Who is afraid of non-normal data? Choosing between parametric and non-parametric tests: a response.
PMID: 32621583 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 6, 2020 Category: Endocrinology Authors: Hoermann R, Midgley JEM, Larisch R, Dietrich JW Tags: Eur J Endocrinol Source Type: research

Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation.
Abstract Objective: Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk of adrenal crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention of AC and improvement of AI management. A standardized education programme was elaborated for patients with chronic AI in Germany. Design: Longitudinal, prospective, questionnaire-based, multi-centre study. Methods: During 2-h sessions, patients (n = 526) were provided with basic knowledge on AI, equipped with emergency cards and sets and trained in self-injection ...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Burger-Stritt S, Eff A, Quinkler M, Kienitz T, Stamm B, Willenberg HS, Meyer G, Klein J, Reisch N, Droste M, Hahner S Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE Subclinical hypothyroidism in children.
Abstract Subclinical hypothyroidism (SH) is biochemically defined as serum TSH levels above the upper limit of the reference range in the presence of normal free T4 (FT4) concentrations. While there is a general agreement to treat subjects with serum TSH levels above 10 mU/L, the management of mild form (TSH concentrations between 4.5 and 10 mU/L) is still a matter of debate. In children, mild SH is often a benign and remitting condition and the risk of progression to overt thyroid dysfunction depends on the underlying condition, being higher in the autoimmune forms. The major concern is to establish whether SH in...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Salerno M, Improda N, Capalbo D Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY Pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus.
Abstract For an endocrinologist, nephrogenic diabetes insipidus (NDI) is an end-organ disease, that is the antidiuretic hormone, arginine-vasopressin (AVP) is normally produced but not recognized by the kidney with an inability to concentrate urine despite elevated plasma concentrations of AVP. Polyuria with hyposthenuria and polydipsia are the cardinal clinical manifestations of the disease. For a geneticist, hereditary NDI is a rare disease with a prevalence of five per million males secondary to loss of function of the vasopressin V2 receptor, an X-linked gene, or loss of function of the water channel AQP2. The...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Bichet DG Tags: Eur J Endocrinol Source Type: research

Postoperative parathyroid hormone levels as a predictor for persistent hypoparathyroidism.
Conclusion: In our study a decrease in PTH levels of>70% after total or completion thyroidectomy is a reliable predictor for persistent hypoparathyroidism, and this should be confirmed in larger cohorts. PMID: 32580147 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Lončar I, Dulfer RR, Massolt ET, Timman R, de Rijke YB, Franssen GJH, Burger PJWA, Smit C, van der Horst FAL, Peeters RP, van Eijck CHJ, van Ginhoven TM Tags: Eur J Endocrinol Source Type: research

Efficacy and safety of dopamine agonists in patients treated with antipsychotics and presenting a macroprolactinoma.
Conclusions: Even if the DA efficacy on PRL levels and tumor volume in patients with macroprolactinoma under antipsychotic drugs is less impressive than that typically observed, it may be considered satisfactory for half of our patients, particularly in cases of optic chiasm compression. Psychotic exacerbation was unusual in these patients, occurring mostly in those with the most severe psychotic forms. DAs may therefore be used as antitumor treatment for macroprolactinoma in patients with visual involvement, severe headaches or invasion into the skull base who receive antipsychotics. PMID: 32583656 [PubMed - in proce...
Source: European Journal of Endocrinology - June 26, 2020 Category: Endocrinology Authors: Allard L, Albarel F, Bertherat J, Caron PJ, Cortet C, Courtillot C, Delemer B, Jublanc C, Maiter D, Nunes ML, Raverot G, Sarfati J, Salenave S, Corruble E, Choucha W, Chanson P Tags: Eur J Endocrinol Source Type: research

Central diabetes insipidus and pituitary stalk thickening in adults: distinction of neoplastic from non-neoplastic lesions.
CONCLUSION: We confirm a relatively high risk of malignancy in adult patients presenting with the association of CDI and PST. Young age, male gender, a very large thickening of the stalk, multiple anterior pituitary deficits and prolactin above 1.3× ULN increase the likelihood of a neoplastic origin. PMID: 32530258 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 13, 2020 Category: Endocrinology Authors: Devuyst F, Kazakou P, Balériaux D, Alexopoulou O, Burniat A, Salenave S, Chanson P, Corvilain B, Maiter D Tags: Eur J Endocrinol Source Type: research

Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women: a randomized controlled trial.
Abstract Objective: We investigated the effects of a 12-week exercise intervention on insulin sensitivity (SI) and hyperinsulinemia and associated changes in regional and ectopic fat. Research design and methods: Healthy, black South African women with obesity (mean age 23 ± 3.5 years) and of isiXhosa ancestry were randomised into a 12-week aerobic and resistance exercise training group (n = 23) and a no exercise group (control, n = 22). Pre and post-intervention testing included assessment of SI, insulin response to glucose (AIRg), insulin secretion rate (ISR), hepatic insulin extraction (FEL) and dis...
Source: European Journal of Endocrinology - June 6, 2020 Category: Endocrinology Authors: Fortuin-de Smidt MC, Mendham AE, Hauksson J, Hakim O, Stefanovski D, Clamp L, Phiri L, Swart J, Goff LM, Micklesfield LK, Kahn SE, Olsson T, Goedecke JH Tags: Eur J Endocrinol Source Type: research

Psychological well-being and personality in relation to weight loss following behavioral modification intervention in obese women with polycystic ovary syndrome: a randomized controlled trial.
Conclusions: Psychological well-being is severely impacted in overweight women with PCOS. Behavioral modification can positively impact dimensions of well-being, although not fully significant, compared to control treatment. Personality factors could contribute to the understanding of successful weight loss. PMID: 32503005 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 6, 2020 Category: Endocrinology Authors: Oberg E, Lundell C, Blomberg L, Gidlöf SB, Egnell PT, Hirschberg AL Tags: Eur J Endocrinol Source Type: research

Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.
Abstract Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD. Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers. Results: Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto's thyroiditis was found in 20.3%, Graves' disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas ...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Fichna M, Małecki PP, Młodzikowska M, Gębarski B, Ruchała M, Fichna P Tags: Eur J Endocrinol Source Type: research

Acromegaly: 'You must know it to think of it'.
Abstract Acromegaly is a debilitating and disfiguring chronic disease, which occurs in both sexes at any age, associated with multiple comorbidities and increased mortality. It is typically caused by a GH-secreting pituitary adenoma that promotes exposure of body tissues to increased concentrations of GH and IGF-I. The diagnosis of acromegaly is still made very late in a substantial number of patients when the disease is already in advanced stages. An epidemiological study from Sweden has elegantly demonstrated that the longer the diagnostic delay in acromegaly, the higher the number of comorbidities. Moreover, ab...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Boguszewski CL Tags: Eur J Endocrinol Source Type: research

Detailed characterization of metastatic lymph nodes improves the prediction accuracy of currently used risk stratification systems in N1 stage papillary thyroid cancer.
Conclusions: The combination of currently used risk stratification systems with detailed characterization of MLNs may improve the predictive accuracy for recurrence/progression in N1 PTC patients. PMID: 32487777 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Lee J, Kim CH, Min IK, Jeong S, Kim H, Choi MJ, Kwon HJ, Jung SG, Jo YS Tags: Eur J Endocrinol Source Type: research

Androgen excess and diagnostic steroid biomarkers for nonclassic 21-hydroxylase deficiency without cosyntropin stimulation.
Abstract Objectives: The clinical presentation of patients with nonclassic 21-hydroxylase deficiency (N21OHD) is similar with that for other disorders of androgen excess. The diagnosis of N21OHD typically requires cosyntropin stimulation. Additionally, the management of such patients is limited by the lack of reliable biomarkers of androgen excess. Herein, we aimed to: (1.) compare the relative contribution of traditional and 11-oxyandrogens in N21OHD patients and (2.) identify steroids that accurately diagnose N21OHD with a single baseline blood draw. Design: We prospectively enrolled patients who underwent ...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Turcu AF, El-Maouche D, Zhao L, Nanba AT, Gaynor A, Veeraraghavan P, Auchus RJ, Merke DP Tags: Eur J Endocrinol Source Type: research

