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Central adrenal insufficiency following traumatic brain injury: a missed diagnosis in the critically injured - Fan E, Skippen PW, Sargent MA, Cochrane DD, Chanoine JP.
BACKGROUND: High-dose steroid administration is no longer recommended in the treatment of acute traumatic brain injury (TBI) as it failed to prove beneficial in improving patients' outcome. However, a masked benefit of steroid administration in TBI managem... (Source: SafetyLit)
Source: SafetyLit - July 24, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The Medical Emergency Of Otto Warmbier
All that the doctors who treated Cincinnati, Ohio resident Otto Warmbier knew is what they had seen or maybe read in the news. They knew he had just been released on June 13 from imprisonment in North Korea where he had been held by for more than 17 months. He had been sentenced in March 2016 to 15 years of hard labor for allegedly removing a propaganda poster from a wall at a Pyongyang hotel where he had been staying. The University of Virginia honors student had been visiting the authoritarian state during a five-day trip with a group called Young Pioneer Tours, which is a group out of China – an important note. Ot...
Source: Healthy Living - The Huffington Post - June 22, 2017 Category: Consumer Health News Source Type: news

Prednisolone May Raise Cholesterol in Adrenal Insufficiency Prednisolone May Raise Cholesterol in Adrenal Insufficiency
The findings point to hydrocortisone as first-line treatment, but it is exceptionally expensive compared with prednisolone, at least in some countries, so studying lower doses of prednisolone may be worthwhile.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - April 3, 2017 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Salivary Cortisol and Cortisone in Adrenal Insufficiency Salivary Cortisol and Cortisone in Adrenal Insufficiency
Find out more about the diagnostic roles of salivary cortisol and cortisone levels in adrenal insufficiency.Journal of the Endocrine Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 24, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Your NEJM Group Today: New Resident Coaching Model, Hydrocortisone Dosing for Adrenal Insufficiency, Rocky Mountain IM Opportunity (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Knowledge+ Blog: A new … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 3, 2016 Category: Primary Care Source Type: news

Diurnal reports positive headline data from pivotal Phase III trial of Infacort to treat paediatric AI
UK-based pharmaceutical company Diurnal has reported positive headline data from its pivotal study of Infacort in Europe to treat paediatric adrenal insufficiency (AI). (Source: Drug Development Technology)
Source: Drug Development Technology - July 11, 2016 Category: Pharmaceuticals Source Type: news

Glucocorticoid Therapy for Adrenal InsufficiencyGlucocorticoid Therapy for Adrenal Insufficiency
How do patients with adrenal insufficiency feel about glucocorticoid therapy -- and how common is the problem of non-adherence? Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 7, 2016 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Morning cortisol rules out adrenal insufficiency
BOSTON – A random morning serum cortisol above 11.1 mcg/dL safely rules out adrenal insufficiency in both inpatients and outpatients, according to a review of 3,300 adrenal insufficiency work-ups at... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - April 6, 2016 Category: Endocrinology Source Type: news

Endocrine Society issues first ever clinical practice guideline on diagnosis & treatment of primary adrenal insufficiency
New guideline details diagnosis and treatment of Addison's Disease. Endocrinology Advisor (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 12, 2016 Category: Endocrinology Source Type: news

New guidelines for treatment of severe primary adrenal insufficiency symptoms
The Endocrine Society has issued a Clinical Practice Guideline (CPG) on diagnosis and treatment of primary adrenal insufficiency. Guidelines (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 25, 2016 Category: Endocrinology Source Type: news

New PAI Guidelines Stress Importance of Treating Adrenal CrisisNew PAI Guidelines Stress Importance of Treating Adrenal Crisis
The first-ever Endocrine Society clinical-practice guidelines on diagnosis and management of primary adrenal insufficiency in adults and children stress the urgency of treating adrenal crisis. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - January 21, 2016 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Experts recommend immediate treatment for severe primary adrenal insufficiency symptoms
A Clinical Practice Guideline (CPG) has been issued on the diagnosis and treatment of primary adrenal insufficiency, a condition commonly known as Addison's disease that occurs when the body produces too little of the hormone cortisol. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 13, 2016 Category: Science Source Type: news

