AIN: Maybe Nephrologists Don't Know It All AIN: Maybe Nephrologists Don't Know It All
Are nephrologists too complacent about acute interstitial nephritis? Tejas Desai, MD, reviews recent data suggesting that AIN is on the rise and is a major contributor to acute kidney injury.Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 6, 2020 Category: Consumer Health News Tags: Nephrology Viewpoint Source Type: news

Novel Antibody Looks Promising in Lupus Nephritis Novel Antibody Looks Promising in Lupus Nephritis
A highly engineered anti-CD20 antibody, obinutuzumab, enhances renal responses in lupus nephritis compared with standard immunotherapy and is well tolerated. A Phase 3 study is planned for 2020.Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - November 19, 2019 Category: Transplant Surgery Tags: Nephrology News Source Type: news

Roche ’s Gazyva (obinutuzumab), in combination with standard of care, more than doubles the percentage of lupus nephritis patients achieving complete renal response, compared to standard of care alone
Roche today announced data from the phase II NOBILITY study, investigating the safety and efficacy of Gazyva ® (obinutuzumab) for adults with proliferative lupus nephritis.1 The study met the primary endpoint with Gazyva, in combination with standard of care (mycophenolate mofetil or mycophenolic acid and corticosteroids), demonstrating superiority compared to placebo plus standard of care. (Source: Roche Media News)
Source: Roche Media News - November 11, 2019 Category: Pharmaceuticals Source Type: news

Roche ’s Gazyva (obinutuzumab), in combination with standard of care, more than doubles the percentage of lupus nephritis patients achieving complete renal response, compared to standard of care alone
Roche today announced data from the phase II NOBILITY study, investigating the safety and efficacy of Gazyva ® (obinutuzumab) for adults with proliferative lupus nephritis.1 The study met the primary endpoint with Gazyva, in combination with standard of care (mycophenolate mofetil or mycophenolic acid and corticosteroids), demonstrating superiority compared to placebo plus standard of care. (Source: Roche Investor Update)
Source: Roche Investor Update - November 11, 2019 Category: Pharmaceuticals Source Type: news

Reminder: Invitation to Roche ’s live audio webcast on Gazyva in lupus nephritis presented at ASN / ACR 2019
We are pleased to invite investors and analysts to participate in a live audio webcast and conference call on Tuesday, 12 November 2019, highlighting Roche data in lupus nephritis presented at the American Society of Nephrology (7 - 10 Nov) as well as the American College of Rheumatology Annual Meetings (8 - 13 Nov) in Washington, DC and Atlanta, United States, respectively. (Source: Roche Investor Update)
Source: Roche Investor Update - November 5, 2019 Category: Pharmaceuticals Source Type: news

Invitation to Roche ’s live audio webcast on Gazyva in lupus nephritis presented at ASN / ACR 2019
We are pleased to invite investors and analysts to participate in a live audio webcast and conference call on Tuesday, 12 November 2019, highlighting Roche data in lupus nephritis presented at the American Society of Nephrology (7 - 10 Nov) as well as the American College of Rheumatology Annual Meetings (8 - 13 Nov) in Washington, DC and Atlanta, United States, respectively. (Source: Roche Investor Update)
Source: Roche Investor Update - October 15, 2019 Category: Pharmaceuticals Source Type: news

Roche bid to recycle Gazyva for lupus nephritis wins FDA breakthrough tag
Roche has won the U.S. Food and Drug Administration's breakthrough therapy tag for its drug Gazyva in lupus nephritis, the Swiss drugmaker said on Wednesday, boosting its efforts to recycle the 2013-approved lymphoma medicine for new indications. (Source: Reuters: Health)
Source: Reuters: Health - September 18, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Roche bid to recycle Gayzva for lupus nephritis wins FDA breakthrough tag
Roche has won the U.S. Food and Drug Administration's breakthrough therapy tag for its drug Gazyva in lupus nephritis, the Swiss drugmaker said on Wednesday, boosting its efforts to recycle the 2013-approved lymphoma medicine for new indications. (Source: Reuters: Health)
Source: Reuters: Health - September 18, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