T2-signal intensity, SSTR expression, and somatostatin analogs efficacy predict response to pasireotide in acromegaly.
Conclusions: Patients unresponsive to SRLs with a lower SST2 receptor expression are more prone to achieve tumor shrinkage during PAS-LAR. Surprisingly, tumor shrinkage is not accompanied by a biochemical response, which is accompanied with a higher T2-signal intensity. PMID: 32375119 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 7, 2020 Category: Endocrinology Authors: Coopmans EC, Schneiders JJ, El-Sayed N, Erler NS, Hofland LJ, van der Lely AJ, Petrossians P, Potorac J, Muhammad A, Neggers SJCMM Tags: Eur J Endocrinol Source Type: research

Growth hormone retesting during puberty: a cohort study.
Conclusions: GH secretion should be retested at mid-puberty. Retesting at puberty may reduce potential side effects and minimize costs, without impairing growth potential and final height. PMID: 32337961 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 28, 2020 Category: Endocrinology Authors: Cavarzere P, Gaudino R, Sandri M, Ramaroli DA, Pietrobelli A, Zaffanello M, Guzzo A, Salvagno GL, Piacentini G, Antoniazzi F Tags: Eur J Endocrinol Source Type: research

Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.
Conclusions: Overall, co-aggregation was more pronounced in monozygotic than in dizygotic twins, suggesting that disease overlap is largely attributable to genetic factors. Co-aggregation was common, and twins faced up to a ten-fold risk of developing diseases not present in their co-twin. Our results validate and refine previous heritability estimates based on smaller twin cohorts. PMID: 32229696 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 3, 2020 Category: Endocrinology Authors: Skov J, Eriksson D, Kuja-Halkola R, Höijer J, Gudbjörnsdottir S, Svensson AM, Magnusson PKE, Ludvigsson JF, Kämpe O, Bensing S Tags: Eur J Endocrinol Source Type: research

Pasireotide for acromegaly: long-term outcomes from an extension to the Phase III (PAOLA) study.
Abstract OBJECTIVE: In the Phase III PAOLA study (clinicaltrials.gov: NCT01137682), enrolled patients had uncontrolled acromegaly despite ≥6 months of octreotide/lanreotide treatment before study start. More patients achieved biochemical control with long-acting pasireotide versus continued treatment with octreotide/lanreotide (active control) at month 6. The current work assessed the extent of comorbidities at baseline and outcomes during a long-term extension. DESIGN/METHODS: Patients receiving pasireotide 40 or 60 mg at core study end could continue on the same dose in an extension phase if biochemicall...
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Colao AAL, Bronstein MD, Brue T, De Marinis L, Fleseriu M, Guitelman M, Raverot G, Shimon I, Fleck J, Gupta P, Pedroncelli AM, Gadelha MR Tags: Eur J Endocrinol Source Type: research

Cardiovascular prognostic value of echocardiography and N terminal pro B-type natriuretic peptide in type 1 diabetes: The Thousand and 1 Study.
Conclusion In patients with type 1 diabetes, preserved ejection fraction, and no known heart disease, NT-proBNP and E/e' were associated with increased risk of MACE and all-cause mortality. The risks associated with NT-proBNP and E/e' combined identified patients at remarkably high risk. PMID: 32209724 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Rørth R, Jørgensen PG, Andersen HU, Christoffersen C, Gøtze JP, Køber L, Rossing P, Jensen MT Tags: Eur J Endocrinol Source Type: research

Prolonged Diagnostic Delay in Acromegaly is Associated with Increased Morbidity and Mortality.
Abstract CONTEXT: Clinical features of acromegaly develop insidiously. Its diagnosis may therefore be delayed. OBJECTIVE: Our aim was to study diagnostic delay and its impact on morbidity and mortality in a nationwide cohort of patients with acromegaly. DESIGN: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish National Patient Registry. Diagnostic codes for predefined comorbidities associated with acromegaly were recorded between 1987 and 2013. Diagnostic delay was calculated as the time between the first registered comorbidity and the diagnosis of acromegaly. ...
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Esposito D, Ragnarsson O, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

