Introduction to diagnostic test accuracy studies.
Abstract Diagnostic accuracy studies are fundamental for the assessment of diagnostic tests. Researchers need to understand the implications of their chosen design, opting for comparative designs where possible. Researchers should analyse test accuracy studies using the appropriate methods, acknowledging the uncertainty of results and avoiding overstating conclusions and ignoring the clinical situation which should inform the trade-off between sensitivity and specificity. Test accuracy studies should be reported with transparency using the STAndards for the Reporting of Diagnostic accuracy studies (STARD) checklis...
Source: European Journal of Endocrinology - January 9, 2021 Category: Endocrinology Authors: Sitch AJ, Dekkers OM, Scholefield BR, Takwoingi Y Tags: Eur J Endocrinol Source Type: research

Presenting features and molecular genetics of primary hyperparathyroidism in the paediatric population.
CONCLUSION: Although far less common than in adults, PHPT can develop in children and is associated with significant morbidity. Consequently, this diagnosis should be considered in children with non-specific complaints and lead to monitoring of mineral homeostasis parameters. A genetic cause of PHPT can be identified in about half of these patients. PMID: 33361469 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: El Allali Y, Hermetet C, Bacchetta J, Amouroux C, Rothenbuhler A, Porquet-Bordes V, Champigny MA, Baron S, Barat P, Bony-Trifunovic H, Bourdet K, Busiah K, Cartigny-Maciejewski M, Compain F, Coutant R, Amsellem-Jager J, De Kerdanet M, Magontier N, Mignot Tags: Eur J Endocrinol Source Type: research

ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.
ek T, Garcia-Centeno R, Ghigo E, Gasco V, Góth MI, Oláh D, Kovacs L, Höybye C, Kocjan T, Mlekuš Kozamernik K, Kužma M, Payer J, Medic-Stojanoska M, Novak A, Miličević T, Pekic S, Miljic D, Perez Luis J, Pico AM, Preda V, Raverot G, Borson-Chazot F, Rochira V, Monzani ML, Sandahl K, Tsagarakis S, Mitravela V, Zacharieva S, Zilaitiene B, Verkauskiene R Abstract Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS: 1) To record current practice of AGHD management t...
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Martel-Duguech LM, Jorgensen JOL, Korbonits M, Johannsson G, Webb SM, Amadidou F, Mintziori G, Arosio M, Giavoli C, Badiu C, Boschetti M, Ferone D, Ricci Bitti S, Brue T, Albarel F, Cannavò S, Cotta OR, Carvalho D, Salazar D, Christ E, Debono M, Dusek T, Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Gonadal dysfunction in congenital adrenal hyperplasia (CAH).
Abstract Gonadal dysfunction is an adverse outcome in patients with congenital adrenal hyperplasia (CAH), which may become apparent already during puberty. Clinical consequences of gonadal dysfunction include menstrual disturbances in females and hypogonadism and impaired fertility in males and females. In males, gonadal dysfunction can be caused by primary gonadal failure due to testicular adrenal rest tumours (TART), and by secondary gonadal failure due to poor hormonal control. In females, gonadal dysfunction can result from an overproduction of adrenal androgens including 11-oxygenated C-19 androgens and proge...
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Claahsen-van der Grinten HL, Stikkelbroeck N, Falhammar H, Reisch N Tags: Eur J Endocrinol Source Type: research

Recent evidence sets therapeutic targets for levothyroxine-treated patients with primary hypothyroidism based on risk of death.
s L Abstract Since the introduction of sensitive assays for serum thyroid stimulating hormone (TSH) clinicians have advised hypothyroid patients to adjust the dose of levothyroxine (L-T4) in order to achieve a normal serum TSH. A minority of patients are dissatisfied with this treatment strategy and experience symptoms. Some indirect evidence suggests that a normal serum TSH may not necessarily reflect euthyroidism at tissue level in patients treated with L-T4. Increasingly hypothyroid patients demand higher doses of L-T4 or liothyronine (L-T3) or animal thyroid extract, often purchased online, and titrate the dos...
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Perros P, Nirantharakumar K, Hegedüs L Tags: Eur J Endocrinol Source Type: research

