Chloroquine Attenuates Lithium-induced NDI and Proliferation of Renal Collecting Duct Cells.
Abstract Lithium is widely used in psychiatry as golden standard for more than 60 years due to its effectiveness. However, its adverse effect has been limiting its long-term use in clinic. About 40% patients taking lithium develop nephrogenic diabetes insipidus (NDI). Lithium can also induce proliferation of collecting duct cells, leading to microcysts formation in the kidney. Lithium was considered as autophagy inducer which may contribute to the therapeutic benefit of neuropsychiatric disorders. Thus, we hypothesized that autophagy may play a role in lithium induced kidney nephrotoxicity. To address our hypothes...
Source: Am J Physiol Renal P... - April 6, 2020 Category: Urology & Nephrology Authors: Du Y, Qian Y, Tang X, Guo Y, Chen S, Jiang M, Yang B, Cao W, Huang S, Zhang A, Jia Z, Zhang Y Tags: Am J Physiol Renal Physiol Source Type: research

Impurities identification and quantification for arginine vasopressin by liquid chromatography-high resolution mass spectrometry.
CONCLUSION: This work complements the AVP impurity profile and facilitates improved separation and discovery of other potential impurities in vasopressin analogues. PMID: 32247289 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 4, 2020 Category: Chemistry Authors: Wu P, Ye S, Li M, Li H, Kan Y, Yang Z Tags: Rapid Commun Mass Spectrom Source Type: research

A case report of empty Sella syndrome secondary to Hantaan virus infection and review of the literature
Rationale: Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in the acute stage of severe clinical forms of hemorrhagic fever with renal syndrome (HFRS), while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after the recovery stage. The relationship between Hantaan virus infection and empty Sella syndrome (ESS) has rarely been reported. Patient concerns: This patient was a 54-year-old previously healthy Chinese male. He presented with fever, headache, and backache with dizziness and oliguria. Physical examination was notable for hypotension and the signs of ...
Source: Medicine - April 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Immune checkpoint inhibitor-associated pituitary adverse events: an observational, retrospective, disproportionality study
AbstractPurposeThe aim of this study was to identify and characterize immune checkpoint inhibitors (ICIs)-associated pituitary adverse events (AEs).MethodsThis is a retrospective disproportionality study based on VigiBase, the World Health Organization (WHO) global database of individual case safety reports (ICSRs), with a study period from January 1, 2011 to March 6, 2019. Information component (IC) and reporting odds ratio (ROR) are measures of disproportionate analysis. IC was used to evaluate the association between ICIs and pituitary AEs, while ROR was used to evaluate the differences in reporting of pituitary AEs bet...
Source: Journal of Endocrinological Investigation - April 1, 2020 Category: Endocrinology Source Type: research

Central diabetes insipidus related to anti-programmed cell-death 1 protein active immunotherapy.
We report a 71-years-old male patient with advanced lung cancer who experienced severe chronic hypernatremia presented as alterations in mental status five months after initiation of treatment with the anti-PD-1 checkpoint inhibitor nivolumab. Combination of persistenthypernatremia, polyuria, high plasma osmolality and hyposthenuria raised suspicion of diabetes insipidus, prompting measurement of serum concentration of arginine vasopressin(AVP). The inappropriately undetectable serum levels of AVP confirmed central diabetes insipidus (CDI). Nivolumab-related hypophysitis was recognized as possible cause of CDI. Further hor...
Source: International Immunopharmacology - March 31, 2020 Category: Allergy & Immunology Authors: Deligiorgi MV, Siasos G, Vergadis C, Trafalis DT Tags: Int Immunopharmacol Source Type: research

A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction.
Abstract Intrauterine infections with the pathogens, including toxoplasmosis, other (syphilis, varicella, mumps, parvovirus, and HIV), rubella, cytomegalovirus, and herpes simplex (TORCH) in susceptible individuals during pregnancy, result in microcephaly, white matter disease, cerebral atrophy, and calcifications in the fetus. Pseudo-TORCH syndrome is an umbrella term, consisting of several syndromes, resultant from different genetic alterations and pathogenetic mechanisms. Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG) is one of these conditions, resultant from biallelic mutations ...
Source: European Journal of Medical Genetics - March 30, 2020 Category: Genetics & Stem Cells Authors: Ekinci F, Yildizdas RD, Horoz OO, Herguner O, Bisgin A Tags: Eur J Med Genet Source Type: research