Carotid body chemosensitivity: early biomarker of dysmetabolism in humans.
Abstract OBJECTIVE: The carotid bodies (CB) are peripheral chemoreceptor organs classically described as being O2 sensors, which are increasingly emerging as core players in metabolic control. Herein we evaluated CB activity in prediabetes patients and determined its correlation with dysmetabolism clinical features. DESIGN AND METHODS: Prediabetes patients were recruited at the Cardiology Service, Hospital Santa Marta, Centro Hospitalar Lisboa Central, EPE (CHLC-EPE). The study was approved by CHLC-EPE and NOVA Medical School Ethics Committee. Thirty-three prediabetic and 14 age-matched, non-prediabetic, volu...
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Cunha-Guimaraes JP, Guarino MP, Timoteo AT, Caires I, Sacramento JF, Ribeiro MJ, Selas M, Santiago JC, Mota Carmo M, Conde SV Tags: Eur J Endocrinol Source Type: research

Reference Intervals of Salivary Cortisol and Cortisone and their Diagnostic Accuracy in Cushing's syndrome.
CONCLUSION: Salivary cortisol and cortisone in late-night samples and after DST showed high accuracy for diagnosing CS, salivary cortisone being slightly, but significantly better. PMID: 32213657 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Bäcklund N, Brattsand G, Israelsson M, Ragnarsson O, Burman P, Edén Engstrom B, Höybye C, Berinder K, Wahlberg J, Olsson T, Dahlqvist P Tags: Eur J Endocrinol Source Type: research

Familial dysalbuminaemic hyperthyroxinemia interferes with current free thyroid hormone immunoassay methods.
CONCLUSIONS: All FT4 immunoassays evaluated are prone to interference by R218H FDH, with their varying susceptibility not being related to assay architecture but likely due to differing assay conditions or buffer composition. Added susceptibility of many FT3 assays to measurement interference, resulting in high FT4 and FT3 with non-suppressed TSH levels, raises the possibility of R218H FDH being misdiagnosed as Resistance to Thyroid Hormone beta or TSH-secreting pituitary tumour, potentially leading to unnecessary investigation and inappropriate treatment. PMID: 32213658 [PubMed - as supplied by publisher] (Source: Eu...
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C Tags: Eur J Endocrinol Source Type: research

Testosterone replacement therapy of opioid induced male hypogonadism improved body composition but not pain perception. A double-blinded, randomized and placebo-controlled trial.
en M Abstract BACKGROUND: Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear. PURPOSE: To measure changes in body composition, pain perception, quality of life and adrenal function after TRT or placebo in opioid treated men with chronic non-malignant pain. METHODS: Double-blind, placebo-controlled study in 41 men (>18 years) with total testosterone
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Glintborg D, Vægter HB, Christensen LL, Bendix E, Graven-Nielsen T, Andersen PG, Andersen M Tags: Eur J Endocrinol Source Type: research

Follow-up of low risk thyroid cancer patients: can we stop follow up after 5 years of complete remission?
Abstract Each year, the proportion of thyroid cancer patients presenting with low-risk disease is increasing. The shift in the landscape of thyroid cancer presentation is forcing clinicians to re-evaluate not only management, but surveillance paradigms. During the follow-up, patients are stratified considering their response to treatment, and classified into one of the following response categories: excellent biochemical incomplete, structural incomplete, or indeterminate. These categories reflect a real-time prognosis and thereby substantially influence and personalise disease management. Although at present, no ...
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Lamartina L, Handkiewicz-Junak D Tags: Eur J Endocrinol Source Type: research

Prothrombotic Fibrin Network Characteristics in Patients with Acromegaly: A Novel Mechanism for Vascular Complications.
This study aims to evaluate whether GH/IGF-1 excess increases vascular disease by adversely affecting fibrin network characteristics. DESIGN: Cross-sectional study in 40 patients with acromegaly (21 males, age 53±13yrs) and 40 age/gender-matched controls. METHODS: Clot structure was analysed using a validated turbidimetric assay and fibrin networks were visualised by laser scanning confocal microscopy (LSCM). Metabolic profile parameters, body composition, plasma fibrinogen and PAI-1 were also assessed. RESULTS: Twenty-two patients had active acromegaly and 18 were in remission. There was no differenc...
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Kyriakakis N, Pechlivani N, Lynch J, Oxley N, Phoenix F, Seejore K, Orme SM, Ajjan R, Murray RD Tags: Eur J Endocrinol Source Type: research