Residual adrenal function in Addison's disease.
Abstract Over the last ten years, evidence has accumulated that autoimmune Addison's disease (AAD) is a heterogeneous disease. Residual adrenal function, characterised by persistent secretion of cortisol, other glucocorticoids and mineralocorticoids is present in around 30% of patients with established AAD, and appears commoner in men. This persistent steroidogenesis is present in some patients with AAD for more than 20 years, but it is commoner in people with shorter disease duration. The clinical significance of residual adrenal function is not fully clear at the moment, but as it signifies an intact adrenocorti...
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Pearce SH, Gan EH, Napier C Tags: Eur J Endocrinol Source Type: research

Multiple testing; when is many too much?
Abstract In almost all medical research, more than a single hypothesis is being tested or more than a single relation is being estimated. Testing multiple hypotheses increases the risk of drawing a false-positive conclusion. We briefly discuss this phenomenon, which is often called multiple testing. Also, methods to mitigate the risk of false-positive conclusions are discussed. PMID: 33300887 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Groenwold RHH, Goeman J, le Cessie S, Dekkers OM Tags: Eur J Endocrinol Source Type: research

Inactivating PTH/PTHrP signaling disorders (iPPSDs): evaluation of the new classification in a multicenter large series of 544 molecularly characterized patients.
CONCLUSIONS: The phenotypic analysis of this large cohort confirmed the utility of the major and minor criteria and their combination to diagnose iPPSD. This report shows the importance of having simple and easily recognizable signs to diagnose with confidence these rare disorders and supports a better management of patients. PMID: 33270042 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Pereda A, Elli FM, Thiele S, de Sanctis L, Rothenbuhler A, Hanna P, Francou B, Ertl DA, Perez de Nanclares G, Linglart A, Mantovani G Tags: Eur J Endocrinol Source Type: research

Metformin use is associated with a lower risk of osteoporosis/vertebral fracture in Taiwanese patients with type 2 diabetes mellitus.
CONCLUSION: Metformin use is associated with a lower risk of OS/VF. PMID: 33270043 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2020 Category: Endocrinology Authors: Tseng CH Tags: Eur J Endocrinol Source Type: research

Safety of GH after treatment for childhood cancer.
PMID: 33136064 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 3, 2020 Category: Endocrinology Authors: van Santen HM Tags: Eur J Endocrinol Source Type: research

Molecular profile of H ürthle cell carcinomas: recurrent mutations in the Wnt/β-catenin pathway.
Conclusions: This series of HCC presents a wide range of mutations in the Wnt/β-catenin, MAPK and PI3K-AKT-mTOR pathways. The recurrent involvement of Wnt/β-catenin pathway, particularly mutations in APC and FAT1, are of particular interest. The data suggest that mutated FAT1 may represent a potential novel driver in HCC tumorigenesis and that the Wnt/β-catenin pathway plays a critical role in this distinct thyroid malignancy. PMID: 33120354 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 31, 2020 Category: Endocrinology Authors: Santana NO, Lerario AM, Schmerling CK, Marui S, Alves VAF, Hoff AO, Kopp P, Danilovic DLS Tags: Eur J Endocrinol Source Type: research

Prediction of hyperaldosteronism subtypes when adrenal vein sampling is unilaterally successful.
Conclusions: Our score could be integrated in clinical practice and guide surgical decision-making in patients with unilateral successful AVS and contralateral suppression. PMID: 33112264 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 30, 2020 Category: Endocrinology Authors: Burrello J, Burrello A, Pieroni J, Sconfienza E, Forestiero V, Amongero M, Rossato D, Veglio F, Williams TA, Monticone S, Mulatero P Tags: Eur J Endocrinol Source Type: research

ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms: the two-faced Janus.
Abstract An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescent assays with high sensitivity and specificity; however, slightly moderately elevated levels could be attributable to various confounding factors. Calcitonin values>100 pg/mL are strongly suspicious of malignancy, whereas in patients with moderately elevated values (10-100 pg/mL) a stimula...
Source: European Journal of Endocrinology - October 30, 2020 Category: Endocrinology Authors: Giannetta E, Guarnotta V, Altieri B, Sciammarella C, Guadagno E, Malandrino P, Puliani G, Feola T, Isidori AM, Colao AAL, Faggiano A Tags: Eur J Endocrinol Source Type: research

Hydrocortisone suspension formulations are not necessarily the same in the treatment of children with congenital adrenal hyperplasia.
PMID: 33105100 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Sarafoglou K, Jaber MM, Al-Kofahi M, Brundage RC Tags: Eur J Endocrinol Source Type: research

Current use of combined hormonal contraception is associated with glucose metabolism disorders in perimenopausal women.
Conclusions: CHC use in perimenopausal women was associated with a significantly increased risk of glucose metabolism disorders. This association should be considered in women with increased metabolic risk. PMID: 33105101 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Mosorin ME, Haverinen A, Ollila MM, Nordström T, Jokelainen J, Keinänen-Kiukaanniemi S, Puukka K, Ruokonen A, Auvinen J, Piltonen T, Morin-Papunen L, Tapanainen JS Tags: Eur J Endocrinol Source Type: research

Genetic alteration of ARMC5 in a patient diagnosed with meningioma and primary macronodular adrenal hyperplasia: a case report.
We describe a case of a 65-year-old female with PBMAH, carrying a heterozygous germline alteration of ARMC5, p.R267*, complicated with meningioma associated with somatic loss of heterozygosity (LOH) of the unaffected allele. Pathogenic alterations of ARMC5 may also contribute to the development of meningioma by the two-hit mechanism. PMID: 33105102 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Jojima T, Kogai T, Iijima T, Kato K, Sagara M, Kezuka A, Kase M, Sakurai S, Akimoto K, Sakumoto J, Namatame T, Ueki K, Hishinuma A, Kamai T, Usui I, Aso Y Tags: Eur J Endocrinol Source Type: research

Response to 'Hydrocortisone suspension formulations are not necessarily the same in the treatment of children with congenital adrenal hyperplasia'.
PMID: 33105103 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Michelet R, Melin J, Parra-Guillen ZP, Neumann U, Whitaker MJ, Stachanow V, Huisinga W, Porter J, Blankenstein O, Ross RJ, Kloft C Tags: Eur J Endocrinol Source Type: research

Genome-wide meta-analysis reveals novel susceptibility loci for thyrotoxic periodic paralysis.
Conclusions: We identified two novel TPP risk loci near TRIM2 and AC140912.1. While rare mutations in TRIM2 and KCNJ2 were implicated in monogenic disorders characterized by muscle paralysis, our study suggested common variants near these genes might dysregulate gene expression and lead to milder phenotypes. PMID: 33105104 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Hoi-Yee Li G, Cheung CL, Zhao SX, Song HD, Wai-Chee Kung A Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Rationale and current evidence for testosterone therapy in the management of obesity and its complications.
Abstract Overt hypogonadism in men adversely affects body composition and metabolic health, which generally improve upon testosterone (TS) therapy. As obese men often display lower serum TS levels, in particular when they present with the metabolic syndrome (MetS) or type 2 diabetes (T2DM), there have been claims that androgen therapy prevents or reverses obesity and improves metabolic health. This has contributed to the increase in TS prescriptions during the past two decades. In this narrative review, based on findings from larger observational studies and randomized controlled intervention trials, we evaluate w...
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Lapauw B, Kaufman JM Tags: Eur J Endocrinol Source Type: research

Clinical and genetic characteristics of Dutch children with central congenital hypothyroidism, early detected by neonatal screening.
Conclusion: Many patients with central CH have neonatal health problems, especially MPHD patients. Despite hospital admission of two-thirds of patients, almost none were diagnosed clinically, but only after the notification of an abnormal screening result was received. This indicates that central CH, especially if isolated, is an easily missed clinical diagnosis. PMID: 33107432 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Naafs JC, Verkerk PH, Fliers E, van Trotsenburg ASP, Zwaveling-Soonawala N Tags: Eur J Endocrinol Source Type: research

