MANAGEMENT OF ENDOCRINE DISEASE: Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency; a position statement of the European Calcified Tissue Society.
Abstract Vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D)
Source: European Journal of Endocrinology - February 1, 2019 Category: Endocrinology Authors: Lips P, Cashman KD, Lamberg-Allardt C, Bischoff-Ferrari HA, Obermayer-Pietsch BR, Bianchi M, Stepan J, El-Hajj Fuleihan G, Bouillon R Tags: Eur J Endocrinol Source Type: research

Risk of all-cause and CHD mortality in women versus men with type 2 diabetes: a systematic review and meta-analysis.
CONCLUSIONS: The effect of diabetes on all-cause and CHD mortality is approximately 17% and 97% greater, respectively, for women than for men. PMID: 30668524 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 1, 2019 Category: Endocrinology Authors: Xu G, You D, Wong L, Duan D, Kong F, Zhang X, Zhao J, Xing W, Li L, Han L Tags: Eur J Endocrinol Source Type: research

Targetable Gene Fusions Identified in Radioactive Iodine-Refractory Advanced Thyroid Carcinoma.
CONCLUSION: Targetable gene fusions were found in 12% of RAI-R thyroid carcinoma without DNA variants, and can be effectively identified in formalin-fixed tissue. These gene fusionsmight provide a preclinical rationale to include specific kinase inhibitors in the treatment regimen for these patients. The latter intends to restore iodine transport and/or take advantage of the direct effect on tumor cell vitality once progressive disease is seen. PMID: 30668525 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 1, 2019 Category: Endocrinology Authors: van der Tuin K, Ventayol M, Corver W, Khalifa M, Ruano D, Corssmit EP, Hes FJ, Links TP, Smit J, Plantinga TS, Kapiteijn E, Van Wezel T, Morreau H Tags: Eur J Endocrinol Source Type: research

Pregnancy in Acromegaly is safe and is associated with improvements in GH/IGF-1 concentrations.
We present a case series of 17 pregnancies in 12 women with acromegaly. 12 women with acromegaly who completed pregnancy were identified from centres involved in the Irish Pituitary Study. 11 women had pituitary macroadenomas, one woman had a microadenoma. Only 5/17 pregnancies had optimal biochemical control of acromegaly pre-conception, as defined by IGF-1 concentration in the age related reference level and plasma GH concentration of
Source: European Journal of Endocrinology - January 1, 2019 Category: Endocrinology Authors: Hannon AM, O'Shea T, Thompson C, Hannon MJ, Dineen R, Khattak AK, Gibney J, O'Halloran D, Hunter S, Thompson CJ, Sherlock M Tags: Eur J Endocrinol Source Type: research

The natural history of autoimmune addison's disease from the detection of autoantibodies to development of the disease: a long follow-up study on 143 patients.
Conclusions A model for estimating the probability to survive free of AAD has been developed and should be a useful tool in designing appropriate follow-up intervals and future therapeutic strategies. PMID: 30608902 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 1, 2019 Category: Endocrinology Authors: Naletto L, Frigo A, Ceccato F, Sabbadin C, Scarpa R, Presotto F, Dalla Costa M, Faggian D, Plebani M, Censi S, Manso J, Furmaniak J, Chen S, Rees Smith B, Masiero S, Pigliaru F, Boscaro M, Scaroni C, Betterle C Tags: Eur J Endocrinol Source Type: research

DEBATE: Screening for hypovitaminosis D: cost-effective or not?
Abstract Few topics have elicited more emotion than the issue of screening for vitamin D status and the discussion on the need for global supplementation with vitamin D metabolites. The importance of the problem is highlighted by the USPSTF posted draft research plan with the aim of making an update recommendations statement, possibly next year. Here, we discuss two different viewpoints on screening for vitamin D status: for and against. In the literature there are scientifically sound opinions supporting pro and cons positions. However, we believe that the best way to definitively elucidate this issue is the impl...
Source: European Journal of Endocrinology - January 1, 2019 Category: Endocrinology Authors: Minisola S, Colangelo L, Cipriani C, Pepe J, Cook DP, Mathieu C Tags: Eur J Endocrinol Source Type: research

