Sport-related concussion preceding adrenal insufficiency and hypopituitarism - Northam WT, Alexander A, Carneiro K.
A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination reveale... (Source: SafetyLit)
Source: SafetyLit - January 13, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Primary Adrenal Insufficiency: New Genetic Causes Primary Adrenal Insufficiency: New Genetic Causes
A new review provides insight into the genetics of primary adrenal insufficiency that can have implications for the management of this condition.Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 6, 2020 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Evaluating the Low-Dose ACTH Stimulation Test in Children Evaluating the Low-Dose ACTH Stimulation Test in Children
Low-dose ACTH stimulation tests are commonly used to diagnose central adrenal insufficiency. What are the optimal times for testing cortisol levels?Journal of Clinical Endocrinology & Metabolism (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Serum Interpretation in Suspected Adrenal Insufficiency Serum Interpretation in Suspected Adrenal Insufficiency
What role does a single measurement of serum cortisol have in the investigation of adrenal insufficiency? Could it help identify which patients require further testing?Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 5, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Daily Adjustment of Glucocorticoids in Adrenal Insufficiency Daily Adjustment of Glucocorticoids in Adrenal Insufficiency
Under what circumstances should daily dose adjustments be initiated in patients with adrenal insufficiency?Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 15, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Avoiding severe complications of postoperative adrenal insufficiency
The use of adrenalectomy in treatment of primary aldosterone can lead to persistent adrenal insufficiency, so postoperative adrenocorticotropic hormone stimulation testing is recommended to avoid adrenal crisis, according to German research published inThe Journal of Clinical Endocrinology& Metabolism.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 3, 2019 Category: Endocrinology Source Type: news

Hidden in the Epidemic: Opioid-Induced Adrenal Insufficiency Hidden in the Epidemic: Opioid-Induced Adrenal Insufficiency
Findings point to the need to screen adrenal function of chronic opioid users.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - April 30, 2019 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Mayo Clinic Q and A: Understanding adrenal insufficiency
DEAR MAYO CLINIC: What is adrenal insufficiency? Is it the same as Addison's disease? ANSWER: There are a few forms of adrenal insufficiency, which is an uncommon disorder caused by the adrenal glands not making enough of certain hormones. Primary adrenal insufficiency, also known as Addison's disease, is one form. Your adrenal glands are located [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 23, 2019 Category: Databases & Libraries Source Type: news

Adrenal insufficiency medical identification inadequate
According to a study, published inClinical Endocrinology, the majority of medical identification jewellery for patients with adrenal insufficiency does not have adequate information on how to treat adrenal crisis.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 16, 2019 Category: Endocrinology Source Type: news

Hydrocortisone muco-adhesive buccal tablets
should not be used off-label for treating adrenal insufficiency in children due to serious risks. There is a risk of insufficient cortisol absorption and li (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - December 19, 2018 Category: Drugs & Pharmacology Source Type: news

Mortality Data From the EU-AIR Mortality Data From the EU-AIR
What can data from the EU-AIR tell us about the characteristics of patients with adrenal insufficiency who have died?Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 27, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Adrenal Emergencies in Patients With Adrenal Insufficiency Adrenal Emergencies in Patients With Adrenal Insufficiency
A new study evaluates the management of emergency situations in patients with chronic adrenal insufficiency.Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 20, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Medical News Today: What is dexamethasone?
Dexamethasone oral tablet is a prescription medication used to treat conditions such as inflammation, allergic reactions, ulcerative colitis, and adrenal insufficiency. It's available as a generic drug and as the brand-name drugs DexPak and Decadron. Learn about side effects, warnings, dosage, and more. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 10, 2018 Category: Consumer Health News Tags: Pharmacy / Pharmacist Source Type: news

Inefficient management of emergency adrenal insufficiency
According to a German study, published inClinical Endocrinology, adrenal insufficiency patients experience highly variable waiting times for glucocorticoid treatment in emergency situations.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 23, 2018 Category: Endocrinology Source Type: news

