Brenda Edwards health: Loose Women panellist has peripheral neuropathy - symptoms
BRENDA EDWARDS catapulted into the spotlight singing her heart out in the second series of The X Factor. Finishing in fourth place, the star has gone on to progress her career in entertainment. Yet, her journey hasn't been without its health struggles, as she revealed she has peripheral neuropathy - what is it? (Source: Daily Express - Health)
Source: Daily Express - Health - January 15, 2021 Category: Consumer Health News Source Type: news

Lung cancer symptoms: Peripheral neuropathy in your fingers or toes is a sign
LUNG cancer is one of the most common and serious types of cancer - around 44,500 people are diagnosed with the condition every year in the UK. Peripheral neuropathy in your fingers or toes is a warning sign - what is it? (Source: Daily Express - Health)
Source: Daily Express - Health - January 13, 2021 Category: Consumer Health News Source Type: news

Lower-limb hypopallesthesia: a risk factor for falls in cognitively intact non-diabetic older adults - Morel J, Gentric A, Annweiler C.
Peripheral neuropathies (PN) in older adults often involve altered vibrational perception, i.e. hypopallesthesia. The main objective of this cross-sectional study was to determine whether age-related lower-limb hypopallesthesia is associated with a history... (Source: SafetyLit)
Source: SafetyLit - December 18, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Peripheral Neuropathy Linked to Mortality in U.S. Population
FRIDAY, Dec. 11, 2020 -- Peripheral neuropathy (PN) is associated with mortality, even among individuals without diabetes, according to a study published online Dec. 8 in the Annals of Internal Medicine. Caitlin W. Hicks, M.D., from the Johns... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 11, 2020 Category: Pharmaceuticals Source Type: news

Peripheral Neuropathy Tied to Mortality in Adults Without Diabetes Peripheral Neuropathy Tied to Mortality in Adults Without Diabetes
Decreased sensation in the foot may be associated with an increased risk of death, even among people with normoglycemia, a study indicates.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - December 7, 2020 Category: Neurology Tags: Internal Medicine News Source Type: news

Yoga for chemotherapy-induced peripheral neuropathy and fall risk: a randomized controlled trial - Bao T, Zhi I, Baser R, Hooper M, Chen C, Piulson L, Li QS, Galantino ML, Blinder V, Robson M, Seidman A, Panageas KS, Mao JJ.
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect that worsens quality of life and increases the risk of falls in cancer survivors. Evidence of yoga's safety and efficacy in treating CIPN is lacking. Me... (Source: SafetyLit)
Source: SafetyLit - November 28, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Fall risk and balance confidence in patients with diabetic peripheral neuropathy: an observational study - Riandini T, Khoo EYH, Tai BC, Tavintharan S, Phua MSLA, Chandran K, Hwang SW, Venkataraman K.
OBJECTIVE: Individuals with diabetic peripheral neuropathy (DPN) have functional deficits that increase their risk of falling. However, psychological aspects such as loss of confidence in undertaking activities could also contribute to this risk. We examin... (Source: SafetyLit)
Source: SafetyLit - November 20, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Vitamin B12 deficiency symptoms: Peripheral neuropathy may occur affecting coordination
VITAMIN B12 deficiency: The essential vitamin is so vital to one's health that lacking in it can affect many parts of the body including a person's coordination. Known as peripheral neuropathy, what is it and how does it affect the body? (Source: Daily Express - Health)
Source: Daily Express - Health - November 17, 2020 Category: Consumer Health News Source Type: news

'Stopping statins left me with pins and needles': DR MARTIN SCURR answers your health questions
DR MARTIN SCURR: Your symptoms are highly suggestive of peripheral neuropathy, a common condition that occurs when the peripheral nerves are damaged. (Source: the Mail online | Health)
Source: the Mail online | Health - November 3, 2020 Category: Consumer Health News Source Type: news

Diabetic Neuropathic Pain Linked to Brain Bioenergic Anomalies Diabetic Neuropathic Pain Linked to Brain Bioenergic Anomalies
Abnormal mitochondrial activity in the somatosensory cortex and right thalamus may explain why some patients with type 2 diabetes experience painful peripheral neuropathy, suggest findings of a UK study.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - October 20, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Can Peripheral Neuropathy Go Away
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - October 16, 2020 Category: General Medicine Source Type: news

