European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Abstract Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best pr...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Bone marrow adiposity and bone, a bad romance?
Abstract Bone marrow adipocytes (BMA-) constitute an original and heterogeneous fat depot whose development appears interlinked with bone status throughout life. The gradual replacement of the haematopoietic tissue by BMA arises in a well-ordered way during childhood and adolescence concomitantly to bone growth and continues at a slower rate throughout the adult life. Importantly, BM adiposity quantity is found well associated with bone mineral density (BMD) loss at different skeletal sites in primary osteoporosis such as in ageing or menopause but also in secondary osteoporosis consecutive to anorexia nervosa. Si...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Rharass T, Lucas S Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 ‘DSDnet’
GENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 ‘DSDnet’ Eur J Endocrinol. 2018 Oct 01;179(4):R197-R206 Authors: Audi L, Ahmed SF, Krone N, Cools M, McElreavey K, McElreavey PM, Greenfield A, Bashamboo A, Hiort O, Wudy SA, McGowan R Abstract The differential diagnosis of differences or disorders of sex development (DSD) belongs to the most complex fields in medicine. It requires a multidisciplinary team conducting a synoptic and complementary approach consistin...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Audi L, Ahmed SF, Krone N, Cools M, McElreavey K, McElreavey PM, Greenfield A, Bashamboo A, Hiort O, Wudy SA, McGowan R Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia
Abstract Glucocorticoids are frequently prescribed to patients with a wide range of inflammatory and autoimmune diseases. The semi-synthetic glucocorticoid prednisolone is most commonly prescribed and in two main patterns. Prednisolone is prescribed short term at medium-high doses to treat an acute inflammatory illness or long term at lower doses to attenuate chronic inflammatory disease progression. In hospitalized patients with acute prednisolone-induced hyperglycaemia, there is a distinct circadian pattern of glucose elevation, which occurs predominantly in the afternoon and evening. As a morning dose of isopha...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Radhakutty A, Burt MG Tags: Eur J Endocrinol Source Type: research

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms
Conclusions: The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs. PMID: 30299890 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Grolmusz VK, Kövesdi A, Borks K, Igaz P, Patócs A Tags: Eur J Endocrinol Source Type: research

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement
Abstract Background: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumors in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). Methods: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987 and 2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% CIs ...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Hammarstrand C, Ragnarsson O, Bengtsson O, Bryngelsson IL, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults
Abstract Objectives: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65–88y, n = 173) and in ...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Elstgeest LEM, de Koning EJ, Brouwer IA, van Schoor NM, Penninx BWJH, Visser M Tags: Eur J Endocrinol Source Type: research

Preserved insulin secretion and kidney function in recipients with functional pancreas grafts 1 year after transplantation: a single-center prospective observational study
This study addresses glucometabolic parameters and kidney function during the first year. Methods: We examined 67 patients with functioning grafts (SPK n = 30, PTA n = 37) transplanted between September 2011 and November 2016 who underwent repeated oral glucose tolerance tests (OGTTs) 8 and 52 weeks after transplantation. Another 19 patients lost their graft the first year post-transplant and 28 patients did not undergo repeated OGTTs and could not be studied. All patients received ATG induction therapy plus tacrolimus, mycophenolate and prednisolone. Glomerular filtration rate was measured...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Nordheim E, Birkeland KI, Åsberg A, Hartmann A, Horneland R, Jenssen T Tags: Eur J Endocrinol Source Type: research

Radiation exposure of adrenal vein sampling: a German Multicenter Study
Conclusions: This first systematic assessment of radiation exposure in AVS not only shows fairly high values for patients, but also states notable differences among the centers. Thus, we not only recommend taking into account the risk of radiation exposure, when referring patients to undergo AVS, but also to establish improved standard operating procedures to prevent unnecessary radiation exposure. PMID: 30299899 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Fuss CT, Treitl M, Rayes N, Podrabsky P, Fenske WK, Heinrich DA, Reincke M, Petersen TO, Fassnach M, Quinkler M, Kickuth R, Hahner S Tags: Eur J Endocrinol Source Type: research

