Lithium Resistance in Bipolar Tied to Deficient Gene Expression Lithium Resistance in Bipolar Tied to Deficient Gene Expression
A decrease in activation of the LEF1 gene may be the reason why many patients with bipolar disorder do not respond to lithium, considered the'gold standard'treatment, new research suggests.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - January 14, 2021 Category: Neurology Tags: Psychiatry News Source Type: news

Childhood maltreatment, prefrontal-paralimbic gray matter volume, and substance use in young adults and interactions with risk for bipolar disorder - Kirsch DE, Tretyak V, Radpour S, Weber WA, Nemeroff CB, Fromme K, Strakowski SM, Lippard ETC.
Childhood maltreatment is associated with adverse effects on the brain, and an increased risk for psychopathology, including mood and substance use disorders. Individuals vary on the degree to which they exhibit neurobiological and clinical differences fo... (Source: SafetyLit)
Source: SafetyLit - January 11, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Severe anhedonia among adolescents with bipolar disorder is common and associated with increased psychiatric symptom burden - Dimick MK, Hird MA, Fiksenbaum LM, Mitchell RHB, Goldstein BI.
BACKGROUND: Anhedonia, a deficit in the ability to experience pleasure, is a cardinal symptom of major depressive episodes. In contrast to adolescent major depressive disorder, there is limited research examining anhedonia in the context of depression am... (Source: SafetyLit)
Source: SafetyLit - January 11, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Examination and comparison of cognitive and executive functions in clinically stable schizophrenia disorder, bipolar disorder, and major depressive disorder - Afshari B, Shiri N, Ghoreishi FS, Valianpour M.
BACKGROUND: Schizophrenia (SC), bipolar disorder (BD), and major depressive disorder (MDD) are associated with various cognitive and executive dysfunctions. The aim of the present study was to evaluate and compare cognitive and executive dysfunctions in ... (Source: SafetyLit)
Source: SafetyLit - January 11, 2021 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Seeding the Ocean: Inside a Michelin-Starred Chef ’s Revolutionary Quest to Harvest Rice From the Sea
There are very few things that Ángel León hasn’t done with the fruits of the sea. In 2008, as a young, unknown chef, he took a loin from one fish and attached it to the loin of another, using collagen to bind the two proteins together. He called them hybrids and served them to unsuspecting diners at Aponiente, his restaurant in the southern Spanish port town of El Puerto de Santa María, just across the bay from Cádiz. He discovered that fish eyes, cooked at 55°C in a thermal circulator until the gelatin collapsed, made excellent thickening agents for umami-rich sauces. Next he found th...
Source: TIME: Science - January 9, 2021 Category: Science Authors: Matt Goulding Tags: Uncategorized climate change feature longform Magazine Source Type: news

Has bipolar disorder become a predominantly female gender related condition? Analysis of recently published large sample studies - Dell'osso B, Cafaro R, Ketter TA.
Bipolar Disorders (BD)  are disabling and severe psychiatric disorders, commonly perceived as equally affecting both men and women. The prevalence of BD in the general population has been growing over the last decade, however, few epidemiological studies... (Source: SafetyLit)
Source: SafetyLit - January 6, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

New clues why gold standard treatment for bipolar disorder doesn't work for majority of patients
(Salk Institute) Lithium is considered the gold standard for treating bipolar disorder (BD), but nearly 70 percent of people with BD don't respond to it. This leaves them at risk for debilitating, potentially life-threatening mood swings. Researchers at the Salk Institute have found that the culprit may lie in gene activity--or lack of it. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 5, 2021 Category: International Medicine & Public Health Source Type: news

