The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women.
CONCLUSIONS: Our results indicate that lower IGF-1 levels are associated with lower handgrip strength and worse physical performance, but less recurrent fallers especially in men. Associations were often more robust in IGF-1-Q2. Future studies on this topic are desirable. PMID: 29789408 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 22, 2018 Category: Endocrinology Authors: Van Nieuwpoort C, Vlot M, Schaap L, Lips P, Drent M Tags: Eur J Endocrinol Source Type: research

Characterization of an Activating R1353H Insulin-like Growth Factor 1 Receptor Variant in a Male with Extreme Tall Height.
Abstract OBJECTIVE: The Insulin-like growth factor 1 receptor (IGF-1R) is important in growth and development, and inactivating IGF1R mutations cause short stature and relatively high levels of serum IGF-I. We identified an unclassified IGF1R R1353H variant in a male with extreme tall height, very low levels of serum IGF-I and delayed and prolonged growth spurt. The index case's mother and three sons all carried the variant, but so far only the eldest son (age 18) presented with tall height. We hypothesized that the variant could constitute an activating mutation. DESIGN: The IGF1RR1353H variant was investiga...
Source: European Journal of Endocrinology - May 22, 2018 Category: Endocrinology Authors: Lin Y, van Duyvenvoorde HA, Liu H, Yang C, Warsito D, Yin C, Kant SG, Haglund F, Wit JM, Larsson O Tags: Eur J Endocrinol Source Type: research

A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly.
CONCLUSIONS: Baseline median IGF-I was 447 and 649 ng/mL in the once- and twice-weekly groups, respectivey. Compared to baseline, at week 14 twice-weekly ATL1103 resulted in a median fall in IGF-I of 27.8% (p=0.0002). Between cohort comparison at week 14 demonstrated the median fall in IGF-I to be 25.8% (p=0.0012) greater with twice-weekly dosing. In the twice-weekly cohort, IGF-I was still declining at week 14, and at week 21 remained lower than at baseline by a median of 18.7% (p=0.0005). Compared to baseline, by week 14 IGFBP3 and ALS had declined by a median of 8.9% (p=0.027) and 16.7% (p=0.017) with twice-weekly ATL11...
Source: European Journal of Endocrinology - May 22, 2018 Category: Endocrinology Authors: Trainer PJ, Newell-Price J, Ayuk J, Aylwin S, Rees DA, Drake W, Chanson P, Brue T, Webb SM, Montañana CF, Aller J, McCormack AI, Torpy DJ, Tachas G, Atley L, Ryder D, Bidlingmaier M Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY : Cell cycle regulation in adrenocortical carcinoma.
Abstract Adrenocortical carcinomas are rather rare endocrine tumors that often have a poor prognosis. The reduced survival rate associated with these tumors is due to their aggressive biological behavior, combined with the scarcity of effective treatment options that are currently available. The recent identification of the genomic alterations present in ACC have provided further molecular mechanisms to develop consistent strategies for the diagnosis, prevention of progression and treatment of advanced ACCs. Taken together, molecular and genomic advances could be leading the way to develop personalized medicine in...
Source: European Journal of Endocrinology - May 17, 2018 Category: Endocrinology Authors: Pereira S, Monteiro MP, Bourdeau I, Lacroix A, Pignatelli D Tags: Eur J Endocrinol Source Type: research

Mortality in Acromegaly decreased in the last decade: A Systematic Review and Meta-Analysis.
CONCLUSION: Mortality in acromegaly is normalized with biochemical control and decreased in the last decade with the more frequent use of SAs as adjuvant therapy. Increased life expectancy has been associated with more deaths due to cancer. PMID: 29764907 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 15, 2018 Category: Endocrinology Authors: Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Which metabolic procedure? Comparing outcomes in Sleeve Gastrectomy and Roux-en Y Gastric Bypass.
h B Abstract Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss. Furthermore, several studies have demonstra...
Source: European Journal of Endocrinology - May 15, 2018 Category: Endocrinology Authors: Billeter AT, de la Garza Herrera J, Scheurlen KM, Nickel F, Billmann F, Müller-Stich B Tags: Eur J Endocrinol Source Type: research