Is receptor profiling useful for predicting pituitary therapy?
IS RECEPTOR PROFILING USEFUL FOR PREDICTING PITUITARY THERAPY? Eur J Endocrinol. 2018 Aug 23;: Authors: Marazuela M, Ramos-Leví AM, Borges de Souza P, Zatelli MC Abstract Medical treatment of pituitary tumours may present important challenges in the presence of resistance to first line therapy. In this setting, the availability of specific markers of responsiveness/resistance could be helpful to provide tailored patients' treatment. Pituitary receptor profiling has emerged as a potentially useful tool for predicting the response to specific pituitary-directed medical therapy, mainly somatostati...
Source: European Journal of Endocrinology - August 23, 2018 Category: Endocrinology Authors: Marazuela M, Ramos-Leví AM, Borges de Souza P, Zatelli MC Tags: Eur J Endocrinol Source Type: research

Long-term Effects of Growth Hormone Replacement Therapy in Childhood-onset Craniopharyngioma: Results of the German Craniopharyngioma Registry (HIT-Endo).
CONCLUSIONS: We conclude that GH substitution was safe with regard to risk of tumor progression/relapse in CP. Growth was improved by GH, whereas the development of obesity was not influenced by GH substitution. However, early initiation of GH substitution after CP diagnosis might have beneficial effects on weight development and neuropsychological outcome. PMID: 30139824 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 23, 2018 Category: Endocrinology Authors: Boekhoff S, Bogusz A, Sterkenburg AS, Eveslage M, Müller HL Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Therapeutics of Vitamin D.
Conclusions The effects of long-term vitamin D supplementation on non-skeletal outcomes, such as type 2 diabetes mellitus (T2DM), cancer and cardiovascular disease (CVD), and the optimal dose and serum 25OHD level that balances extra-skeletal benefits (T2DM) vs. risks (e.g., CVD), may soon be determined by data from large RCTs. PMID: 30131372 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 21, 2018 Category: Endocrinology Authors: Ebeling P, Adler R, Jones G, Liberman UA, Mazziotti G, Minisola S, Munns C, Napoli N, Pittas A, Giustina A, Bilezikian JP, Rizzoli R Tags: Eur J Endocrinol Source Type: research

Active cushing syndrome patients have increased ectopic fat deposition and bone marrow fat content compared to cured patients and healthy subjects: a pilot 1H-MRS study.
CONCLUSIONS: Accumulation of BMF is induced by hypercortisolism. In remission patients BMF reached values of controls. Further studies are needed to determine whether this increase in marrow adiposity in CS is associated with bone loss. PMID: 30108093 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 14, 2018 Category: Endocrinology Authors: Maurice F, Dutour A, Vincentelli C, Abdesselam I, Bernard M, Dufour H, Le Fur Y, Graillon T, Kober F, Cristofari P, Jouve E, Pini L, Fernandez R, Chagnaud C, Brue T, Castinetti F, Gaborit B Tags: Eur J Endocrinol Source Type: research

Reduced Slow-Wave Sleep and Altered Diurnal Cortisol Rhythms in Patients with Addison's Disease.
CONCLUSION: Overall, these results suggest that patients with AD demonstrate different patterns of night-time cortisol concentrations to healthy controls, and that relatively elevated concentrations are associated with a reduction of SWS. These hormonal and sleep architectural aberrations may disrupt the routine sleep-dependent processes of memory consolidation, and hence may explain, at least partially, the memory impairments often experienced by patients with AD. PMID: 30108094 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 14, 2018 Category: Endocrinology Authors: Henry M, Ross IL, Thomas KGF Tags: Eur J Endocrinol Source Type: research

