UC San Diego Health offers new bluetooth-enabled 'pacemaker' for chronic focal nerve pain
(University of California - San Diego) After living with debilitating phantom leg pain for 18 years, Raul Silva is excited about a new dorsal root ganglion (DRG) stimulation device that erased his pain during a testing phase at UC San Diego Health, one of the only health care providers in the region offering the device. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 18, 2018 Category: International Medicine & Public Health Source Type: news

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is characterized by chronic abdominal pain concurrent with altered bowel habit. Polyunsaturated fatty acid (PUFA) metabolites are increased in abundance in IBS and are implicated in the alteration of sensation to mechanical stimuli, which is defined as visceral hypersensitivity. We sought to quantify PUFA metabolites in patients with IBS and evaluate their role in pain. Quantification of PUFA metabolites by mass spectrometry in colonic biopsies showed an increased abundance of 5-oxoeicosatetraenoic acid (5-oxoETE) only in biopsies taken from patients...
Source: Signal Transduction Knowledge Environment - December 18, 2018 Category: Science Authors: Bautzova, T., Hockley, J. R. F., Perez-Berezo, T., Pujo, J., Tranter, M. M., Desormeaux, C., Barbaro, M. R., Basso, L., Le Faouder, P., Rolland, C., Malapert, P., Moqrich, A., Eutamene, H., Denadai-Souza, A., Vergnolle, N., Smith, E. S. J., Hughes, D. I., Tags: STKE Research Articles Source Type: news

Abbott launches FlexAbility cath ventricular tachycardia ablation trial
Abbott (NYSE:ABT) said yesterday that it launched a study aiming to evaluate ablation treatments for patients with ventricular tachycardia, touting it as the first such trial of its kind. In the trial, dubbed the Less-VT study, investigators will explore the safety and effectiveness of ablation with the Chicago-area medtech giant’s FlexAbility ablation catheter in treating monomorphic ventricular tachycardia in patients who are unresponsive to drug therapy. “For some patients with sustained monomorphic ventricular tachycardia, drug therapy is an ineffective treatment option. We want to build a body of clin...
Source: Mass Device - November 20, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Catheters Clinical Trials Featured Abbott Source Type: news

Abbott Nabs Approvals for DRG Invisible Trial System
Abbott Laboratories has nabbed approvals for a chronic pain treatment device that patients can try before getting an implanted version of the technology. The Dorsal Root Ganglion (DRG) Invisible Trial System now has CE mark and a nod from FDA. The Abbott Park, IL-based company said patients who find adequate pain relief with DRG therapy can then have the Proclaim DRG System implanted. The Proclaim DRG includes an implantable neuromodulator that stimulates the dorsal root ganglion (DRG), an Apple iPad for programming the device, and an iPod touch for the patient control of the device. “Abbott's DRG Invisib...
Source: MDDI - November 19, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Source Type: news

Abbott wins CE Mark, FDA nod for DRG Invisible Trial neuromod system
Abbott (NYSE:ABT) said today that it won FDA clearance and CE Mark approval in the European Union for its DRG Invisible Trial System intended to allow patients with complex chronic pain conditions to receive a trial treatment with the company’s dorsal root ganglion stimulation system. Abbott’s DRG therapy targets the dorsal root ganglion, a structure adjacent to the spinal cord populated with nerves that transmit chronic pain to the central nervous system. The therapy is intended to aid people living with neuropathic pain conditions by blocking pain signals with electrical pulses transmitted over the ...
Source: Mass Device - November 15, 2018 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Food & Drug Administration (FDA) Neuromodulation/Neurostimulation Pain Management Regulatory/Compliance Abbott Source Type: news