Anniversary review: 50 years since the discovery of bromocriptine.
Abstract Ergotism is the long term ergot poisoning by ingestion of rye or other grains infected with the fungus Claviceps purpurea and more recently by excessive intake of ergot drugs. It has either neuropsychiatric or vascular manifestations. In the Middle Ages the gangrenous poisoning was known as St Anthony's fire, after the order of the Monks of St Anthony who were particularly skilled at treating the condition. In 1917, Professor Arthur Stoll returned home to Switzerland from Germany, to lead the development of a new pharmaceutical department at Sandoz Chemical Company. Stoll, using the special methods of ext...
Source: European Journal of Endocrinology - May 11, 2018 Category: Endocrinology Authors: Thorner MO Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Differential diagnosis, Investigation and Therapy of Bilateral Adrenal Incidentalomas.
Abstract The investigation and management of unilateral adrenal incidentalomas have been extensively considered in the last decades. While bilateral adrenal incidentalomas represent about 15 percent of adrenal incidentalomas, they have been less frequently discussed. The differential diagnosis of bilateral incidentalomas includes metastasis, primary bilateral macronodular adrenal hyperplasia (BMAH) and bilateral cortical adenomas. Les frequent etiologies are bilateral pheochromocytomas, congenital adrenal hyperplasia, Cushing's disease or ectopic ACTH secretion with secondary bilateral adrenal hyperplasia, primary...
Source: European Journal of Endocrinology - May 10, 2018 Category: Endocrinology Authors: Bourdeau I, El Ghorayeb N, Gagnon N, Lacroix A Tags: Eur J Endocrinol Source Type: research

Gestational diabetes with diabetes and prediabetes risks: A large observational study.
Conclusions The present study indicated that women with prior GDM had significantly increased risks for postpartum diabetes and prediabetes, with the highest risk at the first 3-4 years after delivery, compared with those without GDM. PMID: 29743168 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 9, 2018 Category: Endocrinology Authors: Shen Y, Wang P, Wang L, Zhang S, Liu H, Li W, Li N, Li W, Leng J, Wang J, Tian H, Zhang C, Tuomilehto J, Yang X, Yu Z, Hu G Tags: Eur J Endocrinol Source Type: research

Risk factors for hyperglycemia in pregnancy in the DALI study differ by period of pregnancy and OGTT time point.
CONCLUSION In this population, most clinical characteristics associated with GDM/overt diabetes were non-modifiable and differed by pregnancy period and OGTT time point. The identified risk factors can help define the target population for future intervention trials.  . PMID: 29739812 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 8, 2018 Category: Endocrinology Authors: Mendoza LC, Harreiter J, Simmons D, Desoye G, Adelantado JM, Juarez F, Chico A, Devlieger R, Van Assche A, Galjaard S, Damm P, Mathiesen E, Jensen DM, Andersen LL, Tanvig M, Lapolla A, Dalfra MG, Bertolotto A, Mantaj U, Wender-Ozegowska E, Zawiejska A, Hi Tags: Eur J Endocrinol Source Type: research

Effects of Intravenous Thyrotropin Releasing Hormone on 18F-Fluorodeoxyglucose Uptake in Human Brown Adipose Tissue: A Randomized Controlled Trial.
CONCLUSION: Systemic TRH administration can increase the activity of cold-stimulated BAT in adult men. These findings may assist developing pharmacological strategies for modulating BAT activity in the management of obesity. PMID: 29724865 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 3, 2018 Category: Endocrinology Authors: Heinen CA, Zhang Z, Klieverik LP, de Wit TC, Poel E, Yaqub M, Boelen A, Kalsbeek A, Bisschop PH, van Trotsenburg P, Verberne H, Booij J, Fliers E Tags: Eur J Endocrinol Source Type: research

THERAPY OF ENDOCRINE DISEASE: Growth Hormone Replacement Therapy in Adults: Thirty Years of Personal Clinical Experience.
Abstract The acute metabolic actions of purified human GH was first documented in adult hypopituitary patients more than 50 years ago, and placebo controlled long term GH trials in GH-deficient adults (GHDA) surfaced in 1989 with the availability of biosynthetic human GH. Untreated GHDA is associated with excess morbidity and mortality from cardiovascular disease and the phenotype includes fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular biomarkers. Several of these features reverse and normalize with GH replacement...
Source: European Journal of Endocrinology - May 1, 2018 Category: Endocrinology Authors: Jorgensen JOL, Juul A Tags: Eur J Endocrinol Source Type: research