Effect of 4-phenylbutyrate and valproate on dominant mutations of WFS1 gene in Wolfram syndrome
ConclusionsPBA and VPA could reduce the ER stress and cell apoptosis caused by dominant WFS1 mutants. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 26, 2020 Category: Endocrinology Source Type: research

Results and predictors of outcome of endoscopic endonasal surgery in Cushing ’s disease: 20-year experience of an Italian referral Pituitary Center
AbstractPurposeTo assess outcomes and predictors of early and long-term remission in patients with Cushing ’s disease (CD) due to ACTH-secreting adenomas treated via endoscopic endonasal approach (EEA).MethodsThis is a retrospective study. Consecutive patients operated for CD from 1998 to 2017 in an Italian referral Pituitary Center were enrolled. Clinical, radiological, and histological data at enrollment and follow-up were collected.Results151 patients (107 F) were included; 88.7% were na ïve for treatment, 11.3% had been treated surgically and 11.2% medically. At pre-operative magnetic resonance imaging (MRI)...
Source: Journal of Endocrinological Investigation - March 25, 2020 Category: Endocrinology Source Type: research

Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia
AbstractChronic hypernatremia activates the central osmoregulatory mechanisms and inhibits the function of the hypothalamic –pituitary–adrenal (HPA) axis. Noradrenaline (NE) release into the periventricular anteroventral third ventricle region (AV3V), the supraoptic (SON) and hypothalamic paraventricular nuclei (PVN) from efferents of the caudal ventrolateral (cVLM) and dorsomedial (cDMM) medulla has been shown to be essential for the hypernatremia-evoked responses and for the HPA response to acute restraint. Notably, the medullary NE cell groups highly coexpress prolactin-releasing peptide (PrRP) and nesfatin-...
Source: Anatomy and Embryology - March 21, 2020 Category: Anatomy Source Type: research

Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia.
nai P, Tóth ZE Abstract Chronic hypernatremia activates the central osmoregulatory mechanisms and inhibits the function of the hypothalamic-pituitary-adrenal (HPA) axis. Noradrenaline (NE) release into the periventricular anteroventral third ventricle region (AV3V), the supraoptic (SON) and hypothalamic paraventricular nuclei (PVN) from efferents of the caudal ventrolateral (cVLM) and dorsomedial (cDMM) medulla has been shown to be essential for the hypernatremia-evoked responses and for the HPA response to acute restraint. Notably, the medullary NE cell groups highly coexpress prolactin-releasing peptide (...
Source: Brain Structure and Function - March 21, 2020 Category: Neuroscience Authors: Matuska R, Zelena D, Könczöl K, Papp RS, Durst M, Guba D, Török B, Varnai P, Tóth ZE Tags: Brain Struct Funct Source Type: research

Correlation between the Position of the Pituitary Stalk as Determined by Diffusion Tensor Imaging and Its Location as Determined at the Time of Surgical Resection of Pituitary Adenomas.
Conclusion: This study shows that DTI can identify the position of the HHT and thus the position of the PS with a high degree of reliability. PMID: 32182411 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - March 19, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Pituitary metastases: presentation and outcomes from a pituitary center over the last decade
ConclusionsIn our contemporary series, clinical presentation of PM has evolved; we found increased prevalence of anterior hypopituitarism, decreased rates of DI and longer survival compared with older literature. Increased availability of diagnostic imaging, improvements in screening and recognition of pituitary disease and longer survival of patients with metastatic cancer may be contributing factors. (Source: Pituitary)
Source: Pituitary - March 18, 2020 Category: Endocrinology Source Type: research

Familial central diabetes insipidus.
Authors: Bahíllo-Curieses MP, Palomares-Cardador M, García-Castaño A PMID: 32165002 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 15, 2020 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Outcomes in Pediatric Transsphenoidal Pituitary Surgery Stratified by the Use of Image Guidance: An Analysis of the Kids' Inpatient Database from 1997 to 2016
J Neurol Surg B DOI: 10.1055/s-0040-1701602 Background To evaluate the utilization of image guidance technology for pediatric transsphenoidal pituitary resection (TSPR) and analyze the complication rates, length of stay (LOS), and total cost for such surgeries as function of time and utilization of image guidance. Methods The Healthcare Cost and Utilization Project Kids' Inpatient Database (KID) was queried for all cases of TSPR between 1997 and 2016. Factors extracted included patient demographics, use of image guidance, LOS, total cost, and complications, including panhypopituitarism, diabetes insipidus (...
Source: Journal of Neurological Surgery Part B: Skull Base - March 9, 2020 Category: Neurosurgery Authors: Lovin, Benjamin D. Yu, Justin Choi, Jonathan S. Patel, Akash J. Giannoni, Carla M. Gallagher, K. Kelly Tags: Original Article Source Type: research