Overnight/first morning urine free metanephrines and methoxytyramine for diagnosis of pheochromocytoma and paraganglioma: Is this an option?
CONCLUSIONS: Measurements of urinary free catecholamine metabolites in first morning/overnight urine collections offer an alternative for diagnosis of PPGL to 24-hour collections but remain less accurate than plasma measurements. PMID: 32187575 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Peitzsch M, Kaden D, Pamporaki C, Langton K, Constantinescu G, Conrad C, Fliedner S, Sinnott RO, Prejbisz A, Därr R, Lenders JW, Bursztyn M, Eisenhofer G Tags: Eur J Endocrinol Source Type: research

Persistent cortisol response to desmopressin predicts recurrence of Cushing's Disease in patients with post-operative corticotropic insufficiency.
CONCLUSION: The disappearance of the response to the post-operative DT was independently associated with a lower odds of CD recurrence, and offers an incremental prognostic value, which may help to stratify patients in CI, and refine their follow-up according to the risk of recurrence. PMID: 32187576 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Cambos S, Mohammedi K, Castinetti F, Saie C, Young J, Chanson P, Tabarin A Tags: Eur J Endocrinol Source Type: research

In memoriam: Renato Pasquali (1946-2019).
PMID: 32163915 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Gambineri A, Vicennati V, Di Dalmazi G, Pelusi C, Altieri P, Fanelli F, Repaci A, Garelli S, Ribichini D, Pagotto U Tags: Eur J Endocrinol Source Type: research

Impact of age, body weight and metabolic risk factors on steroid reference intervals in men.
CONCLUSIONS: Obesity and mild unmedicated metabolic risk factors alter the circulating steroid profile and bias the estimation of reference limits for testosterone, dihydrotestosterone, cortisol and corticosterone. Applying age-dependent reference intervals is mandatory for steroid precursors and corticosteroids. PMID: 32130202 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Mezzullo M, Di Dalmazi G, Fazzini A, Baccini M, Repaci A, Gambineri A, Vicennati V, Pelusi C, Pagotto U, Fanelli F Tags: Eur J Endocrinol Source Type: research

In memoriam: Renato Pasquali (1946-2019).
PMID: 32058322 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 16, 2020 Category: Endocrinology Authors: Gambineri A, Vicennati V, Di Dalmazi G, Pelusi C, Altieri P, Fanelli F, Repaci A, Garelli S, Ribichini D, Pagotto U Tags: Eur J Endocrinol Source Type: research

Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome.
se M, JPAS/JRAS Study Group Abstract Objectives: We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA). Design: Multicenter retrospective study by Japan PA study. Method: We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenalectomy to three groups: basal lateralization index (LI) ≥2 with ACTH-stimulated LI ≥4 on the ipsilateral side (Unilateral (U) to U group, n = 245); basal LI
Source: European Journal of Endocrinology - February 11, 2020 Category: Endocrinology Authors: Kobayashi H, Nakamura Y, Abe M, Kurihara I, Itoh H, Ichijo T, Takeda Y, Yoneda T, Katabami T, Tsuiki M, Wada N, Ogawa Y, Sakamoto R, Kawashima J, Sone M, Inagaki N, Yoshimoto T, Yamada T, Okamoto R, Matsuda Y, Fujita M, Watanabe M, Tamura K, Tanabe A, Nar Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY: Glucocorticoid resistance syndrome
Abstract Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans). GC signaling follows several consecutive steps leading to target gene transactivation, including ligand binding, nuclear translocation of ligand-activated GR complexes, DNA binding, and recruitment of functional transcriptional machinery. Generalized glucocorticoid resistance syndrome, due to GR loss-of-function mutations, may be relate...
Source: European Journal of Endocrinology - January 31, 2020 Category: Endocrinology Authors: Vitellius G, Lombes M Tags: Eur J Endocrinol Source Type: research