New Approvals Allow Chronic Pain Sufferers to Try Abbott's Non-Opioid Pain Therapy Before Getting Device Implant
Neurostimulation of the dorsal root ganglion (DRG) can provide pain relief for patients battling chronic pain when previous treatment options were unsuccessful Abbott's new DRG Invisible Trial System brings an intuitive, wireless approach to the tempora... Devices, Neurology, FDA, Regulatory, Product Launch Abbott, dorsal root ganglion, neurostimulation, DRG Invisible Trial (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 15, 2018 Category: Pharmaceuticals Source Type: news

New Approvals Allow Chronic Pain Sufferers to Try Abbott's Non-Opioid Pain Therapy Before Getting Device Implant
- Neurostimulation of the dorsal root ganglion (DRG) can provide pain relief for patients battling chronic pain when previous treatment options were unsuccessful (Source: Abbott.com)
Source: Abbott.com - November 15, 2018 Category: Pharmaceuticals Source Type: news

ASA: Dorsal Root Ganglion Stimulation Disrupts Back Pain
FRIDAY, Oct. 19, 2018 -- Dorsal root ganglion (DRG) neurostimulation therapy may reduce pain and disability in patients with chronic lower extremity and back pain, according to a study presented at the annual meeting of the American Society of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 19, 2018 Category: Pharmaceuticals Source Type: news

Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis
Cancer-associated pain is debilitating. Understanding the mechanisms that cause it can inform drug development that may improve quality of life in patients. Here, we found that the reduced abundance of potassium channels called TRESK in dorsal root ganglion (DRG) neurons sensitized nociceptive sensory neurons and cancer-associated pain. Overexpressing TRESK in DRG neurons suppressed tumor-induced neuronal hyperexcitability and pain hypersensitivity in bone metastasis model rats, whereas knocking down TRESK increased neuronal hyperexcitability and pain hypersensitivity in normal rats. Mechanistically, tumor-associated produ...
Source: Signal Transduction Knowledge Environment - October 16, 2018 Category: Science Authors: Yang, Y., Li, S., Jin, Z.-R., Jing, H.-B., Zhao, H.-Y., Liu, B.-H., Liang, Y.-J., Liu, L.-Y., Cai, J., Wan, Y., Xing, G.-G. Tags: STKE Research Articles Source Type: news

Osteopathic manipulative treatment is an effective treatment alternative to obstructive sleep apnea
(Natural News) If your snoring has gotten so bad that it is cutting off your breathing while you are asleep, you are probably suffering from obstructive sleep apnea. You need to get yourself treated before you get hurt or worse. One possible option is osteopathic manipulative treatment of your sphenopalatine ganglion. Sleep apnea is a sleeping... (Source: NaturalNews.com)
Source: NaturalNews.com - October 10, 2018 Category: Consumer Health News Source Type: news

Abbott wins Aetna nod for Proclaim neurostim in chronic pain
Abbott (NYSE:ABT) said today that it won a reimbursement nod from Aetna (NYSE:AET) for its Proclaim dorsal root ganglion neurostimulation therapy for treating chronic pain. The national coverage decision opens DRG treatment to some 22 million Aetna members, Abbott said. Aetna already covers treatment with Abbott’s spinal cord stimulation devices, the company said. It acquired the neurostim assets when it paid $25 billion for St. Jude Medical back in January 2017. “Since its launch in the U.S., Abbott’s DRG stimulation has had a profound impact for people living with complex pain conditions. One of the mos...
Source: Mass Device - September 4, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Neuromodulation/Neurostimulation Abbott Reimbursement Source Type: news

Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain
Pain-sensing sensory neurons of the dorsal root ganglion (DRG) can become sensitized or hyperexcitable in response to surgically induced peripheral tissue injury. We investigated the potential role and molecular mechanisms of nociceptive ion channel dysregulation in acute pain conditions such as those resulting from skin and soft tissue incision. We used selective pharmacology, electrophysiology, and mouse genetics to link increased current densities arising from the CaV3.2 isoform of T-type calcium channels (T-channels) to nociceptive sensitization using a clinically relevant rodent model of skin and deep tissue incision....
Source: Signal Transduction Knowledge Environment - August 28, 2018 Category: Science Authors: Joksimovic, S. L., Joksimovic, S. M., Tesic, V., Garcia-Caballero, A., Feseha, S., Zamponi, G. W., Jevtovic-Todorovic, V., Todorovic, S. M. Tags: STKE Research Articles Source Type: news

