Resolution of dysglycaemia after treatment of monoclonal gammopathy of endocrine significance
We report a 67-year-old man re-evaluated for hyperinsulinaemic hypoglycaemia that persisted despite distal pancreatectomy. He had no medical history of diabetes mellitus or autoimmune disease but was being monitored for an IgG kappa monoclonal gammopathy of undetermined significance. On glucose tolerance testing, hyperglycaemia occurred at 60 minutes (glucose 216mg/dL), and hypoglycaemia at 300 minutes (52mg/dL) concurrent with an apparent plasma insulin concentration of 52,850pmol/L on immunoassay. Laboratory investigation revealed an IgG2 kappa with very high binding capacity but low affinity (Kd 1.43x10-6 mol/L) for ins...
Source: European Journal of Endocrinology - October 11, 2023 Category: Endocrinology Authors: Bonnie Grant Gowri Ratnayake Claire L Williams Anna Long David J Halsall Robert K Semple James D Cavenagh William M Drake David S Church Source Type: research
Adrenocortical function in patients with Single Large Scale Mitochondrial DNA Deletions: a retrospective single centre cohort study
CONCLUSIONS: Our study highlights that cortisol deficiency due to primary AI represents a relevant part of the clinical spectrum in SLSMDs, with more severe impairment in PS than in KSS. Basal and after-stimulus assessment of adrenocortical axis should be early and regularly investigated to identify any degree of adrenocortical dysfunction. The study allowed the elaboration of a diagnostic process designed for the diagnosis, treatment, and follow-up of adrenocortical abnormalities in SLSMDs.PMID:37815532 | DOI:10.1093/ejendo/lvad137 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 10, 2023 Category: Endocrinology Authors: Barbara Siri Annamaria D'Alessandro Arianna Maiorana Ottavia Porzio Lucilla Rav à Carlo Dionisi-Vici Marco Cappa Diego Martinelli Source Type: research
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
CONCLUSIONS: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.PMID:37807083 | DOI:10.1093/ejendo/lvad136 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 8, 2023 Category: Endocrinology Authors: Åse Bjorvatn Sævik Grethe Ueland Anna-Karin Åkerman Paal Methlie Marcus Quinkler Anders Palmstr øm Jørgensen Charlotte H öybye Aleksandra W J Debowska Bj ørn Gunnar Nedrebø Anne Lise Dahle Siri Carlsen Aneta Tomkowicz Stina Therese Sollid Ingrid N Source Type: research
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
CONCLUSIONS: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.PMID:37807083 | DOI:10.1093/ejendo/lvad136 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 8, 2023 Category: Endocrinology Authors: Åse Bjorvatn Sævik Grethe Ueland Anna-Karin Åkerman Paal Methlie Marcus Quinkler Anders Palmstr øm Jørgensen Charlotte H öybye Aleksandra W J Debowska Bj ørn Gunnar Nedrebø Anne Lise Dahle Siri Carlsen Aneta Tomkowicz Stina Therese Sollid Ingrid N Source Type: research
Pediatric and Adolescent Ectopic Cushing's Syndrome: Systematic Review
CONCLUSIONS: Etiological profile of pediatric and adolescent EAS is distinct from that of adults. Bronchial NETs have the best long-term survival whereas distant metastasis and tumor size predict poor survival.PMID:37801647 | DOI:10.1093/ejendo/lvad133 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Chethan Yami Channaiah Manjiri Karlekar Vijaya Sarathi Anurag Ranjan Lila Shruthi Ravindra Padma Vikram Badhe Gaurav Malhotra Saba Samad Memon Virendra Ashokrao Patil C S Pramesh Tushar Bandgar Source Type: research
Comorbidities in mild autonomous cortisol secretion and the effect of treatment: Systematic review and meta-analysis
CONCLUSIONS: The present systematic review and meta-analysis highlights the relevance of MACS, since both cardiometabolic morbidities and mortality appeared increased in patients with MACS compared to patients with non-functioning incidentalomas. However, due to heterogeneous definitions, various outcomes, selective reporting, and missing data, the reported pooled estimates need to be interpreted with caution. The small number of patients in randomized trials prevents any strong conclusion on the causality between MACS and these comorbidities.PMID:37801655 | DOI:10.1093/ejendo/lvad134 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Iris Pelsma Martin Fassnacht Stylianos Tsagarakis Massimo Terzolo Antoine Tabarin Anju Sahdev John Newell-Price Ljiljana Marina Kerstin Lorenz Irina Bancos Wiebke Arlt Olaf M Dekkers Source Type: research
Risk of Dementia and Psychiatric or Sleep Disorders after Diagnosis of Adrenal Adenomas: A Population-Based Cohort Study
CONCLUSIONS: Patients with adenomas demonstrate a higher incidence of psychiatric and sleep disorders, possibly due to the underlying subtle increase in cortisol secretion.PMID:37801659 | DOI:10.1093/ejendo/lvad135 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Dingfeng Li Sumitabh Singh Catherine D Zhang Ravinder Jeet Kaur Andreas Ebbehoj Elizabeth J Atkinson Sara J Achenbach Nikki H Stricker Michelle M Mielke Walter Rocca Irina Bancos Source Type: research