Outcomes of pubertal development in girls as a function of pubertal onset age.
OUTCOMES OF PUBERTAL DEVELOPMENT IN GIRLS AS A FUNCTION OF PUBERTAL ONSET AGE. Eur J Endocrinol. 2018 Aug 07;: Authors: German A, Shmoish M, Belsky J, Hochberg Z Abstract BACKGROUND: The relationship between pubertal onset and tempo and pubertal growth is controversial. We hypothesized that the age at onset of girls' puberty predicts pubertal tempo and the rate of pubertal progression. METHODS: We analysed the data of 380 girls from the prospective Study of Early Child Care and Youth Development (SECCYD), who were recruited in the USA from 1991-2006 and followed from birth to age 15.5 years. We u...
Source: European Journal of Endocrinology - August 7, 2018 Category: Endocrinology Authors: German A, Shmoish M, Belsky J, Hochberg Z Tags: Eur J Endocrinol Source Type: research

Enzyme autoinduction by mitotane supported by population pharmacokinetic modelling in a large cohort of adrenocortical carcinoma patients.
CONCLUSION: The proposed model describes mitotane pharmacokinetics and can be used to facilitate therapy by predicting plasma concentrations. PMID: 30087117 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 7, 2018 Category: Endocrinology Authors: Arshad U, Taubert M, Kurlbaum M, Frechen S, Herterich S, Megerle F, Hamacher S, Fassnacht M, Fuhr U, Kroiss M Tags: Eur J Endocrinol Source Type: research

Efficacy and Safety of switching to Pasireotide in Acromegaly Patients controlled with Pegvisomant and Somatostatin Analogues: PAPE extension study.
Abstract OBJECTIVE: to assess the efficacy and safety after 48 weeks of treatment with pasireotide long-acting-release (PAS-LAR) alone or in combination with pegvisomant in patients with acromegaly. In addition, we assessed the relation between insulin secretion and pasireotide-induced hyperglycemia. DESIGN: The PAPE extension study is a prospective follow-up study until 48 weeks after the core study of 24 weeks. METHODS: 59 out of 61 patients entered the extension study. Efficacy was defined as the percentage of patients achieving IGF-I normalization (≤ 1.2 x the Upper Limit of Normal (ULN)) at 48-we...
Source: European Journal of Endocrinology - August 3, 2018 Category: Endocrinology Authors: Muhammad A, Coopmans EC, Delhanty P, Dallenga AHG, Haitsma IK, Janssen JAMJL, Van der Lely AJ, Neggers SJCMM Tags: Eur J Endocrinol Source Type: research

Radiation Exposure of Adrenal Vein Sampling - a German Multicenter Study.
CONCLUSION: This first systematic assessment of radiation exposure in AVS not only shows fairly high values for patients, but also states notable differences amongst the centers. Thus, we not only recommend taking into account the risk of radiation exposure, when referring patients to undergo AVS, but also to establish improved standard operating procedures to prevent unnecessary radiation exposure. PMID: 30068731 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 1, 2018 Category: Endocrinology Authors: Fuss CT, Treitl M, Rayes N, Podrabsky P, Fenske WK, Heinrich DA, Reincke M, Petersen TO, Fassnacht M, Quinkler M, Kickuth R, Hahner S Tags: Eur J Endocrinol Source Type: research

Preserved insulin secretion and kidney function in recipients with functional pancreas grafts one year after transplantation.
This study addresses glucometabolic parameters and kidney function during the first year. Methods We examined 67 patients with functioning grafts (SPK n=30, PTA n=37) transplanted between September 2011 and November 2016 who underwent repeated oral glucose tolerance tests (OGTTs) 8 and 52 weeks after transplantation. Another 19 patients lost their graft the first year post-transplant and 28 patients did not undergo repeated OGTTs and could not be studied. All patients received ATG induction therapy plus tacrolimus, mycophenolate and prednisolone. Glomerular filtration rate was measured before and 8 and 52 weeks after trans...
Source: European Journal of Endocrinology - July 30, 2018 Category: Endocrinology Authors: Nordheim E, Birkeland KI, Åsberg A, Hartmann A, Horneland R, Jenssen T Tags: Eur J Endocrinol Source Type: research