What Causes Hyponatremia?
Discussion Normal kidneys regulate water balance to maintain a plasma osmolality of 275-290 mOsm/kg normally. Thirst and arginine vasopressin or antidiuretic hormone (ADH) are the primary regulators of plasma osmolality. ADH is made in the hypothalamus and released by the posterior pituitary gland. ADH acts on the kidney’s distal collecting duct to increase water reabsorption. ADH is appropriately released in hypovolemic states, such as dehydration caused by gastroenteritis. ADH has an ~10 minute half-life and therefore can respond to rapid changes in volume status. Sodium balance is regulated by aldosterone (as part...
Source: PediatricEducation.org - April 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Timing Cortisol Therapy Could Improve Adrenal Insufficiency Timing Cortisol Therapy Could Improve Adrenal Insufficiency
Giving cortisol replacement therapy in a pattern that mimics normal rhythms of human secretion could result in better sleep quality and cognitive function compared with standard dosing, say UK researchers. (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 19, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Timing of cortisol replacement therapy affects cognitive performance
According to a trial, published inPNAS, timing cortisol replacement therapy to more closely match the usual ultradian rhythm can improve cognitive function in patients with adrenal insufficiency.Medical Xpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 12, 2018 Category: Endocrinology Source Type: news

Adrenal Insufficiency: Glucocorticoid Timing and Adverse Effects Adrenal Insufficiency: Glucocorticoid Timing and Adverse Effects
In patients with adrenal insufficiency, a once-daily, modified-release glucocorticoid regimen may reduce the recurrent infections and metabolic effects that can occur with multiple daily doses, researchers in Italy say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 28, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

New drugs approved for rare paediatric disorders
The EU has given approval for the use of new treatments in treating two rare paediatric endocrine disorders, primary adrenal insufficiency and X-linked hypophosphatemia.Medscape (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 20, 2017 Category: Endocrinology Source Type: news

EU Gives Okay to Two Drugs for Rare Pediatric Endocrine Disorders EU Gives Okay to Two Drugs for Rare Pediatric Endocrine Disorders
Pediatric primary adrenal insufficiency and X-linked hypophosphatemia are rare and debilitating conditions for which current treatments are limited.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Once a day glucocorticoid therapy improves health in adrenal insufficiency
According to an Italian study, published in theLancet Diabetes& Endocrinology, adrenal insufficiency patients treated once a day with hydrocortisone have improved immune and metabolic function compared with those on conventional therapy.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 15, 2017 Category: Endocrinology Source Type: news

Central adrenal insufficiency following traumatic brain injury: a missed diagnosis in the critically injured - Fan E, Skippen PW, Sargent MA, Cochrane DD, Chanoine JP.
BACKGROUND: High-dose steroid administration is no longer recommended in the treatment of acute traumatic brain injury (TBI) as it failed to prove beneficial in improving patients' outcome. However, a masked benefit of steroid administration in TBI managem... (Source: SafetyLit)
Source: SafetyLit - July 24, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The Medical Emergency Of Otto Warmbier
All that the doctors who treated Cincinnati, Ohio resident Otto Warmbier knew is what they had seen or maybe read in the news. They knew he had just been released on June 13 from imprisonment in North Korea where he had been held by for more than 17 months. He had been sentenced in March 2016 to 15 years of hard labor for allegedly removing a propaganda poster from a wall at a Pyongyang hotel where he had been staying. The University of Virginia honors student had been visiting the authoritarian state during a five-day trip with a group called Young Pioneer Tours, which is a group out of China – an important note. Ot...
Source: Healthy Living - The Huffington Post - June 23, 2017 Category: Consumer Health News Source Type: news

Prednisolone May Raise Cholesterol in Adrenal Insufficiency Prednisolone May Raise Cholesterol in Adrenal Insufficiency
The findings point to hydrocortisone as first-line treatment, but it is exceptionally expensive compared with prednisolone, at least in some countries, so studying lower doses of prednisolone may be worthwhile.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - April 3, 2017 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Salivary Cortisol and Cortisone in Adrenal Insufficiency Salivary Cortisol and Cortisone in Adrenal Insufficiency
Find out more about the diagnostic roles of salivary cortisol and cortisone levels in adrenal insufficiency.Journal of the Endocrine Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 24, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Your NEJM Group Today: New Resident Coaching Model, Hydrocortisone Dosing for Adrenal Insufficiency, Rocky Mountain IM Opportunity (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Knowledge+ Blog: A new … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 4, 2016 Category: Primary Care Source Type: news

