMC Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 7, 2014 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Therapeutic Human Monoclonal Antibodies in Inflammatory Diseases
Monoclonal antibodies (mAbs) are antibodies of a single antigen specificity produced by identical immune cells, i.e., clones of a common germ cell. They offer unprecedented opportunities to drug development because of their ability to target almost any cell surface or secreted molecule with remarkable efficacy and safety. In this chapter, the application of human mAbs in the treatment of inflammatory diseases is reviewed. We discuss in detail several mAb-based drugs such as anti-tumor necrosis factor (anti-TNF), anti-interleukin-1 (anti-IL-1) receptor, anti-IL-6 receptor, anti-α4 integrin subunit, and anti-CD20 agent...
Source: Springer protocols feed by Immunology - September 20, 2013 Category: Allergy & Immunology Source Type: news

Nonseminomatous Germ Cell Tumor of Testis and Interrupted Treatment
A 22-year-old man presented to the emergency department with a 5-cm painful testicular mass that had increased in size over the previous month. Tumor markers were drawn and an inguinal orchiectomy was performed. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Scientists discover a molecular 'switch' in cancers of the testis and ovary
(University of Cambridge) Cambridge scientists have identified an 'on/off' switch in a type of cancer which typically occurs in the testes and ovaries called 'malignant germ cell tumors'. The research was published today, 01 August, in the journal Cancer Research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 1, 2013 Category: Global & Universal Source Type: news

Chemo-Hyperthermia for Refractory Germ-Cell TumorsChemo-Hyperthermia for Refractory Germ-Cell Tumors
Chemotherapy given in conjunction with regional hyperthermia produces good response rates in children and adolescents with refractory or recurrent germ-cell tumors. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 12, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

ASCO: Dose-Dense Chemo Effective in GETUG 13
(MedPage Today) -- Dose-dense chemotherapy is a new standard for the treatment of poor-prognosis germ-cell tumors, a researcher said here. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - June 6, 2013 Category: Hematology Source Type: news

Retroperitoneal Teratoma With Malignant TransformationRetroperitoneal Teratoma With Malignant Transformation
This interesting report describes a case of papillary renal cell carcinoma in a metastatic testicular germ cell tumor. BMC Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 17, 2013 Category: Consumer Health News Tags: Urology Journal Article Source Type: news

UCLA researchers find potential link between auto pollution, some childhood cancers
Scientists from UCLA's Fielding School of Public Health led by Julia Heck, an assistant researcher in the school's epidemiology department and a member of UCLA's Jonsson Comprehensive Cancer Center, have found a possible link between exposure to traffic-related air pollution and several childhood cancers.   The results of their study — the first to examine air pollution from traffic and a number of rarer childhood cancers — were presented on April 9 in an abstract at the annual meeting of the American Association for Cancer Research in Washington, D.C.   For the study, the UCLA researchers utilized da...
Source: UCLA Newsroom: Health Sciences - April 9, 2013 Category: Universities & Medical Training Source Type: news

N-cadherin Expression in Germ Cell Tumors of the TestisN-cadherin Expression in Germ Cell Tumors of the Testis
Expression of the transmembrane protein N-cadherin may be useful to differentiate embryonal and chorionic carcinomas from other histological subtypes of testicular germ cell tumors. BMC Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 18, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news