Use of late-night salivary cortisol to monitor response to medical treatment in Cushing's disease.
CONCLUSIONS: mUFC and mLNSC are complementary measurements for monitoring treatment response in Cushing's disease, with better clinical outcomes seen for patients in whom both mUFC and mLNSC are controlled. PMID: 31804965 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Newell-Price J, Pivonello R, Tabarin A, Fleseriu M, Witek P, Gadelha MR, Petersenn S, Tauchmanova L, Ravichandran S, Gupta P, Lacroix A, Biller B Tags: Eur J Endocrinol Source Type: research

Impact of total thyroidectomy on quality of life at 6 months: the prospective ThyrQoL multicentre trial.
This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL), and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in case of benign thyroid benign, and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism). DESIGN: The prospective ThyrQoL multicentre trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven Fr...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Mirallié E, Borel F, Trésallet C, Hamy A, Mathonnet M, Lifante JC, Brunaud L, Menegaux F, Hardouin JB, Blanchard C Tags: Eur J Endocrinol Source Type: research

Monozygotic Twins Discordant for Congenital Adrenal Hyperplasia due to Mosaicism.
CONCLUSIONS: The genetic findings are consistent with mosaicism for two CYP21A2 cell lines in both twins. The first cell line is expected, based on parental results, while the second line is due to a postzygotic full gene deletion of the paternally-inherited wildtype CYP21A2. The resultant genotype, compound heterozygosity for c.293-13C>G and a CYP21A2 full gene deletion, is consistent with a salt-wasting CAH phenotype. Differential distribution of the second cell line between the twins is most likely the cause for their discrepant phenotypes. We believe this is the first report of somatic CYP21A2 mosaicism, and represe...
Source: European Journal of Endocrinology - December 1, 2019 Category: Endocrinology Authors: Kluge ML, Graber E, Foley K, Hansen LV, Sellers HL, Milosevic D, Cradic KW, Grebe SK Tags: Eur J Endocrinol Source Type: research

Congenital hypogonadotropic hypogonadism/Kallmann Syndrome is associated with statural gain in both men and women: a monocentric study.
We examined correlations between ∆H and age at diagnosis and therapeutically-induced individual statural gain. RESULTS: Mean AH in men and women with CHH/KS was greater than in the French general population. Patients of both sexes had statural gain (AH>TH). Males with CHH/KS were significantly, albeit moderately, taller than their brothers. ∆H was higher in CHH/KS compared to unaffected siblings (+6.2±7.2 cm versus +3.4±5.2 cm, p
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Maione L, Pala G, Bouvattier C, Trabado S, Papadakis G, Chanson P, Bouligand J, Pitteloud N, Dwyer AA, Maghnie M, Young J Tags: Eur J Endocrinol Source Type: research

Commentary - LONG ACTING PORCINE SEQUENCE ACTH IN THE DIAGNOSIS OF ADRENAL INSUFFICIENCY. A cost effective alternative to the ACTH1-24 test.
Abstract While the ACTH1-24 test has some well documented short comings, it is the most widely used test to diagnose primary and secondary adrenal insufficiency. However, this synthetic ACTH preparation is not readily available in some countries. Research from India has demonstrated that using a long acting porcine sequence ACTH has similar diagnostic performance to ACTH1-24 at around 25% of the cost. This may allow access to a robust test for adrenal insufficiency to developing countries and potentially allow thousands of patients to be identified and appropriately treated. PMID: 31770103 [PubMed - as suppli...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Inder WJ Tags: Eur J Endocrinol Source Type: research

Increased risk of low bone mineral density in patients with non-alcoholic fatty liver disease: a cohort study.
CONCLUSION: NAFLD and its severity were independently associated with an increased incidence of low BMD. Obesity and female gender are risk factors associated with low BMD. Our findings indicated NAFLD can be a significant contributor to low BMD pathogenesis, requiring further studies to elucidate the potential mechanisms. PMID: 31770104 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Shen Z, Cen L, Chen X, Pan J, Li Y, Chen W, Yu C Tags: Eur J Endocrinol Source Type: research