Randomised trial of block and replace vs dose titration thionamide in young people with thyrotoxicosis.
Conclusion: This randomised trial has shown no evidence to suggest that BR, when managing the young patient with thyrotoxicosis, is associated with improved biochemical stability when compared to DT. PMID: 33107439 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2020 Category: Endocrinology Authors: Wood CL, Cole M, Donaldson M, Dunger DB, Wood R, Morrison N, Matthews JNS, Pearce SHS, Cheetham TD Tags: Eur J Endocrinol Source Type: research

Metabolic complications in acromegaly after neurosurgery: a meta-analysis.
Abstract Objective: Neurosurgery is the first-line treatment for acromegaly. Whether metabolic disorders are reversible after neurosurgery is still debated. The meta-analysis aimed to address the following questions: (i) Does neurosurgery affect glycolipid metabolism? (ii) Are these effects related to disease control or follow-up length? Design: A meta-analysis and systematic review of the literature. Methods: Three reviewers searched databases until August 2019 for prospective trials reporting glycometabolic outcomes after neurosurgery. Three other extracted outcomes, all assessed the risk of bias. ...
Source: European Journal of Endocrinology - October 21, 2020 Category: Endocrinology Authors: Cozzolino A, Feola T, Simonelli I, Puliani G, Hasenmajer V, Minnetti M, Giannetta E, Gianfrilli D, Pasqualetti P, Lenzi A, Isidori AM Tags: Eur J Endocrinol Source Type: research

Reevaluation of the value of prolactin in differentiating malignant from benign pituitary stalk thickening: Letter to the Editor.
PMID: 33077687 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 21, 2020 Category: Endocrinology Authors: Wang S, Zhou X, Zhu H Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: The role of surgical adrenalectomy in primary aldosteronism.
Abstract Primary aldosteronism is common and contributes to adverse cardiovascular, kidney, and metabolic outcomes. When instituted early and effectively, targeted therapies can mitigate these adverse outcomes. Surgical adrenalectomy is among the most effective treatments because it has the potential to cure, or attenuate the severity of, pathologic aldosterone excess, resulting in a host of biochemical and clinical changes that improve health outcomes. Herein, we review the role of surgical adrenalectomy in primary aldosteronism while emphasizing the physiologic ramifications of surgical intervention, and compare...
Source: European Journal of Endocrinology - October 21, 2020 Category: Endocrinology Authors: Hundemer GL, Vaidya A Tags: Eur J Endocrinol Source Type: research

Pituitary stalk thickening: neoplastic or not? - author's response to the letter by Wang et al.
ter D PMID: 33077689 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 21, 2020 Category: Endocrinology Authors: Devuyst F, Kazakou P, Balériaux D, Alexopoulou O, Burniat A, Salenave S, Chanson P, Corvilain B, Maiter D Tags: Eur J Endocrinol Source Type: research

Rare CNVs provide novel insights into the molecular basis of GH and IGF-1 insensitivity.
Conclusions: Our cohort was enriched for low frequency CNVs. Our study emphasises the importance of CNV testing in GHI and IGF-1 insensitivity patients, particularly GHI subjects with SRS features. Functional experimental evidence is now required to validate the novel candidate growth genes, interactions and biological pathways identified. PMID: 33055295 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2020 Category: Endocrinology Authors: Cottrell E, Cabrera CP, Ishida M, Chatterjee S, Greening J, Wright N, Bossowski A, Dunkel L, Deeb A, Basiri IA, Rose SJ, Mason A, Bint S, Ahn JW, Hwa V, Metherell LA, Moore GE, Storr HL Tags: Eur J Endocrinol Source Type: research