Endocrine and immunological aspects of burnout: a narrative review.
The objective of this narrative review is to summarize the main endocrine and immune findings in relation to burnout. The literature has primarily focused on dysregulation of the HPA axis. However, albeit the large body of studies, it cannot be concluded that clear effects are seen on HPA axis function in people with burnout. The HPA axis and anabolic acute reactivity to stress might be affected in clinical burnout. Plausible, effects of chronic stress might rather be seen when measuring responses to acute stress rather than resting state hormonal levels. Studies on other hormones, including thyroid hormones, prolactin and...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Jonsdottir I, Sjörs A Tags: Eur J Endocrinol Source Type: research

Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa.
Abstract OBJECTIVE: In anorexia nervosa, a psychiatric disease characterized by self-induced starvation and a model of chronic undernutrition, levels of subcutaneous (SAT) and visceral (VAT) adipose tissue are low, whereas marrow adipose tissue (MAT) levels are elevated compared to normal-weight women. The reason for this paradoxical elevation of an adipose tissue depot in starvation is not known. We sought to understand changes in MAT in response to sub-acute changes in weight and to compare these changes with those of other fat depots and body composition parameters. DESIGN AND METHODS: We conducted a 12-mo...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Fazeli PK, Faje A, Bredella MA, Polineni S, Russell S, Resulaj M, Rosen CJ, Klibanski A Tags: Eur J Endocrinol Source Type: research

Fine-needle aspiration to diagnose primary thyroid lymphoma: a systematic review and meta-analysis.
CONCLUSIONS: The present meta-analysis demonstrated that FNA has low sensitivity in diagnosing PTL. However, this rate increased when considering also FNA reports suspicious for PTL, which is relevant from a clinical standpoint. This result could support indirectly the use of additional imaging and/or core biopsy when PTL is suspected. PMID: 30566902 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Zhang L, Castellana M, Virili C, Crescenzi A, Giorgino F, Zucca E, Ceriani L, Cavalli F, Giovanella L, Trimboli P Tags: Eur J Endocrinol Source Type: research

Non-invasive DXA-derived bone structure assessment of acromegaly patients: A cross-sectional study.
Abstract INTRODUCTION: Impaired bone microarchitecture is involved in vertebral fracture (VF) development among acromegaly (AG) patients. AIM: Comparison of DXA-derived bone parameters; areal BMD (aBMD), trabecular bone score (TBS) and 3D-SHAPER parameters in AG patients with healthy controls. METHODS: This cross-sectional study of acromegaly patients and a group of healthy controls. In all, single measurement of pituitary axis hormone levels, bone turnover markers (BTMs), aBMD, (total hip [TH] and lumbar spine [LS]), TBS and 3D-SHAPER were performed. All subjects underwent VF assessment using the semi-q...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Kužma M, Vanuga P, Sagova I, Pavai D, Jackuliak P, Killinger Z, Binkley N, Winzenrieth R, Genant H, Payer J Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of the patient with non-classic CAH due to 21-hydroxylase deficiency.
Abstract Non-classic congenital adrenal hyperplasia (NCAH) is a relatively common disorder regardless of ethnicity, but most cases are never diagnosed, especially in males. A baseline 17-hydroxyprogesterone measurement may be used for screening, but 17-hydroxyprogesterone measurement after ACTH-stimulation is the gold standard. We advocate a CYP21A2 mutation analysis to verify the diagnosis, for genetic counselling and for better prognostic and treatment guidance. Most patients are diagnosed in adolescence and adult life with hirsutism, acne, a PCOS-like picture and fertility issues. Many men with NCAH never seek ...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Nordenstrom A, Falhammar H Tags: Eur J Endocrinol Source Type: research

Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children.
CONCLUSIONS: Patterns and severity of childhood androgen excess provides pointers to the underlying diagnosis and can be used to guide further investigations. PMID: 30566905 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Idkowiak J, Elhassan YS, Mannion P, Smith K, Webster R, Saraff V, Barrett TG, Shaw NG, Krone N, Dias RP, Kershaw M, Kirk JM, Högler W, Krone RE, O'Reilly MW, Arlt W Tags: Eur J Endocrinol Source Type: research

Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial.
Abstract OBJECTIVE: The increasing prevalence of obesity over the past few decades constitutes a global health challenge. Pharmacological therapy is recommended to accompany life-style modification for obesity management. Here, we perform a clinical trial to investigate the effects of metformin on anthropometric indices and gut microbiota composition in non-diabetic, treatment-naive obese women with a low calorie diet (LCD). DESIGN: Randomized double-blind parallel-group clinical trial Methods: Forty-six obese women were randomly assigned to the metformin (500 mg/tab) or placebo groups using computer-generate...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Ejtahed HS, Tito RY, Siadat SD, Hasani-Ranjbar S, Hoseini-Tavassol Z, Rymenans L, Verbeke K, Soroush AR, Raes J, Larijani B Tags: Eur J Endocrinol Source Type: research