DR MARTIN SCURR answers your health questions
DR MARTIN SCURR: Your symptoms suggest the problem is peripheral neuropathy - the sensations that occur when peripheral nerves, such as those in the arms and legs, are damaged. (Source: the Mail online | Health)
Source: the Mail online | Health - August 24, 2020 Category: Consumer Health News Source Type: news

Type 2 diabetes: Cannabis oil could help with pain and symptoms of peripheral neuropathy
TYPE 2 diabetes: A natural oil rubbed onto the skin could help reduce the risk of developing peripheral neuropathy caused by high blood sugars. How? (Source: Daily Express - Health)
Source: Daily Express - Health - August 24, 2020 Category: Consumer Health News Source Type: news

Type 2 diabetes: Four signs felt in the feet and legs you could have high blood sugar
TYPE 2 diabetes is a condition which is affected by the amount of sugar in the bloodstream. Peripheral neuropathy is nerve damage which is caused by having chronically high blood sugar and this could lead to pain, tingling, burning and numbness felt in the legs or feet. Why? (Source: Daily Express - Health)
Source: Daily Express - Health - August 17, 2020 Category: Consumer Health News Source Type: news

AxoProtego Therapeutics Announces Novel Investigational Agent for Chemotherapy-Induced Peripheral Neuropathy
GLEN BURNIE, Md., July 27, 2020 -- (Healthcare Sales & Marketing Network) -- AxoProtego Therapeutics (AxoProtego) has announced that it has licensed a novel investigational therapy for patients with chemotherapy-induced peripheral neuropathy (CIPN). Curr... Biopharmaceuticals, Oncology, Neurology, Licensing AxoProtego Therapeutics, chemotherapy-induced peripheral neuropathy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 27, 2020 Category: Pharmaceuticals Source Type: news

Averitas Pharma Announces FDA Approval of Qutenza for the Treatment of Neuropathic Pain Associated with Diabetic Peripheral Neuropathy of the Feet
AACHEN, Germany and MORRISTOWN, N.J., July 21, 2020 /PRNewswire/ -- Grünenthal announced today that its U.S. subsidiary Averitas Pharma, Inc. received U.S. Food and Drug Administration (FDA) approval for Qutenza (capsaicin) 8% patch for the... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 21, 2020 Category: Drugs & Pharmacology Source Type: news

Assessment of fall-related self-efficacy: characteristics that influence the perception of patients with chemotherapy-induced peripheral neuropathy - Yamamoto S, Fujikawa N, Asano K, Toki M, Takao A, Arao H.
OBJECTIVE: The present study aims to describe fall-related self-efficacy as perceived by patients with chemotherapy-induced peripheral neuropathy (CIPN). The characteristics of patients associated with low perceived self-efficacy of preventing falls were i... (Source: SafetyLit)
Source: SafetyLit - June 4, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Conditions and injuries affecting the nerves around the elbow - Schickendantz MS, Yalcin S.
Sports-related peripheral neuropathies account for 6% of all peripheral neuropathies and most commonly involve the upper extremity. The routes of the median, radial, and ulnar nerves are positioned in arrangements of pulleys and sheaths to glide smoothly a... (Source: SafetyLit)
Source: SafetyLit - May 27, 2020 Category: International Medicine & Public Health Tags: Egress, Escape, Evacuation, Crowds Source Type: news

What is Gua Sha therapy and how does it help people with diabetic peripheral neuropathy?
(Natural News) Diabetic peripheral neuropathy (DPN) is a complication caused by diabetes. Too much sugar in the blood can damage nerves throughout the body, especially in the legs and feet of diabetics. Depending on the affected nerves, DPN can cause minor symptoms, such as numbness, or excruciating pain. DPN can also cause heart problems and may... (Source: NaturalNews.com)
Source: NaturalNews.com - May 4, 2020 Category: Consumer Health News Source Type: news

Scientists explore the healing effects of Gua Sha therapy on patients with diabetic peripheral neuropathy
(Natural News) In this open-label, randomized controlled study, Chinese researchers examined the effect of gua sha therapy in the treatment of diabetic peripheral neuropathy (DPN). Their results were published in the journal Complementary Therapies in Clinical Practice. A total of 119 subjects were recruited by the researchers, 60 were assigned to the gua sha group and... (Source: NaturalNews.com)
Source: NaturalNews.com - April 15, 2020 Category: Consumer Health News Source Type: news

