Stem cell transplant alleviates symptoms in lupus animal models
(Cell Transplantation Center of Excellence for Aging and Brain Repair) Systemic lupus erythematosus is an autoimmune disease that produces autoantibodies and subsequent immune reactions that can be life threatening when major organs are invaded. When mesenchymal stem cells derived from human bone marrow were transplanted into mice modeled with SLE, inflammation was reduced and nephritis attenuated. The researchers found that MSCs slowed the progression of SLE by suppressing the emergence of the damaging antibodies that are produced with the help of follicular T helper cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 14, 2015 Category: Global & Universal Source Type: news
Lupus Nephritis Therapeutic Development Pipeline Review H1 2015 Market...
RnRMarketResearch.com adds “Lupus Nephritis – Pipeline Review, H1 2015” to its store. The report provides an overview of the Lupus Nephritis’s therapeutic pipeline.(PRWeb June 10, 2015)Read the full story at http://www.prweb.com/releases/lupus-nephritis-pipeline/review-h1-2015-market/prweb12779381.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - June 12, 2015 Category: Pharmaceuticals Source Type: news
Lupus Nephritis: Multiple Factors for Tx Success (CME/CE)
(MedPage Today) -- Absence of anti-dsDNA antibodies, cyclophosphamide induction linked to better outcomes. (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - May 29, 2015 Category: Urology & Nephrology Source Type: news
Male Fetal Cells May Protect Women With Lupus Nephritis (CME/CE)
(MedPage Today) -- SLE female patients previously pregnant with male fetuses had better renal function. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - April 24, 2015 Category: Rheumatology Source Type: news
Proton pump inhibitors increase risk of acute kidney injury
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Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. Antoniou T et al. CMAJ Open 2015;Apr;3:E166-E171.
Full Text
Previous studies have suggested that use of proton pump inhibitors (PPIs) increases risk of acute interstitial nephritis, especially in elderly patients. Using information from several large computerized databases containing medical information about patients in Ontario, Canada, the authors carried out a population-based cohort study of patients in Ontario aged 66 years and older who were newly prescribed PPIs, compared with match...
Source: The Poison Review - April 23, 2015 Category: Toxicology Authors: Leon Tags: Medical acute kidney injury interstitial nephritis lansoprazole omeprazole proton pump inhibitor Source Type: news
Drug-induced glomerular disease: direct cellular injury - Markowitz GS, Bomback AS, Perazella MA.
The potential of medications to cause kidney injury is well known. Although nephrotoxicity is most commonly associated with injury in the tubulointerstitial compartment as either acute tubular necrosis or acute interstitial nephritis, a growing body of lit... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - April 17, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Proton pump inhibitors are associated with an increased risk of acute kidney failure and acute interstitial nephritis in older patients
(Source: St. Michael's Hospital News and Media)
Source: St. Michael's Hospital News and Media - April 16, 2015 Category: Hospital Management Tags: Hospital News Source Type: news
Azathioprine and Mycophenolate Mofetil Comparable in Lupus NephritisAzathioprine and Mycophenolate Mofetil Comparable in Lupus Nephritis
In a 10-year follow-up study, European investigators found no difference in long-term outcomes between patients given mycophenolate mofetil (MMF) or azathioprine as maintenance therapy for proliferative lupus nephritis. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 14, 2015 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Lupus Nephritis Histology Predicts Long-Term Outcomes (CME/CE)
(MedPage Today) -- Class IV disease associated with poorer 5-year remission rates. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 13, 2015 Category: Primary Care Source Type: news
Two Regimens Equivalent in Lupus Nephritis (CME/CE)
(MedPage Today) -- 10-year study confirms: it's a toss-up between mycophenolate mofetil and azathioprine. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 11, 2015 Category: Primary Care Source Type: news
NephMadness 2015: Genetic Nephrology RegionNephMadness 2015: Genetic Nephrology Region
Autosomal dominant (AD) tubulointerstitial nephritis takes on the autosomal recessive (AR) trait. Who will win in this and 3 other match-ups? The National Kidney Foundation (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - March 2, 2015 Category: Urology & Nephrology Tags: Nephrology Article Source Type: news
The Kidney Biopsy in Lupus NephritisThe Kidney Biopsy in Lupus Nephritis
Besides the kidney biopsy, which has traditionally been the gold standard for the diagnosis of lupus nephritis, what other options are available to clinicians? Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 23, 2015 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
Predicting Renal Disease in Lupus Nephritis Predicting Renal Disease in Lupus Nephritis
Dr Deane reviews the findings of an experiment demonstrating the mechanistic role of vimentin in lupus nephritis and its potential for identifying pharmacologic targets and biomarkers. Medscape Rheumatology (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - January 27, 2015 Category: Urology & Nephrology Tags: Rheumatology Viewpoint Source Type: news
34 years—and counting—with a transplanted kidney
Joe and his sister Kathi. She donated a kidney that has lasted Joe 34 years.
Joe Sullivan started gaining weight in the summer of 1978, when he was 17 years old. He put on 40 pounds—all water, but he didn’t know that.
By October, the swelling in his legs and ankles kept him out of school, and a tutor started coming to his house. Months passed. High doses of prednisone—the drug required to treat the swelling—kept him up at night, but, “presto magic,” recalls Joe, “I got better, went back to school and graduated with everyone in May. I didn’t understand what was going on. My parents weren&...
Source: Thrive, Children's Hospital Boston - January 19, 2015 Category: Pediatrics Authors: Boston Children's Hospital staff Tags: Our patients’ stories kidney transplant Source Type: news
Tacrolimus Similar to MMF as Induction for Lupus NephritisTacrolimus Similar to MMF as Induction for Lupus Nephritis
In combination with steroids, tacrolimus (TAC) seems to have similar efficacy and safety as mycophenolate mofetil (MMF) as induction therapy for lupus nephritis, researchers reported December 30 in Annals of the Rheumatic Diseases Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 10, 2015 Category: Consumer Health News Tags: Rheumatology News Source Type: news