UCLA bioengineers show magnetic gel ’s use to ease pain
UCLA bioengineers have demonstrated that a gel-like material containing tiny magnetic particles could be used to manage chronic pain from disease or injury. Broadly, the study demonstrates the promising use of biomechanical forces  that push and pull on cells to treat disease.“Much of mainstream modern medicine centers on using pharmaceuticals to make chemical or molecular changes inside the body to treat disease,” said Dino Di Carlo, UCLA professor of bioengineering and the principal investigator of the study. “However, recent breakthroughs in the control of force s at small scales have opened up a ...
Source: UCLA Newsroom: Health Sciences - August 7, 2018 Category: Universities & Medical Training Source Type: news

New retinal ganglion cell subtypes emerge from single-cell RNA sequencing
(Jackson Laboratory) Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center (UConn Health) and The Jackson Laboratory (JAX) have identified 40 subtypes of retinal ganglion cells (RGCs) along with the genetic markers and transcription factors that differentiate them. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2018 Category: International Medicine & Public Health Source Type: news

Sphenopalatine Ganglion Blocks in Chronic Migraine With MOH Sphenopalatine Ganglion Blocks in Chronic Migraine With MOH
This fMRI study examined how a series of sphenopalatine ganglion blockade treatments might modulate functional connectivity between brain networks in chronic migraine with medication overuse headache.Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 13, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

A method for single-neuron chronic recording from the retina in awake mice
We report a nonsurgical method to achieve chronically stable in vivo recordings from single retinal ganglion cells (RGCs) in awake mice. We developed a noncoaxial intravitreal injection scheme in which injected mesh electronics unrolls inside the eye and conformally coats the highly curved retina without compromising normal eye functions. The method allows 16-channel recordings from multiple types of RGCs with stable responses to visual stimuli for at least 2 weeks, and reveals circadian rhythms in RGC responses over multiple day/night cycles. (Source: ScienceNOW)
Source: ScienceNOW - June 28, 2018 Category: Science Authors: Hong, G., Fu, T.-M., Qiao, M., Viveros, R. D., Yang, X., Zhou, T., Lee, J. M., Park, H.-G., Sanes, J. R., Lieber, C. M. Tags: Neuroscience, Techniques reports Source Type: news

UMKC lands $1.97M grant for glaucoma treatment
Researchers at the University of Missouri-Kansas City School of Medicine landed $1.937 million to develop a way to treat patients with end-stage glaucoma. The five-year grant from the National Institutes of Health will support principal investigator Karl Kador's research on ways to restore vision to patients with glaucoma and other eye disorders. Kador, an assistant professor of ophthalmology and biomedical sciences, studies disease and injuries that lead to the death of retinal ganglion cells,… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - April 26, 2018 Category: American Health Authors: Elise Reuter Source Type: news

ATP and Pain
P2XRs Play a Key RoleIn dorsal root ganglion (DRG) neurons, ATP is an important neurotransmitter in nociceptive signaling through P2 receptors (P2Rs) such as P2X2/3R, and adenosine is also involved in anti-nociceptive signaling through adenosine A1R.ENNPs interact with P2XRs to metabolize ATP to AMP in DRGs. Kentaro Nishida, Yuka Nomura, Kanako Kawamori, Akihiro Ohishi, Kazuki Nagasawa.ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion. European Journal of Histochemistry 2018; 62:2877.Images: Rat DRG stained withNeuromics P2X2Rand ENPP1.Modulating ATP Processing in DRG...
Source: Neuromics - April 19, 2018 Category: Neuroscience Source Type: news