Standards of Care for Hypoparathyroidism in Adults.
Abstract PURPOSE: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. We excluded letters, reviews and editorials. The quality of evidence was ev...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Khan AA, Koch C, Van Uum SHM, Baillargeon JP, Bollerslev J, Brandi ML, Marcocci C, Rejnmark L, Rizzoli R, Shrayyef MZ, Thakker RV, Yildiz BO, Clarke B Tags: Eur J Endocrinol Source Type: research

MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post-hoc analysis.
Conclusions Patients with hypointense vs isointense GH-secreting macroadenomas had greater reductions in IGF-1 following primary treatment with lanreotide autogel, and were more likely to achieve tumor response. Assessment of T2 signal intensity at baseline may help to predict long-term responses to primary treatment with SSAs. PMID: 30540560 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Bonneville F, Rivière LD, Petersenn S, Bevan J, Houchard A, Sert C, Caron PJ Tags: Eur J Endocrinol Source Type: research

Mechanisms of disease: The endocrinology of obstructive sleep apnoea.
Abstract Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA....
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Lavrentaki A, Ali A, Cooper B, Tahrani A Tags: Eur J Endocrinol Source Type: research

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.
Abstract INTRODUCTION: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking. METHODS: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. A meta-analysis was performed to estimate po...
Source: European Journal of Endocrinology - December 1, 2018 Category: Endocrinology Authors: Nederstigt C, Uitbeijerse B, Janssen L, Corssmit EP, de Koning E, Dekkers O Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Estrogens in consumer milk: is there a risk to human reproductive health?
Abstract Possible effects of xenoestrogens on human health, in particular on male reproductive health, have attracted considerable attention in recent years. Cow's milk was suggested in numerous publications as one of possible sources of xenoestrogens that could affect human health. Although milk has undoubtedly many beneficial health effects and could even have a role in reducing incidence of some cancers, concerns were raised about presumably high levels of estrogens in cow's milk. In intensive farming, concentrations of estrogens in milk are higher due to long milking periods that today extend long into the pre...
Source: European Journal of Endocrinology - November 8, 2018 Category: Endocrinology Authors: Snoj T, Majdič G Tags: Eur J Endocrinol Source Type: research

Association between the metabolically healthy obese phenotype and the risk of myocardial infarction: results from the Kailuan study.
This study aimed to determine if the metabolically healthy obese (MHO) is associated with an increased risk of myocardial infarction (MI) in Chinese population. Design The Kailuan study is a community-based prospective cohort study. Methods BMI and metabolic syndrome (MetS) were assessed in 91 866 participants without a history of MI or stroke. Participants were categorised into six mutually exclusive groups according to the BMI-MetS status: normal weight (BMI: ≤ 18.5to
Source: European Journal of Endocrinology - November 8, 2018 Category: Endocrinology Authors: Xu Y, Li H, Wang A, Su Z, Yang G, Luo Y, Tao L, Chen S, Wu S, Wang Y, Guo X Tags: Eur J Endocrinol Source Type: research

ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later
Abstract The thionamide antithyroid drugs were discovered in large part following serendipitous observations by a number of investigators in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. This prompted Prof. Edwin B Astwood to pioneer the use of these compounds to treat hyperthyroidism in the early 1940s and to develop the more potent and less toxic drugs that are used today. Despite their simple molecular structure and ease of use, many uncertainties remain, including their mechanism(s) of action, clinical role, optimal use in pregnancy and the prediction and prevention of r...
Source: European Journal of Endocrinology - October 12, 2018 Category: Endocrinology Authors: Burch HB, Cooper DS Tags: Eur J Endocrinol Source Type: research

Excess mortality in Finnish diabetic subjects due to alcohol, accidents and suicide: a nationwide study
Conclusions: The findings from this large nationwide cohort indicate higher mortality attributable to suicide, alcoholrelated causes and accidents among diabetic patients than among the non-diabetic population. The results emphasize the importance of effective psychosocial interventions among high-risk diabetic patients. PMID: 30320503 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 12, 2018 Category: Endocrinology Authors: Niskanen L, Partonen T, Auvinen A, Haukka J Tags: Eur J Endocrinol Source Type: research