Nonglycemic Factors Up Risk for Peripheral Neuropathy in T1DM
THURSDAY, March 12, 2020 -- Several nonglycemic factors may increase the risk for the development of diabetic peripheral neuropathy (DPN) among people with type 1 diabetes (T1D), according to a study recently published in Diabetes Care. Kara R.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 12, 2020 Category: Pharmaceuticals Source Type: news

#MayoClinicRadio: 3/7/20
Click the media player below: On the Mayo Clinic Radio program, Dr. John Kisiel, a Mayo Clinic gastroenterologist, discusses colorectal cancer. and the importance of recommended screening tests. March is Colorectal Cancer Awareness Month. Also on the program, Dr. Michelle Mauermann, a Mayo Clinic neurologist, explains peripheral neuropathy, a nerve condition that causes numbness and pain in the [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 8, 2020 Category: Databases & Libraries Source Type: news

Does the presence of cognitive impairment exacerbate the risk of falls in people with peripheral neuropathy? An application of body-worn inertial sensors to measure gait variability - Kang GE, Yang J, Najafi B.
People with peripheral neuropathy (PN) are at risk of falling. Many people with PN have comorbid cognitive impairment, an independent risk factor of falls, which may further increase the risk of falling in people with PN. However, the negative synergic eff... (Source: SafetyLit)
Source: SafetyLit - March 6, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

A new approach to identifying the effect of diabetic peripheral neuropathy on the ability to drive safely - Perazzolo M, Reeves ND, Bowling FL, Boulton AJM, Raffi M, Marple-Horvat DE.
The purpose of this study was to estimate the potential for impaired driving performance in current drivers with diabetic peripheral neuropathy compared to healthy controls. We analysed, using a driving simulator, three important aspects of driving - use o... (Source: SafetyLit)
Source: SafetyLit - March 3, 2020 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Novel Treatment Offers New Hope for Peripheral Neuropathy Novel Treatment Offers New Hope for Peripheral Neuropathy
Using principles of quantum mechanics and physics, a new therapeutic modality successfully treats painful peripheral neuropathy through improved blood flow and nerve regeneration.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 2, 2020 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

What Are the Different Types of Myasthenia Gravis?
Discussion Myasthenia gravis (MG) is a problem of the neuromuscular junction which causes muscle weakness. It can occur in all ages and have a range of symptoms from mild localized disease to mortality-threatening respiratory failure. MG occurs in 1.7-30 cases/million, with a prevalence of 77.7 cases/million. Pediatric patients comprise 10-15% of all patients with MG. In various Asian populations, the juvenile MG can be up to 50% of all of the MG cases. Fluctuations in muscle weakness is a hallmark of the disease. As a reminder, “[i]n normal synaptic transmission in the neuromuscular junction, the axon is depolarize...
Source: PediatricEducation.org - February 17, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Out of balance - Postural control in cancer patients before and after neurotoxic chemotherapy - M üller J, Ringhof S, Vollmer M, Jäger LB, Stein T, Weiler M, Wiskemann J.
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect deriving from neurotoxic chemotherapeutic agents. The underlying nerve injury can affect proprioception causing impaired postural control, gait difficulties and a higher... (Source: SafetyLit)
Source: SafetyLit - February 12, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Laboratory Evaluation of Peripheral Neuropathy Laboratory Evaluation of Peripheral Neuropathy
What role does laboratory testing play in the evaluation of peripheral neuropathy?Seminars in Neurology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2020 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

A Clinician's Approach to Peripheral Neuropathy A Clinician's Approach to Peripheral Neuropathy
This article describes a stepwise approach to the evaluation and workup of peripheral neuropathy.Seminars in Neurology (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - December 26, 2019 Category: Infectious Diseases Tags: Neurology & Neurosurgery Journal Article Source Type: news

Test-retest reliability, internal consistency, construct validity and factor structure of a falls risk perception questionnaire in older adults with type 2 diabetes mellitus: a prospective cohort study - Gravesande J, Richardson J, Griffith L, Scott F.
BACKGROUND: Older adults with type 2 diabetes (DM2) are at increased risk of falling due to complications including: diabetic peripheral neuropathy, diabetic retinopathy, autonomic neuropathy and diabetic foot ulcers. The purpose of this study was to deter... (Source: SafetyLit)
Source: SafetyLit - December 17, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