Altered brain creatine cycle metabolites in bipolar I disorder with childhood abuse: a (1)H magnetic resonance spectroscopy study - Bio DS, Moreno RA, Garcia-Otaduy MC, Nery F, Lafer B, Soeiro-de-Souza MG.
BACKGROUND: Childhood abuse (CA) is a risk factor for a number of psychiatric disorders and has been associated with higher risk of developing bipolar disorders (BD). CA in BD has been associated with more severe clinical outcomes, but the neurobiologica... (Source: SafetyLit)
Source: SafetyLit - January 4, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Performance on the Wechsler Adult Intelligence Scale (WAIS) in Japanese patients with bipolar and major depressive disorders in euthymic and depressed states - Matsuo J, Hori H, Ishida I, Hiraishi M, Ota M, Hidese S, Yomogida Y, Kunugi H.
This study aimed to examine the cognitive performance of patients with bipolar disorder (BD) stratified by illness phase compared to that of patients with major depressive disorder (MDD) and healthy controls. METHODS: Participants were 139 ... (Source: SafetyLit)
Source: SafetyLit - December 31, 2020 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Subanesthetic ketamine infusions for suicide ideation in patients with bipolar and unipolar treatment refractory depression - Kang MJY, Kulcar E, Chandrasena R, Anjum MR, Fairbairn J, Hawken ER, Vazquez GH.
We evaluated the effects of repeated subanesthetic ketamine infusions on suicidal ideation (SI) in patients with major depression. 82 subjects with treatment-resistant unipolar and bipolar depression completed a two-site open-label case-series of repeat... (Source: SafetyLit)
Source: SafetyLit - December 31, 2020 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

The acute antisuicidal effects of single-dose intravenous ketamine and intranasal esketamine in individuals with major depression and bipolar disorders: a systematic review and meta-analysis - Xiong J, Lipsitz O, Chen-Li D, Rosenblat JD, Rodrigues NB, Carvalho I, Lui LMW, Gill H, Narsi F, Mansur RB, Lee Y, McIntyre RS.
The efficacy of ketamine in reducing suicidal ideation (SI) has been previously reported. We aimed to evaluate acute anti-SI effects of single-dose ketamine in different formulations/routes of administration by pooling results from randomized controlled... (Source: SafetyLit)
Source: SafetyLit - December 30, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Nicky Campbell health: Wheel of Fortune star diagnosed with bipolar disorder - symptoms
NICKY CAMPBELL revealed he'd been diagnosed with bipolar disorder this year - a mental health condition that affects your mood. What are the symptoms of the condition to spot? (Source: Daily Express - Health)
Source: Daily Express - Health - December 25, 2020 Category: Consumer Health News Source Type: news

Is short-term antidepressant treatment effective and safe in bipolar depression? Results from an observational multicenter study - Tundo A, Musetti L, Del Grande C, de Filippis R, Proietti L, Cambiali E, Franceschini C, Dell'osso L.
OBJECTIVES: To investigate the short-term effectiveness and the short-term and long-term safety of acute antidepressant (AD) treatment of bipolar depression in a naturalistic setting. METHODS: Patients with bipolar (n = 86) or unipolar (n = 111) de... (Source: SafetyLit)
Source: SafetyLit - December 25, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Neuroimaging correlates of emotional response-inhibition discriminate between young depressed adults with and without sub-threshold bipolar symptoms (Emotional Response-inhibition in Young Depressed Adults) - Cha J, Speaker S, Hu B, Altinay M, Koirala P, Karne H, Spielberg J, Kuceyeski A, Dhamala E, Anand A.
This study investigated, for the first time, using emotional inhibition tasks, whether the neural organization of MDD+ subjects is more similar to bipolar dep... (Source: SafetyLit)
Source: SafetyLit - December 22, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

A qualitative exploration of how people with bipolar disorder consider risk-taking in everyday decisions - Wah A, Hodge S, Jones SH, Perez Algorta G.
BACKGROUND: Difficulties with decision making and risk taking in individuals with bipolar disorder (BD) have been associated with mood episodes. However, there is limited information about these experiences during euthymia, the mood state where people with... (Source: SafetyLit)
Source: SafetyLit - December 21, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Discriminating suicide attempters and predicting suicide risk using altered frontolimbic resting-state functional connectivity in patients with bipolar II disorder - Zhu R, Tian S, Wang H, Jiang H, Wang X, Shao J, Wang Q, Yan R, Tao S, Liu H, Yao Z, L ü Q.
This study aimed to integrate altered brain functionality in t... (Source: SafetyLit)
Source: SafetyLit - December 18, 2020 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Global Experts Map the Latest in Bipolar Management Global Experts Map the Latest in Bipolar Management
A new monograph by an international team of experts takes a sweeping look at the latest research and clinical guidance on bipolar disorder.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2020 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Nightmares in patients with major depressive disorder, bipolar disorder, and psychotic disorders: a systematic review - Akkaoui MA, Lejoyeux M, d'Ortho MP, Geoffroy PA.
Chronic nightmares are very common in psychiatric disorders, affecting up to 70% of patients with personality or post-traumatic stress disorders. In other psychiatric disorders, the relationships with nightmares are poorly known. This review aimed to clari... (Source: SafetyLit)
Source: SafetyLit - December 17, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