Palmitoylation of {delta}-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain
Palmitoylation of -catenin is critical to synapse plasticity and memory formation. We found that -catenin palmitoylation is also instrumental in the development of neuropathic pain. The abundances of palmitoylated -catenin and the palmitoyl acyltransferase DHHC3 were increased in dorsal root ganglion (DRG) sensory neurons in rat models of neuropathic pain. Inhibiting palmitoyl acyltransferases or decreasing -catenin abundance in the DRG by intrathecal injection of 2-bromopalmitate or shRNA, respectively, alleviated oxaliplatin or nerve injury–induced neuropathic pain in the rats. The palmitoylation of -catenin, which...
Source: Signal Transduction Knowledge Environment - March 27, 2018 Category: Science Authors: Zhang, X.-L., Ding, H.-H., Xu, T., Liu, M., Ma, C., Wu, S.-L., Wei, J.-Y., Liu, C.-C., Zhang, S.-B., Xin, W.-J. Tags: STKE Research Articles Source Type: news

Why Are Devices the Last-in-Line Treatment for Chronic Pain?
Between 2000 and 2016, more than 600,000 people died from drug overdoses. More than half of those deaths involved opioids, according to the U.S. Centers for Disease Control and Prevention (CDC). Although the amount of opioids prescribed is gradually decreasing, it's still too high—about three times as high as in 1999, a CDC report states. CDC guidelines call for using acetaminophen, nonsteroidal anti-inflammatory medications, exercise therapy, and cognitive behavioral therapy (CBT) for chronic pain. Guidelines don't list minimally invasive care such as spinal cord stimulators (SCS) and other neuromodulation devices. ...
Source: MDDI - February 27, 2018 Category: Medical Devices Authors: Heather R. Johnson Tags: Electronics Source Type: news

Dr Martin Scurr answers questions on ganglions
Ganglions are small fluid-filled swellings thought to be linked to mild damage in the connective tissue around the tendons, and are most commonly found around the wrist, hand or foot. (Source: the Mail online | Health)
Source: the Mail online | Health - February 5, 2018 Category: Consumer Health News Source Type: news

Studying Apoptosis
By Cancer Researchers OurApoptosis Kits have proven rock solid in the hands of cancer researchers.Here's data from a study of the impact of Vestibular schwannoma (VS) on hearing loss.Images: Spiral Ganglion Cells labeled with our polycaspase kit stain to identify apoptotic cells. (Source: Neuromics)
Source: Neuromics - January 31, 2018 Category: Neuroscience Tags: Apoptosis Assays Apoptosis Detection Polcaspase Kits Spiral Ganglion Cells Vestibular Schwannoma Source Type: news

Microvascular Endothelial Cells
Tested, Characterized and Research ReadyOurMicrovascular Endothelial Cells continue to work and work in the hands of our customers.Check out these pubs:1. Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017).Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567 2. Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015).Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relev...
Source: Neuromics - January 9, 2018 Category: Neuroscience Tags: Diabetic retinopathy endothelial cells human microvascular endotothelial cells Human Retinal Microvascular Endothelial Cells Source Type: news

Abbott launches Proclaim DRG neurostim
Abbott (NYSE:ABT) said today it launched its Proclaim dorsal root ganglion neurostimulator system designed to treat pain in patients with complex regional pain syndrome of the lower limbs. The company’s Proclaim DRG system is designed to be used via Bluetooth with an Apple (NSDQ:AAPL) iPod touch as a system controller and is magnetic resonance-conditional and recharge free, all upgrades from previous versions of the device, the Abbott Park, Ill.-based company said. Abbott said it originally launched the DRG therapy system in 2016 and data from the Accurate study of it showed the system delivers “...
Source: Mass Device - October 16, 2017 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Neuromodulation/Neurostimulation Pain Management Abbott Source Type: news