V2 vasopressin receptor mutations.
Abstract V2 vasopressin receptor (V2R) is a member of the G protein-coupled receptor (GPCR) family in which many disease-causing mutations have been identified and thus generated much interest. Loss-of-function V2R mutations cause nephrogenic diabetes insipidus (NDI) whereas gain-of-function mutations cause nephrogenic syndrome of inappropriate antidiuresis (NSIAD). The mechanisms underlying a V2R loss-of-function can be theoretically classified as either protein expression, localization (ER retention) or functional disorders. Functional analyses have revealed however that these mechanisms are likely to be complex...
Source: Vitamins and Hormones - March 8, 2020 Category: Endocrinology Authors: Makita N, Manaka K, Sato J, Iiri T Tags: Vitam Horm Source Type: research

Amyloid-like aggregation of provasopressin.
Abstract The antidiuretic hormone vasopressin is synthesized as a longer precursor protein. After folding in the endoplasmic reticulum (ER), provasopressin is transported through the secretory pathway, forms secretory granules in the trans-Golgi network (TGN), is processed, and finally secreted into the circulation. Mutations in provasopressin cause autosomal dominant diabetes insipidus. They prevent native protein folding and cause fibrillar, amyloid-like aggregation in the ER, which eventually results in cell death. Secretory granules of peptide hormones were proposed to constitute functional amyloids and thus m...
Source: Vitamins and Hormones - March 8, 2020 Category: Endocrinology Authors: Spiess M, Beuret N, Prescianotto Baschong C, Rutishauser J Tags: Vitam Horm Source Type: research

Vasopressin inactivation: Role of insulin-regulated aminopeptidase.
Abstract The physiological importance of vasopressin inactivation has long been appreciated, but the mechanisms and potential pathophysiologic roles of this process remain active subjects of research. Human Placental Leucine Aminopeptidase (P-LAP, encoded by the LNPEP gene) is an important determinant of vasopressinase activity during pregnancy and is associated with gestational diabetes insipidus and preeclampsia. Insulin-Regulated Aminopeptidase (IRAP), the rodent homologue of P-LAP, is coregulated with the insulin-responsive glucose transporter, GLUT4, in adipose and muscle cells. Recently, the Tether containin...
Source: Vitamins and Hormones - March 8, 2020 Category: Endocrinology Authors: Li DT, Habtemichael EN, Bogan JS Tags: Vitam Horm Source Type: research

Intracranial Pure Germinoma With Optic Nerve Infiltration
Abstract: A 19-year-old man presented with a 3-year history of episodic headaches, right hemiparesis, and progressive vision loss in both eyes. Initially, extensive laboratory testing was unrevealing. MRI later demonstrated progressive enlargement and enhancement of the left optic nerve poorly correlated with the timing of his clinical manifestations. There was no clinical or radiological response to treatment with corticosteroids, mycophenolate mofetil, or rituximab administered empirically for possible inflammatory processes. Later in the disease course, he developed diabetes insipidus (DI), worsening vision to light p...
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Diagnosis and differential diagnosis of diabetes insipidus: update
Publication date: Available online 28 February 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Julie Refardt (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 28, 2020 Category: Endocrinology Source Type: research

Gestational diabetes insipidus: diagnosis and management
Publication date: Available online 27 February 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Sonia Ananthakrishnan (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 28, 2020 Category: Endocrinology Source Type: research