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults.
CONCLUSIONS: Our study suggests that over 6 years an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality. PMID: 30054306 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 27, 2018 Category: Endocrinology Authors: Elstgeest LEM, de Koning EJ, Brouwer IA, van Schoor NM, Penninx BWJH, Visser M Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Approach to the management of children and adolescents with Gender Dysphoria.
Abstract Over the past 20 years, the care for transgender adolescents has developed throughout many countries following the "Dutch Approach" initiated in the 90's in pioneer countries as the Netherlands, United States and Canada, with increasing numbers of children and adolescents seeking care in transgender clinics. This medical approach has considerable positive impacts on the psychological outcomes of these adolescents and several studies have been recently published underlining the relative safety of such treatments. This paper reviews the current standards of care for transgender children and adoles...
Source: European Journal of Endocrinology - July 26, 2018 Category: Endocrinology Authors: Martinerie L, Condat A, Bargiacchi A, Bremont-Weill C, de Vries MC, Hannema SE Tags: Eur J Endocrinol Source Type: research

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement.
Abstract BACKGROUND: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumours in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). METHOD: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987-2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% confiden...
Source: European Journal of Endocrinology - July 26, 2018 Category: Endocrinology Authors: Hammarstrand C, Ragnarsson O, Bengtsson O, Bryngelsson IL, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Abstract Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best pr...
Source: European Journal of Endocrinology - July 24, 2018 Category: Endocrinology Authors: Fassnacht M, Dekkers O, Else T, Baudin E, Berruti A, de Krijger RR, Haak HR, Mihai R, Assie G, Terzolo M Tags: Eur J Endocrinol Source Type: research

Bilateral adrenal hyperplasia and NR3C1 mutations causing glucocorticoid resistance: Is there an association?
Abstract Glucocorticoids signal through their cognate, ubiquitously expressed glucocorticoid receptor (GR), which influences the transcription of a large number of target genes. Several genetic defects, including point mutations, deletions or insertions in the NR3C1 gene that encodes the GR, have been associated with familial or sporadic generalized glucocorticoid resistance or Chrousos syndrome. One of the clinical manifestations of this rare endocrine condition is bilateral adrenal hyperplasia due to compensatory elevations of plasma ACTH concentrations. In this commentary, we discuss the interesting findings of...
Source: European Journal of Endocrinology - July 13, 2018 Category: Endocrinology Authors: Nicolaides N, Chrousos G Tags: Eur J Endocrinol Source Type: research

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms.
Conclusions The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs. PMID: 30006373 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 13, 2018 Category: Endocrinology Authors: Grolmusz VK, Kövesdi A, Borka K, Igaz P, Patocs A Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia.
Abstract Glucocorticoids are frequently prescribed to patients with a wide range of inflammatory and autoimmune diseases. The semi-synthetic glucocorticoid prednisolone is most commonly prescribed and in two main patterns. Prednisolone is prescribed short-term at medium-high doses to treat an acute inflammatory illness or long-term at lower doses to attenuate chronic inflammatory disease progression. In hospitalized patients with acute prednisolone-induced hyperglycaemia there is a distinct circadian pattern of glucose elevation, which occurs predominantly in the afternoon and evening. As a morning dose of isophan...
Source: European Journal of Endocrinology - July 10, 2018 Category: Endocrinology Authors: Radhakutty A, Burt MG Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Bone Marrow Adiposity and bone, a bad romance?
Abstract Bone marrow adipocytes (BMA) constitute an original and heterogeneous fat depot whose development appears interlinked with bone status throughout life. The gradual replacement of the hematopoietic tissue by BMA arises in a well-ordered way during childhood and adolescence concomitantly to bone growth and continues at a slower rate throughout the adult life. Importantly, BM adiposity quantity is found well associated with BMD (Bone Mineral Density) loss at different skeletal sites in primary osteoporosis such as in ageing or menopause but also in secondary osteoporosis consecutive to anorexia nervosa. Sinc...
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Rharass T, Lucas S Tags: Eur J Endocrinol Source Type: research