Prolactin ≤1 ng/mL Predicts Macroprolactinoma Reduction after Cabergoline Therapy.
CONCLUSIONS: A prolactin level ≤1 ng/mL at 3 months after cabergoline treatment was correlated with a significant tumor size reduction in patients with macroprolactinoma. This finding may help clinical decision-making when treating macroprolactinoma patients. PMID: 31770105 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Kim D, Ku CR, Kim K, Jung H, Lee EJ Tags: Eur J Endocrinol Source Type: research

Plasma levels of ghrelin, des-acyl ghrelin and leap2 in children with obesity: correlation with age and insulin resistance.
CONCLUSIONS: Our findings suggest that ghrelin tone is increased in childhood obesity, due to a decrease on plasma levels of des-acyl ghrelin and LEAP2, and that des-acyl ghrelin is associated to insulin resistance, particularly in children with overweight/obesity. PMID: 31770106 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Fittipaldi A, Hernandez J, Castrogiovanni D, Lufrano D, De Francesco PN, Garrido V, Vitaux P, Fasano MV, Fehrentz JA, Fernández A, Andreoli MF, Perello M Tags: Eur J Endocrinol Source Type: research

Safety and rapid efficacy of guideline-based gender affirming hormone therapy: an analysis of 388 individuals diagnosed with gender dysphoria.
Abstract OBJECTIVE: Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of individuals under guideline-based treatment. DESIGN/METHODS: Cohort study of medical files of n=155 male-to-female (transwomen) and n=233 female-to-male transgender persons (transmen) of an Endocrine outpatient clinic between 2009 and 2017. RESULTS: Median time to reach amenorrhoea i...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Meyer G, Mayer M, Mondorf A, Fluegel AK, Herrmann E, Bojunga J Tags: Eur J Endocrinol Source Type: research

Genetic investigation of patients with tall stature.
CONCLUSION: A systematic molecular approach of patients with tall stature was able to identify the etiology in 13 out of 30 (43.3%) syndromic and 1 out of 12 (8.3%) non-syndromic patients, contributing to the genetic counseling and avoiding unfavorable outcomes in the syndromic subgroup. PMID: 31751304 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Vasco de Albuquerque Albuquerque E, Ferreira de Assis Funari M, Pereira de Souza Quedas E, Sayuri Honjo Kawahira R, Soares Jallad R, Homma TK, Martin R, Brito VN, Malaquias AC, Lerario AM, Rosenberg C, Victorino Krepischi AC, Ae Kim C, Arnhold IJ, Jorge A Tags: Eur J Endocrinol Source Type: research

Effectiveness and toxicity of lenvatinib in refractory thyroid cancer: Dutch real-life data.
CONCLUSIONS: PFS in our non-trial population was significantly shorter than in the SELECT trial population. In the interpretation of results, differences in the real life population and the SELECT study population regarding patient characteristics should be taken into account. PMID: 31751307 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Aydemirli MD, Kapiteijn E, Ferrier KRM, Ottevanger N, Links TP, van der Horst-Schrivers ANA, Broekman KE, Groenwold RHH, Zwaveling J Tags: Eur J Endocrinol Source Type: research

Actual Causes of Death in Thyroid Cancer Patients in Korea: A Nationwide Case Control Cohort Study.
CONCLUSIONS: Excellent overall survival was observed in TC patients. The most common cause of death was TC-specific mortality, suggesting the importance of thyroid cancer treatment. The overall and cause-specific mortality risks, particularly CVD mortality risk, did not differ between TC patients and the general population. PMID: 31721722 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Kim KJ, Jang S, Kim KJ, An JH, Kim NH, Shin DY, Yoo HJ, Kim HY, Seo JA, Kim NH, Lee J, Choi KM, Baik SH, Kim SG Tags: Eur J Endocrinol Source Type: research

Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity.
Abstract OBJECTIVES: In men of black west African (BAM) and white European (WEM) ethnicity, we aimed to 1) compare adipose tissue, peripheral and hepatic insulin sensitivity, and 2) investigate associations between ectopic fat and insulin sensitivity by ethnicity. DESIGN AND METHODS: In overweight BAM (n=21) and WEM (n=23) with normal glucose tolerance, we performed a two-step hyperinsulinaemic-euglycaemic clamp with infusion of [6,6 2H2]-glucose and [2H5]-glycerol to measure whole body, peripheral, hepatic and adipose tissue insulin sensitivity (lipolysis). Visceral adipose tissue (VAT), intrahepatic lipids ...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Bello O, Ladwa M, Hakim O, Marathe C, Shoajee-Moradie F, Charles-Edwards G, Peacock JL, Umpleby MA, Amiel S, Goff L Tags: Eur J Endocrinol Source Type: research

