Aquaporin water channels - from transfusion medicine to malaria
NIH Director’s Wednesday Afternoon Lecture Series Biochemical analysis of the Rhesus blood group antigen led to the serendipitous discovery of AQP1, the first molecular water channel. Found throughout nature, aquaporin water channels confer high water permeability to cell membranes. AQP1 has been characterized biophysically, and the atomic structure of AQP1 is known. Identification of the Colton blood group antigen on the extracellular domain of AQP1 allowed identification of rare individuals who are AQP1-null and manifest a subclinical form of nephrogenic diabetes insipidus. Thirteen homologous proteins exist in hu...
Source: Videocast - All Events - September 1, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video