Long-acting FC-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults.
CONCLUSIONS: GX-H9 has the potential for up to twice-monthly administration. PMID: 29973375 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Ku CR, Brue T, Schilbach K, Ignatenko S, Magony S, Chung YS, Kim BJ, Hur KY, Kang HC, Kim JH, Kim MS, Kowalska A, Bolanowski M, Ruchala M, Damjanovic S, Payer J, Choi YJ, Heo SJ, Kim TK, Heo M, Lee J, Lee EJ Tags: Eur J Endocrinol Source Type: research

Should 45,X/46,XY boys with no or mild anomaly of external genitalia be investigated and followed-up?
CONCLUSION: This study emphasizes the need to identify and follow-up 45,X/46,XY patients born with normal male phenotype until adulthood, as they present similar prognosis than those born with severe genital anomalies. Currently, most patients are diagnosed in adulthood with azoospermia, consistent with our observations of decreased testicular function at the end of puberty. Early management of these patients may lead to fertility preservation strategies. PMID: 29973376 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Dumeige L, Chatelais L, Bouvattier C, De Kerdanet M, Capucine H, Esteva B, Samara-Boustani D, Zénaty D, Nicolino M, Baron S, Metz C, Catherine NS, Dupuis C, Leger J, Siffroi JP, Donadille B, Christin-Maitre S, Carel JC, Coutant R, Martinerie L Tags: Eur J Endocrinol Source Type: research

MRI texture analysis as a predictor of tumor recurrence or progression in patients with clinically non-functioning pituitary adenomas.
CONCLUSIONS: Our data suggest that MRI texture analysis can predict the risk of tumor recurrence or progression in patients with NFPAs. PMID: 29973377 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Galm BP, Martinez-Salazar EL, Swearingen B, Torriani M, Klibanski A, Bredella MA, Tritos N Tags: Eur J Endocrinol Source Type: research

Mechanisms in endocrinology: endocrinology of opioids.
MECHANISMS IN ENDOCRINOLOGY: ENDOCRINOLOGY OF OPIOIDS. Eur J Endocrinol. 2018 Jul 04;: Authors: Fountas A, Chai ST, Kourkouti C, Karavitaki N Abstract The use of opioids has grown substantially over the past two decades reaching the dimensions of a global epidemic. These drugs have effects on multiple levels of the endocrine system through mechanisms which are still not fully elucidated, and awareness of their endocrine sequelae is vital for all specialists prescribing or managing patients on them. Hypogonadism is the most well recognised consequence of opioid use (prevalence 21-86%) which, however, m...
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Fountas A, Chai ST, Kourkouti C, Karavitaki N Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 "DSDnet".
GENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 "DSDnet". Eur J Endocrinol. 2018 Jul 04;: Authors: Audí L, Ahmed SF, Krone N, Cools M, McElreavey K, Holterhus PM, Greenfield A, Bashamboo A, Hiort O, Wudy SA, McGowan R Abstract The differential diagnosis of differences or disorders of sex development (DSD) belongs to the most complex fields in medicine. It requires a multidisciplinary team conducting a synoptic and complementary approach consisting of thoro...
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Audí L, Ahmed SF, Krone N, Cools M, McElreavey K, Holterhus PM, Greenfield A, Bashamboo A, Hiort O, Wudy SA, McGowan R Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis; mutant mice challenging old paradigms.
In conclusion, our findings challenge two dogmas of the hormonal regulation of male fertility: (1) high ITT concentration is not necessary for spermatogenesis, and (2) strong FSH stimulation can maintain spermatogenesis without T. These findings have clinical relevance for the development of hormonal male contraception and for the treatment of idiopathic oligozoospermia. PMID: 29959220 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 29, 2018 Category: Endocrinology Authors: Huhtaniemi I Tags: Eur J Endocrinol Source Type: research

Gender disparities in screening for congenital hypothyroidism using thyroxine as a primary screen.
CONCLUSIONS: Natural differences in thyroid hormone levels in male and female infants leads to male infants being disproportionately represented in the false positive category. PMID: 29945892 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 26, 2018 Category: Endocrinology Authors: DeMartino L, McMahon R, Caggana M, Tavakoli NP Tags: Eur J Endocrinol Source Type: research

Diagnosis and follow-up of type 2 diabetes in women with PCOS. A role of OGTT?
Abstract Polycystic ovary syndrome (PCOS) is common in premenopausal women. The majority of women with PCOS have insulin resistance and the risk of type 2 diabetes mellitus (T2D) is higher in women with PCOS compared to controls. In non-pregnant women with PCOS, glycemic status may be assessed by oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), or HbA1c. OGTT has been reckoned gold standard test for diagnosing T2D, but OGTT is rarely used for diagnostic purpose in other non-pregnant individuals at risk of T2D, apart from PCOS. OGTT has questionable reproducibility, and the high sensitivity of the ...
Source: European Journal of Endocrinology - June 19, 2018 Category: Endocrinology Authors: Andersen MS, Glintborg D Tags: Eur J Endocrinol Source Type: research

DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment.
CONCLUSION: Promoter hypermethylation is a frequent event in MEN1-related and sporadic PanNETs. Targeting DNA methylation could be of therapeutic value in MEN1 patients with advanced PanNETs. PMID: 29903750 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 14, 2018 Category: Endocrinology Authors: Conemans EB, Lodewijk L, Moelans CM, Offerhaus GJA, Pieterman CRC, Morsink FH, Dekkers OM, de Herder WW, Hermus AR, van der Horst-Schrivers ANA, Drent ML, Bisschop PH, Havekes B, Brosens LAA, Dreijerink KMA, Borel Rinkes IHM, Timmers HTM, Valk GD, Vriens Tags: Eur J Endocrinol Source Type: research

Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines.
CONCLUSIONS: According to the 2015 ATA guidelines, most of metastatic patients wouldn't have been treated after surgery, with the risk of late diagnosis and delayed treatment. PMID: 29899030 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 13, 2018 Category: Endocrinology Authors: Albano D, Bertagna F, Bonacina M, Durmo R, Cerudelli E, Gazzilli M, Panarotto MB, Formenti AM, Mazziotti G, Giustina A, Giubbini R Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Hypophysitis - diagnosis and treatment.
We describe the presenting features, investigation and diagnostic approach of the patient with likely hypophysitis, including existing conventional techniques and those in the research/development arena. Hypophysitis usually results in acute and persistent pituitary hormone deficiency requiring long-term replacement. Management of hypophysitis includes control of the inflammatory pituitary mass using a variety of treatment strategies including surgery and medical therapy. Glucocorticoids remain the mainstay of medical treatment but other immunosuppressive agents (e.g. azathioprine, rituximab) show benefit in some cases but...
Source: European Journal of Endocrinology - June 7, 2018 Category: Endocrinology Authors: Joshi MN, Whitelaw B, Carroll PV Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY: Genetic diagnosis of endocrine diseases by NGS: novel scenarios and unpredictable risks.
Abstract The technological advancements in genetics produced a profound impact on the research and diagnostics of non-communicable diseases. The availability of Next Generation Sequencing (NGS) allowed the identification of novel candidate genes but also an in depth modification of the understanding of the architecture of several endocrine diseases. Several different NGS approaches are available allowing the sequencing of several regions of interest or the whole exome or genome (WGS, WES, or targeted NGS), with highly variable costs, potentials and limitations that should be clearly known before designing the expe...
Source: European Journal of Endocrinology - June 7, 2018 Category: Endocrinology Authors: Persani L, de Filippis T, Colombo C, Gentilini D Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Rare Defects in Adrenal Steroidogenesis.
Abstract Congenital adrenal hyperplasia (CAH) is a group of genetic disorders of adrenal steroidogenesis that impair cortisol synthesis, with compensatory increases in ACTH leading to hyperplastic adrenals. The term 'CAH' is generally used to mean 'steroid 21-hydroxylase deficiency' (21OHD) as 21OHD accounts for about 95% of CAH in most populations; the incidences of the rare forms of CAH vary with ethnicity and geography. These forms of CAH are easily understood on the basis of the biochemistry of steroidogenesis. Defects in the steroidogenic acute regulatory protein, StAR, disrupt all steroidogenesis and are the...
Source: European Journal of Endocrinology - June 7, 2018 Category: Endocrinology Authors: Miller W Tags: Eur J Endocrinol Source Type: research