A comparison of 5-year administration of cyproterone acetate or leuprolide acetate in combination with estradiol in transwomen.
Conclusions: Both regimens were effective in suppression of T production. CPA+E worsened the metabolic profile with a slight increase in PRL levels. All subjects presented an increase in BMD regardless of treatment. These preliminary data could have clinical implications in the choice of GAHT, in particular for those TW not requiring gender-affirming surgery. PMID: 33055297 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2020 Category: Endocrinology Authors: Gava G, Mancini I, Alvisi S, Seracchioli R, Meriggiola MC Tags: Eur J Endocrinol Source Type: research

Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism.
Conclusions: The concordance of 11C-MTO-PET with AVS was clinically suboptimal, and did not outperform adrenal CT. In a subgroup with CYP11B2-positive adenoma, 11C-MTO-PET identified 53% of cases. 11C-MTO-PET appeared to be inferior to AVS for subtype classification of PA. PMID: 33055298 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2020 Category: Endocrinology Authors: Soinio M, Luukkonen AK, Seppänen M, Kemppainen J, Seppänen J, Pienimäki JP, Leijon H, Vesterinen T, Arola J, Lantto E, Helin S, Tikkanen I, Metso S, Mirtti T, Heiskanen I, Norvio L, Tiikkainen M, Tikkanen T, Sane T, Välimäki M, Gomez-Sanchez CE, Pör Tags: Eur J Endocrinol Source Type: research

Evaluation of an individualized education program in pituitary diseases: a pilot study.
Conclusion: Individualizing the educational objectives of patients with pituitary disease improves the way they live with their disease. If confirmed in other cohorts, this approach could become the gold standard for education programs in rare endocrine diseases. PMID: 33055299 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2020 Category: Endocrinology Authors: Albarel F, Pellegrini I, Rahabi H, Baccou C, Gonin L, Rochette C, Vermalle M, Cuny T, Castinetti F, Brue T Tags: Eur J Endocrinol Source Type: research

Study design: what's in a name?
Abstract The name of the study should properly reflect the actual conduct and analysis of the study. This short paper provides guidance on how to properly name the study design. The first distinction is between a trial (intervention given to patients to study its effect) and an observational study. For observational studies, it should further be decided whether it is cross-sectional or whether follow-up time is taken into account (cohort or case-control study). The distinction prospective-retrospective has two disadvantages: prospective is often seen as marker of higher quality, which is not necessarily true; ther...
Source: European Journal of Endocrinology - October 20, 2020 Category: Endocrinology Authors: Dekkers OM, Groenwold RHH Tags: Eur J Endocrinol Source Type: research

Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease.
Conclusions: Our data highlight a potential relevance of autoimmunity against NIS for thyroid disease, whereas an assessment of PDS-aAb in thyroid patients seems not to be of diagnostic value (yet). PMID: 33055303 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2020 Category: Endocrinology Authors: Eleftheriadou AM, Mehl S, Renko K, Kasim RH, Schaefer JA, Minich WB, Schomburg L Tags: Eur J Endocrinol Source Type: research

Prevalence and progression of aortic dilatation in adult patients with Turner syndrome: a cohort study.
Abstract Objective: Turner syndrome (TS) is a rare disorder affecting 1/2500 female newborn. Aortic dilatation (AD) and aortic dissection represent a major concern in TS. The aims of our study were to describe the aortic root growth, potential aortic dilatation (AD) risk factors and cardiovascular outcomes in a cohort of patients with TS. Methods: Among 204 adult patients included, 197 were studied using a standardized 1.5 Tesla MRI protocol. AD was defined as an aortic diameter ≥20 mm/m2 at the Valsalva sinuses and/or at the ascending aorta, when indexed to body surface area. Results: At baseline, AD...
Source: European Journal of Endocrinology - August 23, 2020 Category: Endocrinology Authors: Donadille B, Tuffet S, Cholet C, Nedelcu M, Bourcigaux N, Iserin L, Monnier-Cholley L, Rousseau A, Christin-Maitre S Tags: Eur J Endocrinol Source Type: research