FDA grants Breakthrough Therapy Designation for Roche ’s Gazyva (obinutuzumab) in Lupus Nephritis
Roche today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) to Gazyva ® (obinutuzumab) for adults with lupus nephritis. (Source: Roche Investor Update)
Source: Roche Investor Update - September 18, 2019 Category: Pharmaceuticals Source Type: news

FDA grants Breakthrough Therapy Designation for Roche ’s Gazyva (obinutuzumab) in Lupus Nephritis
Roche today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) to Gazyva ® (obinutuzumab) for adults with lupus nephritis. (Source: Roche Media News)
Source: Roche Media News - September 18, 2019 Category: Pharmaceuticals Source Type: news

Cyclosporine benefits patients through more rapid remission of proteinuria in lupus nephritis
(European League Against Rheumatism) The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2019) suggest maintenance therapy with cyclosporine (CYA) results in more rapid remission of proteinuria compared to mycophenolate mofetil (MMF) or azathioprine (AZA) in patients with lupus nephritis. The efficacy of CYA, MMF and AZA in obtaining and maintaining remission of lupus nephritis (LN) is comparable over the long term. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 12, 2019 Category: International Medicine & Public Health Source Type: news

Roche ’s Gazyva (obinutuzumab) delivers positive topline results for phase II lupus nephritis study
Roche today announced positive topline results for NOBILITY, a phase II clinical trial investigating the safety and efficacy of Gazyva ® (obinutuzumab) for adults with proliferative lupus nephritis. (Source: Roche Investor Update)
Source: Roche Investor Update - June 11, 2019 Category: Pharmaceuticals Source Type: news

Podcast: Immunosuppressive treatment for people with proliferative lupus nephritis
Systemic lupus erythematosus, or SLE, is an autoimmune disease that can affect any part of the body. About half the people with it develop lupus nephritis. In the June 2018 update of their Cochrane Review, David Tunnicliffe from the Centre for Kidney Research in the Children ’s Hospital at Westmead and the University of Sydney’s School of Public Health in Australia and colleagues brought together the studies that have tested a range of treatments." Lupus nephritis is a serious condition, leading to end-stage kidney disease in 15% of patients after 10 years. It mainly affects women of child-bearing age, and...
Source: Cochrane News and Events - May 30, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Researchers developing early detection, home monitoring tests for lupus nephritis
(University of Houston) With $5 million in grants from the National Institutes of Health (NIH), two University of Houston biomedical researchers are transforming the way lupus is managed, putting biomarkers in the hands of patients to monitor their own disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 2, 2019 Category: Biology Source Type: news

Peptide shows promise for protecting kidneys from nephritis
(Medical College of Georgia at Augusta University) A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 25, 2019 Category: International Medicine & Public Health Source Type: news

Low-Income SLE Patients at High Risk for Fracture (CME/CE)
(MedPage Today) -- Fracture risk was about 2.5-fold higher in this SLE subgroup with nephritis versus non-SLE patients (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - February 8, 2019 Category: Endocrinology Source Type: news

Nephrotic Syndrome: A Hindrance to Lupus Treatment?
(MedPage Today) -- In patients with lupus nephritis, lower renal response seen at 1 year (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 6, 2019 Category: Primary Care Source Type: news

Kidney Transplant Boosts Survival in Lupus Nephritis Kidney Transplant Boosts Survival in Lupus Nephritis
Kidney transplantation is associated with a survival benefit for patients with lupus nephritis and end-stage renal disease (LN-ESRD), researchers have found.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 23, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Renal Transplant Improves Survival in ESRD Due to Lupus
WEDNESDAY, Jan. 23, 2019 -- For patients with end-stage renal disease (ESRD) due to lupus nephritis (LN), renal transplant is associated with a survival benefit, according to a study published online Jan. 22 in the Annals of Internal Medicine. April... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 23, 2019 Category: Pharmaceuticals Source Type: news

Voclosporin Effective in Lupus Nephritis
(MedPage Today) -- Results from AURA-LV trial in patients with active disease (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 24, 2018 Category: Primary Care Source Type: news

Recurrent Post-Transplant Lupus Nephritis Declining
(MedPage Today) -- Single-center study credits improvements in immunosuppression (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 23, 2018 Category: Rheumatology Source Type: news