Who is afraid of non-normal data? Choosing between parametric and non-parametric tests.
Abstract When statistically comparing outcomes between two groups, researchers have to decide whether to use parametric methods, such as the t-test, or non-parametric methods, like the Mann-Whitney test. In endocrinology, for example, many studies compare hormone levels between groups, or at different points in time. Many papers apply non-parametric tests to compare groups. We will explain that non-parametric tests have clear drawbacks in medical research, and, that's the good news, they are often not necessary. PMID: 31910149 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 8, 2020 Category: Endocrinology Authors: le Cessie S, Goeman JJ, Dekkers OM Tags: Eur J Endocrinol Source Type: research

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity.
Abstract Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are currently no data showing that more sophisticated methods are more useful to guide the endocrine work-up in obesity. An increased BMI leads to a number of hormonal changes. Additionally, concomitant hormonal diseases can be present in obesity and have to be properly diagnosed - which in turn might be more difficult due to alterations caused by body fatness itself. The present European Society of Endocrinology Clinical Guidel...
Source: European Journal of Endocrinology - December 21, 2019 Category: Endocrinology Authors: Pasquali R, Casanueva F, Haluzik M, van Hulsteijn L, Ledoux S, Monteiro MP, Salvador J, Santini F, Toplak H, Dekkers OM Tags: Eur J Endocrinol Source Type: research

High frequency of pathogenic ACAN variants including an intragenic deletion in selected individuals with short stature.
CONCLUSIONS: ACAN pathogenic variants presented a common cause of familial ISS. The selection criteria used in our study were suggested for a personalized approach to genetic testing of ACAN gene in clinical practice. Our results expanded the number of pathogenic ACAN variants, including the first intragenic deletion, and suggested CNV evaluation in patients with typical clinical features of aggrecanopathy as reasonable. Intra-familial phenotypic variability in growth patterns should be considered. PMID: 31841439 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Stavber L, Hovnik T, Kotnik P, Lovrečić L, Kovac J, Tesovnik T, Bertok S, Dovč K, Debeljak M, Battelino T, Avbelj Stefanija M Tags: Eur J Endocrinol Source Type: research

Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes.
Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes. Eur J Endocrinol. 2019 Dec 01;: Authors: Jensen NJ, Nilsson M, Ingerslev JS, Olsen DA, Fenger M, Svart M, Møller N, Zander M, Miskowiak KW, Rungby J Abstract OBJECTIVE: Cognitive impairment in type 2 diabetes is associated with cerebral glucose hypometabolism. Providing a glucose substitute such as ketone bodies might restore metabolic balance in glucose compromised neurones and improve cognitive performance. We aimed to investigate if β-hydroxybutyrate (ketone body) infusion acutely affects cognitive performa...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Jensen NJ, Nilsson M, Ingerslev JS, Olsen DA, Fenger M, Svart M, Møller N, Zander M, Miskowiak KW, Rungby J Tags: Eur J Endocrinol Source Type: research

Pancreatic Alpha Cell Mass Across Adult Human Lifespan.
We examined human pancreatic autopsy tissue from 66 lean non-diabetic individuals aged from 30-102 years, grouped into deciles: 3rd(30-39 years), 4th(40-49 years), 5th(50-59 years), 6th(60-69 years), 7th(70-79 years), 8th(80-89 years) and 9th deciles(90+ years). Sections of pancreas were immunostained for glucagon and analyzed for fractional alpha-cell area. Population-based pancreatic volume data was used to calculate alpha-cell mass. RESULTS: With advanced age, the exocrine pancreas undergoes atrophy demonstrated by increased fat area (as % exocrine area) (0.05±0.01 vs 1.6±0.7% fat area of total exocri...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Moin ASM, Cory M, Gurlo T, Saisho Y, Rizza R, Butler BP, Butler A Tags: Eur J Endocrinol Source Type: research