High prevalence of smoking in patients with adrenal incidentalomas: causality or case selection?
n O Abstract Objective: Autonomous cortisol secretion and possible autonomous cortisol secretion (ACS/pACS) are associated to an increase of cardiovascular risk factors such as hypertension, diabetes mellitus and dyslipidaemia. To our knowledge, the prevalence of smoking, another well-established risk factor for cardiovascular disease, has not been studied in detail in people with ACS/pACS or adrenal incidentalomas. Methods: Patients with adrenal incidentalomas were examined with the 1-mg overnight dexamethasone suppression test (cortisolONDST). Information about current smoking was collected from the patient...
Source: European Journal of Endocrinology - July 29, 2020 Category: Endocrinology Authors: Olsen H, Kjellbom A, Löndahl M, Lindgren O Tags: Eur J Endocrinol Source Type: research

Contralateral adrenal thinning as a distinctive feature of mild autonomous cortisol excess of the adrenal tumors.
Abstract Objective: To identify radiologic features that correlate with mild autonomous cortisol excess using planar and volumetric analysis. Design: Cross-sectional study. Methods: In the study, 64 patients with overt Cushing syndrome (CS), 59 patients with mild autonomous cortisol excess (MACE), and 64 patients with nonfunctioning adrenal tumors (NFAT) with evaluable CT scans were included. Patients with NFAT and MACE were BMI-matched with those with overt CS. Planar and volumetric analyses of CT scans were performed in DICOM images using OsiriX software. Results: The mean age was 56.6 ± 1....
Source: European Journal of Endocrinology - July 29, 2020 Category: Endocrinology Authors: Kong SH, Kim JH, Shin CS Tags: Eur J Endocrinol Source Type: research

Patients with chronic autoimmune thyroiditis are not at higher risk for developing clinically overt thyroid cancer: a 10-year follow-up study.
Abstract Objective: The association between chronic autoimmune thyroiditis (CAT) and differentiated thyroid cancer (DTC) remains controversial. The incidence of DTC increases when screening procedures are implemented, as typically occurs in CAT patients being routinely submitted to thyroid ultrasound (US). The aim of this study was to longitudinally evaluate the long-term development of DTC in patients with CAT. Design and methods: A retrospective longitudinal cohort study was designed. For the study, 510 patients with chronic autoimmune thyroiditis (CAT) with a 10-year follow-up were enrolled. Patients were ...
Source: European Journal of Endocrinology - July 29, 2020 Category: Endocrinology Authors: Rotondi M, Groppelli G, Croce L, Latrofa F, Ancona G, Coperchini F, Pasquali D, Cappelli C, Fugazza A, Guazzoni V, Radetti G, Chiovato L Tags: Eur J Endocrinol Source Type: research

Who is afraid of non-normal data? Choosing between parametric and non-parametric tests: a response.
PMID: 32621583 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 6, 2020 Category: Endocrinology Authors: Hoermann R, Midgley JEM, Larisch R, Dietrich JW Tags: Eur J Endocrinol Source Type: research

Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation.
Abstract Objective: Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk of adrenal crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention of AC and improvement of AI management. A standardized education programme was elaborated for patients with chronic AI in Germany. Design: Longitudinal, prospective, questionnaire-based, multi-centre study. Methods: During 2-h sessions, patients (n = 526) were provided with basic knowledge on AI, equipped with emergency cards and sets and trained in self-injection ...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Burger-Stritt S, Eff A, Quinkler M, Kienitz T, Stamm B, Willenberg HS, Meyer G, Klein J, Reisch N, Droste M, Hahner S Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE Subclinical hypothyroidism in children.
Abstract Subclinical hypothyroidism (SH) is biochemically defined as serum TSH levels above the upper limit of the reference range in the presence of normal free T4 (FT4) concentrations. While there is a general agreement to treat subjects with serum TSH levels above 10 mU/L, the management of mild form (TSH concentrations between 4.5 and 10 mU/L) is still a matter of debate. In children, mild SH is often a benign and remitting condition and the risk of progression to overt thyroid dysfunction depends on the underlying condition, being higher in the autoimmune forms. The major concern is to establish whether SH in...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Salerno M, Improda N, Capalbo D Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY Pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus.
Abstract For an endocrinologist, nephrogenic diabetes insipidus (NDI) is an end-organ disease, that is the antidiuretic hormone, arginine-vasopressin (AVP) is normally produced but not recognized by the kidney with an inability to concentrate urine despite elevated plasma concentrations of AVP. Polyuria with hyposthenuria and polydipsia are the cardinal clinical manifestations of the disease. For a geneticist, hereditary NDI is a rare disease with a prevalence of five per million males secondary to loss of function of the vasopressin V2 receptor, an X-linked gene, or loss of function of the water channel AQP2. The...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Bichet DG Tags: Eur J Endocrinol Source Type: research