An early warning system for diabetic automobile drivers with peripheral neuropathy - Esparza J, Gudimetla P, De Silva S, Unsworth CA.
Purpose: People with Type 2 diabetes exhibit peripheral neuropathy that results in the progressive loss of sensation in their feet. This may adversely affect their ability to drive as there is the potential for their foot to slip off the accelerator... (Source: SafetyLit)
Source: SafetyLit - November 16, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Massage Therapy Gives Relief From Chemo-Related Neuropathy Massage Therapy Gives Relief From Chemo-Related Neuropathy
Patients with chemotherapy-induced peripheral neuropathy who received massage therapy experienced symptomatic relief.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - October 28, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Driving simulator performance in Charcot-Marie-Tooth disease type 1A - Jerath NU, Aksan N, Dawson JD, Rizzo M, Uc EY, Shy ME.
This study evaluates driving ability in those with Charcot-Marie-Tooth Disease Type 1A, a hereditary peripheral neuropathy. Methods: Individuals with Charcot-Marie-Tooth Disease Type 1A (n = 18, age = 42 ± 7) and controls (n = 19; age = ... (Source: SafetyLit)
Source: SafetyLit - October 26, 2019 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Medical News Today: How to treat peripheral neuropathy naturally
Peripheral neuropathy involves damage to the peripheral nerves. This can cause various sensations, including pain. Here, learn more about the symptoms and causes and which natural treatments may help. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 24, 2019 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Balance training as a promising intervention for reducing the risk of fall in elderly patients with chemotherapy-induced peripheral neuropathy - Mortazavi H.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - October 16, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Researchers determine local acupuncture needling is important for treating peripheral neuropathy successfully
(Natural News) Researchers recently found a connection between local acupuncture points and the peripheral nerves involved in neuropathy and neuropathic pain. They concluded that stimulating those local points with needles ensures the successful treatment of peripheral neuropathy. Numerous studies show that acupuncture improves medical conditions like chronic lower back pain, migraine and tension headaches, and chemotherapy-related... (Source: NaturalNews.com)
Source: NaturalNews.com - September 2, 2019 Category: Consumer Health News Source Type: news

Chemotherapy-induced peripheral neuropathy: association with increased risk of falls and injuries - Autissier E.
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and degenerative side effect of many commonly used chemotherapy agents. Symptoms manifest as sensory and motor neuropathies. CIPN may necessitate chemotherapy dose reduction or... (Source: SafetyLit)
Source: SafetyLit - July 23, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Textured shoe insoles to improve balance performance in adults with diabetic peripheral neuropathy: study protocol for a randomised controlled trial - Hatton AL, Gane EM, Maharaj JN, Burns J, Paton J, Kerr G, Rome K.
INTRODUCTION: Peripheral neuropathy is a major risk factor for falls in adults with diabetes. Innovative footwear devices which artificially manipulate the sensory environment at the feet, such as textured shoe insoles, are emerging as an attractive option... (Source: SafetyLit)
Source: SafetyLit - July 23, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

FDA Approves First Generics of Lyrica
July 22, 2019 -- On July 19, the U.S. Food and Drug Administration approved multiple applications for first generics of Lyrica (pregabalin) for the management of neuropathic pain associated with diabetic peripheral neuropathy, for the management of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 22, 2019 Category: Pharmaceuticals Source Type: news

FDA approves first generics of Lyrica
On July 19, the U.S. Food and Drug Administration approved multiple applications for first generics of Lyrica (pregabalin) for the management of neuropathic pain associated with diabetic peripheral neuropathy, for the management of postherpetic neuralgia, as an adjunctive therapy for the treatment of partial onset seizures in patients 17 years of age and older, for the management of fibromyalgia, and for the management of neuropathic pain associated with spinal cord injury. (Source: World Pharma News)
Source: World Pharma News - July 22, 2019 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Looking for an optimal pedal layout to improve the driving performance of patients with diabetic peripheral neuropathy - Ma S, Wu C, Zhang J, Zeng X, Zhao G, Sun X.
This study sought to investigate how diabetic peripheral neuropathy (DPN), a common complication of diabetes... (Source: SafetyLit)
Source: SafetyLit - July 11, 2019 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Avastin Improves Quality of Life for Mesothelioma Patients
A research team from France has documented the health-related quality-of-life benefits of adding Avastin (bevacizumab) to chemotherapy for pleural mesothelioma patients, endorsing its addition to standard-of-care treatment. The recent quality-of-life analysis was a secondary endpoint of an earlier, multicenter clinical trial in France that showed an almost three-month median survival improvement when adding Avastin. The latest study demonstrated that adding Avastin to cisplatin and Alimta (pemetrexed) did not negatively impact quality of life — a problem with several other cancers because of the increased toxicity. &...
Source: Asbestos and Mesothelioma News - July 8, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