Diurnal reports positive headline data from pivotal Phase III trial of Infacort to treat paediatric AI
UK-based pharmaceutical company Diurnal has reported positive headline data from its pivotal study of Infacort in Europe to treat paediatric adrenal insufficiency (AI). (Source: Drug Development Technology)
Source: Drug Development Technology - July 12, 2016 Category: Pharmaceuticals Source Type: news

Glucocorticoid Therapy for Adrenal InsufficiencyGlucocorticoid Therapy for Adrenal Insufficiency
How do patients with adrenal insufficiency feel about glucocorticoid therapy -- and how common is the problem of non-adherence? Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 7, 2016 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Morning cortisol rules out adrenal insufficiency
BOSTON – A random morning serum cortisol above 11.1 mcg/dL safely rules out adrenal insufficiency in both inpatients and outpatients, according to a review of 3,300 adrenal insufficiency work-ups at... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - April 6, 2016 Category: Endocrinology Source Type: news

Endocrine Society issues first ever clinical practice guideline on diagnosis & treatment of primary adrenal insufficiency
New guideline details diagnosis and treatment of Addison's Disease. Endocrinology Advisor (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 12, 2016 Category: Endocrinology Source Type: news

New guidelines for treatment of severe primary adrenal insufficiency symptoms
The Endocrine Society has issued a Clinical Practice Guideline (CPG) on diagnosis and treatment of primary adrenal insufficiency. Guidelines (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 25, 2016 Category: Endocrinology Source Type: news

New PAI Guidelines Stress Importance of Treating Adrenal CrisisNew PAI Guidelines Stress Importance of Treating Adrenal Crisis
The first-ever Endocrine Society clinical-practice guidelines on diagnosis and management of primary adrenal insufficiency in adults and children stress the urgency of treating adrenal crisis. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - January 21, 2016 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Experts recommend immediate treatment for severe primary adrenal insufficiency symptoms
A Clinical Practice Guideline (CPG) has been issued on the diagnosis and treatment of primary adrenal insufficiency, a condition commonly known as Addison's disease that occurs when the body produces too little of the hormone cortisol. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 13, 2016 Category: Science Source Type: news

Experts recommend immediate treatment for severe primary adrenal insufficiency symptoms
(The Endocrine Society) The Endocrine Society today issued a Clinical Practice Guideline (CPG) on diagnosis and treatment of primary adrenal insufficiency, a condition commonly known as Addison's disease that occurs when the body produces too little of the hormone cortisol. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 13, 2016 Category: Global & Universal Source Type: news

ACTH testing may be ‘misleading’ in identifying adrenal insufficiency
Both low-dose and high-dose adrenocorticotropic hormone stimulation tests have similar diagnostic accuracy in identifying adrenal insufficiency; however, the tests have limitations and cannot necessarily rule out the condition, according to research in The Journal of Clinical Endocrinology & Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 15, 2015 Category: Endocrinology Source Type: news

Cosyntropin may help diagnose adrenal insufficiency
The diagnosis of adrenal insufficiency may be made using the serum free cortisol response to cosyntropin as an alternative to serum total cortisol, according to recent findings reported in The Journal of Clinical Endocrinology and Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 14, 2015 Category: Endocrinology Source Type: news

Relative Adrenal Insufficiency in Premature Infants: State of the Art
This article discusses of the development of the hypothalamic-pituitary-adrenal axis during gestation, aspects of what is considered normal function, and the diagnosis and management of the entity of relative adrenal insufficiency in the premature infant. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - July 31, 2015 Category: Pediatrics Authors: Weiss, M. E., Caldarelli, L., Hageman, J. R., Littlejohn, E. Tags: Pediatric Drug Labeling Update Articles Source Type: news

Spike In Dolphin Deaths Directly Tied To Deepwater Horizon Oil Spill, Researchers Say
A dramatic increase in dolphin deaths in the Gulf of Mexico is directly linked to the Deepwater Horizon oil spill, scientists concluded in a report published Wednesday. Following the 2010 explosion on the drilling rig owned by British Petroleum (BP) and the subsequent spill of 4.9 million barrels (205.8 million gallons) of oil into the ocean, scientists have documented 1,281 dead and stranded cetaceans, primarily bottlenose dolphins, along the northern coast of the Gulf of Mexico. In this photo taken May 10, 2015, a dead dolphin washes ashore in the Gulf of Mexico on Grand Isle, Louisiana. In 2011, Louisiana saw 163 do...
Source: Science - The Huffington Post - May 21, 2015 Category: Science Source Type: news