Postoperative parathyroid hormone levels as a predictor for persistent hypoparathyroidism.
Conclusion: In our study a decrease in PTH levels of>70% after total or completion thyroidectomy is a reliable predictor for persistent hypoparathyroidism, and this should be confirmed in larger cohorts. PMID: 32580147 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Lončar I, Dulfer RR, Massolt ET, Timman R, de Rijke YB, Franssen GJH, Burger PJWA, Smit C, van der Horst FAL, Peeters RP, van Eijck CHJ, van Ginhoven TM Tags: Eur J Endocrinol Source Type: research

Efficacy and safety of dopamine agonists in patients treated with antipsychotics and presenting a macroprolactinoma.
Conclusions: Even if the DA efficacy on PRL levels and tumor volume in patients with macroprolactinoma under antipsychotic drugs is less impressive than that typically observed, it may be considered satisfactory for half of our patients, particularly in cases of optic chiasm compression. Psychotic exacerbation was unusual in these patients, occurring mostly in those with the most severe psychotic forms. DAs may therefore be used as antitumor treatment for macroprolactinoma in patients with visual involvement, severe headaches or invasion into the skull base who receive antipsychotics. PMID: 32583656 [PubMed - in proce...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Allard L, Albarel F, Bertherat J, Caron PJ, Cortet C, Courtillot C, Delemer B, Jublanc C, Maiter D, Nunes ML, Raverot G, Sarfati J, Salenave S, Corruble E, Choucha W, Chanson P Tags: Eur J Endocrinol Source Type: research

Central diabetes insipidus and pituitary stalk thickening in adults: distinction of neoplastic from non-neoplastic lesions.
CONCLUSION: We confirm a relatively high risk of malignancy in adult patients presenting with the association of CDI and PST. Young age, male gender, a very large thickening of the stalk, multiple anterior pituitary deficits and prolactin above 1.3× ULN increase the likelihood of a neoplastic origin. PMID: 32530258 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 13, 2020 Category: Endocrinology Authors: Devuyst F, Kazakou P, Balériaux D, Alexopoulou O, Burniat A, Salenave S, Chanson P, Corvilain B, Maiter D Tags: Eur J Endocrinol Source Type: research

Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women: a randomized controlled trial.
Abstract Objective: We investigated the effects of a 12-week exercise intervention on insulin sensitivity (SI) and hyperinsulinemia and associated changes in regional and ectopic fat. Research design and methods: Healthy, black South African women with obesity (mean age 23 ± 3.5 years) and of isiXhosa ancestry were randomised into a 12-week aerobic and resistance exercise training group (n = 23) and a no exercise group (control, n = 22). Pre and post-intervention testing included assessment of SI, insulin response to glucose (AIRg), insulin secretion rate (ISR), hepatic insulin extraction (FEL) and dis...
Source: European Journal of Endocrinology - June 6, 2020 Category: Endocrinology Authors: Fortuin-de Smidt MC, Mendham AE, Hauksson J, Hakim O, Stefanovski D, Clamp L, Phiri L, Swart J, Goff LM, Micklesfield LK, Kahn SE, Olsson T, Goedecke JH Tags: Eur J Endocrinol Source Type: research

Psychological well-being and personality in relation to weight loss following behavioral modification intervention in obese women with polycystic ovary syndrome: a randomized controlled trial.
Conclusions: Psychological well-being is severely impacted in overweight women with PCOS. Behavioral modification can positively impact dimensions of well-being, although not fully significant, compared to control treatment. Personality factors could contribute to the understanding of successful weight loss. PMID: 32503005 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 6, 2020 Category: Endocrinology Authors: Oberg E, Lundell C, Blomberg L, Gidlöf SB, Egnell PT, Hirschberg AL Tags: Eur J Endocrinol Source Type: research

Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.
Abstract Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD. Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers. Results: Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto's thyroiditis was found in 20.3%, Graves' disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas ...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Fichna M, Małecki PP, Młodzikowska M, Gębarski B, Ruchała M, Fichna P Tags: Eur J Endocrinol Source Type: research

Acromegaly: 'You must know it to think of it'.
Abstract Acromegaly is a debilitating and disfiguring chronic disease, which occurs in both sexes at any age, associated with multiple comorbidities and increased mortality. It is typically caused by a GH-secreting pituitary adenoma that promotes exposure of body tissues to increased concentrations of GH and IGF-I. The diagnosis of acromegaly is still made very late in a substantial number of patients when the disease is already in advanced stages. An epidemiological study from Sweden has elegantly demonstrated that the longer the diagnostic delay in acromegaly, the higher the number of comorbidities. Moreover, ab...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Boguszewski CL Tags: Eur J Endocrinol Source Type: research

Detailed characterization of metastatic lymph nodes improves the prediction accuracy of currently used risk stratification systems in N1 stage papillary thyroid cancer.
Conclusions: The combination of currently used risk stratification systems with detailed characterization of MLNs may improve the predictive accuracy for recurrence/progression in N1 PTC patients. PMID: 32487777 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Lee J, Kim CH, Min IK, Jeong S, Kim H, Choi MJ, Kwon HJ, Jung SG, Jo YS Tags: Eur J Endocrinol Source Type: research

Androgen excess and diagnostic steroid biomarkers for nonclassic 21-hydroxylase deficiency without cosyntropin stimulation.
Abstract Objectives: The clinical presentation of patients with nonclassic 21-hydroxylase deficiency (N21OHD) is similar with that for other disorders of androgen excess. The diagnosis of N21OHD typically requires cosyntropin stimulation. Additionally, the management of such patients is limited by the lack of reliable biomarkers of androgen excess. Herein, we aimed to: (1.) compare the relative contribution of traditional and 11-oxyandrogens in N21OHD patients and (2.) identify steroids that accurately diagnose N21OHD with a single baseline blood draw. Design: We prospectively enrolled patients who underwent ...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Turcu AF, El-Maouche D, Zhao L, Nanba AT, Gaynor A, Veeraraghavan P, Auchus RJ, Merke DP Tags: Eur J Endocrinol Source Type: research

T2-signal intensity, SSTR expression, and somatostatin analogs efficacy predict response to pasireotide in acromegaly.
Conclusions: Patients unresponsive to SRLs with a lower SST2 receptor expression are more prone to achieve tumor shrinkage during PAS-LAR. Surprisingly, tumor shrinkage is not accompanied by a biochemical response, which is accompanied with a higher T2-signal intensity. PMID: 32375119 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 7, 2020 Category: Endocrinology Authors: Coopmans EC, Schneiders JJ, El-Sayed N, Erler NS, Hofland LJ, van der Lely AJ, Petrossians P, Potorac J, Muhammad A, Neggers SJCMM Tags: Eur J Endocrinol Source Type: research

Growth hormone retesting during puberty: a cohort study.
Conclusions: GH secretion should be retested at mid-puberty. Retesting at puberty may reduce potential side effects and minimize costs, without impairing growth potential and final height. PMID: 32337961 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 28, 2020 Category: Endocrinology Authors: Cavarzere P, Gaudino R, Sandri M, Ramaroli DA, Pietrobelli A, Zaffanello M, Guzzo A, Salvagno GL, Piacentini G, Antoniazzi F Tags: Eur J Endocrinol Source Type: research