Should we avoid using ketoconazole in patients with severe Cushing ’s syndrome and increased levels of liver enzymes?
Should we avoid using ketoconazole in patients with severe Cushing’s syndrome and increased levels of liver enzymes? Eur J Endocrinol. 2018 Oct 12;179(5):L1-L2 Authors: Ollivier M, Haissaguerre M, Ferriere F, Tabarin A Abstract We read with interest the paper of Young et al. in which the authors recommend avoiding ketoconazole in the treatment of Cushing’s syndrome when patients display increased liver enzymes (>2-fold the upper limit of normal (ULN)). We found in a small series of patients that We read with interest the paper of Young et al. in which the authors recommend avoiding keto...
Source: European Journal of Endocrinology - October 12, 2018 Category: Endocrinology Authors: Ollivier M, Haissaguerre M, Ferriere F, Tabarin A Tags: Eur J Endocrinol Source Type: research

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Abstract Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best pr...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Bone marrow adiposity and bone, a bad romance?
Abstract Bone marrow adipocytes (BMA-) constitute an original and heterogeneous fat depot whose development appears interlinked with bone status throughout life. The gradual replacement of the haematopoietic tissue by BMA arises in a well-ordered way during childhood and adolescence concomitantly to bone growth and continues at a slower rate throughout the adult life. Importantly, BM adiposity quantity is found well associated with bone mineral density (BMD) loss at different skeletal sites in primary osteoporosis such as in ageing or menopause but also in secondary osteoporosis consecutive to anorexia nervosa. Si...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Rharass T, Lucas S Tags: Eur J Endocrinol Source Type: research

GENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 ‘DSDnet’
GENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 ‘DSDnet’ Eur J Endocrinol. 2018 Oct 01;179(4):R197-R206 Authors: Audi L, Ahmed SF, Krone N, Cools M, McElreavey K, McElreavey PM, Greenfield A, Bashamboo A, Hiort O, Wudy SA, McGowan R Abstract The differential diagnosis of differences or disorders of sex development (DSD) belongs to the most complex fields in medicine. It requires a multidisciplinary team conducting a synoptic and complementary approach consistin...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Audi L, Ahmed SF, Krone N, Cools M, McElreavey K, McElreavey PM, Greenfield A, Bashamboo A, Hiort O, Wudy SA, McGowan R Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia
Abstract Glucocorticoids are frequently prescribed to patients with a wide range of inflammatory and autoimmune diseases. The semi-synthetic glucocorticoid prednisolone is most commonly prescribed and in two main patterns. Prednisolone is prescribed short term at medium-high doses to treat an acute inflammatory illness or long term at lower doses to attenuate chronic inflammatory disease progression. In hospitalized patients with acute prednisolone-induced hyperglycaemia, there is a distinct circadian pattern of glucose elevation, which occurs predominantly in the afternoon and evening. As a morning dose of isopha...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Radhakutty A, Burt MG Tags: Eur J Endocrinol Source Type: research

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms
Conclusions: The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs. PMID: 30299890 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Grolmusz VK, Kövesdi A, Borks K, Igaz P, Patócs A Tags: Eur J Endocrinol Source Type: research

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement
Abstract Background: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumors in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). Methods: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987 and 2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% CIs ...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Hammarstrand C, Ragnarsson O, Bengtsson O, Bryngelsson IL, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults
Abstract Objectives: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65–88y, n = 173) and in ...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Elstgeest LEM, de Koning EJ, Brouwer IA, van Schoor NM, Penninx BWJH, Visser M Tags: Eur J Endocrinol Source Type: research

Preserved insulin secretion and kidney function in recipients with functional pancreas grafts 1 year after transplantation: a single-center prospective observational study
This study addresses glucometabolic parameters and kidney function during the first year. Methods: We examined 67 patients with functioning grafts (SPK n = 30, PTA n = 37) transplanted between September 2011 and November 2016 who underwent repeated oral glucose tolerance tests (OGTTs) 8 and 52 weeks after transplantation. Another 19 patients lost their graft the first year post-transplant and 28 patients did not undergo repeated OGTTs and could not be studied. All patients received ATG induction therapy plus tacrolimus, mycophenolate and prednisolone. Glomerular filtration rate was measured...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Nordheim E, Birkeland KI, Åsberg A, Hartmann A, Horneland R, Jenssen T Tags: Eur J Endocrinol Source Type: research

