The transcription factor C/EBP{beta} in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity
We report that peripheral nerve trauma caused by chronic constriction injury (CCI) increased the abundance of the transcription factor C/EBPβ (CCAAT/enhancer binding protein β) in the DRG. Blocking this increase mitigated the development and maintenance of CCI-induced mechanical, thermal, and cold pain hypersensitivities without affecting basal responses to acute pain and locomotor activity. Conversely, mimicking this increase produced hypersensitivity to mechanical, thermal, or cold pain. In the ipsilateral DRG, C/EBPβ promoted a decrease in the abundance of the voltage-gated potassium channel subunit Kv1.2...
Source: Signal Transduction Knowledge Environment - July 11, 2017 Category: Science Authors: Li, Z., Mao, Y., Liang, L., Wu, S., Yuan, J., Mo, K., Cai, W., Mao, Q., Cao, J., Bekker, A., Zhang, W., Tao, Y.-X. Tags: STKE Research Articles Source Type: news
Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons
Neuropeptides released from dorsal root ganglion (DRG) neurons play essential roles in the neurotransmission of sensory inputs, including those underlying nociception and pathological pain. Neuropeptides are released from intracellular vesicles through two modes: a partial release mode called "kiss-and-run" (KAR) and a full release mode called "full fusion–like" (FFL). Using total internal reflection fluorescence (TIRF) microscopy, we traced the release of pH-sensitive green fluorescent protein–tagged neuropeptide Y (pHluorin-NPY) from individual dense-core vesicles in the soma and axon of single DRG neurons af...
Source: Signal Transduction Knowledge Environment - June 20, 2017 Category: Science Authors: Wang, Y., Wu, Q., Hu, M., Liu, B., Chai, Z., Huang, R., Wang, Y., Xu, H., Zhou, L., Zheng, L., Wang, C., Zhou, Z. Tags: STKE Research Articles Source Type: news
US Army invests $2million in injection to beat PTSD
Numerous military doctors around the world use stellate ganglion block injections to 'reset' the nervous system in soldiers tormented by past trauma. Now the Pentagon is backing US research on it. (Source: the Mail online | Health)
Source: the Mail online | Health - June 12, 2017 Category: Consumer Health News Source Type: news
Regenerating optic pathways from the eye to the brain
Humans are highly visual. Retinal ganglion cells (RGCs), the neurons that connect the eyes to the brain, fail to regenerate after damage, eventually leading to blindness. Here, we review research on regeneration and repair of the optic system. Intrinsic developmental growth programs can be reactivated in RGCs, neural activity can enhance RGC regeneration, and functional reformation of eye-to-brain connections is possible, even in the adult brain. Transplantation and gene therapy may serve to replace or resurrect dead or injured retinal neurons. Retinal prosthetics that can restore vision in animal models may too have pract...
Source: ScienceNOW - June 8, 2017 Category: Science Authors: Laha, B., Stafford, B. K., Huberman, A. D. Tags: Neuroscience special/review Source Type: news
Pain and Spine Clinics Now Offering Effective PTSD Treatment with...
Pain and Spine Clinics is now offering effective PTSD treatment with stellate ganglion blocks. The outpatient procedure has been shown to be extremely effective for relieving the symptoms of PTSD for...(PRWeb April 24, 2017)Read the full story at http://www.prweb.com/releases/PTSD-treatment/phoenix-arizona/prweb14256071.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 24, 2017 Category: Pharmaceuticals Source Type: news
Helping the retina regenerate
A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 31, 2017 Category: Science Source Type: news
Helping the retina regenerate
A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain. Authored by Monica Vetter, Ph.D., University of Utah, and Peter Hitchcock, Ph.D., University of Michigan, the report stems from a 2016 workshop sponsored by the National Eye Institute (NEI) Audacious Goals Initiative (AGI). (Source: News from NEI)
Source: News from NEI - March 30, 2017 Category: Opthalmology Authors: haysdc Source Type: news
Minimally-invasive migraine treatment for adults works on kids, too
[Image from Tagosaku on Flickr]Migraine treatment that has been safe for adults has recently proven to be safe for use in children as well. The minimally-invasive treatment only takes a few minutes for children and teenagers to be able to feel the effects.