Identification of exosomal miRNA biomarkers for diagnosis of papillary thyroid cancer by small RNA sequencing.
CONCLUSIONS: Plasma exosomal miR-485-3p and miR-4433a-5p might serve as biomarkers for PTC diagnosis. Plasma exosomal miR-485-3p could enable discrimination between high-risk and low-risk PTC. PMID: 31721725 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Dai D, Tan Y, Guo L, Tang A, Zhao Y Tags: Eur J Endocrinol Source Type: research

Relationships between metabolic status, seminal adipokines and reproductive functions in men from infertile couples.
CONCLUSIONS: These results suggest an involvement of seminal adipokines to modulate fertility in men with MS, and that seminal IL-6 could play a beneficial role on sperm functionality. Further mechanistic studies are necessary to investigate the precise roles of these adipokines in male reproduction. PMID: 31705791 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Elfassy Y, Bongrani A, Levy P, Foissac F, Fellahi S, Faure C, McAvoy C, Capeau J, Dupont J, Fève B, Levy R, Bastard JP Tags: Eur J Endocrinol Source Type: research

Geoffrey Harris Award 2019: Translational research in pituitary tumors.
Abstract Although effective treatment regimens (surgical resection, drug treatment with dopamine agonists or somatostatin analogues, radiotherapy) have been established for the therapy of most pituitary tumours, a considerable proportion of affected patients cannot completely cured due to incomplete resection or drug resistance. Moreover, even if hormone levels have been normalized, patients with hormone secreting tumours still show persistent pathophysiological alterations in metabolic, cardiovascular or neuropsychiatric parameters and have an impaired quality of life. In this review reasons for the discrepancy b...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Stalla G, Dimopoulou C, Jung-Sievers C, Arzt E, Paez Pereda M, Theodoropoulou M, Ciato D, Renner U Tags: Eur J Endocrinol Source Type: research

Is MRI follow-up relevant in patients with GH-secreting pituitary adenomas primarily treated and responsive to long-acting somatostatin analogues (SMSa)?
Abstract OBJECTIVE: Primary SMSa treatment can be associated with hormonal control and tumor shrinkage in patients with GH-secreting pituitary adenomas. The aim of this study was to evaluate whether regular MRI follow-up was necessary in patients with acromegaly treated and responsive to first generation long-acting SMSa. PATIENTS AND METHODS: In this retrospective monocentric study we included patients with GH/IGF-1 hypersecretion and pituitary adenomas with normal visual field, primarily treated with first generation long-acting SMSa between 1995 and 2015, and regularly monitored (clinical evaluation, GH/IG...
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Grandgeorge N, Barchetti G, Grunenwald S, Bonneville F, Caron PJ Tags: Eur J Endocrinol Source Type: research

Relation of IGF-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and NT-proBNP.
CONCLUSIONS: The study detected significant relations between IGF-I and long-term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities. PMID: 31705797 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2019 Category: Endocrinology Authors: Eichner M, Wallaschofski H, Schminke U, Volzke H, Dörr M, Felix SB, Nauck M, Friedrich N Tags: Eur J Endocrinol Source Type: research

CLCN2 clicks with aldosterone-producing adenomas, too!
Abstract Germline mutations in the chloride channel gene CLCN2 have been described as cause of familial hyperaldosteronism type II. In this issue, Dutta and colleagues in a groundbreaking study identify a somatic (tumor-specific) CLCN2 mutation in an aldosterone-producing adenoma, expanding the disease spectrum associated with CLCN2 mutations. PMID: 31585437 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2019 Category: Endocrinology Authors: Scholl UI Tags: Eur J Endocrinol Source Type: research

USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status.
Conclusion USP8 mutations occur in functioning and silent corticotrophinomas. They have pleiotropic effect, not limited to EGFR signalling, and affect expression levels of many genes involved in different pathways. Expression of GABA-related genes GABBR2, GNAL, GABARD and KCNJ5 correspond to functional status of the tumours. PMID: 31581124 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 1, 2019 Category: Endocrinology Authors: Bujko M, Kober P, Boresowicz J, Rusetska N, Paziewska A, Dabrowska M, Piascik A, Pekul M, Zielinski G, Kunicki J, Bonicki W, Ostrowski J, Siedlecki JA, Maksymowicz M Tags: Eur J Endocrinol Source Type: research