Radiation exposure of adrenal vein sampling: a German Multicenter Study
Conclusions: This first systematic assessment of radiation exposure in AVS not only shows fairly high values for patients, but also states notable differences among the centers. Thus, we not only recommend taking into account the risk of radiation exposure, when referring patients to undergo AVS, but also to establish improved standard operating procedures to prevent unnecessary radiation exposure. PMID: 30299899 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Fuss CT, Treitl M, Rayes N, Podrabsky P, Fenske WK, Heinrich DA, Reincke M, Petersen TO, Fassnach M, Quinkler M, Kickuth R, Hahner S Tags: Eur J Endocrinol Source Type: research

Is receptor profiling useful for predicting pituitary therapy?
IS RECEPTOR PROFILING USEFUL FOR PREDICTING PITUITARY THERAPY? Eur J Endocrinol. 2018 Aug 23;: Authors: Marazuela M, Ramos-Leví AM, Borges de Souza P, Zatelli MC Abstract Medical treatment of pituitary tumours may present important challenges in the presence of resistance to first line therapy. In this setting, the availability of specific markers of responsiveness/resistance could be helpful to provide tailored patients' treatment. Pituitary receptor profiling has emerged as a potentially useful tool for predicting the response to specific pituitary-directed medical therapy, mainly somatostati...
Source: European Journal of Endocrinology - August 23, 2018 Category: Endocrinology Authors: Marazuela M, Ramos-Leví AM, Borges de Souza P, Zatelli MC Tags: Eur J Endocrinol Source Type: research

Long-term Effects of Growth Hormone Replacement Therapy in Childhood-onset Craniopharyngioma: Results of the German Craniopharyngioma Registry (HIT-Endo).
CONCLUSIONS: We conclude that GH substitution was safe with regard to risk of tumor progression/relapse in CP. Growth was improved by GH, whereas the development of obesity was not influenced by GH substitution. However, early initiation of GH substitution after CP diagnosis might have beneficial effects on weight development and neuropsychological outcome. PMID: 30139824 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 23, 2018 Category: Endocrinology Authors: Boekhoff S, Bogusz A, Sterkenburg AS, Eveslage M, Müller HL Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Therapeutics of Vitamin D.
Conclusions The effects of long-term vitamin D supplementation on non-skeletal outcomes, such as type 2 diabetes mellitus (T2DM), cancer and cardiovascular disease (CVD), and the optimal dose and serum 25OHD level that balances extra-skeletal benefits (T2DM) vs. risks (e.g., CVD), may soon be determined by data from large RCTs. PMID: 30131372 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 21, 2018 Category: Endocrinology Authors: Ebeling P, Adler R, Jones G, Liberman UA, Mazziotti G, Minisola S, Munns C, Napoli N, Pittas A, Giustina A, Bilezikian JP, Rizzoli R Tags: Eur J Endocrinol Source Type: research

Active cushing syndrome patients have increased ectopic fat deposition and bone marrow fat content compared to cured patients and healthy subjects: a pilot 1H-MRS study.
CONCLUSIONS: Accumulation of BMF is induced by hypercortisolism. In remission patients BMF reached values of controls. Further studies are needed to determine whether this increase in marrow adiposity in CS is associated with bone loss. PMID: 30108093 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 14, 2018 Category: Endocrinology Authors: Maurice F, Dutour A, Vincentelli C, Abdesselam I, Bernard M, Dufour H, Le Fur Y, Graillon T, Kober F, Cristofari P, Jouve E, Pini L, Fernandez R, Chagnaud C, Brue T, Castinetti F, Gaborit B Tags: Eur J Endocrinol Source Type: research

Reduced Slow-Wave Sleep and Altered Diurnal Cortisol Rhythms in Patients with Addison's Disease.
CONCLUSION: Overall, these results suggest that patients with AD demonstrate different patterns of night-time cortisol concentrations to healthy controls, and that relatively elevated concentrations are associated with a reduction of SWS. These hormonal and sleep architectural aberrations may disrupt the routine sleep-dependent processes of memory consolidation, and hence may explain, at least partially, the memory impairments often experienced by patients with AD. PMID: 30108094 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 14, 2018 Category: Endocrinology Authors: Henry M, Ross IL, Thomas KGF Tags: Eur J Endocrinol Source Type: research