The treatment involves a sphenopalatine ganglion (SPG) block that does not need needles. It uses a small, flexible catheter that is put into each nostril that delivers a local anesthetic to the SPG, which has often been considered the nerve bundle that causes migraines, that is in the back of the nose. The treatment disables the SPG and resets the headache circuit, reduc...
Source: Mass Device - March 13, 2017 Category: Medical Equipment Authors: Danielle Kirsh Tags: Pain Management MedTech migraines Phoenix Children's Hospital radiology Source Type: news
Retinal Degeneration Ongoing in Pediatric MS Retinal Degeneration Ongoing in Pediatric MS
Children with multiple sclerosis showed more progressive ganglion cell layer thinning than healthy kids or those with monophasic demyelination -- and there was more retinal atrophy in girls than in boys.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 1, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
[Perspective] Relief for retinal neurons under pressure
Advancing age predisposes us to a number of neurodegenerative diseases, yet the underlying mechanisms are poorly understood. With some 70 million individuals affected, glaucoma is the world's leading cause of irreversible blindness. Glaucoma is characterized by the selective loss of retinal ganglion cells that convey visual messages from the photoreceptive retina to the brain. Age is a major risk factor for glaucoma, with disease incidence increasing near exponentially with increasing age. Treatments that specifically target retinal ganglion cells or the effects of aging on glaucoma susceptibility are currently lacking. On...
Source: ScienceNOW - February 16, 2017 Category: Science Authors: Jonathan Crowston Tags: Neurodegenerative Disease Source Type: news
Stem cell secretions may protect against glaucoma
NEI scientists find that stem cell exosomes promote survival of retinal ganglion cells in rats. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - January 27, 2017 Category: American Health Source Type: news
MassDevice.com +5 | The top 5 medtech stories for January 18, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry.
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5. Allergan pays $15m for failing to disclose Actavis ‘white knight’ offer
The SEC said yesterday that Allergan will pay a $15 million fine for failing to disclose its 2014 merger talks with Actavis.
In June 2014, Valeant Phar...
Source: Mass Device - January 18, 2017 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news
Abbott launches dorsal root ganglion neurostim system in Europe
Abbott (NYSE:ABT) said today that it launched its Proclaim dorsal root ganglion neurostimulation system in Europe for patients suffering from chronic neuropathic pain.
The Abbott Park, Il.-based company’s system targets sensory nerves packed within the dorsal root ganglion to directly target the area of the body where pain occurs and provide stronger pain relief compared to traditional spinal cord stimulation therapy.
“Many patients battling chronic neuropathic pain have not found adequate relief from other forms of treatment, which is why dorsal root ganglion stimulation has been such an important therapeutic ...
Source: Mass Device - January 18, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Neuromodulation/Neurostimulation Pain Management Regulatory/Clearance Wall Street Beat Abbott Source Type: news
MassDevice.com +5 | The top 5 medtech stories for January 17, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry.
Get this in your inbox everyday by subscribing to our newsletters.
5. FDA warns again on Pentax duodenoscopes
The FDA issued a statement today warning that Hoya subsidiary Pentax Medical’s ED-3490TK video duodenoscopes have a potential risk associated with the design and manufacturing of the de...
Source: Mass Device - January 17, 2017 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news
Abbott touts dorsal root ganglion stim study
Abbott (NYSE:ABT) today touted short- and long-term data published in the journal Pain, which demonstrated that its dorsal root ganglion stimulation therapy benefits patients suffering from complex regional pain syndrome more than traditional spinal cord stimulation.
The Abbott Park, Ill.-based company said it’s the only company in the world approved to offer DRG stimulation. The newly-published data is from the company’s ACCURATE study, which evaluated DRG stimulation in patients for 3 and 12 months.
“Historically, many patients with chronic pain resulting from complex regional pain syndrome or pain re...
Source: Mass Device - January 17, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Clinical Trials Pain Management Research & Development Spinal Abbott Source Type: news