Persisting adverse body composition changes 2 years after cessation of androgen deprivation therapy for localised prostate cancer.
Abstract OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associated with insulin resistance and decreased quality of life (QoL). Our objective was to assess whether adverse body composition changes improve after cessation of ADT. DESIGN: Prospective case-control study in a tertiary referral hospital. Thirty-four men newly commencing ADT (cases, median age 67.6 years [interquartile range 64.6, 72.0]) and 29 age-matched (70.6 years [65.3, 72.9]) prostate cancer controls not on ADT were assessed 2 years after cessation of ADT (median 4.4...
Source: European Journal of Endocrinology - April 30, 2018 Category: Endocrinology Authors: Cheung AS, Tinson A, Milevski S, Hoermann R, Zajac J, Grossmann M Tags: Eur J Endocrinol Source Type: research

Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
CONCLUSIONS: Preconception intervention with low-dose liraglutide added to metformin is superior to metformin alone in increasing PRs per ET and cumulative PRs in infertile obese women with PCOS, despite comparable weight reduction in both groups. A potential direct crosstalk between GLP-1 and reproductive system needs further exploration. PMID: 29703793 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 27, 2018 Category: Endocrinology Authors: Salamun V, Jensterle M, Janez A, Vrtacnik Bokal E Tags: Eur J Endocrinol Source Type: research

TIRADS score is of limited clinical value for risk stratification of indeterminate cytological results.
Abstract CONTEXT: Thyroid nodules with cytological indeterminate results represent a daily and recurrent issue for patient management. OBJECTIVE: The primary aim of our study was to determine if TIRADS (Thyroid Imaging Reporting and Data System) could be used to stratify the malignancy risk of these nodules and to help in their clinical management. Secondary objective was to estimate if this risk stratification would change after reclassification of encapsulated non-invasive follicular variant of papillary carcinomas (FVPTC) as NIFTP. PATIENTS AND METHODS: Single-center retrospective study of a cohort of...
Source: European Journal of Endocrinology - April 27, 2018 Category: Endocrinology Authors: Chaigneau E, Russ G, Royer B, Bigorgne C, Bienvenu M, Rouxel A, Leenhardt L, Belin L, Buffet C Tags: Eur J Endocrinol Source Type: research

THERAPY OF ENDOCRINE DISEASE: Denosumab versus bisphosphonates for the treatment of postmenopausal osteoporosis.
In conclusion, both bisphosphonates and denosumab are safe and efficient therapeutic options although their particularities should be carefully considered in an individual base. PMID: 29691303 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 24, 2018 Category: Endocrinology Authors: Anastasilakis AD, Polyzos SA, Makras P Tags: Eur J Endocrinol Source Type: research

EJE PRIZE 2018: A gut feeling about glucagon.
This article summarises the physiological regulation of glucagon secretion in humans and considers new findings suggesting that the liver and the gut play key roles in determining fasting and postabsorptive circulating glucagon levels. PMID: 29678923 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 20, 2018 Category: Endocrinology Authors: Knop FK Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited.
Abstract The syndrome of primary aldosteronism (PA) is characterized by hypertension with excessive, autonomous aldosterone production and is usually caused by either a unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). The diagnostic workup of PA is a sequence of three phases comprising screening tests, confirmatory tests and the differentiation of unilateral from bilateral forms. The latter step is necessary to determine the optimal treatment approach of unilateral laparoscopic adrenalectomy (for patients with unilateral PA) or medical treatment with a mineralocorticoid recept...
Source: European Journal of Endocrinology - April 19, 2018 Category: Endocrinology Authors: Williams TA, Reincke M Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: A sense of time of the glucocorticoid circadian clock: from the ontogeny to the diagnosis of Cushing's syndrome.
Abstract The circadian rhythm of glucocorticoids has long been recognised within the last 75 years. Since the beginning, researchers have sought to identify basic mechanisms underlying the origin and emergence of the corticosteroid circadian rhythmicity among mammals. Accordingly, Young, Hall and Rosbash, laureates of the 2017 Nobel Prize in Physiology or Medicine, as well as Takahashi's group among others, have characterised the molecular cogwheels of the circadian system, describing interlocking transcription/translation feedback loops essential for normal circadian rhythms. Plasma glucocorticoid circadian varia...
Source: European Journal of Endocrinology - April 16, 2018 Category: Endocrinology Authors: Moreira AC, Antonini SRR, De Castro M Tags: Eur J Endocrinol Source Type: research