History of suicide attempts in patients with bipolar disorder type I: socio-demographic and clinical factors, quality of life and functioning - Almeida VF, Bezerra-Filho S, Studart-Bott ó P, Léda-Rego G, Silva ITF, Kapczinski F, Miranda-Scippa.
This study aims to evaluate sociodemographic and clinical factors, quality of life (QoL) and functioning associated with history of suicide attempts (SA) in a sample of bipolar disorder (BD) type I patients. METHODS: A total of 417 BD typ... (Source: SafetyLit)
Source: SafetyLit - December 16, 2020 Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news

Can early drug intervention prevent weight gain in children with mental illness?
(University of Houston) A University of Houston pharmacological researcher believes that prescribing the drug Metformin for children and teens as soon as they are diagnosed with mental illnesses, like bipolar disorder and schizophrenia, may save them from gaining an enormous amount of weight. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 16, 2020 Category: International Medicine & Public Health Source Type: news

DR TOM JEFFERSON: I fear this mania for mass Covid testing is a hugely expensive blunder 
DR TOM JEFFERSON: One family tells me how their mother caught Covid-19 in hospital in October but continues to test positive, causing problems for her treatment for cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - December 13, 2020 Category: Consumer Health News Source Type: news

Alembic Pharma gets USFDA nod for bipolar disorder treatment drug
In a regulatory filing, Alembic Pharmaceuticals said it has received approval from the US Food and Drug Administration (USFDA) for its abbreviated new drug application (ANDA) for Asenapine Sublingual Tablets in the strengths of 5 mg and 10 mg. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 11, 2020 Category: Pharmaceuticals Source Type: news

Southern Ocean upwelling, Earths obliquity, and glacial-interglacial atmospheric CO2 change
Previous studies have suggested that during the late Pleistocene ice ages, surface-deep exchange was somehow weakened in the Southern Ocean’s Antarctic Zone, which reduced the leakage of deeply sequestered carbon dioxide and thus contributed to the lower atmospheric carbon dioxide levels of the ice ages. Here, high-resolution diatom-bound nitrogen isotope measurements from the Indian sector of the Antarctic Zone reveal three modes of change in Southern Westerly Wind–driven upwelling, each affecting atmospheric carbon dioxide. Two modes, related to global climate and the bipolar seesaw, have been proposed previo...
Source: ScienceNOW - December 10, 2020 Category: Science Authors: Ai, X. E., Studer, A. S., Sigman, D. M., Martinez-Garcia, A., Fripiat, F., Thöle, L. M., Michel, E., Gottschalk, J., Arnold, L., Moretti, S., Schmitt, M., Oleynik, S., Jaccard, S. L., Haug, G. H. Tags: Geochemistry, Geophysics reports Source Type: news

Alterations in gray matter volumes and intrinsic activity in the prefrontal cortex are associated with suicide attempts in patients with bipolar disorder - Zhao Y, Wang L, Edmiston EK, Womer FY, Jiang X, Wu F, Kong L, Zhou Y, Wang F, Tang Y, Wei S.
Bipolar disorder (BD) is associated with increased suicidal behavior. Understanding the neural features of suicide attempts (SA) in patients with BD is critical to preventing suicidal behavior. The prefrontal cortex (PFC) is a key region related to SA. In ... (Source: SafetyLit)
Source: SafetyLit - December 5, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Moderators of the association between depressive, manic, and mixed mood symptoms and suicidal ideation and behavior: an analysis of the National Network of Depression Centers Mood Outcomes Program - Fiedorowicz JG, Persons JE, Assari S, Ostacher MJ, Goes FS, Nurnberger JI, Coryell WH.
BACKGROUND: It has not been established that suicide risk with mixed symptoms is any greater than the depressive component or if there is synergy between depressive and manic symptoms in conveying suicide risk. METHODS: The National Network of Depressi... (Source: SafetyLit)
Source: SafetyLit - November 28, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Midnight Mania! Jake Paul vs. Conor McGregor is ‘bound to happen’
Bringing you the weird and wild from the world of MMA each and every weeknight! (Source: Reuters: Health)
Source: Reuters: Health - November 27, 2020 Category: Consumer Health News Source Type: news