Experts recommend immediate treatment for severe primary adrenal insufficiency symptoms
(The Endocrine Society) The Endocrine Society today issued a Clinical Practice Guideline (CPG) on diagnosis and treatment of primary adrenal insufficiency, a condition commonly known as Addison's disease that occurs when the body produces too little of the hormone cortisol. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 13, 2016 Category: Global & Universal Source Type: news

ACTH testing may be ‘misleading’ in identifying adrenal insufficiency
Both low-dose and high-dose adrenocorticotropic hormone stimulation tests have similar diagnostic accuracy in identifying adrenal insufficiency; however, the tests have limitations and cannot necessarily rule out the condition, according to research in The Journal of Clinical Endocrinology & Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 15, 2015 Category: Endocrinology Source Type: news

Cosyntropin may help diagnose adrenal insufficiency
The diagnosis of adrenal insufficiency may be made using the serum free cortisol response to cosyntropin as an alternative to serum total cortisol, according to recent findings reported in The Journal of Clinical Endocrinology and Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 14, 2015 Category: Endocrinology Source Type: news

Relative Adrenal Insufficiency in Premature Infants: State of the Art
This article discusses of the development of the hypothalamic-pituitary-adrenal axis during gestation, aspects of what is considered normal function, and the diagnosis and management of the entity of relative adrenal insufficiency in the premature infant. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - July 31, 2015 Category: Pediatrics Authors: Weiss, M. E., Caldarelli, L., Hageman, J. R., Littlejohn, E. Tags: Pediatric Drug Labeling Update Articles Source Type: news

Spike In Dolphin Deaths Directly Tied To Deepwater Horizon Oil Spill, Researchers Say
A dramatic increase in dolphin deaths in the Gulf of Mexico is directly linked to the Deepwater Horizon oil spill, scientists concluded in a report published Wednesday. Following the 2010 explosion on the drilling rig owned by British Petroleum (BP) and the subsequent spill of 4.9 million barrels (205.8 million gallons) of oil into the ocean, scientists have documented 1,281 dead and stranded cetaceans, primarily bottlenose dolphins, along the northern coast of the Gulf of Mexico. In this photo taken May 10, 2015, a dead dolphin washes ashore in the Gulf of Mexico on Grand Isle, Louisiana. In 2011, Louisiana saw 163 do...
Source: Science - The Huffington Post - May 20, 2015 Category: Science Source Type: news

How Do You Treat Adrenal Crisis?
Discussion Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive. The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Management of adrenal crisis
Adrenal crisis (AC) is a life-threatening emergency that may occur in patients with chronic adrenal insufficiency (AI). Due to the rarity of AI, physicians are often unfamiliar with the correct emergency treatment of AC. However, objective data supporting this assumption are lacking. Hahner et al. conducted a prospective study to assess the current management of AC with a special focus on the time needed for initiation of parenteral glucocorticoid treatment in a well characterised cohort of patients with chronic AI and compared the results with expert opinion on optimal time targets and time limits in AC. Their data demo...
Source: Society for Endocrinology - April 27, 2015 Category: Endocrinology Source Type: news

Opioid EndocrinopathyOpioid Endocrinopathy
Are opioids adverse effects more of a "pain" than you realized? Learn how opioids may be associated with hypogonadism, adrenal insufficiency, and other endocrine disorders. Endocrine Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2015 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

High rates of adrenal crisis seen in patients with chronic insufficiency
A prospective study carried out by researchers at the University of Wuerzburg has found that adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease; the study was published this week in The Journal of Clinical Endocrinology & Metabolism. Healio   (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 10, 2014 Category: Endocrinology Source Type: news

Adrenal insufficiency - 2014 Lancet review
Adrenal insufficiency is the deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from:- primary adrenal failure- secondary adrenal disease due to impairment of the hypothalamic—pituitary axis Prompt diagnosis and management are essential. The clinical manifestations of primary adrenal insufficiency result from deficiency of all adrenocortical hormones, but they can also include signs of other concurrent autoimmune conditions. In secondary or tertiary adrenal insufficiency, the clinical picture...
Source: Clinical Cases and Images - November 12, 2014 Category: Journals (General) Tags: Endocrinology Lancet Source Type: news

Evaluation of adrenal function in critically ill children
The activation of the hypothalamic-pituitary-adrenal axis in response to critical illness and the resulting release of cortisol from the adrenal cortex are essential to stress adaptation and maintenance of cardiovascular homeostasis. However, there is no consensus on adequate adrenal response to critical illness.   Balbão et al., conducted  a prospective study  to evaluate adrenal function in critically ill children compared with a control group of healthy children by measuring  salivary cortisol and serum total cortisol at baseline and after ACTH stimulation test. Another ...
Source: Society for Endocrinology - October 21, 2014 Category: Endocrinology Source Type: news