Role of MRI T2-DRIVE in the Assessment of Pituitary Stalk Abnormalities without Gadolinium in Pituitary Diseases.
CONCLUSION: T2-DRIVE sequence is extremely precise and reliable for the evaluation of PS size and the recognition of PS abnormalities; the use of gadolinium-based contrast media does not add significant information and may thus be avoided. PMID: 29650689 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 12, 2018 Category: Endocrinology Authors: Godano E, Morana G, Di Iorgi N, Pistorio A, Allegri AEM, Napoli F, Gastaldi R, Calcagno A, Patti G, Gallizia A, Notarnicola S, Giaccardi M, Noli S, Severino M, Tortora D, Rossi A, Maghnie M Tags: Eur J Endocrinol Source Type: research

The Genetic Characteristics of Congenital Hypothyroidism in China by Comprehensive Screening of 21 Candidate Genes.
Conclusions Most cases of congenital hypothyroidism in China were caused by thyroid dyshormonogenesis rather than thyroid dysgenesis. This study identified previously reported causative genes for 57/110 Chinese patients, and revealed DUOX2 was the most frequently mutated gene in these patients. Our study expanded the mutation spectrum of CH in Chinese patients, which was significantly different from western countries. PMID: 29650690 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 12, 2018 Category: Endocrinology Authors: Sun F, Zhang JX, Yang CY, Gao GQ, Zhu WB, Han B, Zhang LL, Wan YY, Ye XP, Ma YR, Zhang MM, Yang L, Zhang QY, Liu W, Guo CC, Chen G, Zhao SX, Song KY, Song H Tags: Eur J Endocrinol Source Type: research

Predictive score for the development or progression of graves' orbitopathy in patients with newly diagnosed graves' hyperthyroidism.
Conclusions: In patients without GO at diagnosis, 15% will develop GO (13% mild, 2% moderate-to-severe) during subsequent treatment with ATD for 18 months. A predictive score called PREDIGO composed of four baseline determinants, was better in predicting those patients who will not develop obvious GO than who will. PMID: 29650691 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 12, 2018 Category: Endocrinology Authors: Wiersinga WM, Žarković M, Bartalena L, Donati S, Perros P, Okosieme O, Morris D, Fichter N, Lareida J, von Arx G, Daumerie C, Burlacu MC, Kahaly GJ, Pitz S, Beleslin B, Ćirić J, Ayvaz G, Konuk O, Balos Toruner F, Salvi M, Covelli D, Currò N, Hegedüs Tags: Eur J Endocrinol Source Type: research

Primary Aldosteronism: Key Characteristics at Diagnosis - a Trend towards Milder Forms.
CONCLUSIONS: Our results are in accordance with an increased screening intensity for PA. We identified a trend towards diagnosing milder forms, increasingly more females and less unilateral cases of PA. PMID: 29636356 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 10, 2018 Category: Endocrinology Authors: Heinrich DA, Adolf C, Rump LC, Quack I, Quinkler M, Hahner S, Januszewicz A, Seufert J, Willenberg HS, Nirschl N, Sturm L, Beuschlein F, Reincke M Tags: Eur J Endocrinol Source Type: research

Differences between ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications performance in identifying cytological high-risk thyroid nodules.
In this study we aimed to estimate and compare the performance of ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications in discriminating nodules with high-risk cytology. DESIGN: Cross sectional study Methods 1077 thyroid nodules undergoing fine needle aspiration were classified according to ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications by an automated algorithm. Odds ratios and receiver operating characteristic (ROC) curves for high-risk cytology categories (TIR3b, TIR4 and TIR5) were calculated for the different US categories and compared. RESULTS: Cytological categories of risk increased ...
Source: European Journal of Endocrinology - April 6, 2018 Category: Endocrinology Authors: Lauria A, Maddaloni E, Briganti SI, Beretta Anguissola G, Perrella E, Taffon C, Palermo A, Pozzilli P, Manfrini S, Crescenzi A Tags: Eur J Endocrinol Source Type: research

Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma.
CONCLUSIONS: A structure to function relationship is suggested between microstructural WM alterations in cingulum and in hippocampus with cognitive deficits in CP. PMID: 29599407 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2018 Category: Endocrinology Authors: Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A, Erfurth EM Tags: Eur J Endocrinol Source Type: research

Non-parathyroid hypercalcemia associated with paraffin oil injection in 12 younger male bodybuilders.
CONCLUSION: The hypercalcemia and associated hypercalciuria seems to be due to an intestinal hyperabsorption of calcium. It remains to be elucidated, whether an increased calcitriol synthesis within granulomas is the only (main) mechanism by which intestinal calcium absorption is increased. Glucocorticoids seem most appropriate as the first choice for treatment. Bodybuilders should be warned against use of intramuscular oil injections (and other substances), as this may have severe adverse health consequences. PMID: 29599408 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2018 Category: Endocrinology Authors: Sølling ASK, Tougaard B, Harsløf T, Langdahl B, Kongsbak Brockstedt H, Byg KE, Ivarsen P, Karstoft Ystrøm I, Holden Mose F, Lissel Isaksson G, Steen Svarer Hansen M, Nagarajah S, Ejersted C, Bendstrup E, Rejnmark L Tags: Eur J Endocrinol Source Type: research

Aggressive pituitary tumours and carcinomas: two sides of the same coin?
Abstract The European Society of Endocrinology (ESE) survey reported on the largest cohort of 125 aggressive pituitary tumours (APT) and 40 pituitary carcinomas (PC). Whilst the survey focused on treatment effectiveness, all pathological data were not explored in detail. Here we comment on some interesting pathological findings, notably the difference between APT and PC. PMID: 29588294 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 27, 2018 Category: Endocrinology Authors: Trouillas J, Burman P, McCormack AI, Petersenn S, Popovic V, Dekkers O, Raverot G Tags: Eur J Endocrinol Source Type: research

Antipsychotic Medication and Type 2 Diabetes and Impaired Glucose Regulation.
Conclusion It remains unclear whether these antipsychotic medications exacerbate an underlying predisposition to the development of T2DM or have a direct effect. Potential risks need to be weighed up and balanced between improved and lasting mental health benefits and any detrimental physical health side effects. Achieving parity of esteem between mental and physical health is a worldwide priority if we wish to improve life-expectancy and quality of life in people with severe mental illness. PMID: 29559497 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 20, 2018 Category: Endocrinology Authors: Whicher C, Price HC, Holt RI Tags: Eur J Endocrinol Source Type: research

Post partum and non-post partum relapsing Graves' hyperthyroidism display different response to anti-thyroid drugs.
CONCLUSIONS: Relapsing Graves' hyperthyroidism in the PP period is more prone to undergo a remission after a second course of MMI treatment. In these patients a conservative therapeutic approach is more appropriate. PMID: 29559498 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 20, 2018 Category: Endocrinology Authors: Rotondi M, Capelli V, Coperchini F, Pinto S, Croce L, Tonacchera M, Chiovato L Tags: Eur J Endocrinol Source Type: research

Short-term effects of transdermal estradiol in men undergoing androgen deprivation therapy for prostate cancer: a randomized placebo-controlled trial.
CONCLUSION: In men with castrate levels of E2 and T, daily transdermal E2 0.9-1.8mg increases median serum E2 concentrations into the reference range reported for healthy men, but with substantial variability. E2 treatment reduced hot flushes and bone resorption. Larger studies will be required to test whether low dose E2 treatment can mitigate ADT-associated adverse effects without E2-related toxicity. PMID: 29549104 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 16, 2018 Category: Endocrinology Authors: Russell N, Hoermann R, Cheung AS, Ching M, Zajac J, Handelsman DJ, Grossmann M Tags: Eur J Endocrinol Source Type: research

Continuous subcutaneous insulin infusion versus multiple daily injections in pregnant women with type 1 diabetes mellitus - a systematic review and meta-analysis of randomised controlled trials and observational studies.
CONCLUSIONS: In T1DM-complicated pregnancy, CSII compared to MDI therapy resulted in better first trimester glycaemic control; this difference decreased in subsequent trimesters. CSII therapy was associated with lower insulin requirements, higher GWG, and altered risk for infants being LGA and SGA. PMID: 29545258 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 15, 2018 Category: Endocrinology Authors: Rys P, Ludwig-Słomczyńska AH, Cyganek K, Malecki MT Tags: Eur J Endocrinol Source Type: research

Insulin Stimulated Glucose Uptake in Skeletal Muscle, Adipose Tissue and Liver: A Positron Emission Tomography Study.
CONCLUSIONS: We have provided threshold values which can be used to identify tissue specific insulin resistance. In addition, we found that insulin resistance measured by GU was only partially similar across all insulin sensitive tissues studied, skeletal muscle, adipose tissue and liver, and was affected by obesity, aging and gender. PMID: 29535167 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 13, 2018 Category: Endocrinology Authors: Honka MJ, Latva-Rasku A, Bucci M, Virtanen KA, Hannukainen JC, Kalliokoski KK, Nuutila P Tags: Eur J Endocrinol Source Type: research

METS-IR, a novel score to evaluate insulin sensitivity, is predictive of visceral adiposity and incident type 2 diabetes.
;ndez L, Mehta RP, Caballeros-Barragán CR, Aguilar-Salinas C Abstract OBJECTIVE: We developed a novel non-insulin based fasting score to evaluate insulin sensitivity validated against the EHC. We also evaluated its correlation with ectopic fact accumulation and its capacity to predict incident T2D cases. DESIGN & METHODS: The discovery sample was composed by 125 subjects (57 without and 68 with T2D) that underwent an EHC. We defined METS-IR as Ln[(2*G0)+TG0]*BMI)/(Ln[HDL-c]) and compared its diagnostic performance against the MFFM obtained by an EHC. METS-IR was validated in a sample with EHC data,...
Source: European Journal of Endocrinology - March 13, 2018 Category: Endocrinology Authors: Bello-Chavolla OY, Almeda-Valdes P, Gomez-Velasco D, Viveros-Ruiz T, Cruz-Bautista I, Romo-Romo A, Sánchez-Lázaro D, Meza-Oviedo D, Vargas-Vazquez A, Arellano Campos O, Sevilla-González MDR, Martagón AJ, Muñoz Hernández L, Mehta RP, Caballeros-Barra Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during Pregnancy: solved and unsolved questions.
Abstract With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. The predominant cause is adrenal adenoma (sometimes without decreased ACTH), rather than Cushing's disease. There are considerable imaging pitfalls in Cushing's disease. Aberrant receptors may, in rare cases, lead to...
Source: European Journal of Endocrinology - March 9, 2018 Category: Endocrinology Authors: Brue T, Amodru V, Castinetti F Tags: Eur J Endocrinol Source Type: research

Longitudinally evaluated the relationship between body fat percentage and the risk for type 2 diabetes mellitus: Korean Genome and Epidemiology Study (KoGES).
Abstract BACKGROUND: Body fat plays the significant role in maintaining glucose homeostasis. However, it is not fully identified how body fat percentage (BF%) has an impact on the development of type 2 diabetes mellitus (T2DM). Thus, this study was to evaluate the incidental risk for T2DM according to BF% level. METHODS: In a community based Korean cohort, 5,972 Korean adults were divided into quintile groups by BF% and followed-up for 10 years to monitor the development of T2DM. Cox proportional hazard model was used to evaluate the hazard ratios (HRs) for T2DM according to BF% quintile. Additionally, subgro...
Source: European Journal of Endocrinology - March 9, 2018 Category: Endocrinology Authors: Park SK, Ryoo JH, Oh CM, Choi JM, Jung JY Tags: Eur J Endocrinol Source Type: research

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas.
CONCLUSIONS: in apparently asymptomatic patients, mild autonomous cortisol secretion can sustain early cardiac and vascular remodeling, independently of other risk factors. The morphological and functional cardiovascular changes observed in pACS underline the need for further studies to correctly define the long-term management of this relatively common condition. PMID: 29510982 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 6, 2018 Category: Endocrinology Authors: Sbardella E, Minnetti M, D'Aluisio D, Rizza L, Di Giorgio MR, Vinci F, Pofi R, Giannetta E, Venneri MA, Vestri A, Morelli S, Lenzi A, Isidori AM Tags: Eur J Endocrinol Source Type: research

Developmental milestones at one year for the offspring of mothers with congenital hypothyroidism: a population-based study.
Abstract OBJECTIVE: Maternal thyroid dysfunction during pregnancy is associated with neurodevelopmental impairment in the offspring. No data are currently available for the offspring of patients treated early for congenital hypothyroidism(CH). The aim of this study was to investigate motor and language milestones at one year of age in a population-based registry of children born to young women with CH. DESIGN AND METHODS: We assessed 110 children born to mothers with CH, and 1367 children from the EDEN French population-based birth cohort study prospectively, at the age of one year, with identical questionnai...
Source: European Journal of Endocrinology - March 2, 2018 Category: Endocrinology Authors: Leger J, Forhan A, Dos Santos S, Larroque B, Ecosse E, Charles MA, Heude B Tags: Eur J Endocrinol Source Type: research

PHENOTYPIC SPECTRUM AND RESPONSES TO RECOMBINANT HUMAN IGF1 (rhIGF1) THERAPY IN PATIENTS WITH HOMOZYGOUS INTRONIC PSEUDOEXON GROWTH HORMONE RECEPTOR MUTATION.
CONCLUSION: In addition to phenotypic heterogeneity in the cohort, there was mismatch between clinical and biochemical features in individual patients with 6Ψ GHR mutations. rhIGF1 treatment improved height outcomes. PMID: 29500309 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 2, 2018 Category: Endocrinology Authors: Chatterjee S, Shapiro L, Rose SJ, Mushtaq T, Clayton PE, Ten S, Bhangoo A, Kumbattae U, Dias R, Savage MO, Metherell LA, Storr HL Tags: Eur J Endocrinol Source Type: research

Safety and Convenience of Once-Weekly Somapacitan in Adult GH Deficiency: A 26-Week Randomized, Controlled Trial.
CONCLUSIONS: In this 26-week trial in patients with AGHD, somapacitan was well tolerated and no safety issues were identified. Once-weekly somapacitan was reported to be more convenient than once-daily Norditropin®. PMID: 29500310 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 2, 2018 Category: Endocrinology Authors: Johannsson G, Feldt-Rasmussen U, Holme Håkonsson I, Biering H, Rodien P, Tahara S, Toogood AA, Rasmussen MH Tags: Eur J Endocrinol Source Type: research

Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome): Letter to the Editor.
PMID: 29440267 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 16, 2018 Category: Endocrinology Authors: Thomson M Tags: Eur J Endocrinol Source Type: research

Differentiation of pathologic/neoplastic hypercortisolism (Cushing syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as Pseudo-Cushing syndrome): response to Letter to the Editor.
PMID: 29440268 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 16, 2018 Category: Endocrinology Authors: Findling JW, Raff H Tags: Eur J Endocrinol Source Type: research

Calcium supplementation in osteoporosis: useful or harmful.
Abstract Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis. However, recently the usefulness of calcium supplementation (alone or with concomitant vitamin D) h...
Source: European Journal of Endocrinology - February 12, 2018 Category: Endocrinology Authors: Chiodini I, Bolland MJ Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Diabetic Cardiomyopathy - Pathophysiology and Potential Metabolic Interventions.
Abstract Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease specific myocardial structural, functional and metabolic changes. This review will focus on the contemporary contributions of state of the art non-invasive technologies to our understanding of diabetic cardiomyopathy, including data on cardiac disease phenotype, cardiac energy metabolism and energetic deficiency, ectopic and visceral adiposity, diabetic liver disease, metabolic modulation strategies, and cardiovascu...
Source: European Journal of Endocrinology - February 12, 2018 Category: Endocrinology Authors: Levelt E, Gulsin GS, Neubauer S, McCann GP Tags: Eur J Endocrinol Source Type: research

Preoperative medical treatment in Cushing's syndrome. Frequency of use and its impact on postoperative assessment. Data from ERCUSYN.
Trainer PJ, Wass JAH, Tabarin A Abstract BACKGROUND: Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical treatment (PMT) affects postoperative outcome remains controversial. OBJECTIVE: 1) Evaluate how frequently PMT is given to CS patients across Europe 2) examine differences in preoperative characteristics of patients who receive PMT and those who undergo primary surgery; 3) determine if PMT influences postoperative outcome in pituitary-dependent CS (PIT-CS). PATIENTS AND METHODS: 1143 CS patients entered i...
Source: European Journal of Endocrinology - February 12, 2018 Category: Endocrinology Authors: Valassi E, Franz H, Brue T, Feelders RA, Netea-Maier RT, Tsagarakis S, Webb SM, Yaneva MK, Reincke M, Droste M, Komerdus I, Maiter D, Kastelan D, Chanson P, Pfeifer M, Strasburger CJ, Toth M, Chabre O, Krsek M, Montañana CF, Bolanowski M, Santos A, Train Tags: Eur J Endocrinol Source Type: research

Association of fetuin-A with incident type 2 diabetes: Results from the MONICA/KORA Augsburg study and a systematic meta-analysis.
Conclusions Higher fetuin-A levels are associated with incident T2D in both males and females independently of subclinical inflammation, adiponectin, and liver fat content. PMID: 29439057 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2018 Category: Endocrinology Authors: Sujana C, Huth C, Zierer A, Meesters S, Sudduth-Klinger J, Koenig W, Herder C, Peters A, Thorand B Tags: Eur J Endocrinol Source Type: research

Congenital Hypogonadotropic Hypogonadism and Constitutional Delay of Growth and Puberty Have Distinct Genetic Architectures.
CONCLUSIONS: Our data suggests that CDGP and CHH have distinct genetic profiles, and this finding may facilitate the differential diagnosis in patients presenting with delayed puberty. PMID: 29419413 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 1, 2018 Category: Endocrinology Authors: Cassatella D, Howard S, Acierno J, Xu C, Papadakis G, Santoni FA, Dwyer AA, Santini S, Sykiotis G, Chambion C, Meylan J, Marino L, Favre L, Li J, Liu X, Zhang JG, Bouloux P, De Geyter C, De Paepe A, Dhillo WS, Ferrara JM, Hauschild M, Lang-Muritano M, Lem Tags: Eur J Endocrinol Source Type: research

The comprehensive impact on human body induced by resolution of growth hormone excess.
CONCLUSIONS: The rapid resolution of excessive GH led to the reversible changes of systemic comorbidities in a time-dependent and organ-specific manner. PMID: 29386229 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 31, 2018 Category: Endocrinology Authors: Zhang Z, Li Q, He W, Qiu H, Ye H, Wang Y, Shen M, He M, Yu Y, Shou X, Huang C, Yu H, Huang G, Tang W, Geng D, Fu C, Liu C, Ma Z, Ye Z, Zhang Q, Zhang Y, Shen Y, Yang Y, Wang M, Liu X, Lu Y, Ming HR, Mao Y, Zhou L, Li YM, Li S, Tritos NA, Zhao Y Tags: Eur J Endocrinol Source Type: research

Effects of active acromegaly on bone mRNA and microRNA expression patterns.
Abstract OBJECTIVE: To evaluate the response of bone to chronic long-term growth hormone (GH) and insulin-like growth factor-1 (IGF1) excess by measuring the expression of selected mRNA and microRNA (miR) in bone samples of patients with active acromegaly. DESIGN: case-control study Methods: bone samples were obtained during transsphenoidal adenomectomy from the sphenoid bone (sella turcica) from 14 patients with clinically and biochemically-confirmed acromegaly and 10 patients with clinically non-functioning pituitary adenoma (NFPA) matched by sex and age. Expression of genes involved in the regulation of bo...
Source: European Journal of Endocrinology - January 26, 2018 Category: Endocrinology Authors: Belaya Z, Grebennikova T, Melnichenko GA, Nikitin A, Solodovnikov A, Brovkina O, Grigoriev A, Rozhinskaya L, Lutsenko A, Dedov II Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors; clinical benefits by restoration of normal diurnal metabolism?
Abstract Type 2 diabetes (T2D) is associated with inhibition of autophagic and lysosomal housekeeping processes that detrimentally affect key organ functioning; a process likely to be exacerbated by conventional insulin-driven anabolic therapies. We propose that the cardio-renal benefits demonstrated with sodium-glucose cotransporter-2 inhibitor (SGLT2i) treatment in T2D partly may be explained by their ability to drive consistent, overnight periods of increased catabolism brought about by constant glucosuria. Key steps driving this catabolic mechanism include: a raised glucagon/insulin ratio initially depleting g...
Source: European Journal of Endocrinology - January 25, 2018 Category: Endocrinology Authors: Esterline RL, Vaag A, Oscarsson J, Vora J Tags: Eur J Endocrinol Source Type: research

Poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia.
Abstract Objectives To evaluate risks of depression and all-cause mortality, healthcare utilisation costs, and treatment adherence in congenital adrenal hyperplasia (CAH) in the UK. Design and Methods A retrospective, matched-cohort study using UK primary-care data from the Clinical Practice Research Datalink linked to hospital and death-certification data. Patients diagnosed with CAH and having ≥1 corticosteroid prescription were matched 1:10 to reference subjects. Risk of death and lifetime prevalence of depression were compared using Cox regression models. Direct financial costs were estimated for healthcare...
Source: European Journal of Endocrinology - January 25, 2018 Category: Endocrinology Authors: Jenkins-Jones S, Parviainen L, Porter J, Withe M, Whitaker M, Holden SE, Morgan CL, Currie C, Ross RJ Tags: Eur J Endocrinol Source Type: research