The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort.
CONCLUSIONS: Prediabetes and T2DM were positively linked to serum concentration of progesterone, and negatively related to pregnenolone in dose-response manner in Chinese rural population. PMID: 31581126 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 1, 2019 Category: Endocrinology Authors: Jiang J, Liu X, Liu X, Tian Z, Zhang H, Qian X, Luo Z, Wei D, Jin S, Wang C, Mao Z Tags: Eur J Endocrinol Source Type: research

Association of adrenal insufficiency with patient-oriented health-care outcomes in adult medical inpatients.
Abstract OBJECTIVE Adrenal insufficiency in the outpatient setting is associated with excess morbidity, mortality, and impaired quality of life. Evidence on its health-care burden in medical inpatients is scarce. The aim of this study was to assess the health-care burden of primary (PAI) and secondary adrenal insufficiency (SAI) among hospitalized inpatients. DESIGN and METHODS In this nationwide cohort study, adult medical patients with either PAI or SAI hospitalized between 2011 and 2015 were compared with propensity-matched (1:1) medical controls, respectively. The primary outcome was 30-day all-cause in-hospit...
Source: European Journal of Endocrinology - October 1, 2019 Category: Endocrinology Authors: Ebrahimi F, Widmer A, Wagner U, Mueller B, Schuetz P, Christ-Crain M, Kutz A Tags: Eur J Endocrinol Source Type: research

Commentary on article: Adrenal crisis in treated patients with Cushing's syndrome.
Abstract A study has examined the rates of adrenal crises in patients treated with pituitary or adrenal surgery. Rates were substantial (approximately 9 per 100 patient years), perhaps representing suppression of corticotrope ACTH secretion and deprivation of normal corticotrope number postoperatively. Hormone withdrawal syndrome may have contributed to the rates of apparent adrenal crises given the definition used. Higher rates were seen in patients given relatively high dose glucocorticoids postoperatively in one of the two centres where patients were treated - perhaps some of the patients in the high dose centr...
Source: European Journal of Endocrinology - September 12, 2019 Category: Endocrinology Authors: Torpy DJ Tags: Eur J Endocrinol Source Type: research

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia.
Abstract BACKGROUND: HLA-G is an immune checkpoint molecule, naturally expressed during pregnancy, playing a critical role in the tolerance of the fetal semi-allograft from the maternal immune system. While HLA-G expression levels are associated with progesterone, the influence of other hormones is still unclear. Congenital adrenal hyperplasia (CAH) represents an adequate model to study the hormonal influence on biomarkers as it leads to impaired cortisol biosynthesis and increased progesterone and androgens production due to 21-hydroxylase enzyme deficiency. METHODS: In a cross-sectional study of CAH patient...
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Nguyen LS, Rouas-Freiss N, Funck-Brentano C, Leban M, Carosella E, Touraine P, Varnous S, Bachelot A, Salem JE Tags: Eur J Endocrinol Source Type: research

IGF-1 and IGF-1 SDS - fit for purpose?
Abstract Three recent publications in this journal have reported that the differences in IGF-1 normative data significantly impact the classification of patients with growth hormone (GH)- excess and deficiency disorders in such a way that clinical performance is severely flawed. This concerns not only pediatric but also adult patients. With this letter, we aim to address additional issues, not previously addressed, which add to the complexity of the interpretation of IGF-1 results. Specifically, the relation between analytical performance of IGF-1 assays and acceptable clinical performance is discussed. PMID:...
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Kos S, Cobbaert C, Kuijper MT, Oostdijk W, Hannema SE, Wit JM, Biermasz NR, Ballieux BE Tags: Eur J Endocrinol Source Type: research

Brown adipose tissue activity is reduced in women with polycystic ovary syndrome.
CONCLUSIONS: BAT activity was reduced in women with PCOS possibly due to increased central adiposity. In PCOS women, BAT activity did not correlate with plasma irisin levels. PMID: 31491743 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Oliveira FR, Mamede M, Bizzi MF, Rocha AL, Ferreira CN, Gomes KB, Cândido AL, Reis FM Tags: Eur J Endocrinol Source Type: research

Case report: A somatic mutation in CLCN2 identified in a sporadic aldosterone producing adenoma.
Conclusion In this study, we identified a CLCN2 mutation in a sporadic APA comprising about 1% of all APAs investigated. This mutation was complementary to mutations in other susceptibility genes for sporadic APAs and may thus be a driving mutation in APA formation. PMID: 31491746 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Dutta RK, Arnesen T, Heie A, Walz MK, Alesina P, Söderkvist P, Gimm O Tags: Eur J Endocrinol Source Type: research

Bone mineral density, body composition and metabolic profiles in adult women with complete androgen insensitivity syndrome and removed gonads using oral or transdermal estrogens.
CONCLUSIONS: Our results reinforce the importance of adequate hormonal treatment in women living with CAIS, suggesting a better effect from the transdermal route over the oral route. PMID: 31491747 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Gava G, Mancini I, Orsili I, Bertelloni S, Alvisi S, Seracchioli R, Meriggiola MC Tags: Eur J Endocrinol Source Type: research

DIAGNOSIS OF ENDOCRINE DISEASE: Pituitary stalk interruption syndrome: etiology and clinical manifestations.
Abstract Pituitary stalk interruption syndrome (PSIS) is a congenital pituitary anatomical defect. This syndrome is an antenatal developmental defect belonging to the holoprosencephaly phenotype spectrum. It is heterogeneous regarding clinical, biological and radiological presentation and is characterized by the following triad: thin or interrupted pituitary stalk connecting the hypothalamus to the pituitary gland, missing or ectopic posterior lobe, and hypoplasia or aplasia of the anterior lobe. This review reports current knowledge about the composite pathogenesis, for which underlying mechanisms remain unclear....
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Vergier J, Castinetti F, Saveanu A, Girard N, Brue T, Reynaud R Tags: Eur J Endocrinol Source Type: research

High mortality within 90 days of diagnosis in patients with Cushing's syndrome - Results from the ERCUSYN registry.
Conclusion Mortality rate was highest in patients with ectopic CS. Infectious diseases were the commonest cause of death soon after diagnosis, emphasizing the need for clinical vigilance at that time, especially in patients with diabetes mellitus. PMID: 31480014 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Valassi E, Tabarin A, Brue T, Feelders RA, Reincke M, Netea-Maier R, Toth M, Zacharieva S, Webb SM, Tsagarakis S, Chanson P, Pfeifer M, Droste M, Komerdus I, Kastelan D, Maiter D, Chabre O, Franz H, Santos A, Strasburger CJ, Trainer PJ, Newell-Price J, Ra Tags: Eur J Endocrinol Source Type: research

Determinants Of The Growth Hormone Nadir During Oral Glucose Tolerance Test In Adults - commentary.
Abstract N/A. PMID: 31480015 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2019 Category: Endocrinology Authors: Trainer PJ, Monaghan P Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Immune check point inhibitors-induced hypophysitis.
Abstract In recent years, the development of immunotherapy has constituted a revolution in the therapy for many cancers, with a specific toxicity profile including endocrine immune-related adverse events. Immune check point inhibitors (ICI)-induced hypophysitis is a common endocrine side effect, particularly with CTLA-4 antibodies and combination therapy, with frequent hormonal deficiencies at diagnosis. It can be difficult to evoke such diagnosis as the initial clinical symptoms are not specific (headache, asthenia…); thus, patients receiving such immunomodulatory therapies should be closely monitored by s...
Source: European Journal of Endocrinology - July 18, 2019 Category: Endocrinology Authors: Albarel F, Castinetti F, Brue T Tags: Eur J Endocrinol Source Type: research

Primary hyperparathyroidism with surgical indication and negative or equivocal scintigraphy: safety and reliability of PTH washout. A systematic review and meta-analysis.
Conclusions: In patients with biochemically proven PHPT and discordant imaging, FNA-PTH was a safe and accurate procedure. In this specific setting of patients, FNA-PTH could be used as a rule-in test for minimally invasive parathyroidectomy. PMID: 31311003 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 18, 2019 Category: Endocrinology Authors: Castellana M, Virili C, Palermo A, Giorgino F, Giovanella L, Trimboli P Tags: Eur J Endocrinol Source Type: research

DIAGNOSIS OF ENDOCRINE DISEASE: Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview.
Abstract In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities via different mechanisms, including direct alteration of hormone production, changes in the regulation of the feedback axis, on hormonal transport, binding and signaling, as well as similar changes to counter-regulatory hormone systems. Furthermore, drugs can interfere with the hormonal assays, leading to erroneous laboratory results that disorientate clinicians from the right diagn...
Source: European Journal of Endocrinology - June 28, 2019 Category: Endocrinology Authors: Diamanti-Kandarakis E, Duntas L, Kanakis GA, Kandaraki E, Karavitaki N, Kassi E, Livadas S, Mastorakos G, Migdalis I, Miras AD, Nader S, Papalou O, Poladian R, Popovic V, Rachoń D, Tigas S, Tsigos C, Tsilchorozidou T, Tzotzas T, Bargiota A, Pfeifer M Tags: Eur J Endocrinol Source Type: research

New genetic findings in a large cohort of congenital hypogonadotropic hypogonadism.
Conclusions: This is a large study of the molecular genetics of CHH providing new genetic findings for this complex and heterogeneous genetic condition. NGS has been shown to be a fast, reliable and effective tool in the molecular diagnosis of congenital CHH and being able to targeting clinical genetic testing in the future. PMID: 31200363 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 16, 2019 Category: Endocrinology Authors: Amato LGL, Montenegro LR, Lerario AM, Jorge AAL, Guerra Junior G, Schnoll C, Renck AC, Trarbach EB, Costa EMF, Mendonca BB, Latronico AC, Silveira LFG Tags: Eur J Endocrinol Source Type: research

The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes.
CONCLUSIONS: The diurnal variation in bone formation is attenuated in patients with type 2 diabetes. This is not explained by changes in incretin hormone levels, but possibly mediated by sclerostin. PMID: 31189129 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Hygum K, Starup-Linde JK, Harsløf T, Joergensen NR, Hartmann B, Holst JJ, Langdahl B Tags: Eur J Endocrinol Source Type: research

Lean non-alcoholic fatty liver disease and development of diabetes: A cohort study.
CONCLUSIONS: In this large cohort study, the presence and severity of NAFLD in normal-weight adults was associated with an increased incidence of diabetes independently of established risk factors. Indeed, isolated lean NAFLD was a stronger risk factor for incident diabetes than the presence of overweight/obesity without NAFLD. Subjects with lean NAFLD require careful monitoring for the development of metabolic abnormalities. PMID: 31176297 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Sinn DH, Kang D, Cho SJ, Paik SW, Guallar E, Cho J, Gwak GY Tags: Eur J Endocrinol Source Type: research

Effects of GLP-1 on counter-regulatory responses during hypoglycemia after GBP surgery.
CONCLUSIONS/INTERPRETATION: Short term exposure to a GLP-1 receptor agonist does not seem to impact the counter-regulatory hormonal and metabolic responses in post-GBP subjects during hypoglycemic conditions, suggesting that the reduction of postprandial symptoms post-GBP seen with exogenous GLP-1 may be mediated by mechanism not directly involved in counter-regulation. PMID: 31176298 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Almby KE, Abrahamsson N, Lundqvist MH, Hammar U, Thombare K, Panagiotou A, Karlsson FA, Sundbom M, Wiklund U, Eriksson J Tags: Eur J Endocrinol Source Type: research

Hypophysitis secondary to nivolumab and pembrolizumab is a clinical entity distinct from ipilimumab-associated hypophysitis.
Abstract OBJECTIVE: Little has been published describing hypophysitis after nivolumab or pembrolizumab treatment. We aimed to (i) assess the risk of hypophysitis following nivolumab or pembrolizumab treatment, (ii) characterize the clinical presentation and outcomes in these patients, and (iii) compare these patients to hypophysitis following ipilimumab and ipilimumab plus nivolumab (combo). We hypothesized that headaches, pituitary enlargement on MRI, and multiple anterior pituitary hormone deficiencies would occur less often in the nivolumab/pembrolizumab group versus ipilimumab or combo hypophysitis patients. ...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Faje A, Reynolds K, Zubiri L, Lawrence D, Cohen J, Sullivan R, Nachtigall LB, Tritos N Tags: Eur J Endocrinol Source Type: research