Intracranial Pure Germinoma With Optic Nerve Infiltration
Abstract: A 19-year-old man presented with a 3-year history of episodic headaches, right hemiparesis, and progressive vision loss in both eyes. Initially, extensive laboratory testing was unrevealing. MRI later demonstrated progressive enlargement and enhancement of the left optic nerve poorly correlated with the timing of his clinical manifestations. There was no clinical or radiological response to treatment with corticosteroids, mycophenolate mofetil, or rituximab administered empirically for possible inflammatory processes. Later in the disease course, he developed diabetes insipidus (DI), worsening vision to light p...
Source: Journal of Neuro-Ophthalmology - February 27, 2020 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Clinical Characteristics of Pediatric Patients With Sellar and Suprasellar Lesions Who Initially Present With Central Diabetes Insipidus: A Retrospective Study of 55 Cases From a Large Pituitary Center in China
Conclusion: For pediatric SSR lesions that first manifest as CDI, we should comprehensively consider clinical characteristics and imaging features to aid in their early differential diagnosis. Tumor markers and surgical histopathology are also great complements for the differential diagnosis. Additionally, various treatment strategies should be adopted according to different causes to improve the child's prognosis and quality of life. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 20, 2020 Category: Endocrinology Source Type: research

Comments About Diabetes Insipidus After Discontinuation of Vasopressin Infusion for Treatment of Shock
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 15, 2020 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Transient diabetes insipidus post endoscopic third ventriculostomy: Case report and literature review
ConclusionOverinflation of the balloon during ETV and subsequent hypothalamic injury can cause DI, a rare but potentially dangerous complication of this procedure. Postoperative surveillance and management of electrolytes disturbances is crucial to prevent any long term injury. ETV must be reconsidered if the prepontine cistern is not clearly patent to avoid complications. (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - February 14, 2020 Category: Neurosurgery Source Type: research

Portopulmonary hypertension caused by portal hypertension that is complicated by central diabetes insipidus
This report reviews how vasopressin affects those diseases. AbstractWe discuss the pathophysiology, diagnosis, differential diagnosis, and therapy of a case with central diabetes insipidus, idiopathic portal hypertension, and portopulmonary hypertension. This report reviews how vasopressin affects those diseases. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 13, 2020 Category: General Medicine Authors: Tingting Zhao, Qian Xing, Xiaojuan Yang, Xiaofeng Yao, Ying Ba, Haicheng Zhou, Dan Liu Tags: CASE REPORT Source Type: research

[Home monitoring of sodium in children with adipsic diabetes insipidus].
ía E PMID: 32057712 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - February 10, 2020 Category: Pediatrics Authors: Peinado Barraso MC, García García E Tags: An Pediatr (Barc) Source Type: research

Systematic review and network meta-analysis assess the comparative efficacy and safety of transsphenoidal surgery for pituitary tumor
AbstractTo quantitatively synthesize the comparative efficacy and safety of the most common surgical approaches including endonasal transsphenoidal endoscopic surgery (ETES), sublabial transsphenoidal microsurgery (STMS) and endonasal transsphenoidal microsurgery (ETMS) for all kinds of pituitary tumors. This systematic review and network meta-analysis was performed on randomized controlled trials (RCTs) and comparison studies from databases of Pubmed, EMBASE, and the Cochrane library. We selected the rate of gross complete resection as our primary outcome of efficacy. And the incidence of all complications, cerebrospinal ...
Source: Neurosurgical Review - February 8, 2020 Category: Neurosurgery Source Type: research

Epidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors.
CONCLUSIONS: Neurohypophyseal iGCTs are insidious tumors that may pose a diagnostic dilemma, as evidenced by the prolonged latency before radiographic confirmation. Serial imaging and close endocrine follow-up are recommended in patients with a characteristic clinical syndrome and negative imaging, due to the propensity for radiographic latency. Pretreatment biochemical abnormalities may indicate higher risk of posttreatment pituitary insufficiency, and all patients should receive careful endocrine follow-up. Local radiotherapy is prone to treatment failure, while whole-ventricle treatment is associated with improved survi...
Source: Journal of Neurosurgery - February 7, 2020 Category: Neurosurgery Authors: Takami H, Graffeo CS, Perry A, Giannini C, Daniels DJ Tags: J Neurosurg Source Type: research

Management of central diabetes insipidus
Publication date: Available online 31 January 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Aoife Garrahy, Christopher J. ThompsonAbstractThe treatment of central diabetes insipidus has not changed significantly in recent decades, dDAVP and replacement of free water deficit remain the cornerstones of treatment. Oral dDAVP has replaced nasal dDAVP as a more reliable mode of treatment for chronic central diabetes insipidus. Hyponatraemia is common, occurring in one in four patients, and should be avoided by allowing a regular break from dDAVP and resultant aquaresis. Hypernatraemi...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - January 31, 2020 Category: Endocrinology Source Type: research

