Fight Aging! Newsletter, December 25th 2017

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents Final Reminder for 2017: Help Us Fund Rejuvenation Research, and Claim the Last of the Challenge Fund to Match Donations The Calorie Restriction Issue of the Journals of Gerontology Describing an Inflammatory Feedback Loop in Alzheimer's Disease Reviewing the Mitochondrial Contribution to Aging and Age-Related Disease AGEs and RAGE in the Aging Arteries All of Medicine has a History of the Strange and the Wrong, Slowly Shed Over Time Faustian Bargains Struck in Search of Life Extension Brain Rhythms are Disr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

p J Abstract Nowadays, cancer is one of the most dangerous and deadly disease all around the world. Cancer that is diagnosed at early stages is more likely to be treated successfully. Treatment of progressed cancer is very difficult, and generally surviving rates are much lower. Therefore, much research has been focused on developing non-invasive methods for detection of cancer and monitoring of its progress. Within this contribution, we present a novel strategy for selective isolation and detection of breast cancer cell lines (MCF-7 and BT-20) based on surface enhanced Raman scattering (SERS). A simplified protoc...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract This work reports an approach for imaging the localization, distribution, and level of miRNA in different organelles based on an activated fluorescence signal triggered by an alteration of the specific binding-induced conformation of the designed activatable probe. We selected miR-150 as an miRNA example to image its localization, distribution, and level in human cervical cancer cells (HeLa cells). The results indicate that miR-150 is localized and distributed in different subcellular organelles (mainly in mitochondria and lysosomes) and that its levels (actually its concentrations) in lysosomes are highe...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract A simple, precise and sensitive method in which, a nano optical sensor binuclear Pt-2-aminobenzimidazole-bipyridine, Pt(abi)(bpy) complex doped in sol gel is used for the early diagnosis of liver cancer. The idea depends on the assessment of the concentration of alpha fetoprotein (AFP) in the serum samples of different liver patients. The nano binuclear Pt(abi)(bpy) has strong emission spectrum upon excitation at 380 nm in distilled water. The assessment of alpha fetoprotein (AFP) depends on the quenching of the emission spectrum of the optical sensor at 610 nm in water by the alpha fetoprotein (AFP)....
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Lung cancer has the highest mortality rate of all malignant tumours. The current effects of cancer treatment, as well as its diagnostics, are unsatisfactory. Therefore it is very important to introduce modern diagnostic tools, which will allow for rapid classification of lung cancers and their degree of malignancy. For this purpose, the authors propose the use of Fourier Transform InfraRed (FTIR) spectroscopy combined with Principal Component Analysis-Linear Discriminant Analysis (PCA-LDA) and a physics-based computational model. The results obtained for lung cancer tissues, adenocarcinoma and squamous ce...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Specific nucleic acids amplification at a constant and mild temperature is important for imaging assay of endogenous microRNAs (miRNAs) in living cells. Duplex-specific nuclease (DSN) is attractive in one-step isothermal assay of miRNA; however, its intrinsic limitations of low amplification specificity and high reaction temperature greatly restrict the application scope. Herein, we present a short-probe-based DSN signal amplification (spDSNSA) strategy enabling analysis of miRNAs at body temperature with significantly high specificity. From systematic investigation of amplification reaction on different ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Highly selective and sensitive chemiluminescence biosensor for adenosine detection based on carbon quantum dots catalyzing luminescence released from aptamers functionalized graphene@magnetic β-cyclodextrin polymers. Talanta. 2018 Aug 15;186:238-247 Authors: Sun Y, Ding C, Lin Y, Sun W, Liu H, Zhu X, Dai Y, Luo C Abstract In this work, a highly selective and sensitive chemiluminescence (CL) biosensor was prepared for adenosine (AD) detection based on carbon quantum dots (CQDs) catalyzing the CL system of luminol-H2O2 under alkaline environment and CQDs was released from the surface of AD aptamers...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract In this paper, we will describe a novel lable-free electrochemiluminescent (ECL) immunosensor for the detection of glutamate decarboxylase antibody (GADA) in which Au nanoparticles (AuNPs) had pre-functionalized the indium tin oxide (ITO) glass to support the sensing interface. The preparation of the basal electrode only need a simple two-step drop coating, a thin polymer of hydrolyzed 3-aminopropyl trimethoxysilane, and the AuNPs gel on the ITO substrate. The AuNPs not only enhanced the ECL signal of luminol, but also acted to immobilize the glutamate decarboxylase (GAD) to build the sensing host. This i...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
The cafeteria diet is widely used as a model for inducing obesity in animals, and the zebrafish (Danio rerio) has emerged as a promising model for this purpose. In this context, this study evaluated the effect of a cafeteria diet on the composition of fatty acids in zebrafish fillets. Zebrafish grown in tanks for a period of 60 days were treated with standard (ST) and cafeteria (CAF) diets. The CAF diet presented higher total lipid and energy values than ST diet, due to the addition of peanut, chocolate and biscuit in its preparation. Moreover, CAF diet showed the highest concentrations of palmitic (19.44 ± 0.55 mg ...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP01631C, PaperYibo Jin, Yunxiang Sun, Jiangtao Lei, Guanghong Wei Alzheimer's disease (AD) is associated with the aggregation of amyloid-[small beta] (A[small beta]) peptides into toxic fibrillar aggregates. Finding effective inhibitors of A[small beta] aggregation is a crucial step for the development of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Amirthalingam V, Sharma TD, Rai PC, Singh TT, Devi KP Abstract Mixed germ cell tumors are very rare in young females. Patient survival, preservation of ovarian function and fertility are becoming an important issue. A locally advanced (III), bulky malignant mixed germ cell tumour in a 12-year-old girl presented to the Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur, in January 2011 with abdominal distension for one month. On physical examination, there was a large lower abdominal mass approximately 16x 14 cm2. Abdominal and pelvic CTs showed a lobulated 19x 15x10 cm soft...
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
More News: Alzheimer's | Antidoxidants | Biochemistry | Biology | Biomedical Science | Brain | Brain Cancers | Calcium | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Cancer Therapy | Cardiology | Cardiovascular | Chemistry | Chemotherapy | Child Development | Children | Clinical Trials | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Diets | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Esophagus Cancer | Eyes | Fortamet | France Health | Gastroschisis Repair | Gene Therapy | Genetics | Geriatrics | Germany Health | Hand, Foot and Mouth | Health Management | Heart | Heart Disease | Heart Transplant | History of Medicine | Hypertension | Infectious Diseases | International Medicine & Public Health | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Learning | Liver | Liver Transplant | Men | Menopause | Metformin | Mitochondria | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Nutrition | Obesity | Oral Cancer | Organ Donation | Pathology | Pensions | Pineapples | Profits and Losses | Research | Respiratory Medicine | Salaries | Science | Skin | Sleep Disorders | Sleep Medicine | Smokers | Sports Medicine | Study | Sugar | Toxicology | Tracheal Cancer | Transplant Surgery | Transplants | UK Health | Universities & Medical Training | Urology & Nephrology | USA Health | Venture Capital | Weight Loss | Women