Patients Battling Complex Regional Pain Syndrome Find a Host of New Benefits in Abbott's Proclaim ™ DRG System
- The new Proclaim ™ DRG System combines the superior pain relief of dorsal root ganglion (DRG) stimulation with an intuitive iOS™ controller and programming platform for a positive patient experience (Source: Abbott.com)
Source: Abbott.com - October 16, 2017 Category: Pharmaceuticals Source Type: news

Ganglion Cell Loss May Trigger Retinal Problems in Congenital Zika Syndrome Ganglion Cell Loss May Trigger Retinal Problems in Congenital Zika Syndrome
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 14, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Ganglion Cyst
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - September 8, 2017 Category: General Medicine Source Type: news

A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and inflammation. Profiling of tissue-specific precursor abundance and biosynthetic gene expression predicted that inflamed skin would be abundant in four previously unknown 11-hydroxy-epoxy- or 11-keto-epoxy-octadecenoate linoleic acid derivatives and four previously identified 9- or 13-hydroxy-epoxy- or 9- or 13-keto-epoxy-octadecenoate linoleic acid derivatives. All of these me...
Source: Signal Transduction Knowledge Environment - August 22, 2017 Category: Science Authors: Ramsden, C. E., Domenichiello, A. F., Yuan, Z.-X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M. R., Mehta, N. N. Tags: STKE Research Articles Source Type: news

The transcription factor C/EBP{beta} in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity
We report that peripheral nerve trauma caused by chronic constriction injury (CCI) increased the abundance of the transcription factor C/EBPβ (CCAAT/enhancer binding protein β) in the DRG. Blocking this increase mitigated the development and maintenance of CCI-induced mechanical, thermal, and cold pain hypersensitivities without affecting basal responses to acute pain and locomotor activity. Conversely, mimicking this increase produced hypersensitivity to mechanical, thermal, or cold pain. In the ipsilateral DRG, C/EBPβ promoted a decrease in the abundance of the voltage-gated potassium channel subunit Kv1.2...
Source: Signal Transduction Knowledge Environment - July 11, 2017 Category: Science Authors: Li, Z., Mao, Y., Liang, L., Wu, S., Yuan, J., Mo, K., Cai, W., Mao, Q., Cao, J., Bekker, A., Zhang, W., Tao, Y.-X. Tags: STKE Research Articles Source Type: news

Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons
Neuropeptides released from dorsal root ganglion (DRG) neurons play essential roles in the neurotransmission of sensory inputs, including those underlying nociception and pathological pain. Neuropeptides are released from intracellular vesicles through two modes: a partial release mode called "kiss-and-run" (KAR) and a full release mode called "full fusion–like" (FFL). Using total internal reflection fluorescence (TIRF) microscopy, we traced the release of pH-sensitive green fluorescent protein–tagged neuropeptide Y (pHluorin-NPY) from individual dense-core vesicles in the soma and axon of s...
Source: Signal Transduction Knowledge Environment - June 20, 2017 Category: Science Authors: Wang, Y., Wu, Q., Hu, M., Liu, B., Chai, Z., Huang, R., Wang, Y., Xu, H., Zhou, L., Zheng, L., Wang, C., Zhou, Z. Tags: STKE Research Articles Source Type: news

US Army invests $2million in injection to beat PTSD
Numerous military doctors around the world use stellate ganglion block injections to 'reset' the nervous system in soldiers tormented by past trauma. Now the Pentagon is backing US research on it. (Source: the Mail online | Health)
Source: the Mail online | Health - June 12, 2017 Category: Consumer Health News Source Type: news

