Fight Aging! Newsletter, April 25th 2022

We examined central genetic and environmental lifespan regulators (putative anti-aging interventions, PAAIs; the following PAAIs were examined: mTOR loss-of-function, loss-of-function in growth hormone signaling, dietary restriction) for a possible countering of the signs and symptoms of aging. Importantly, in our study design, we included young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. In parallel to our studies in mice, we assessed genetic variants for their effects on age-sensitive phenotypes in humans. We observed that, surprisingly, many PAAI effects influenced phenotypes long before the onset of detectable age-dependent changes, rather than altering the rate at which these phenotypes developed with age. Accordingly, this subset of PAAI effects does not reflect a targeting of age-dependent phenotypic change. Overall, our findings suggest that comprehensive phenotyping, including the controls built in our study, is critical for the investigation of PAAIs as it facilitates the proper interpretation of the mechanistic mode by which PAAIs influence biological aging. Evidence Supporting the View that Familial Longevity is Largely Cultural https://www.fightaging.org/archives/2022/04/evidence-supporting-the-view-that-familial-longevity-is-largely-cultural/ Researchers have spent a great deal of effort looking for genetic determinants of longevity in long-lived families. Elsewhere, i...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs