USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation
CONCLUSION: USP25 plays a crucial role in mitigating renal histopathological and functional damage during anti-GBM GN in mice. This protective effect is primarily attributed to USP25's ability to inhibit the differentiation of naïve CD4+ T cells into Th17 cells. The underlying mechanism may involve the downregulation of RORγt. Additionally, during increased inflammatory responses or Th17 cell differentiation, USP25 expression is activated, forming a negative feedback regulatory loop that attenuates immune activation.PMID:38616174 | DOI:10.1080/0886022X.2024.2338932 (Source: Renal Failure)
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Ranran Xu Fei Huang Qingquan Liu Yongman Lv Liu Hu Qian Zhang Source Type: research
Immunohistochemical Evaluation of Renal Biopsy with Anti-PD1 and p53 to Solve the Dilemma between Platinum- and Pembrolizumab-Induced AKI: Case Report and Review
Discussion: Combining checkpoint inhibitors and platinum-based therapies may result in AKI. The standard method of examining kidney tissue may not provide sufficient information about the effects of these drugs on the kidneys. To address this issue, we recommend incorporating an assessment of the analysis of the expression of PDL1 and p53. This personalized approach will help identify the best treatment option for the patient while ensuring the best possible cancer treatment plan.PMID:38610593 | DOI:10.3390/jcm13071828 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Nicoletta Mancianti Sergio Antonio Tripodi Alessandra Pascucci Marta Calatroni Edoardo La Porta Andrea Guarnieri Guido Garosi Source Type: research
Efficacy and safety of telitacicept in patients with lupus nephritis: a single-center, real-world retrospective study
CONCLUSIONS: Telitacicept treatment reduced disease severity in patients with LN. The initial clinical trial provided supportive evidence for the effectiveness and safety of Telitacicept as a viable treatment option for LN, allowing a reduction in the daily glucocorticoid intake while maintaining a good safety profile, and improving hypocomplementation in LN management.PMID:38613741 | DOI:10.1007/s10157-024-02501-x (Source: Herpes)
Source: Herpes - April 13, 2024 Category: Infectious Diseases Authors: Xiaolu Huang Fuan Lin Hongpu Chen Source Type: research
Immunohistochemical Evaluation of Renal Biopsy with Anti-PD1 and p53 to Solve the Dilemma between Platinum- and Pembrolizumab-Induced AKI: Case Report and Review
Discussion: Combining checkpoint inhibitors and platinum-based therapies may result in AKI. The standard method of examining kidney tissue may not provide sufficient information about the effects of these drugs on the kidneys. To address this issue, we recommend incorporating an assessment of the analysis of the expression of PDL1 and p53. This personalized approach will help identify the best treatment option for the patient while ensuring the best possible cancer treatment plan.PMID:38610593 | PMC:PMC11012688 | DOI:10.3390/jcm13071828 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Nicoletta Mancianti Sergio Antonio Tripodi Alessandra Pascucci Marta Calatroni Edoardo La Porta Andrea Guarnieri Guido Garosi Source Type: research
Efficacy and safety of telitacicept in patients with lupus nephritis: a single-center, real-world retrospective study
ConclusionsTelitacicept treatment reduced disease severity in patients with LN. The initial clinical trial provided supportive evidence for the effectiveness and safety of Telitacicept as a viable treatment option for LN, allowing a reduction in the daily glucocorticoid intake while maintaining a good safety profile, and improving hypocomplementation in LN management. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 13, 2024 Category: Urology & Nephrology Source Type: research
Calcineurin inhibitors experience in unplanned pregnancies with active lupus disease: A retrospective observational study
CONCLUSION: This study reveals that tacrolimus can be effectively used in unplanned pregnancies with active lupus disease, providing favorable maternal and fetal outcomes. The findings emphasize the importance of considering CNIs, particularly tacrolimus, in the management of SLE pregnancies, even in cases of unplanned pregnancies with a history of lupus nephritis.PMID:38606855 | DOI:10.5414/CP204528 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 12, 2024 Category: Drugs & Pharmacology Authors: İbrahim Vasi Derya Y ıldırım R ıza Can Kardaş Burcug ül Kaya Rahime Duran Gizem Tu ğçe Alp Hazan Karadeniz Asl ıhan Avanoğlu Güler Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Abdulsamet Erden Source Type: research
Calcineurin inhibitors experience in unplanned pregnancies with active lupus disease: A retrospective observational study
CONCLUSION: This study reveals that tacrolimus can be effectively used in unplanned pregnancies with active lupus disease, providing favorable maternal and fetal outcomes. The findings emphasize the importance of considering CNIs, particularly tacrolimus, in the management of SLE pregnancies, even in cases of unplanned pregnancies with a history of lupus nephritis.PMID:38606855 | DOI:10.5414/CP204528 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 12, 2024 Category: Drugs & Pharmacology Authors: İbrahim Vasi Derya Y ıldırım R ıza Can Kardaş Burcug ül Kaya Rahime Duran Gizem Tu ğçe Alp Hazan Karadeniz Asl ıhan Avanoğlu Güler Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Abdulsamet Erden Source Type: research
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
CONCLUSION: Our results present an important pathophysiological role for macrophages in LN, and our preliminary results demonstrate significant pro-inflammatory effects of LGALS9 gene in LN macrophages.PMID:38610007 | DOI:10.1186/s13075-024-03311-y (Source: Cell Research)
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Shuping Wei Haiyun Shen Yidan Zhang Chunrui Liu Shoushan Li Jing Yao Zhibin Jin Hongliang Yu Source Type: research
Calcineurin inhibitors experience in unplanned pregnancies with active lupus disease: A retrospective observational study
CONCLUSION: This study reveals that tacrolimus can be effectively used in unplanned pregnancies with active lupus disease, providing favorable maternal and fetal outcomes. The findings emphasize the importance of considering CNIs, particularly tacrolimus, in the management of SLE pregnancies, even in cases of unplanned pregnancies with a history of lupus nephritis.PMID:38606855 | DOI:10.5414/CP204528 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 12, 2024 Category: Drugs & Pharmacology Authors: İbrahim Vasi Derya Y ıldırım R ıza Can Kardaş Burcug ül Kaya Rahime Duran Gizem Tu ğçe Alp Hazan Karadeniz Asl ıhan Avanoğlu Güler Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Abdulsamet Erden Source Type: research
Calcineurin inhibitors experience in unplanned pregnancies with active lupus disease: A retrospective observational study
CONCLUSION: This study reveals that tacrolimus can be effectively used in unplanned pregnancies with active lupus disease, providing favorable maternal and fetal outcomes. The findings emphasize the importance of considering CNIs, particularly tacrolimus, in the management of SLE pregnancies, even in cases of unplanned pregnancies with a history of lupus nephritis.PMID:38606855 | DOI:10.5414/CP204528 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 12, 2024 Category: Drugs & Pharmacology Authors: İbrahim Vasi Derya Y ıldırım R ıza Can Kardaş Burcug ül Kaya Rahime Duran Gizem Tu ğçe Alp Hazan Karadeniz Asl ıhan Avanoğlu Güler Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Abdulsamet Erden Source Type: research
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify potential therapeutic targets. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin and Hongliang Yu Tags: Research Source Type: research
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
Conclusion
The intricate interplay involving DC3s, T cells and tubular epithelial cells within kidneys may substantially contribute to LN pathogenesis. The enumeration of renal DC3 holds potential as a valuable stratification feature for guiding LN patient treatment decisions in clinical practice. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Chen, W., Jin, B., Cheng, C., Peng, H., Zhang, X., Tan, W., Tang, R., Lian, X., Diao, H., Luo, N., Li, X., Fan, J., Shi, J., Yin, C., Wang, J., Peng, S., Yu, L., Li, J., Wu, R.-Q., Kuang, D.-M., Shi, G.-P., Zhou, Y., Wang, F., Jiang, X. Tags: ARD, Autoimmunity Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
Huanglian Decoction treats Henoch-Schonlein purpura nephritis by inhibiting NF- κB/NLRP3 signaling pathway and reducing renal IgA deposition
This study aimed to investigate the protective mechanism of HLD treatment in HSPN. The effects of HLD on HSPN biochemical indices, kidney injury and NF-κB/NLRP3 signaling pathway were analyzed by biochemical analysis, ELISA, HE and PAS staining, immunohistochemistry, immunofluorescence, and Western Blot. In addition, the effects of HLD on HSPN cells were analyzed. We found that HLD treatment significantly reduced renal tissue damage, decreased the levels of IL-17, IL-18, TNF-α, and IL-1β, and increased the levels of TP and ALB in HSPN mice. It also inhibited the deposition of IgA, IgG, and C3 in kidney tissues and signi...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Lian Hu Linlin Li Hong Che Bingjie Zhao L I Xiao Peijia Liu Wenjing Yi Songshan Liu Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