Pituitary Metastasis of Lung Adenocarcinoma: Case Report and Literature Review
ConclusionDiagnosis and management of pituitary metastases are complex and depend on many factors. Endoscopic surgical resection and debulking alleviates symptoms and provides the definitive diagnosis which has great importance in cases with clinical presentation that does not strongly point to pituitary metastasis to avoid unnecessary radiotherapy and chemotherapy when possible. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 24, 2020 Category: Surgery Source Type: research

Orbitofrontal approach for the fenestration of a symptomatic sellar arachnoid cyst.
Conclusion: SACs are rare with no consensus on the indications for surgery. Our experience suggests that fenestration of SAC through transcranial approach is a valid option for patients with visual deficit and/or pituitary dysfunction. PMID: 31966929 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - January 24, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Transsphenoidal Resection of Pituitary Tumors in the United States, 2009 to 2011: Effects of Hospital Volume on Postoperative Complications
Conclusions Our analysis shows that increased case volume is related to superior perioperative outcomes for TNTS pituitary tumor resections. Despite the recent adoption of newer endoscopic techniques and concerns of technical learning curves, this VOR remains undisturbed. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - January 24, 2020 Category: Neurosurgery Authors: Li, Daphne Johans, Stephen Martin, Brendan Cobb, Adrienne Kim, Miri Germanwala, Anand V. Tags: Original Article Source Type: research

Pituitary tumors: epidemiology and clinical presentation spectrum.
Authors: Araujo-Castro M, Berrocal VR, Pascual-Corrales E Abstract Pituitary tumors (PTs) are a heterogeneous group of lesions of the central nervous system that are usually benign. Most of them occur sporadically, but 5% can do so within family syndromes, usually at a young age. There are differences by sex, age, race, and genetic factors in the prevalence of different tumor cell types and clinical presentation. Functioning-PTs (FPTs) are usually diagnosed earlier than non-functioning PTs (NFPTs). However, this depends on the PT type. Headaches and visual disturbances are the most frequent mass-effect symptoms, bu...
Source: Hormones - January 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review.
Authors: Li Y, Gao H, Li Z, Zhang X, Ding Y, Li F Abstract Background: IgG4-related hypophysitis (IgG4-RH) is a rare disease, and its prevalence remains unclear. In recent years, an increasing number of cases have been reported because of the increasing recognition of this disease. We aimed to summarize case reports of IgG4-RH and outline the clinical features and outcomes. Methods: We performed PubMed search of articles using the search terms "hypophysitis [AND] IgG4." Consequently, only 54 English articles (76 cases) met Leporati's diagnostic criteria. Results: Of the 76 cases, the ratio of men ...
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

An uncommon case of arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome and review of the renal involvement: Questions
AbstractArthrogryposis, renal dysfunction, and cholestasis syndrome is a rare autosomal recessive disorder caused by mutations in the VPS33B and VIPAR genes. Most cases are fatal within the first year of life. Here we describe one of the two oldest patients with arthrogryposis, renal dysfunction, and cholestasis syndrome. This is a 12-year-old Hispanic female, from a non-consanguineous parents, diagnosed with an incomplete phenotype of arthrogryposis, renal dysfunction, and cholestasis syndrome with arthrogryposis and renal tubular dysfunction but without cholestasis. At 11 years of age, she was found to have impaired rena...
Source: Pediatric Nephrology - January 2, 2020 Category: Urology & Nephrology Source Type: research

Sport-Related Concussion Preceding Adrenal Insufficiency and Hypopituitarism
A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Laboratory testing revealed critically low serum cortisol, hypernatremia, and urine studies suggesting diabetes insipidus. The patient was referred to the emergency department. Intravenous fluid resuscitation, corticos...
Source: Current Sports Medicine Reports - January 1, 2020 Category: Sports Medicine Tags: Case Report Source Type: research