Association between Polycyclic Aromatic Hydrocarbons Exposure and Bone Turnover in Adults.
Abstract BACKGROUND: Cigarette smoking is a risk factor of osteoporosis and bone fracture. Tobacco smoke contains several polycyclic aromatic hydrocarbons. Thus, we hypothesized that environmental polycyclic aromatic hydrocarbon exposure is associated with bone loss and fracture risk. The present study examined the association between polycyclic aromatic hydrocarbon exposure and bone turnover in the general adult population. METHODS: A total of 1408 eligible participants from the National Health and Nutrition Examination Survey (NHANES 2001-2006) were included in this cross-sectional analysis. The levels of u...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Chen YY, Kao TW, Wang CC, Wu CJ, Chou YC, Chen WL Tags: Eur J Endocrinol Source Type: research

Use of late-night salivary cortisol to monitor response to medical treatment in Cushing's disease.
CONCLUSIONS: mUFC and mLNSC are complementary measurements for monitoring treatment response in Cushing's disease, with better clinical outcomes seen for patients in whom both mUFC and mLNSC are controlled. PMID: 31804965 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Newell-Price J, Pivonello R, Tabarin A, Fleseriu M, Witek P, Gadelha MR, Petersenn S, Tauchmanova L, Ravichandran S, Gupta P, Lacroix A, Biller B Tags: Eur J Endocrinol Source Type: research

Impact of total thyroidectomy on quality of life at 6 months: the prospective ThyrQoL multicentre trial.
This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL), and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in case of benign thyroid benign, and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism). DESIGN: The prospective ThyrQoL multicentre trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven Fr...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Mirallié E, Borel F, Trésallet C, Hamy A, Mathonnet M, Lifante JC, Brunaud L, Menegaux F, Hardouin JB, Blanchard C Tags: Eur J Endocrinol Source Type: research

Monozygotic Twins Discordant for Congenital Adrenal Hyperplasia due to Mosaicism.
CONCLUSIONS: The genetic findings are consistent with mosaicism for two CYP21A2 cell lines in both twins. The first cell line is expected, based on parental results, while the second line is due to a postzygotic full gene deletion of the paternally-inherited wildtype CYP21A2. The resultant genotype, compound heterozygosity for c.293-13C>G and a CYP21A2 full gene deletion, is consistent with a salt-wasting CAH phenotype. Differential distribution of the second cell line between the twins is most likely the cause for their discrepant phenotypes. We believe this is the first report of somatic CYP21A2 mosaicism, and represe...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Kluge ML, Graber E, Foley K, Hansen LV, Sellers HL, Milosevic D, Cradic KW, Grebe SK Tags: Eur J Endocrinol Source Type: research

Congenital hypogonadotropic hypogonadism/Kallmann Syndrome is associated with statural gain in both men and women: a monocentric study.
We examined correlations between ∆H and age at diagnosis and therapeutically-induced individual statural gain. RESULTS: Mean AH in men and women with CHH/KS was greater than in the French general population. Patients of both sexes had statural gain (AH>TH). Males with CHH/KS were significantly, albeit moderately, taller than their brothers. ∆H was higher in CHH/KS compared to unaffected siblings (+6.2±7.2 cm versus +3.4±5.2 cm, p
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Maione L, Pala G, Bouvattier C, Trabado S, Papadakis G, Chanson P, Bouligand J, Pitteloud N, Dwyer AA, Maghnie M, Young J Tags: Eur J Endocrinol Source Type: research

Commentary - LONG ACTING PORCINE SEQUENCE ACTH IN THE DIAGNOSIS OF ADRENAL INSUFFICIENCY. A cost effective alternative to the ACTH1-24 test.
Abstract While the ACTH1-24 test has some well documented short comings, it is the most widely used test to diagnose primary and secondary adrenal insufficiency. However, this synthetic ACTH preparation is not readily available in some countries. Research from India has demonstrated that using a long acting porcine sequence ACTH has similar diagnostic performance to ACTH1-24 at around 25% of the cost. This may allow access to a robust test for adrenal insufficiency to developing countries and potentially allow thousands of patients to be identified and appropriately treated. PMID: 31770103 [PubMed - as suppli...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Inder WJ Tags: Eur J Endocrinol Source Type: research