Regenerating optic pathways from the eye to the brain
Humans are highly visual. Retinal ganglion cells (RGCs), the neurons that connect the eyes to the brain, fail to regenerate after damage, eventually leading to blindness. Here, we review research on regeneration and repair of the optic system. Intrinsic developmental growth programs can be reactivated in RGCs, neural activity can enhance RGC regeneration, and functional reformation of eye-to-brain connections is possible, even in the adult brain. Transplantation and gene therapy may serve to replace or resurrect dead or injured retinal neurons. Retinal prosthetics that can restore vision in animal models may too have pract...
Source: ScienceNOW - June 8, 2017 Category: Science Authors: Laha, B., Stafford, B. K., Huberman, A. D. Tags: Neuroscience special/review Source Type: news

Pain and Spine Clinics Now Offering Effective PTSD Treatment with...
Pain and Spine Clinics is now offering effective PTSD treatment with stellate ganglion blocks. The outpatient procedure has been shown to be extremely effective for relieving the symptoms of PTSD for...(PRWeb April 24, 2017)Read the full story at http://www.prweb.com/releases/PTSD-treatment/phoenix-arizona/prweb14256071.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 24, 2017 Category: Pharmaceuticals Source Type: news

Helping the retina regenerate
A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 31, 2017 Category: Science Source Type: news

Helping the retina regenerate
A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain. Authored by Monica Vetter, Ph.D., University of Utah, and Peter Hitchcock, Ph.D., University of Michigan, the report stems from a 2016 workshop sponsored by the National Eye Institute (NEI) Audacious Goals Initiative  (AGI). (Source: News from NEI)
Source: News from NEI - March 30, 2017 Category: Opthalmology Authors: haysdc Source Type: news

Minimally-invasive migraine treatment for adults works on kids, too
[Image from Tagosaku on Flickr]Migraine treatment that has been safe for adults has recently proven to be safe for use in children as well. The minimally-invasive treatment only takes a few minutes for children and teenagers to be able to feel the effects. The treatment involves a sphenopalatine ganglion (SPG) block that does not need needles. It uses a small, flexible catheter that is put into each nostril that delivers a local anesthetic to the SPG, which has often been considered the nerve bundle that causes migraines, that is in the back of the nose. The treatment disables the SPG and resets the headache circuit, reduc...
Source: Mass Device - March 13, 2017 Category: Medical Equipment Authors: Danielle Kirsh Tags: Pain Management MedTech migraines Phoenix Children's Hospital radiology Source Type: news

Retinal Degeneration Ongoing in Pediatric MS Retinal Degeneration Ongoing in Pediatric MS
Children with multiple sclerosis showed more progressive ganglion cell layer thinning than healthy kids or those with monophasic demyelination -- and there was more retinal atrophy in girls than in boys.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 1, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

[Perspective] Relief for retinal neurons under pressure
Advancing age predisposes us to a number of neurodegenerative diseases, yet the underlying mechanisms are poorly understood. With some 70 million individuals affected, glaucoma is the world's leading cause of irreversible blindness. Glaucoma is characterized by the selective loss of retinal ganglion cells that convey visual messages from the photoreceptive retina to the brain. Age is a major risk factor for glaucoma, with disease incidence increasing near exponentially with increasing age. Treatments that specifically target retinal ganglion cells or the effects of aging on glaucoma susceptibility are currently lacking. On...
Source: ScienceNOW - February 16, 2017 Category: Science Authors: Jonathan Crowston Tags: Neurodegenerative Disease Source Type: news

Stem cell secretions may protect against glaucoma
NEI scientists find that stem cell exosomes promote survival of retinal ganglion cells in rats. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - January 27, 2017 Category: American Health Source Type: news

MassDevice.com +5 | The top 5 medtech stories for January 18, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Allergan pays $15m for failing to disclose Actavis ‘white knight’ offer The SEC said yesterday that Allergan will pay a $15 million fine for failing to disclose its 2014 merger talks with Actavis. In June 2014, Vale...
Source: Mass Device - January 18, 2017 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news