Sport-Related Concussion Preceding Adrenal Insufficiency and Hypopituitarism.
Abstract A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Laboratory testing revealed critically low serum cortisol, hypernatremia, and urine studies suggesting diabetes insipidus. The patient was referred to the emergency department. Intravenous fluid resus...
Source: Current Sports Medicine Reports - January 1, 2020 Category: Sports Medicine Authors: Northam WT, Alexander A, Carneiro K Tags: Curr Sports Med Rep Source Type: research

Various Strategies of Transsphenoidal Pseudocapsule-Based Extracapsular Resection in Noninvasive Functional Pituitary Adenomas and their Effectiveness and Safety
Conclusion: With our various surgical strategies of ER, the patients can achieve content imaging resection, high and sustained endocrine remission, which are effective and safe for NIFPAs. (Source: Neurology India)
Source: Neurology India - December 20, 2019 Category: Neurology Authors: Qing-Xin Li Wei-Hong Wang Xian-Xiang Wang Source Type: research

Imaging findings in hypophysitis: a review
AbstractHypophysitis (HP) is a rare acute or chronic inflammatory condition of the pituitary gland. The greatest challenge in the management of HP is establishing a diagnosis through clinical criteria and non-invasive methods and predicting the patients ’ clinical outcome. The aim of this review is to describe the neuroradiological findings of this rare disease, providing some information regarding the possible differential diagnosis in order to avoid unnecessary surgery. Gadolinium-enhanced pituitary magnetic resonance imaging (MRI) is considere d the neuroradiological investigation of choice. The features suggestiv...
Source: La Radiologia Medica - December 20, 2019 Category: Radiology Source Type: research

Primary pituitary abscess case series and a review of the literature.
CONCLUSION: Presentation of fever, headache, diabetes insipidus, hypopituitarism and a sellar cystic mass with an enhanced rim after gadolinium contrast on pituitary magnetic resonance imaging may be suggestive of a pituitary abscess. Transsphenoidal endoscopic surgery, proper antibiotics and appropriate hormone replacement therapy when necessary are the keys of pituitary abscess treatment. PMID: 31785217 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Pituitary Involvement in Granulomatosis with Polyangiitis: A Retrospective Analysis in a Single Chinese Hospital and a Literature Review.
Conclusions: GPA should be carefully considered as a potential cause of pituitary dysfunction (PD), especially when multisystem dysfunction exists. Conventional treatment with corticosteroids and/or immunosuppressive agents improves systemic symptoms, but pituitary disorders persisted in most patients. PMID: 31781205 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Role of protein aggregation and degradation in autosomal dominant neurohypophyseal diabetes insipidus
Publication date: Available online 27 November 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Martin Spiess, Michael Friberg, Nicole Beuret, Cristina Prescianotto-Baschong, Jonas RutishauserAbstractThis review focuses on the cellular and molecular aspects underlying familial neurohypophyseal diabetes insipidus (DI), a rare disorder that is usually transmitted in an autosomal-dominant fashion. The disease, manifesting in infancy or early childhood and gradually progressing in severity, is caused by fully penetrant heterozygous mutations in the gene encoding prepro-vasopressin-neurophysin II, the precursor of the...
Source: Molecular and Cellular Endocrinology - November 29, 2019 Category: Endocrinology Source Type: research

Extended Survival After Surgical Resection for Pituitary Metastases: Clinical Features, Management, and Outcomes of Metastatic Disease to the Sella.
We describe the presentation, management, and outcomes of patients with PM. SUBJECTS, MATERIALS, AND METHODS: We performed a retrospective review of patients diagnosed with PM at a single institution from 1996 to 2015. Eighty-five patients diagnosed with metastasis to the pituitary or sella turcica by pathology or based on a combination of neuroimaging and clinical findings were included. Univariate and multivariable Cox regressions evaluated associations between clinical factors and overall survival. RESULTS: The most frequent sites of primary malignancies resulting in PM were lung (26%) and breast (26%). Median...
Source: The Oncologist - November 29, 2019 Category: Cancer & Oncology Authors: Patel KR, Zheng J, Tabar V, Cohen MA, Girotra M Tags: Oncologist Source Type: research

