Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function. On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/ A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously proven. Intermittently provoking hematopoietic stem cells to leave the bone marrow via CXCL12 upregulation, for example. Humans are not completely uniform in their major blood vessel networks, there are variant populations with more redundancy. The value of that greater redundancy is illustrated here by a look at a patient possessing a Kugel's artery, a rare additional vessel that can allow survival in cases of obstructed coronary arteries due to the progression of atherosclerosis. Redundancy in blood vessel networks is a poor substitute for addressing the causes of atherosclerosis, such that no-one suffers blocked vessels, but if redundancy can be engineered, then it would be a benefit. Kugel's artery is defined as a rare anatomical variant of the coronary artery vascular bed consisting of an anastomotic connection between branches of the right coron...
Immune checkpoint inhibitors can be effective in patients with non-small cell lung cancer and mild interstitial lung disease, but with a greater risk.Medscape Medical News
AbstractPurposeGenetic variants may influence the pharmacokinetics and pharmacodynamics (PKPD) of cyclophosphamide (CY). CY plays a critical role in conditioning chemotherapy for hematopoietic cell transplantation (HCT), but its use is limited by toxicity. We explored the effect of genetic variants, potentially affecting PKPD of CY, and outcomes after HCT.MethodsThis observational pharmacogenomic study included 85 adults with hematologic malignancies who received reduced intensity conditioning with CY, fludarabine, and total body irradiation. We collected recipient DNA prior to HCT and evaluated 97 candidate variants in 66...
Oncogene, Published online: 27 January 2022; doi:10.1038/s41388-021-02158-wSELENOF is a new tumor suppressor in breast cancer
Journal of Human Hypertension, Published online: 27 January 2022; doi:10.1038/s41371-021-00651-zMalignant hypertension and atypical hemolytic uremic syndrome: a possible continuum between two entities?
Journal of Human Hypertension, Published online: 27 January 2022; doi:10.1038/s41371-021-00652-yFocus on today’s evidence while keeping an eye on the future: lessons derived from hypertension in women
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT04315C, PaperXiang Wang, Kang Song, Yong Deng, Jie Liu, Qin Peng, Xiao Lao, Jiayu Xu, Dong Wang, Turong Shi, Yuhao Li, Dan Deng, Yuqing Miao Photodynamic therapy (PDT) is an effective non-invasive treatment for tumors. The structure of the photosensitizer has an important influence on the light utilization and the efficiency of singlet-oxygen generation. In... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC06330H, CommunicationXiao-Jie Dong, Wen-Yan Li, Qun Guan, Yan-An Li, Yu-Bin Dong A COF-based multifunctional nanomedicine CuS@COF-BDP, which can be used as a PTT/PDT bimodal therapeutic agent to inhibit cancer cell proliferation under visible- and NIR-II-light irradiation, is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC05792H, CommunicationElena Atri án-Blasco, Lucie de Cremoux, Xudong Lin, Rufus Mitchell-Heggs, Laurent Sabater, Sébastien Blanchard, Christelle Hureau Keggin-type POMs extract Cu(II) from the Alzheimer's-related amyloid- β peptide. They prevent Cu(Aβ) ROS production, while ill-defined Cu(Aβ) aggregates are switched to fibrils due to Cu(POM) modulation of the apo-Aβ's assembly. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
ConclusionEmphysematous changes and lower levels of plasma irisin were associated with CLAD, especially in patients with BOS, after bilateral LDLLT.
ConclusionThe present report revealed important clinical features of this entity. However, there are still some issues that need to be discussed, and further research is needed.
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