New Hope for Cluster Headache Sufferers?
The sphenopalatine ganglion (SPG) has recently been the target of a novel treatment for patients with cluster headaches. A sham-controlled randomized study of an implantable stimulator of the SGP offers encouraging preliminary results. (Source: Consultant Live)
Source: Consultant Live - July 9, 2013 Category: Primary Care Source Type: news
Nerve Stimulation Gains Ground in Headache TreatmentNerve Stimulation Gains Ground in Headache Treatment
Encouraging results from studies of sphenopalatine ganglion and occipital nerve stimulation released at international headache meeting. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 3, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
P2X3 Receptors and Migraine
P2X3 Receptors of Trigeminal Sensory Neurons and Familial Hemiplegic Migraine Type 1 (FHM-1). Our P2X Receptor Markers continue to be used in interesting and novel ways. Here researchers use our P2X3 Receptor Antibody to study expression using primary rat ganlia cultures: Swathi K. Hullugundi,Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Andrea Nistri. Andrea Nistri. The Mechanism of Functional Up-Regulation of P2X3 Receptors of Trigeminal Sensory Neurons in a Genetic Mouse Model of Familial Hemiplegic Migraine Type 1 (FHM-1). PLoS ONE 8(4): e60677. doi:10.1371/journal.pone.0060677 Abstract: A knock-in (KI) mouse mo...
Source: Neuromics - April 14, 2013 Category: Neuroscience Tags: sensory neurons Immunhistochemistry Purinergic Receptor Antibodies Familial Hemiplegic Migraine Type 1 Dorsal Root Ganglia Nociceptive Pain Nociception P2X3 Antibody Source Type: news
M-Current Recording from Acute DRG Slices
Electrophysiological recordings from an acutely sliced preparation provide information on ionic currents and excitability of native neurons under near physiological conditions. Although this technique is commonly used on central nervous system structures such as spinal cord and brain, structures within the peripheral nervous system (including sensory ganglia and fibers) have proven to be much more difficult to study in acute preparations. Here we describe a method for patch-clamp recordings from rat dorsal root ganglion (DRG) slices. (Source: Springer protocols feed by Cell Biology)
Source: Springer protocols feed by Cell Biology - April 12, 2013 Category: Cytology Source Type: news
Transient Overexpression of Genes in Neurons Using Nucleofection
Nucleofection is a transfection method used to introduce substrates such as cDNA plasmids into primary cells or other cell lines. The method can be successfully applied to cells that are considered difficult to transfect or suffer from low transfection efficiency as seen with traditional transfection techniques. Neurons in primary cultures retain many properties of their in vivo state and therefore, in many instances, are considered better experimental systems than immortalized cell lines, thus becoming increasingly desirable cell types for biomedical research. However, being post-mitotic, primary neuronal cultures are par...
Source: Springer protocols feed by Cell Biology - April 12, 2013 Category: Cytology Source Type: news
OCT: A Role in Monitoring Multiple Sclerosis?OCT: A Role in Monitoring Multiple Sclerosis?
Thinning of the retinal ganglion cell/inner plexiform layer as measured by OCT could be a way of monitoring disease progression in multiple sclerosis. Medscape Optometry (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 12, 2013 Category: Consumer Health News Tags: Viewpoint Source Type: news
A SAD Tale
For those who suffer from Seasonal Affective Disorder, spring can't come soon enough. Still, there's hope even if Punxsutawney Phil sees his shadow on Saturday.read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - January 29, 2013 Category: Psychiatry & Psychology Authors: Meir H. Kryger, M.D. Tags: Depression Neuroscience Psychiatry Sleep burrow circadian clock daylight exposure depressive symptoms early spring february 2 ganglion cells melanopsin northern climes northern populations pigment Punxsutawney Phil retina Source Type: news
Light in the womb controls eye development | Mo Costandi
New findings could improve understanding of diseases that cause blindness in premature babiesProper brain development is highly dependent upon sensory experiences in early life. From the minute you are born, the light entering your eyes began to tune the responses of cells in your visual cortex and shaped the overall growth of your visual pathways. And your parents' cuddles and caresses drove the development of your somatosensory system, the pathway that detects touch and pain. Now a team of American researchers provides evidence that sensory experiences before birth play an important role in development of the eye. In a s...
Source: Guardian Unlimited Science - January 23, 2013 Category: Science Tags: Blogposts Health guardian.co.uk Neuroscience Source Type: news
Ophthalmic drugs as part of polypharmacy in nursing home residents with glaucoma
Source: Drugs and Aging
Area: Evidence > Medicines Management > References
Background: Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug interactions, of particular importance in frail nursing home resident populations.
Objective: The aim of the present study was to investigate anti-glaucoma pharmacotherapy in nursing home residents in the context of m...
Source: NeLM - Care of Older People - January 23, 2013 Category: Geriatrics Source Type: news
KLF Family Members Regulate Intrinsic Axon Regeneration Ability
Glaucoma is a family of neurodegenerative diseases that can lead to death of retinal ganglion cells (RGCs), which results in progressive vision loss and ultimately blindness. RGCs are neurons in the optic nerve that relay visual impulses from the retina to the brain where final visual processing occurs. Although the causes of RGC degeneration are not completely understood, axon loss is an early component in the disease. Axons are the fiber-like extensions of a neuron which transmit electrical signals to other neuronal cells. Developing neurons can regenerate new axons; however, adult neurons cannot. (Source: News from NEI)
Source: News from NEI - September 17, 2010 Category: Opthalmology Tags: News and Events Source Type: news
Focus on Glaucoma--NEI 40th Anniversary Symposium
The symposium "Focus on Glaucoma" is open to the wide scientific community interested in glaucoma and nerve degeneration/ regeneration, within and outside the NIH. The talks will cover research on: control of axon growth by retinal ganglion cells and the mechanisms of neurodegeneration; genetics defects that predispose to inherited glaucoma and computational methods supporting this research; - translational medicine for glaucoma and clinical trials. (Source: News from NEI)
Source: News from NEI - February 10, 2010 Category: Opthalmology Tags: News and Events Source Type: news