Hydroxycloroquine Blood Concentration in Lupus Nephritis Hydroxycloroquine Blood Concentration in Lupus Nephritis
Abnormally low hydroxychloroquine blood levels may suggest non-adherence and predict poor outcomes in lupus nephritis.Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 19, 2018 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Stroke Risk High for Minority Lupus Patients
(MedPage Today) -- Notable risks for young patients and those with lupus nephritis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 1, 2018 Category: Cardiology Source Type: news

Manmade human antibody helps reverse nephritis in kidneys
A manmade version of a human antibody helped inhibit a chronic inflammation called nephritis that often leads to kidney failure and dialysis, a study found. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 30, 2018 Category: Consumer Health News Source Type: news

Inflammation inhibitor delivered directly to kidneys reverses course of destructive nephritis
(Medical College of Georgia at Augusta University) Using a manmade version of a human antibody to directly deliver a drug that inhibits a powerful driver of inflammation, can reverse a disease course that often leads to kidney failure and dialysis, investigators report. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 30, 2018 Category: International Medicine & Public Health Source Type: news

Abatacept Misses the Mark in Lupus Nephritis
(MedPage Today) -- But further analyses planned because of " provocative " findings (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - June 19, 2018 Category: Rheumatology Source Type: news

In Lupus, Time on Dialysis Matters
(MedPage Today) -- Survival in lupus nephritis worsens after 24 months of dialysis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 18, 2018 Category: Primary Care Source Type: news

Identification and Management of Lupus Nephritis Identification and Management of Lupus Nephritis
Find out what there is to know regarding the diagnosis and medical management of lupus nephritis.Journal for Nurse Practitioners (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 12, 2018 Category: Consumer Health News Tags: Nursing Journal Article Source Type: news

Deteriorating Serology May Precede Delayed Lupus Nephritis (CME/CE)
(MedPage Today) -- DLN likely to become more common with rising life expectancy in SLE (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - January 20, 2018 Category: Rheumatology Source Type: news

Manifestations of Lupus in the Kidney and How to Manage Them Manifestations of Lupus in the Kidney and How to Manage Them
Find out what there is to know regarding the diagnosis of lupus nephritis and the available and emerging treatment strategies.Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2017 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

How harmful can herbal remedies be? A case of severe acute tubulointerstitial nephritis - Beniwal P, Gaur N, Singh SK, Raveendran N, Malhotra V.
Acute interstitial nephritis (AIN) is a condition in which acute kidney injury (AKI) is characterized by the histological finding of interstitial inflammation. Hyponidd is an ayurvedic drug containing Momordica charantia, Gymnema sylvestre, Swertia chirata... (Source: SafetyLit)
Source: SafetyLit - December 11, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Biomarker Predicts Lupus Nephritis Flares (CME/CE)
(MedPage Today) -- C4d more accurate than conventional complement C3 and C4 (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - December 7, 2017 Category: Rheumatology Source Type: news

Researchers developing home test kit for lupus nephritis flares
(University of Houston) With a four-year $1.4 million grant from the National Institutes of Health (NIH), two University of Houston engineering professors are developing a home test kit for kidney nephritis, or inflammation, in patients who have Systemic Lupus Erythematosus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 25, 2017 Category: Biology Source Type: news

Medical News Today: Lupus: Probiotics could help to reduce kidney inflammation
Researchers suggest that women with lupus nephritis - that is, lupus-induced kidney inflammation - may benefit from adding Lactobacillus to their diets. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 3, 2017 Category: Consumer Health News Tags: Lupus Source Type: news

First Guidelines Issued on Class II/V Pediatric Lupus Nephritis (CME/CE)
(MedPage Today) -- Focus on timely diagnosis and treatment aimed at complete renal response (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - September 15, 2017 Category: Pediatrics Source Type: news

Selena Gomez Received Kidney Transplant For Lupus Nephritis
Gomez's struggles with lupus may bring more attention to a disease that's still very misunderstood. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 15, 2017 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

Snakebite induced thrombotic microangiopathy leading to renal cortical necrosis - Gn YM, Ponnusamy A, Thimma V.
Renal complications from snakebite result in high mortality and morbidity. Acute kidney injury (AKI) occurs in 5-30% of cases. Renal manifestation could include acute tubular necrosis, cortical necrosis, interstitial nephritis, glomerulonephritis, and vasc... (Source: SafetyLit)
Source: SafetyLit - September 13, 2017 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