Abbott launches dorsal root ganglion neurostim system in Europe
Abbott (NYSE:ABT) said today that it launched its Proclaim dorsal root ganglion neurostimulation system in Europe for patients suffering from chronic neuropathic pain. The Abbott Park, Il.-based company’s system targets sensory nerves packed within the dorsal root ganglion to directly target the area of the body where pain occurs and provide stronger pain relief compared to traditional spinal cord stimulation therapy. “Many patients battling chronic neuropathic pain have not found adequate relief from other forms of treatment, which is why dorsal root ganglion stimulation has been such an important therapeutic ...
Source: Mass Device - January 18, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Neuromodulation/Neurostimulation Pain Management Regulatory/Clearance Wall Street Beat Abbott Source Type: news

MassDevice.com +5 | The top 5 medtech stories for January 17, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. FDA warns again on Pentax duodenoscopes The FDA issued a statement today warning that Hoya subsidiary Pentax Medical’s ED-3490TK video duodenoscopes have a potential risk associated with the design and manufacturing of th...
Source: Mass Device - January 17, 2017 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news

Abbott touts dorsal root ganglion stim study
Abbott (NYSE:ABT) today touted short- and long-term data published in the journal Pain, which demonstrated that its dorsal root ganglion stimulation therapy benefits patients suffering from complex regional pain syndrome more than traditional spinal cord stimulation. The Abbott Park, Ill.-based company said it’s the only company in the world approved to offer DRG stimulation. The newly-published data is from the company’s ACCURATE study, which evaluated DRG stimulation in patients for 3 and 12 months. “Historically, many patients with chronic pain resulting from complex regional pain syndrome or...
Source: Mass Device - January 17, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Clinical Trials Pain Management Research & Development Spinal Abbott Source Type: news

New Data Confirms Abbott's Dorsal Root Ganglion Stimulation Offers Greater Treatment Success over Traditional Spinal Cord Stimulation
ACCURATE STUDY CONFIRMS DRG STIMULATION PROVIDES SUPERIOR, TARGETED AND CONSISTENT PAIN RELIEF FOR PATIENTS WITH COMPLEX REGIONAL PAIN SYNDROME (Source: Abbott.com)
Source: Abbott.com - January 17, 2017 Category: Pharmaceuticals Source Type: news

Habitual Cannabis Use May Slow Visual Perception Habitual Cannabis Use May Slow Visual Perception
An electrophysiology study of retinal cell function finds altered processing with substantial delay in the transmission of action potentials by the ganglion cells in regular cannabis users.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 8, 2016 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

French study suggests Cannabis 'affects your eyesight'
A small study in France has found prolonged marijuana use could wear down retinal ganglion cells, the nerves that sit just behind the retina. (Source: the Mail online | Health)
Source: the Mail online | Health - December 8, 2016 Category: Consumer Health News Source Type: news

OCT for Tracking Glaucoma Progression OCT for Tracking Glaucoma Progression
Researchers hypothesized that the macular ganglion cell layer would prove a more advantageous measure of glaucoma progression, but their results indicated otherwise.Medscape Ophthalmology (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - November 14, 2016 Category: Opthalmology Tags: Ophthalmology Viewpoint Source Type: news

Vancouver man with recurring cyst pops the lump with a fish hook and push pin
Jason, from Vancouver, has been battling this recurring ganglion cyst for years. But now, he thinks he has found the fail-safe solution: a humble push pin. (Source: the Mail online | Health)
Source: the Mail online | Health - September 21, 2016 Category: Consumer Health News Source Type: news

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway - Chrysostomou V, Galic S, van Wijngaarden P, Trounce IA, Steinberg GR, Crowston JG.
Retinal ganglion cells (RGCs) become increasingly vulnerable to injury with advancing age. We recently showed that this vulnerability can be strongly modified in mice by exercise. However, the characteristics and underlying mechanisms of retinal protection... (Source: SafetyLit)
Source: SafetyLit - September 14, 2016 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

What Causes Hyperphosphatemia?
Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdo...
Source: PediatricEducation.org - September 12, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news