Win as Priadel remains available for patients
A new low price for Priadel, a lithium medication used by bipolar patients, has been agreed between the Department for Health and Social Care (DHSC) and the drug’s manufacturer, Essential Pharma (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - November 24, 2020 Category: Drugs & Pharmacology Source Type: news

Physicians investigate whether magnetic seizure therapy can treat bipolar depression
(University of Texas Health Science Center at Houston) Researchers are assessing whether magnetic seizure therapy (MST) can help relieve treatment-resistant depression in bipolar patients in a clinical trial led by UTHealth. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 23, 2020 Category: International Medicine & Public Health Source Type: news

Smartphone App Differentiates Bipolar Disorder, BPD Smartphone App Differentiates Bipolar Disorder, BPD
Researchers in the UK have developed a smartphone app enabling patients to briefly characterize their current mood daily, as well as a machine learning model to analyze the data as their moods evolve.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 6, 2020 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Prediction of suicide-related events by analyzing electronic medical records from PTSD patients with bipolar disorder - Fan P, Guo X, Qi X, Matharu M, Patel R, Sakolsky D, Kirisci L, Silverstein JC, Wang L.
Around 800,000 people worldwide die from suicide every year and it's the 10th leading cause of death in the US. It is of great value to build a mathematic model that can accurately predict suicide especially in high-risk populations. Several different ML-b... (Source: SafetyLit)
Source: SafetyLit - November 3, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The end of Minshew Mania? Jags QB could be benched if he continues to struggle
Jacksonville Jaguars starting quarterback Gardner Minshew is in danger of being benched if he continues to struggle, and that could... (Source: Reuters: Health)
Source: Reuters: Health - October 25, 2020 Category: Consumer Health News Source Type: news

Which factors delay treatment in bipolar disorder? A nationwide study focussed on duration of untreated illness - Buoli M, Cesana BM, Fagiolini A, Albert U, Maina G, de Bartolomeis A, Pompili M, Bondi E, Steardo L, Amore M, Bellomo A, Bertolino A, Di Nicola M, Di Sciascio G, Fiorillo A, Rocca P, Sacchetti E, Sani G, Siracusano A, Di Lorenzo G, Tortorella A, Altamura AC, Dell'osso B, ISBD Italian Chapter Epidemiologic Group.
AIM: The aim of the present study was to detect factors associated with duration of untreated illness (DUI) in bipolar disorder (BD). METHOD: A total of 1575 patients were selected for the purposes of the study. Correlation analyses were performed to a... (Source: SafetyLit)
Source: SafetyLit - October 22, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Add-On Psychotherapy a Win in Bipolar Disorder Add-On Psychotherapy a Win in Bipolar Disorder
New research provides further evidence that adjunctive psychotherapy is effective for people with bipolar disorder, particularly when delivered in family or group settings.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - October 22, 2020 Category: Internal Medicine Tags: Psychiatry News Source Type: news

What's Best for Treating Bipolar Disorder?
MONDAY, Oct. 19, 2020 -- Combining medication with group or family-based therapy gives patients struggling with bipolar disorder their best shot at living stable lives, a new review suggests. " People with bipolar disorder have significant mood... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 19, 2020 Category: General Medicine Source Type: news

Pharmacotherapy, Psychotherapy Combo Best for Bipolar Disorder
Manualized treatments linked to significantly reduced recurrence rates versus control treatments (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - October 16, 2020 Category: Psychiatry Tags: Pharmacy, Psychiatry, Journal, Source Type: news

Sugar, high-fructose corn syrup linked to ADHD, bipolar, aggressive behavior, researchers say
Diets high in sugar may increase a person's risk for developing attention deficit hyperactivity disorder, bipolar disorder and aggressive behaviors, a report published by the Evolution and Human Behavior said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 16, 2020 Category: Consumer Health News Source Type: news