What is the Genetic Inheritance of Alport Syndrome?
Discussion Alport Syndrome is a genetic disease classically associated with progressive renal disease often leading to end stage renal disease, variable sensory neuronal deafness and ocular findings (perimacular retinopathy). A. Cecil Alport built on the work of others evaluating families with nephritis and/or hematuria. However he very clearly describes the third generation of a family with an X-linked dominant pattern and also emphasizes the syndrome’s associated deafness. Alport writes: “It will be seen from this that nearly all the children of three generations of one family suffer from hematuria or nep...
Source: PediatricEducation.org - August 28, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Aurinia begins voclosporin dosing in Phase III trial for LN
Canadian-based biopharmaceutical firm Aurinia Pharmaceuticals has begun dosing patients in the Phase III AURORA clinical trial of voclosporin to treat lupus nephritis (LN). (Source: Drug Development Technology)
Source: Drug Development Technology - May 19, 2017 Category: Pharmaceuticals Source Type: news

Boehringer begins enrolment in Phase II trial of BI 655064 to treat lupus nephritis
Pharmaceutical company Boehringer Ingelheim has begun patient enrolment in the Phase II clinical trial of BI 655064 for the treatment of lupus nephritis (LN). (Source: Drug Development Technology)
Source: Drug Development Technology - May 11, 2017 Category: Pharmaceuticals Source Type: news

Phase II Trial now enrolling patients with Lupus Nephritis
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - May 10, 2017 Category: Research Source Type: news

Renal Data Reassuring in Lupus Pregnancy (CME/CE)
(MedPage Today) -- De novo nephritis numbers were miniscule in prospective study (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - May 4, 2017 Category: OBGYN Source Type: news

Mid-Stage Voclosporin Data Look Good in Lupus Nephritis (CME/CE)
(MedPage Today) -- 48-week findings of AURA-LV reported high rates of complete, partial remission (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 21, 2017 Category: Primary Care Source Type: news

What Causes Uveitis?
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - April 3, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Editorial: federal restrictions on gun research should be lifted - Leopold SS.
Question: What do Parkinson ’s disease, sepsis, liver disease, gun violence, traffic accidents, poisoning, and nephritis have in common? Answer: They all kill about 30,000 people a year in the United States (stated another way, about 10 deaths per 1... (Source: SafetyLit)
Source: SafetyLit - March 31, 2017 Category: Global & Universal Tags: Commentary Source Type: news

Infection Rates High in Kids with SLE (CME/CE)
(MedPage Today) -- Highest rates seen in those with lupus nephritis (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - February 23, 2017 Category: Infectious Diseases Source Type: news

Lupus Nephritis Treatment
Title: Lupus Nephritis TreatmentCategory: Doctor's& Expert's views on SymptomsCreated: 3/1/2002 12:00:00 AMLast Editorial Review: 1/12/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - January 12, 2017 Category: Rheumatology Source Type: news

Novel Agent Showing Promise, a First in Lupus Nephritis Novel Agent Showing Promise, a First in Lupus Nephritis
An induction regimen that includes a calcineurin inhibitor can help patients with acute lupus nephritis achieve complete or partial remission, early research suggests.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 21, 2016 Category: Consumer Health News Tags: Nephrology News Source Type: news

Aurinia reports positive AURA –LV study outcome of voclosporin in treating lupus nephritis
Canadian-based clinical stage bio-pharmaceutical company Aurinia has reported positive results from its AURA –LV study of voclosporin in combination with mycophenolate mofetil against placebo to treat lupus nephritis (LN). (Source: Drug Development Technology)
Source: Drug Development Technology - October 3, 2016 Category: Pharmaceuticals Source Type: news

Pathophysiology and Treatment of Human Lupus Nephritis Pathophysiology and Treatment of Human Lupus Nephritis
Gain a better understanding of the pathophysiology of lupus nephritis and learn about the best therapeutic strategies for this disease.Current Opinion in Rheumatology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - September 12, 2016 Category: Intensive Care Tags: Rheumatology Journal Article Source Type: news