Outcomes of pubertal development in girls as a function of pubertal onset age.
OUTCOMES OF PUBERTAL DEVELOPMENT IN GIRLS AS A FUNCTION OF PUBERTAL ONSET AGE. Eur J Endocrinol. 2018 Aug 07;: Authors: German A, Shmoish M, Belsky J, Hochberg Z Abstract BACKGROUND: The relationship between pubertal onset and tempo and pubertal growth is controversial. We hypothesized that the age at onset of girls' puberty predicts pubertal tempo and the rate of pubertal progression. METHODS: We analysed the data of 380 girls from the prospective Study of Early Child Care and Youth Development (SECCYD), who were recruited in the USA from 1991-2006 and followed from birth to age 15.5 years. We u...
Source: European Journal of Endocrinology - August 7, 2018 Category: Endocrinology Authors: German A, Shmoish M, Belsky J, Hochberg Z Tags: Eur J Endocrinol Source Type: research

Enzyme autoinduction by mitotane supported by population pharmacokinetic modelling in a large cohort of adrenocortical carcinoma patients.
CONCLUSION: The proposed model describes mitotane pharmacokinetics and can be used to facilitate therapy by predicting plasma concentrations. PMID: 30087117 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 7, 2018 Category: Endocrinology Authors: Arshad U, Taubert M, Kurlbaum M, Frechen S, Herterich S, Megerle F, Hamacher S, Fassnacht M, Fuhr U, Kroiss M Tags: Eur J Endocrinol Source Type: research

Efficacy and Safety of switching to Pasireotide in Acromegaly Patients controlled with Pegvisomant and Somatostatin Analogues: PAPE extension study.
Abstract OBJECTIVE: to assess the efficacy and safety after 48 weeks of treatment with pasireotide long-acting-release (PAS-LAR) alone or in combination with pegvisomant in patients with acromegaly. In addition, we assessed the relation between insulin secretion and pasireotide-induced hyperglycemia. DESIGN: The PAPE extension study is a prospective follow-up study until 48 weeks after the core study of 24 weeks. METHODS: 59 out of 61 patients entered the extension study. Efficacy was defined as the percentage of patients achieving IGF-I normalization (≤ 1.2 x the Upper Limit of Normal (ULN)) at 48-we...
Source: European Journal of Endocrinology - August 3, 2018 Category: Endocrinology Authors: Muhammad A, Coopmans EC, Delhanty P, Dallenga AHG, Haitsma IK, Janssen JAMJL, Van der Lely AJ, Neggers SJCMM Tags: Eur J Endocrinol Source Type: research

Radiation Exposure of Adrenal Vein Sampling - a German Multicenter Study.
CONCLUSION: This first systematic assessment of radiation exposure in AVS not only shows fairly high values for patients, but also states notable differences amongst the centers. Thus, we not only recommend taking into account the risk of radiation exposure, when referring patients to undergo AVS, but also to establish improved standard operating procedures to prevent unnecessary radiation exposure. PMID: 30068731 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 1, 2018 Category: Endocrinology Authors: Fuss CT, Treitl M, Rayes N, Podrabsky P, Fenske WK, Heinrich DA, Reincke M, Petersen TO, Fassnacht M, Quinkler M, Kickuth R, Hahner S Tags: Eur J Endocrinol Source Type: research

Preserved insulin secretion and kidney function in recipients with functional pancreas grafts one year after transplantation.
This study addresses glucometabolic parameters and kidney function during the first year. Methods We examined 67 patients with functioning grafts (SPK n=30, PTA n=37) transplanted between September 2011 and November 2016 who underwent repeated oral glucose tolerance tests (OGTTs) 8 and 52 weeks after transplantation. Another 19 patients lost their graft the first year post-transplant and 28 patients did not undergo repeated OGTTs and could not be studied. All patients received ATG induction therapy plus tacrolimus, mycophenolate and prednisolone. Glomerular filtration rate was measured before and 8 and 52 weeks after trans...
Source: European Journal of Endocrinology - July 30, 2018 Category: Endocrinology Authors: Nordheim E, Birkeland KI, Åsberg A, Hartmann A, Horneland R, Jenssen T Tags: Eur J Endocrinol Source Type: research

