Fight Aging! Newsletter, July 23rd 2018

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents Evidence for Herpesvirus Infection to be a Significant Cause of Alzheimer's Disease Oisin Biotechnologies Produces Impressive Mouse Life Span Data from an Ongoing Study of Senescent Cell Clearance Hematopoietic Cells are Impacted by Cellular Senescence in Old Humans Thoughts on the Ending Age-Related Diseases Conference The Restrictive Political Anarchy of Off-Label Use is Why it Matters Whether or Not Aging is an Accepted FDA Indication Juvenescence Announces a Small Molecule Senolytics Joint Venture with Antox...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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What can serum calprotectin levels tell us about disease activity and severity in inflammatory rheumatic diseases?Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
A new review of preliminary medical literature has suggested that probiotics -- foods or supplements containing microbes thought to exert a positive influence on our gut -- could help ease depression.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Authors: Mjaess G, Karam A, Aoun F, Albisinni S, Roumeguère T Abstract COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help und...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
TYPE 2 diabetes affects roughly more than one in 16 people in the UK with around 3.9 million living with the dangerous condition. Finding healthy ways to help lower your blood sugar is pertinent when it comes to living with the condition and according to experts, drinking this beverage will help lower your blood sugar. What is it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Almost 11 million students began taking China’s university entrance exam after a delay as the country worked to bring down coronavirus infections
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
AbstractBackgroundThe aim of the study was to determine factors predicting lymph node metastasis in patients with T1 or T2 colon cancer.MethodsA total of 906 patients with T1 or T2 colon cancer who underwent colon resection with regional lymphadenectomy in a tertiary hospital, from January 2008 to December 2013, were analyzed. The prognostic factors for LN metastasis and the risk factors for survival were analyzed.ResultsThere were 728 patients (80.4%) without lymph node metastasis (LN-negative group) and 178 patients (19.6%) with lymph node metastasis (LN-positive group). Tumor invasion depth (P
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionsThe addition of ICT before NCRT seemingly shows no survival benefit on patients with LARC, and might increase the toxicity.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
SummaryChemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has demonstrated limited success and is associated with severe side effects. This research aimed to investigate the antitumor efficacy and cytotoxic safety of the conjugate ZHER2:V2-pemetrexed, a novel targeted chemotherapeutic drug. In this context, human epidermal growth factor receptor 2 (HER2)  + A549 lung xenografts were treated using ZHER2:V2-pemetrexed, pemetrexed or physiological saline. Therapeutic efficacy was monit...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Conclusion Panitumumab (6  mg/kg iv q 2 weeks) with BKM120 60 mg given 5 out of 7 days per week was declared the RP2D. Toxicities including fatigue, rash and mucositis. There was little evidence of activity in this biomarker unselected cohort.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing 2-chloroethyl and oligopeptide moieties was designed and synthesized. The most cytotoxic derivative was triazine with an Ala-Ala-OMe substituent on the ring (compound7b). This compound induced time- and dose-dependent cytotoxicity in the DLD-1 and HT-29 colon cancer cell lines. The triazine derivative furthermore induced apoptosis through intracellular signaling pathway attenuati...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
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