Women more likely to develop diabetic neuropathy
Findings, published inBMJ Open Diabetes Research& Care, suggest that being female, rather than low vitamin D levels, is linked to a greater risk of peripheral neuropathy in type 2 diabetes.Endocrinology Advisor (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 3, 2019 Category: Endocrinology Source Type: news

Genetic marker linked to increased risk of diabetic peripheral neuropathy
(Joslin Diabetes Center) This is the first real effort to have a genome wide search for genes predisposing to diabetic peripheral neuropathy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 11, 2019 Category: International Medicine & Public Health Source Type: news

How Common is Restless Legs Syndrome in Children?
Discussion Restless legs syndrome (RLS) is also known as Willis-Ekbom disease. RLS is a clinical diagnosis with criteria being: 1. An urge to move the legs usually accompanied by uncomfortable and unpleasant sensations in the lower extremities (Note: sometimes other body parts can be affected) 2. The urge to move begins or worsens when sitting or lying down 3. The urge to move is partially or totally relieved by movement (Note: relief by activity may not be noticable if severely affected but must have been previously present) 4. The urge to move the legs and any accompanying unpleasant sensations during rest or in activ...
Source: PediatricEducation.org - June 10, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

i-Fect Scores Again
This study is the first to demonstrate that the stabilization of HIF1A expression underpins the development of bortezomib-induced neuropathic pain. Crucially, these findings reveal that the initiation and maintenance of bortezomib-induced neuropathic pain are regulated by distinct mechanisms. (Source: Neuromics)
Source: Neuromics - May 13, 2019 Category: Neuroscience Tags: chemotherapy i-Fect RNAi siRNA siRNA delivery in-vivo Source Type: news

i-Fect in Action
This study is the first to demonstrate that the stabilization of HIF1A expression underpins the development of bortezomib-induced neuropathic pain. Crucially, these findings reveal that the initiation and maintenance of bortezomib-induced neuropathic pain are regulated by distinct mechanisms.Looking to up your odds for high percentage siRNA Transfection? Try i-Fect. (Source: siRNA and DsiRNA Transfection Efficiency)
Source: siRNA and DsiRNA Transfection Efficiency - May 9, 2019 Category: Neuroscience Tags: Chemotherapy i-Fect in vivo RNAi neuropathic pain siRNA delivery in-vivo Source Type: news

Oral Fluoroquinolones Carry Small Risk of Peripheral Neuropathy Oral Fluoroquinolones Carry Small Risk of Peripheral Neuropathy
Oral fluoroquinolone exposure is associated with a small increase in risk of peripheral neuropathy, according to findings from The Health Improvement Network (THIN) database.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - May 3, 2019 Category: Surgery Tags: Infectious Diseases News Source Type: news

NeurExo Sciences and Henry Ford present preclinical data on exosomes at ISEV2019
(Henry Ford Health System) NeurExo Sciences, LLC and Henry Ford Health System today announced the presentation of new data on exosomes at the International Society for Extracellular Vesicles (ISEV) 2019 Annual Meeting being held April 24-28, 2019 in Kyoto, Japan. Among their key findings, Henry Ford researchers demonstrated the ability of exosomes to suppress chemotherapy-induced peripheral neuropathy and enhance the anti-tumor effects of platinum drugs, which are commonly used to treat cancers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 26, 2019 Category: International Medicine & Public Health Source Type: news

Active ingredient of aconite root against peripheral neuropathic pain is identified as neoline
(Nagoya City University) Aconite root is used in East Asian traditional medicines to treat pain. Since its toxicity, it is used after heat-processing for detoxifying. The present study revealed that processed aconite root could relief neuropathic pain in murine peripheral neuropathy model induced by oxaliplatin, paclitaxel, or partial ligation of the sciatic nerve (Seltzer model), and identified that its active ingredient is not benzoylmesaconine, a degraded compound of toxic mesaconitine, but neoline, a stable compound by detoxifying heat-processing. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 10, 2019 Category: Biology Source Type: news