Adrenal venous sampling: cosyntropin stimulation or not?
Abstract Notwithstanding the high prevalence of primary aldosteronism (PA), probably the most common form of secondary hypertension, the diagnosis of PA is often neglected, or delayed, thus precluding target treatment, which is curative in many cases. For selection of the most appropriate treatment a fundamental step is the distinction between a lateralized form, mainly aldosterone-producing adenoma (APA), and bilateral adrenocortical hyperplasia (BAH), also known as idiopathic hyperaldosteronism (IHA). To this aim all current guidelines recommend adrenal vein sampling (AVS), a technically challenging procedure th...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Deinum J, Groenewoud H, Wilt GJV, Rossi G, Lenzini L Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Unmet therapeutic, educational and scientific needs in parathyroid disorders.
Abstract PARAT, a new European Society of Endocrinology program, aims to identify unmet scientific and educational needs of parathyroid disorders, such as primary hyperparathyroidism (PHPT), including parathyroid cancer (PC), and hypoparathyroidism (HypoPT). The discussions and consensus statements from the first PARAT workshop (September 2018) are reviewed. PHPT has a high prevalence in Western communities, PHPT has a high prevalence in Western communities, yet evidence is sparse concerning the natural history and whether morbidity and long-term outcomes are related to hypercalcemia or plasma PTH concentrations, ...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Bollerslev J, Schalin-Jantti C, Rejnmark L, Siggelkow H, Morreau H, Thakker RV, Sitges-Serra A, Cetani F, Marcocci C Tags: Eur J Endocrinol Source Type: research

Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46,XY disorder of sex development.
r A Abstract Testosterone production by the fetal testis depends on a functional relationship between hCG and the LH/chorionic gonadotrophin receptor (LHCGR). Failure of the receptor to correctly respond to its ligand leads to impaired sexual differentiation in males. A phenotypically-female patient with pubertal delay, had a 46,XY karyotype and was diagnosed with 46X,Y disorder of sex development (DSD). Novel compound heterozygous LHCGR mutations were found in the signal peptide: a duplication p.L10_Q17dup of maternal origin, and a deletion (p.K12_L15del) and a p.L16Q missense mutation of paternal origin. cAMP pr...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Potorac I, Trehan A, Szymanska K, Fudvoye J, Thiry A, Huhtaniemi IT, Daly AF, Beckers A, Parent AS, Rivero-Müller A Tags: Eur J Endocrinol Source Type: research

Excellent response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma - commentary.
Abstract Recent publications suggested that pasireotide could be a good therapeutic option in some dopamine resistant or aggressive prolactinomas. We discussed the 2 published cases and describe another case of poorly-differentiated plurihormonal PIT-1 positive adenoma with moderate SSTR2 expression and intense STTR5 expression succeffuly treated with PAS-LAR 40mg/month. PMID: 31167164 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Raverot G, Vasiljevic A, Jouanneau E, Lasolle H Tags: Eur J Endocrinol Source Type: research

The incidence of adrenal crisis in the postoperative period of HPA-axis insufficiency after surgical treatment for Cushing's syndrome.
CONCLUSIONS: The incidence of adrenal crises after treatment for Cushing's syndrome is substantial, and patients who suffered from an adrenal crisis have higher risk for recurrent crisis. Adrenal crisis tends to present early after remission of Cushing's syndrome, which is probably the period of severest HPA-axis suppression, despite in general higher hydrocortisone replacement doses for withdrawal complaints in this period. Additional pituitary hormone deficiencies may be a risk marker for increased risk of adrenal crisis. However, further risk factor analysis is needed to identify risks for a first crisis. Effective educ...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Broersen LHA, Van Haalen FM, Kienitz T, Dekkers O, Strasburger CJ, Pereira AM, Biermasz NR Tags: Eur J Endocrinol Source Type: research

Diagnosing Metabolic Syndrome in Craniopharyngioma Patients: Body Composition versus BMI.
CONCLUSION: Using BMI to evaluate obesity underestimates the true prevalence of metabolic syndrome in patients with craniopharyngioma. Furthermore, fat percentage contributes to a better evaluation of obesity than BMI. The contribution of DXA-scan might be limited for identification of the metabolic syndrome. PMID: 31167166 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: van Santen SS, Olsson DS, Hammarstrand C, Wijnen M, van den Heuvel-Eibrink MM, Van der Lely AJ, Johannsson G, Janssen JAMJL, Neggers SJCMM Tags: Eur J Endocrinol Source Type: research