Increased risk of low bone mineral density in patients with non-alcoholic fatty liver disease: a cohort study.
CONCLUSION: NAFLD and its severity were independently associated with an increased incidence of low BMD. Obesity and female gender are risk factors associated with low BMD. Our findings indicated NAFLD can be a significant contributor to low BMD pathogenesis, requiring further studies to elucidate the potential mechanisms. PMID: 31770104 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Shen Z, Cen L, Chen X, Pan J, Li Y, Chen W, Yu C Tags: Eur J Endocrinol Source Type: research

Prolactin ≤1 ng/mL Predicts Macroprolactinoma Reduction after Cabergoline Therapy.
CONCLUSIONS: A prolactin level ≤1 ng/mL at 3 months after cabergoline treatment was correlated with a significant tumor size reduction in patients with macroprolactinoma. This finding may help clinical decision-making when treating macroprolactinoma patients. PMID: 31770105 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Kim D, Ku CR, Kim K, Jung H, Lee EJ Tags: Eur J Endocrinol Source Type: research

Plasma levels of ghrelin, des-acyl ghrelin and leap2 in children with obesity: correlation with age and insulin resistance.
CONCLUSIONS: Our findings suggest that ghrelin tone is increased in childhood obesity, due to a decrease on plasma levels of des-acyl ghrelin and LEAP2, and that des-acyl ghrelin is associated to insulin resistance, particularly in children with overweight/obesity. PMID: 31770106 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Fittipaldi A, Hernandez J, Castrogiovanni D, Lufrano D, De Francesco PN, Garrido V, Vitaux P, Fasano MV, Fehrentz JA, Fernández A, Andreoli MF, Perello M Tags: Eur J Endocrinol Source Type: research

Safety and rapid efficacy of guideline-based gender affirming hormone therapy: an analysis of 388 individuals diagnosed with gender dysphoria.
Abstract OBJECTIVE: Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of individuals under guideline-based treatment. DESIGN/METHODS: Cohort study of medical files of n=155 male-to-female (transwomen) and n=233 female-to-male transgender persons (transmen) of an Endocrine outpatient clinic between 2009 and 2017. RESULTS: Median time to reach amenorrhoea i...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Meyer G, Mayer M, Mondorf A, Fluegel AK, Herrmann E, Bojunga J Tags: Eur J Endocrinol Source Type: research

Genetic investigation of patients with tall stature.
CONCLUSION: A systematic molecular approach of patients with tall stature was able to identify the etiology in 13 out of 30 (43.3%) syndromic and 1 out of 12 (8.3%) non-syndromic patients, contributing to the genetic counseling and avoiding unfavorable outcomes in the syndromic subgroup. PMID: 31751304 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Vasco de Albuquerque Albuquerque E, Ferreira de Assis Funari M, Pereira de Souza Quedas E, Sayuri Honjo Kawahira R, Soares Jallad R, Homma TK, Martin R, Brito VN, Malaquias AC, Lerario AM, Rosenberg C, Victorino Krepischi AC, Ae Kim C, Arnhold IJ, Jorge A Tags: Eur J Endocrinol Source Type: research

Effectiveness and toxicity of lenvatinib in refractory thyroid cancer: Dutch real-life data.
CONCLUSIONS: PFS in our non-trial population was significantly shorter than in the SELECT trial population. In the interpretation of results, differences in the real life population and the SELECT study population regarding patient characteristics should be taken into account. PMID: 31751307 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Aydemirli MD, Kapiteijn E, Ferrier KRM, Ottevanger N, Links TP, van der Horst-Schrivers ANA, Broekman KE, Groenwold RHH, Zwaveling J Tags: Eur J Endocrinol Source Type: research

Actual Causes of Death in Thyroid Cancer Patients in Korea: A Nationwide Case Control Cohort Study.
CONCLUSIONS: Excellent overall survival was observed in TC patients. The most common cause of death was TC-specific mortality, suggesting the importance of thyroid cancer treatment. The overall and cause-specific mortality risks, particularly CVD mortality risk, did not differ between TC patients and the general population. PMID: 31721722 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Kim KJ, Jang S, Kim KJ, An JH, Kim NH, Shin DY, Yoo HJ, Kim HY, Seo JA, Kim NH, Lee J, Choi KM, Baik SH, Kim SG Tags: Eur J Endocrinol Source Type: research