Pharmacotherapy, Psychotherapy Combo Best for Bipolar Disorder
FRIDAY, Oct. 16, 2020 -- Manualized psychotherapy interventions combined with pharmacotherapy seem beneficial for bipolar disorder, according to a study published online Oct. 14 in JAMA Psychiatry. David J. Miklowitz, Ph.D., from the University of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 16, 2020 Category: Pharmaceuticals Source Type: news

High fructose intake may drive aggressive behaviors, ADHD, bipolar
(University of Colorado Anschutz Medical Campus) New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviors may be linked with sugar intake, and that it may have an evolutionary basis. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 16, 2020 Category: International Medicine & Public Health Source Type: news

Train Faith Leaders to Tackle Africa ’s Mental Health Needs
In countries like Malawi, there are simply not enough mental health professionals to go around. The local faith community can help fill this void. Credit: Unsplash /Melanie Wasser. By Chiwoza BandaweBLANTYRE, Malawi, Oct 14 2020 (IPS) The world is actually in the throes of two pandemics. The first is COVID-19. The second is the wave of stress and anxiety, depression and substance use it has unleashed around the world. Most mental health disorders are treatable. This so called “second pandemic” is raging in poor and wealthy countries alike. But across Africa, and in much of the Global South, people facing menta...
Source: IPS Inter Press Service - Health - October 14, 2020 Category: International Medicine & Public Health Authors: Chiwoza Bandawe Tags: Africa Headlines Health TerraViva United Nations Source Type: news

Melrose Orchestra Launches Fundraiser To Share Mental Health Victories
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 14, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Entertainment Health Syndicated CBSN Boston Syndicated Local Caroline Whiddon liam martin Melrose News Ronald Braunstein Source Type: news

Prevention of suicidal behavior in bipolar disorder - Tondo L, Vazquez GH, Baldessarini RJ.
BACKGROUND: Excess mortality is a critical hallmark of bipolar disorder (BD) due to co-occurring general medical disorders and especially from suicide. It is timely to review of the status of suicide in BD and to consider the possibility of limiting suicid... (Source: SafetyLit)
Source: SafetyLit - October 14, 2020 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Therapy plus medication better than medication alone in bipolar disorder
(University of California - Los Angeles Health Sciences) A review of 39 randomized clinical trials by scientists from UCLA and their colleagues from other institutions has found that combining the use medication with psychoeducational therapy is more effective at preventing a recurrence of illness in people with bipolar disorder than medication alone. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 14, 2020 Category: International Medicine & Public Health Source Type: news

FDA advisers set stage for approval of schizophrenia, bipolar disorder drug
Alkermes hopes to introduce a new treatment for schizophrenia and bipolar disorder that minimizes weight gain. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 9, 2020 Category: American Health Authors: Allison DeAngelis Source Type: news

Letters to the Editor: Trump is on a steroid that can cause mania. We should be worried
A reader describes her son's behavior while on dexamethasone, including feelings of euphoria and overconfidence. (Source: L.A. Times - Health)
Source: L.A. Times - Health - October 9, 2020 Category: Consumer Health News Source Type: news

FDA Advisory Committee Votes in Support of ALKS 3831 for the Treatment of Schizophrenia and Bipolar I Disorder
DUBLIN, Oct. 9, 2020 /PRNewswire/ -- Alkermes plc (Nasdaq: ALKS) today announced positive voting outcomes from the joint meeting of the Psychopharmacologic Drugs Advisory Committee and the Drug Safety and... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - October 9, 2020 Category: Drugs & Pharmacology Source Type: news

Drugmaker halts plan to pull bipolar treatment after competition probe
Essential Pharma threatened to withdraw drug in a move doctors said would push up NHS costs (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - October 6, 2020 Category: Pharmaceuticals Source Type: news

RPS welcomes pause in withdrawal of Priadel
We havetoday welcomed news that the withdrawal of Priadel, a brand of lithium taken by people with bipolar disorder, will be paused while the Competition and Markets Authority investigates. This foll (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 6, 2020 Category: Drugs & Pharmacology Source Type: news