Fight Aging! Newsletter, September 18th 2017

In this study, researchers put some numbers to the correlation, and improve on previous attempts to rule out wealth and other effects as significant contributing causes. A study finds that a Chinese policy is unintentionally causing people in northern China to live 3.1 years less than people in the south, due to air pollution concentrations that are 46 percent higher. These findings imply that every additional 10 micrograms per cubic meter of particulate matter pollution reduces life expectancy by 0.6 years. The elevated mortality is entirely due to an increase in cardiorespiratory deaths, indicating that air pollution is the cause of reduced life expectancies to the north. "These results greatly strengthen the case that long-term exposure to particulates air pollution causes substantial reductions in life expectancy." The study exploits China's Huai River policy, which provided free coal to power boilers for winter heating to people living north of the river and provided almost no resources toward heating south of the river. The policy's partial provision of heating was implemented because China did not have enough resources to provide free coal nationwide. Additionally, since migration was greatly restricted, people exposed to pollution were generally not able to migrate to less polluted areas. Together, the discrete change in policy at the river's edge and the migration restrictions provide the basis for a powerful natural experiment that offers a...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 28 January 2020Source: Urology Case ReportsAuthor(s): Shinro Hata, Satoki AbeAbstractIn the Checkmate-025 trial, nivolumab treatment prolonged overall survival among patients with previously treated advanced renal cell carcinoma (RCC) compared with treatment with everolimus. Although effective, nivolumab is associated with immune-related adverse events (irAEs). However, the occurrence of hematological irAEs is rare. Some studies have reported on nivolumab-induced thrombocytopenia. Nivolumab associated thrombocytopenia in almost all patients improved with administration of various drugs. H...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
We present the case of pre-operative pelvic lymph node sampling with the use of MRI/TRUS fusion-guided biopsy at the time of prostate biopsy. Lymph node pathology revealed metastatic, poorly differentiated prostate cancer, concurrent with Gleason 4+5 disease showing perineural invasion. The use of MRI fusion guided biopsy for nodal sampling may be an effective method pre-operative staging and treatment planning for prostate adenocarcinoma.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionsThese voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse. However, diagnostic and treatment decisions should always be individualised based on patient-specific factors, such as disease extent and location, prior lines of therapy, comorbidities, and treatment preferences, together with current and emerging clinical evidence and logistic and economic constraints. Clinical trial enrolment for men with advanced prostate cancer should be strongly encouraged. Importantly, APCCC 2019...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Beginning in 2018, the Trump administration launched an aggressive effort to persuade states to pursue experiments under Section 1115 waivers, which allow states flexibility in the way they serve Medicaid beneficiaries. Many states have used these waivers to launch work-requirement programs that withhold coverage from most working-age, poor adults who fail to fulfill “community engagement” obligations. These obligations include documentation of nearly year-round work or other allowed activities, such as job training or volunteering for at least 20 hours per week. Some people may qualify for an exemption if they...
Source: The Commonwealth Fund: Blog - Category: International Medicine & Public Health Authors: Source Type: blogs
CONCLUSIONCleaners' direct involvement in maternity patients' care is an alarming symptom of overburdened health facilities, insufficient staffing and inadequate training. This key yet overlooked cadre of health care staff deserves appropriate support and further research to understand and alleviate health system shortcomings, and to improve the quality of maternity health care provision.
Source: The Guttmacher Institute - Category: International Medicine & Public Health Authors: Source Type: news
ConclusionsThis study showed that natalizumab dominated fingolimod with lower costs and higher QALYs in patients with high-activity RRMS. These results are consistent with previous published international literature.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 28 January 2020Source: Preventive MedicineAuthor(s): Elizabeth A. Sarma, Katharine A. Rendle, Sarah C. KobrinAbstractSymptom awareness may improve cancer outcomes by prompting timely help-seeking and diagnosis. Research in the UK has shown lower symptom awareness among sociodemographic groups at higher risk of poor cancer outcomes; however, no population-based surveys in the US have assessed whether cancer symptom awareness varies across sociodemographic groups. We therefore examined associations between sociodemographic factors and recognition of 11 cancer symptoms using a novel populati...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 27 January 2020Source: Preventive MedicineAuthor(s): Louis Jacob, Lee Smith, Sarah E. Jackson, Jae Il Shin, Josep Maria Haro, Davy Vancampfort, Brendon Stubbs, Ai KoyanagiAbstractData on the association between informal caregiving and physical activity (PA) levels are scarce, especially from low- and middle-income countries (LMICs). Furthermore, previous research has yielded conflicting results. Thus, we investigated this association in adults from 38 LMICs. Data from the World Health Survey (WHS), a cross-sectional, predominantly nationally representative survey conducted in 2002–2...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 27 January 2020Source: Preventive MedicineAuthor(s): Nilofer S. Azad, Ira L. Leeds, Waruguru Wanjau, Eun J. Shin, William V. PadulaAbstractThe incidence of colorectal cancer (CRC) is increasing in patients under the age of 50. The purpose of this study was to assess the cost-utility of available screening modalities starting at 40 years in the general population compared to standard screening at 50 years old. A decision tree modeling average-risk of the CRC in the United States population was constructed for the cost per quality-adjusted life year (QALY) of the five most common and ef...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Individuals with chronic pain are at an elevated risk of suicide, yet psychosocial factors that might be involved in increasing or decreasing vulnerability for suicidal ideation and behaviour have received little attention. Extant literature on the topic o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
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