The challenges of sodium measurements - indirect versus direct ion selective method.
Abstract BACKGROUND: Diagnosis and treatment of dysnatremia is challenging and further complicated by the pitfalls of different sodium measurement methods. Routinely used sodium measurements are the indirect (plasma/serum) and direct (whole blood) ion selective electrode (ISE) method, showing discrepant results especially in the setting of acute illness. Few clinicians are aware of differences between the methods in clinically stable patients or healthy volunteers. METHODS: Data of 140 patients and 91 healthy volunteers undergoing osmotic stimulation with hypertonic saline infusion were analyzed. Sodium level...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Refardt J, Sailer COO, Chifu I, Winzeler B, Schnyder I, Fassnacht M, Fenske WK, Christ-Crain M Tags: Eur J Endocrinol Source Type: research

Excellent response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma.
Abstract Prolactinomas are the most commonly encountered pituitary adenomas in the clinical setting. While most can be controlled by dopamine agonists, a subset of prolactinomas are dopamine-resistant and very aggressive. In such tumors, the treatment of choice is neurosurgery and radiotherapy, with or without temozolomide. Here, we report a patient with an highly aggressive, dopamine-resistant prolactinoma, who only achieved biochemical and tumor control during pasireotide long-acting release (PAS-LAR) therapy , a second-generation somatostatin receptor ligand (SRL). Interestingly, cystic degeneration, tumor cell...
Source: European Journal of Endocrinology - June 1, 2019 Category: Endocrinology Authors: Coopmans EC, van Meyel SWF, Pieterman KJ, van Ipenburg JA, Hofland L, Donga E, Daly AF, Beckers A, Van der Lely AJ, Neggers SJCMM Tags: Eur J Endocrinol Source Type: research

Risk factor screening for gestational diabetes mellitus based on the 2013 WHO criteria
Conclusions: By applying selective screening by European guidelines, about 50% of women would need an OGTT with the lowest number of missed cases (33%) by the Dutch guidelines. Screening with age ≥30 years and/or BMI ≥25, reduced the number of missed cases to 18.6% but 70% would need an OGTT. PMID: 31120231 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 25, 2019 Category: Endocrinology Authors: Benhalima K, Van Crombrugge P, Moyson C, Verhaeghe J, Vandeginste S, Verlaenen H, Vercammen C, Maes T, Dufraimont E, De Block C, Jacquemyn Y, Mekahli F, De Clippel K, Van Den Bruel A, Loccufier A, Laenen A, Minschart C, Devlieger R, Mathieu C Tags: Eur J Endocrinol Source Type: research

Diagnostic performance of 18F-FDG-PET/CT in DTC patients with thyroglobulin elevation and negative iodine scintigraphy: a meta-analysis.
CONCLUSIONS: On patient-based analysis, 18-FDG-PET/CT has high diagnostic accuracy for detection of recurrent and/or metastatic diseases in DTC patients with thyroglobulin elevation and negative iodine scintigraphy, but existing studies were limited by high heterogeneity and possible publication bias. The diagnostic performance of sPET/CT may be not superior to nsPET/CT. PMID: 31117054 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - May 1, 2019 Category: Endocrinology Authors: Wan Q, Bai L, Zhao G, Zhang Y, Ma Q, Wang R, Ji B Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment.
Abstract Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert physiological actions on the skeleton throughout life, by stimulating longitudinal bone growth in children, the acquisition of bone mass during adolescence and the maintenance of skeletal architecture in adults. When GH and IGF-I are secreted in excess, bone remodeling is enhanced leading to deterioration of bone microstructrure and impairment of bone strength. Indeed, acromegaly causes skeletal fragility, and vertebral fractures are reported in a remarkable number of patients exposed to GH and IGF-I excess. The management of skeletal frag...
Source: European Journal of Endocrinology - May 1, 2019 Category: Endocrinology Authors: Mazziotti G, Lania A, Canalis E Tags: Eur J Endocrinol Source Type: research