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults.
CONCLUSIONS: Our study suggests that over 6 years an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality. PMID: 30054306 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 27, 2018 Category: Endocrinology Authors: Elstgeest LEM, de Koning EJ, Brouwer IA, van Schoor NM, Penninx BWJH, Visser M Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Approach to the management of children and adolescents with Gender Dysphoria.
Abstract Over the past 20 years, the care for transgender adolescents has developed throughout many countries following the "Dutch Approach" initiated in the 90's in pioneer countries as the Netherlands, United States and Canada, with increasing numbers of children and adolescents seeking care in transgender clinics. This medical approach has considerable positive impacts on the psychological outcomes of these adolescents and several studies have been recently published underlining the relative safety of such treatments. This paper reviews the current standards of care for transgender children and adoles...
Source: European Journal of Endocrinology - July 26, 2018 Category: Endocrinology Authors: Martinerie L, Condat A, Bargiacchi A, Bremont-Weill C, de Vries MC, Hannema SE Tags: Eur J Endocrinol Source Type: research

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement.
Abstract BACKGROUND: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumours in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). METHOD: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987-2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% confiden...
Source: European Journal of Endocrinology - July 26, 2018 Category: Endocrinology Authors: Hammarstrand C, Ragnarsson O, Bengtsson O, Bryngelsson IL, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Abstract Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best pr...
Source: European Journal of Endocrinology - July 24, 2018 Category: Endocrinology Authors: Fassnacht M, Dekkers O, Else T, Baudin E, Berruti A, de Krijger RR, Haak HR, Mihai R, Assie G, Terzolo M Tags: Eur J Endocrinol Source Type: research

Bilateral adrenal hyperplasia and NR3C1 mutations causing glucocorticoid resistance: Is there an association?
Abstract Glucocorticoids signal through their cognate, ubiquitously expressed glucocorticoid receptor (GR), which influences the transcription of a large number of target genes. Several genetic defects, including point mutations, deletions or insertions in the NR3C1 gene that encodes the GR, have been associated with familial or sporadic generalized glucocorticoid resistance or Chrousos syndrome. One of the clinical manifestations of this rare endocrine condition is bilateral adrenal hyperplasia due to compensatory elevations of plasma ACTH concentrations. In this commentary, we discuss the interesting findings of...
Source: European Journal of Endocrinology - July 13, 2018 Category: Endocrinology Authors: Nicolaides N, Chrousos G Tags: Eur J Endocrinol Source Type: research

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms.
Conclusions The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs. PMID: 30006373 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 13, 2018 Category: Endocrinology Authors: Grolmusz VK, Kövesdi A, Borka K, Igaz P, Patocs A Tags: Eur J Endocrinol Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia.
Abstract Glucocorticoids are frequently prescribed to patients with a wide range of inflammatory and autoimmune diseases. The semi-synthetic glucocorticoid prednisolone is most commonly prescribed and in two main patterns. Prednisolone is prescribed short-term at medium-high doses to treat an acute inflammatory illness or long-term at lower doses to attenuate chronic inflammatory disease progression. In hospitalized patients with acute prednisolone-induced hyperglycaemia there is a distinct circadian pattern of glucose elevation, which occurs predominantly in the afternoon and evening. As a morning dose of isophan...
Source: European Journal of Endocrinology - July 10, 2018 Category: Endocrinology Authors: Radhakutty A, Burt MG Tags: Eur J Endocrinol Source Type: research

MECHANISMS IN ENDOCRINOLOGY: Bone Marrow Adiposity and bone, a bad romance?
Abstract Bone marrow adipocytes (BMA) constitute an original and heterogeneous fat depot whose development appears interlinked with bone status throughout life. The gradual replacement of the hematopoietic tissue by BMA arises in a well-ordered way during childhood and adolescence concomitantly to bone growth and continues at a slower rate throughout the adult life. Importantly, BM adiposity quantity is found well associated with BMD (Bone Mineral Density) loss at different skeletal sites in primary osteoporosis such as in ageing or menopause but also in secondary osteoporosis consecutive to anorexia nervosa. Sinc...
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Rharass T, Lucas S Tags: Eur J Endocrinol Source Type: research

Long-acting FC-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults.
CONCLUSIONS: GX-H9 has the potential for up to twice-monthly administration. PMID: 29973375 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 4, 2018 Category: Endocrinology Authors: Ku CR, Brue T, Schilbach K, Ignatenko S, Magony S, Chung YS, Kim BJ, Hur KY, Kang HC, Kim JH, Kim MS, Kowalska A, Bolanowski M, Ruchala M, Damjanovic S, Payer J, Choi YJ, Heo SJ, Kim TK, Heo M, Lee J, Lee EJ Tags: Eur J Endocrinol Source Type: research