Surviving ectopic Cushing's syndrome: Quality of life, cardiovascular and metabolic outcomes in comparison to Cushing's disease during long-term follow-up.
CONCLUSIONS Our data support the concept that time of exposure to glucocorticoid excess appears to be a better predictor than peak serum cortisol levels at time of diagnosis regarding long-term psychiatric morbidity and QoL. PMID: 29875286 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 6, 2018 Category: Endocrinology Authors: Osswald A, Deutschbein T, Berr CM, Plomer E, Mickisch A, Ritzel K, Schopohl J, Beuschlein F, Fassnacht M, Hahner S, Reincke M Tags: Eur J Endocrinol Source Type: research

Reduction of arrhythmias in primary hyperparathyroidism, by parathyroidectomy, evaluated with 24 hour ecg monitoring.
REDUCTION OF ARRHYTHMIAS IN PRIMARY HYPERPARATHYROIDISM, BY PARATHYROIDECTOMY, EVALUATED WITH 24 HOUR ECG MONITORING. Eur J Endocrinol. 2018 Jun 06;: Authors: Pepe J, Cipriani C, Curione M, Biamonte F, Colangelo L, Danese V, Cecchetti V, Sonato C, Ferrone F, Cilli M, Minisola S Abstract OBJECTIVE: Hypercalcemia may induce arrhythmias. There are no data on the prevalence of arrhythmias in primary hyperparathyroidism (PHPT) in daily life. Aim of the study was to investigate both the prevalence of arrhythmias in patients with PHPT compared to controls and the impact of parathyroidectomy, evaluated by 24 ...
Source: European Journal of Endocrinology - June 6, 2018 Category: Endocrinology Authors: Pepe J, Cipriani C, Curione M, Biamonte F, Colangelo L, Danese V, Cecchetti V, Sonato C, Ferrone F, Cilli M, Minisola S Tags: Eur J Endocrinol Source Type: research

False positive findings on 6-[18F]fluor-L-3,4-dihydroxyphenylalanine Positron Emission Tomography (18F-FDOPA-PET) performed for imaging of neuroendocrine tumors.
CONCLUSIONS: Pathological uptake of 18F-FDOPA does not always indicate the presence of a NET. The possibility of 18F-FDOPA uptake by tumor types other than NETs, although rare, should be considered. PMID: 29875288 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 6, 2018 Category: Endocrinology Authors: Berends AMA, Kerstens MN, Bolt JW, Links TP, Korpershoek E, de Krijger RR, Walenkamp AME, Noordzij W, van Etten B, Kats-Ugurlu G, Brouwers A, van der Horst-Schrivers ANA Tags: Eur J Endocrinol Source Type: research

Do aggressive variants of papillary thyroid carcinoma have worse clinical outcome than classical papillary thyroid carcinoma?
CONCLUSIONS: When other clinicopathological factors were similar, patients with TCV did not exhibit unfavorable clinical outcome whereas those with CCV had significantly poorer clinical outcome. Individualized therapeutic approach might be necessary for each type of AV-PTCs. PMID: 29875289 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 6, 2018 Category: Endocrinology Authors: Song E, Jeon MJ, Oh HS, Han M, Lee YM, Kim TY, Chung KW, Kim WB, Shong YK, Song DE, Kim WG Tags: Eur J Endocrinol Source Type: research