How Do You Treat Adrenal Crisis?
Discussion Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive. The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Management of adrenal crisis
Adrenal crisis (AC) is a life-threatening emergency that may occur in patients with chronic adrenal insufficiency (AI). Due to the rarity of AI, physicians are often unfamiliar with the correct emergency treatment of AC. However, objective data supporting this assumption are lacking. Hahner et al. conducted a prospective study to assess the current management of AC with a special focus on the time needed for initiation of parenteral glucocorticoid treatment in a well characterised cohort of patients with chronic AI and compared the results with expert opinion on optimal time targets and time limits in AC. Their data demo...
Source: Society for Endocrinology - April 27, 2015 Category: Endocrinology Source Type: news

Opioid EndocrinopathyOpioid Endocrinopathy
Are opioids adverse effects more of a "pain" than you realized? Learn how opioids may be associated with hypogonadism, adrenal insufficiency, and other endocrine disorders. Endocrine Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2015 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

High rates of adrenal crisis seen in patients with chronic insufficiency
A prospective study carried out by researchers at the University of Wuerzburg has found that adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease; the study was published this week in The Journal of Clinical Endocrinology & Metabolism. Healio   (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 10, 2014 Category: Endocrinology Source Type: news

Adrenal insufficiency - 2014 Lancet review
Adrenal insufficiency is the deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from:- primary adrenal failure- secondary adrenal disease due to impairment of the hypothalamic—pituitary axis Prompt diagnosis and management are essential. The clinical manifestations of primary adrenal insufficiency result from deficiency of all adrenocortical hormones, but they can also include signs of other concurrent autoimmune conditions. In secondary or tertiary adrenal insufficiency, the clinical picture...
Source: Clinical Cases and Images - November 12, 2014 Category: Journals (General) Tags: Endocrinology Lancet Source Type: news

Evaluation of adrenal function in critically ill children
The activation of the hypothalamic-pituitary-adrenal axis in response to critical illness and the resulting release of cortisol from the adrenal cortex are essential to stress adaptation and maintenance of cardiovascular homeostasis. However, there is no consensus on adequate adrenal response to critical illness.   Balbão et al., conducted  a prospective study  to evaluate adrenal function in critically ill children compared with a control group of healthy children by measuring  salivary cortisol and serum total cortisol at baseline and after ACTH stimulation test. Another ...
Source: Society for Endocrinology - October 21, 2014 Category: Endocrinology Source Type: news

5ɑ-reductase and adrenal insufficiency
Patients with critical illness or hepatic failure exhibit impaired cortisol response to ACTH, or ‘relative adrenal insufficiency’. The mechanism could be that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases, leading to downregulation of the hypothalamic–pituitary–adrenal axis and adrenocortical atrophy. Livingstone and colleagues investigated the consequences of 5α-reductase type 1 deficiency in mice. Their results confirm that impaired peripheral clearance of glucocorticoids can cause ‘relative adrenal insufficiency&rs...
Source: Society for Endocrinology - August 29, 2014 Category: Endocrinology Source Type: news

Wednesday's pick of the day
Today sees our two nurses' sessions, as well as two more Plenary Lectures together with a further satellite symposia New insights in the management of adrenal insufficiency and the importance of circadian rhythm, sponsored by ViraPharma Make sure you're up and about for our first ever Society for Endocrinology Journal Awards. Five authors of winning papers from the Society's five official journals will present their work from  8am in room 1C. We're also looking forward to our second Education Workshop:  Practical publishing advice at 9.30, room 3B in which seven speakers will guide you t...
Source: Society for Endocrinology - March 26, 2014 Category: Endocrinology Source Type: news

Boy who could be killed by argument: Morgan Taylor's body could shut down in stressful event
Four-year-old Morgan Taylor, from Burnley, has adrenal insufficiency which means his body does not produce the stress hormone cortisol. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2013 Category: Consumer Health News Source Type: news