Neurological Involvement in Primary Systemic Vasculitis
Neurological Involvement in Primary Systemic Vasculitis Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasculitis in the nervous system. Introduction Primary systemic vasculitis (PSV) can be defined as a heterogeneous group of uncommon diseases characterized by blood vessel inflammation and necrosis. Unlike secondary systemic vasculitis, which usually results from infections, connective tissue diseases, neoplasms, and drugs, PSV is considered to occur with no identified etiology (1). Nevertheless, recent researches have demonstrated that PSV might be associated with farming (2), silica exposure (2, 3), solvent exposure and hydrocarbons (2, 4, 5), allergy and family history of atopy (2, 6). Despite of unknown causes, two mechanisms, deposition of immune complexes and cell-mediated immunity, were found to possibly participate in the pathophysiology of PSV by causing immunological inflammation and necrosis...
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