Distinguishing between post-trauma pituitary stalk disruption and genetic pituitary stalk interruption syndrome - case presentation and literature overview.
CONCLUSIONS: MRI image together with medical history of the head trauma and its strict temporal relation with transient diabetes insipidus and the occurrence of CPHD signs, as well as the lack of extrapituitary midline defects differentiate posttraumatic pituitary stalk transection syndrome (PSTS) from genetic PSIS. In every case of severe traumatic head injury hormonal evaluation and MRI of hypothalamic-pituitary axis should be performed. PMID: 31769274 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Ruszała A, Wójcik M, Krystynowicz A, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Urinary disorders of Wolfram syndrome. Clinical and urodynamic analysis from 6 observations].
CONCLUSION: Urinary dysfunction is common in Wolfram syndrome, mainly characterized by overactive bladder and urinary retention. The urological risk is major requiring a systelmatic follow-up of these patients. LEVEL OF EVIDENCE: 4. PMID: 31761518 [PubMed - as supplied by publisher] (Source: Progres en Urologie)
Source: Progres en Urologie - November 27, 2019 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion.
In this study, we evaluated plasma AVP concentrations during a hypertonic saline infusion test using a new AVP radioimmunoassay (RIA) which is now available in Japan. Thirteen control subjects, mostly with hypothalamo-pituitary disease but without CDI, and 13 patients with CDI were enrolled in the study. Whether or not subjects had CDI was determined based on the totality of clinical data, which included urine volumes and osmolality. Regression analysis of plasma AVP and serum Na concentrations revealed that the gradient was significantly lower in the CDI group than in the control group. The area under the receiver-operati...
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Diabetes Insipidus After Discontinuation of Vasopressin Infusion for Treatment of Shock
Conclusions: Despite a paucity of published reports, diabetes insipidus after discontinuation of vasopressin infusion appears not to be a rare phenomenon, and is likely to be encountered by intensivists who regularly employ vasopressin for the treatment of vasoplegic shock. Previous reports consisted predominantly of neurosurgical patients. Our findings demonstrate the occurrence of diabetes insipidus after discontinuation of vasopressin infusion among patients with septic shock as well as vasoplegic shock after cardiothoracic intervention. The mechanism of diabetes insipidus after discontinuation of vasopressin infusion...
Source: Critical Care Medicine - November 16, 2019 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Pituitary gland recovery following fully endoscopic transsphenoidal surgery for nonfunctioning pituitary adenoma: results of a prospective multicenter study.
CONCLUSIONS: Fully endoscopic pituitary surgery resulted in improvement of pituitary gland function in a substantial minority of patients. The deficiency from which patients were most likely to recover was adrenal insufficiency. Overall rates of postoperative permanent diabetes insipidus were low. This study provides multicenter benchmark neuroendocrine clinical outcome data for the endoscopic technique. PMID: 31731279 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 15, 2019 Category: Neurosurgery Authors: Little AS, Gardner PA, Fernandez-Miranda JC, Chicoine MR, Barkhoudarian G, Prevedello DM, Yuen KCJ, Kelly DF, TRANSSPHER Study Group Tags: J Neurosurg Source Type: research

Evaluation of pharmacochaperone-mediated rescue of mutant V2 receptor proteins.
In this study, in order to analyze the effects of two pharmacological chaperones, SR121463B and SR49059, we performed total ELISA and surface ELISA studies and cAMP accumulation assays on mutant receptors (G12E, R68W, V88M, ΔR67_G69/G107W, R106C, V162A and T273M). We observed that pharmacological chaperones may act differently on mutated AVPR2s. Cell surface expression of the mutant receptors and cAMP accumulation response, after stimulation with AVP, were mostly improved by these pharmacological chaperones. We believe that, this study presents important results with respect to the process of the variable type of mut...
Source: European Journal of Pharmacology - November 15, 2019 Category: Drugs & Pharmacology Authors: Tuncdemir BE, Mergen H, Ozer ES Tags: Eur J Pharmacol Source Type: research

National trends in hospital readmission following transsphenoidal surgery for pituitary lesions
AbstractPurposeSeveral institutions recently published their experiences with unplanned readmissions rates after transsphenoidal surgery for pituitary lesions. Readmission rates on a national level, however, have not been explored in depth. We investigated nationwide trends in this procedure and associated independent predictors, costs, and causes of 30-day readmission.MethodsThe Nationwide Readmissions Database was queried to identify patients 18 and older who underwent transsphenoidal surgery for pituitary lesion resection (2010 –2015). National trends and statistical variances were calculated based on weighted, cl...
Source: Pituitary - November 14, 2019 Category: Endocrinology Source Type: research