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What Causes Hypernatremia?
Discussion Hypernatremia is a serum sodium of> 150 mEq/L. Basic causes are too much sodium or too little free water. If body weight is normal or increased, there is an increase in total body sodium without an appropriate increase in total body water. Normally when the serum sodium is increased there is transient hypertonicity of the plasma which causes the thirst center to be stimulated and antidiuretic hormone (ADH) to be released. The thirst center tells the person to drink more water and ADH causes the kidney to retain free water. This normally will allow the plasma tonicity to go back to normal. Treatment is by tr...
Source: PediatricEducation.org - October 30, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Central diabetes insipidus and hyperglycemic hyperosmolar state following accidental carbon monoxide poisoning - Ul Abideen Z, Mahmud SN, Rasheed A, Farooq Qasim Y, Ali F.
Carbon monoxide poisoning is common and carries significant morbidity and mortality. The nervous system, particularly the brain, is frequently affected by it, owing to its high metabolic activity and oxygen requirements. Carbon monoxide damages the nervous... (Source: SafetyLit)
Source: SafetyLit - July 14, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

State-of-the-art review of lithium poisoning: almost a must-read
4 out of 5 stars Lithium Poisoning: State of the Art.  Baird-Gunning J et al. J Intensive Care Med 2016 Aug 11 [Epub ahead of print] Abstract This is a very good paper, the best comprehensive review I can remember reading on lithium. It is up to date, with 78 references as recent as 2015. A major reason I liked it so much is that the authors are quire frank about how much we don’t know, and resist giving, for instance, mandates about when to start hemodialysis based on lithium levels. This is a temptation that the authors of the recent ExTRIP review  succumbed to. Interestingly, the two papers sha...
Source: The Poison Review - August 20, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical lithium poisoning Review TUSH ultrasound Source Type: news

Women, young adults with non-functioning pituitary adenoma at higher risk for premature death
Women and young adults with non-functioning pituitary adenoma have a higher risk for premature death, particularly women with hypopituitarism or diabetes insipidus, according to research in The Journal of Clinical Endocrinology & Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - June 17, 2015 Category: Endocrinology Source Type: news

Full bladder wakes 2 in 3 women at night
Getting up at night to use the bathroom is often thought of as a problem mainly for older men. Not so—two in three women over age 40 wake up at least once each night because of a full bladder. And nearly half of them make two or more nighttime trips to the bathroom. That’s the upshot from a survey of more than 2,000 northern California women ages 40 years and older. They were asked questions related to possible reasons for nocturia, the medical term for getting up to urinate twice or more per night. Factors that increased the likelihood that a woman woke at night to urinate included older age, having had a hyst...
Source: New Harvard Health Information - December 12, 2014 Category: Consumer Health News Authors: Howard LeWine, M.D. Tags: Incontinence Women's Health bladder nocturia Source Type: news

Lithium-Induced NDI (Nephrogenic Diabetes...
Lithium-induced NDI (nephrogenic diabetes insipidus) is a serious condition that can result from taking the medication Lithium for treatment of bipolar disorder or major depressive disorder. More ... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Determined to get back in the game
Seventeen-year-old Kyle Arieta lives for football, but as his mother is quick to note, football doesn’t define him. Instead, she points to a quiet determination that he’s learned from his years on the playing field. It’s an attitude of pushing through and moving beyond that’s served him well in the game, and which drove him to get back on his feet after the brain tumor. When the southeastern Massachusetts native went to bed one night last May, he’d been having headaches off and on for a while. They weren’t all that bad, more like a mild cold that wouldn’t go away. That next morning...
Source: Thrive, Children's Hospital Boston - April 24, 2014 Category: Pediatrics Authors: Tom Ulrich Tags: All posts Dana-Farber/Boston Children's Cancer and Blood Disorders Center Edward Smith football neurosurgery our patients' stories Source Type: news

Genetic testing in suspected FCDI
Differentiating familial cranial diabetes insipidus (CDI) from primary polydipsia can be difficult especially in the early phase of cranial diabetes insipidus (CDI) when AVP secretion is declining. Srinivasan et al. report of a 3-month old boy with polydipsia and who had a family history of autosomal dominant CDI.  He was initially diagnosed with familial CDI and treated with DDAVP. However, 2 months later he developed hyponatraemia and DDAVP was stopped. Genetic analysis of the AVP gene was undertaken to establish a molecular defect and results showed that he did not have a pathogenic mutation and hence was not...
Source: Society for Endocrinology - November 14, 2013 Category: Endocrinology Source Type: news

WFS1 variants in Finnish patients with diabetes mellitus, sensorineural hearing impairment or optic atrophy, and in suicide victims - Kytövuori L, Seppänen A, Martikainen MH, Moilanen JS, Kamppari S, Sarkioja T, Remes AM, Rasanen P, Rönnemaa T, Majamaa K.
Mutations in the wolframin gene, WFS1, cause Wolfram syndrome, a rare recessive neurodegenerative disorder. The clinical features include early-onset bilateral optic atrophy (OA), diabetes mellitus (DM), diabetes insipidus, hearing impairment, urinary trac... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - April 23, 2013 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news