The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women.
CONCLUSIONS: Our results indicate that lower IGF-1 levels are associated with lower handgrip strength and worse physical performance, but less recurrent fallers especially in men. Associations were often more robust in IGF-1-Q2. Future studies on this topic are desirable. PMID: 29789408 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 22, 2018 Category: Endocrinology Authors: Van Nieuwpoort C, Vlot M, Schaap L, Lips P, Drent M Tags: Eur J Endocrinol Source Type: research

Characterization of an Activating R1353H Insulin-like Growth Factor 1 Receptor Variant in a Male with Extreme Tall Height.
Abstract OBJECTIVE: The Insulin-like growth factor 1 receptor (IGF-1R) is important in growth and development, and inactivating IGF1R mutations cause short stature and relatively high levels of serum IGF-I. We identified an unclassified IGF1R R1353H variant in a male with extreme tall height, very low levels of serum IGF-I and delayed and prolonged growth spurt. The index case's mother and three sons all carried the variant, but so far only the eldest son (age 18) presented with tall height. We hypothesized that the variant could constitute an activating mutation. DESIGN: The IGF1RR1353H variant was investiga...
Source: European Journal of Endocrinology - May 22, 2018 Category: Endocrinology Authors: Lin Y, van Duyvenvoorde HA, Liu H, Yang C, Warsito D, Yin C, Kant SG, Haglund F, Wit JM, Larsson O Tags: Eur J Endocrinol Source Type: research

A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly.
CONCLUSIONS: Baseline median IGF-I was 447 and 649 ng/mL in the once- and twice-weekly groups, respectivey. Compared to baseline, at week 14 twice-weekly ATL1103 resulted in a median fall in IGF-I of 27.8% (p=0.0002). Between cohort comparison at week 14 demonstrated the median fall in IGF-I to be 25.8% (p=0.0012) greater with twice-weekly dosing. In the twice-weekly cohort, IGF-I was still declining at week 14, and at week 21 remained lower than at baseline by a median of 18.7% (p=0.0005). Compared to baseline, by week 14 IGFBP3 and ALS had declined by a median of 8.9% (p=0.027) and 16.7% (p=0.017) with twice-weekly ATL11...
Source: European Journal of Endocrinology - May 22, 2018 Category: Endocrinology Authors: Trainer PJ, Newell-Price J, Ayuk J, Aylwin S, Rees DA, Drake W, Chanson P, Brue T, Webb SM, Montañana CF, Aller J, McCormack AI, Torpy DJ, Tachas G, Atley L, Ryder D, Bidlingmaier M Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY : Cell cycle regulation in adrenocortical carcinoma.
Abstract Adrenocortical carcinomas are rather rare endocrine tumors that often have a poor prognosis. The reduced survival rate associated with these tumors is due to their aggressive biological behavior, combined with the scarcity of effective treatment options that are currently available. The recent identification of the genomic alterations present in ACC have provided further molecular mechanisms to develop consistent strategies for the diagnosis, prevention of progression and treatment of advanced ACCs. Taken together, molecular and genomic advances could be leading the way to develop personalized medicine in...
Source: European Journal of Endocrinology - May 17, 2018 Category: Endocrinology Authors: Pereira S, Monteiro MP, Bourdeau I, Lacroix A, Pignatelli D Tags: Eur J Endocrinol Source Type: research

Mortality in Acromegaly decreased in the last decade: A Systematic Review and Meta-Analysis.
CONCLUSION: Mortality in acromegaly is normalized with biochemical control and decreased in the last decade with the more frequent use of SAs as adjuvant therapy. Increased life expectancy has been associated with more deaths due to cancer. PMID: 29764907 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 15, 2018 Category: Endocrinology Authors: Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Which metabolic procedure? Comparing outcomes in Sleeve Gastrectomy and Roux-en Y Gastric Bypass.
h B Abstract Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss. Furthermore, several studies have demonstra...
Source: European Journal of Endocrinology - May 15, 2018 Category: Endocrinology Authors: Billeter AT, de la Garza Herrera J, Scheurlen KM, Nickel F, Billmann F, Müller-Stich B Tags: Eur J Endocrinol Source Type: research