5ɑ-reductase and adrenal insufficiency
Patients with critical illness or hepatic failure exhibit impaired cortisol response to ACTH, or ‘relative adrenal insufficiency’. The mechanism could be that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases, leading to downregulation of the hypothalamic–pituitary–adrenal axis and adrenocortical atrophy. Livingstone and colleagues investigated the consequences of 5α-reductase type 1 deficiency in mice. Their results confirm that impaired peripheral clearance of glucocorticoids can cause ‘relative adrenal insufficiency&rs...
Source: Society for Endocrinology - August 29, 2014 Category: Endocrinology Source Type: news

Wednesday's pick of the day
Today sees our two nurses' sessions, as well as two more Plenary Lectures together with a further satellite symposia New insights in the management of adrenal insufficiency and the importance of circadian rhythm, sponsored by ViraPharma Make sure you're up and about for our first ever Society for Endocrinology Journal Awards. Five authors of winning papers from the Society's five official journals will present their work from  8am in room 1C. We're also looking forward to our second Education Workshop:  Practical publishing advice at 9.30, room 3B in which seven speakers will guide you t...
Source: Society for Endocrinology - March 26, 2014 Category: Endocrinology Source Type: news

Boy who could be killed by argument: Morgan Taylor's body could shut down in stressful event
Four-year-old Morgan Taylor, from Burnley, has adrenal insufficiency which means his body does not produce the stress hormone cortisol. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2013 Category: Consumer Health News Source Type: news

What Is the Best Approach to Tailoring Hydrocortisone Dose?What Is the Best Approach to Tailoring Hydrocortisone Dose?
Do you consider circadian rhythm when dosing hydrocortisone for patients with adrenal insufficiency? Clinical Endocrinology (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - May 3, 2013 Category: Endocrinology Tags: Diabetes & Endocrinology Journal Article Source Type: news

Predictive Factors of Adrenal InsufficiencyPredictive Factors of Adrenal Insufficiency
What is the strongest predictor for potential adrenal failure? BMC Endocrine Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 28, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

What Causes Hypercalcemia?
Discussion Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here. Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium. Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Opioids can cause endocrine dysfunction
3 out of 5 stars The Effect of Opioid Therapy on Endocrine Function. Brennan MJ. Am J Med 2013 Mar;126:S12-S18. Abstract In recent months, TPR has discussed recent medical literature detailing various averse effects of chronic opioid therapy, including narcotic bowel syndrome and opioid-induced hyperalgesia, Additional adverse effects include sedation, immune suppression, and worsening sleep apnea. This well done review article provides a helpful outline of yet another complication: depressed endocrine function. The author notes that opioids affect 2 endocrine pathways. The first pathway is the hyp...
Source: The Poison Review - February 26, 2013 Category: Toxicology Authors: Leon Tags: Medical adrenal endocrine function gonads hypothalamus narcotics opiates opioids ovaries pituitary testes Source Type: news

Tired and listless? You may need more stress hormone
Kaye Occleston was diagnosed with a potentially fatal disorder called adrenal insufficiency, 12 years after she became ill. (Source: the Mail online | Health)
Source: the Mail online | Health - February 19, 2013 Category: Consumer Health News Source Type: news

Personalized Medicine Eliminates Need For Drug In 2 Children
Using genome-wide analysis, investigators at the Sainte-Justine University Hospital Research Center and the University of Montreal have potentially eliminated a lifetime drug prescription that two children with a previously unknown type of adrenal insufficiency had been receiving for 14 years. Over a lifespan, the adjustment in treatment represents an approximate saving of $10,000 in drug and test costs per patient. Moreover, the less invasive treatment regime can potentially reduce the lifetime risk of hypertension in the patients... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

Personalized medicine eliminates need for drug in 2 children
(University of Montreal) Using genome-wide analysis, investigators at the Sainte-Justine University Hospital Research Center and the University of Montreal have potentially eliminated a lifetime drug prescription that two children with a previously unknown type of adrenal insufficiency had been receiving for 14 years. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 31, 2013 Category: Global & Universal Source Type: news