Pediatric and Adolescent Ectopic Cushing's Syndrome: Systematic Review
CONCLUSIONS: Etiological profile of pediatric and adolescent EAS is distinct from that of adults. Bronchial NETs have the best long-term survival whereas distant metastasis and tumor size predict poor survival.PMID:37801647 | DOI:10.1093/ejendo/lvad133 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Chethan Yami Channaiah Manjiri Karlekar Vijaya Sarathi Anurag Ranjan Lila Shruthi Ravindra Padma Vikram Badhe Gaurav Malhotra Saba Samad Memon Virendra Ashokrao Patil C S Pramesh Tushar Bandgar Source Type: research
Comorbidities in mild autonomous cortisol secretion and the effect of treatment: Systematic review and meta-analysis
CONCLUSIONS: The present systematic review and meta-analysis highlights the relevance of MACS, since both cardiometabolic morbidities and mortality appeared increased in patients with MACS compared to patients with non-functioning incidentalomas. However, due to heterogeneous definitions, various outcomes, selective reporting, and missing data, the reported pooled estimates need to be interpreted with caution. The small number of patients in randomized trials prevents any strong conclusion on the causality between MACS and these comorbidities.PMID:37801655 | DOI:10.1093/ejendo/lvad134 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Iris Pelsma Martin Fassnacht Stylianos Tsagarakis Massimo Terzolo Antoine Tabarin Anju Sahdev John Newell-Price Ljiljana Marina Kerstin Lorenz Irina Bancos Wiebke Arlt Olaf M Dekkers Source Type: research
Risk of Dementia and Psychiatric or Sleep Disorders after Diagnosis of Adrenal Adenomas: A Population-Based Cohort Study
CONCLUSIONS: Patients with adenomas demonstrate a higher incidence of psychiatric and sleep disorders, possibly due to the underlying subtle increase in cortisol secretion.PMID:37801659 | DOI:10.1093/ejendo/lvad135 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Dingfeng Li Sumitabh Singh Catherine D Zhang Ravinder Jeet Kaur Andreas Ebbehoj Elizabeth J Atkinson Sara J Achenbach Nikki H Stricker Michelle M Mielke Walter Rocca Irina Bancos Source Type: research
Pediatric and Adolescent Ectopic Cushing's Syndrome: Systematic Review
CONCLUSIONS: Etiological profile of pediatric and adolescent EAS is distinct from that of adults. Bronchial NETs have the best long-term survival whereas distant metastasis and tumor size predict poor survival.PMID:37801647 | DOI:10.1093/ejendo/lvad133 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Chethan Yami Channaiah Manjiri Karlekar Vijaya Sarathi Anurag Ranjan Lila Shruthi Ravindra Padma Vikram Badhe Gaurav Malhotra Saba Samad Memon Virendra Ashokrao Patil C S Pramesh Tushar Bandgar Source Type: research
Comorbidities in mild autonomous cortisol secretion and the effect of treatment: Systematic review and meta-analysis
CONCLUSIONS: The present systematic review and meta-analysis highlights the relevance of MACS, since both cardiometabolic morbidities and mortality appeared increased in patients with MACS compared to patients with non-functioning incidentalomas. However, due to heterogeneous definitions, various outcomes, selective reporting, and missing data, the reported pooled estimates need to be interpreted with caution. The small number of patients in randomized trials prevents any strong conclusion on the causality between MACS and these comorbidities.PMID:37801655 | DOI:10.1093/ejendo/lvad134 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Iris Pelsma Martin Fassnacht Stylianos Tsagarakis Massimo Terzolo Antoine Tabarin Anju Sahdev John Newell-Price Ljiljana Marina Kerstin Lorenz Irina Bancos Wiebke Arlt Olaf M Dekkers Source Type: research
Risk of Dementia and Psychiatric or Sleep Disorders after Diagnosis of Adrenal Adenomas: A Population-Based Cohort Study
CONCLUSIONS: Patients with adenomas demonstrate a higher incidence of psychiatric and sleep disorders, possibly due to the underlying subtle increase in cortisol secretion.PMID:37801659 | DOI:10.1093/ejendo/lvad135 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Dingfeng Li Sumitabh Singh Catherine D Zhang Ravinder Jeet Kaur Andreas Ebbehoj Elizabeth J Atkinson Sara J Achenbach Nikki H Stricker Michelle M Mielke Walter Rocca Irina Bancos Source Type: research
In vitro regulation of fibroblast growth factor 23 by 25(OH)D and 1,25(OH)2D3 synthesized by osteocyte-like MC3T3-E1 cells
Eur J Endocrinol. 2023 Oct 5:lvad131. doi: 10.1093/ejendo/lvad131. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is produced and secreted by osteocytes and is essential for maintaining phosphate homeostasis. One of the main regulators of FGF23, 1,25-dihydroxyvitamin D (1,25(OH)2D3), is primarily synthesized in the kidney from 25-hydroxyvitamin D (25(OH)D) by 1α-hydroxylase (encoded by CYP27B1). Hitherto, it is unclear whether osteocytes can convert 25(OH)D and thereby allow for 1,25(OH)2D3 to induce FGF23 production and secretion locally. Here, we differentiated MC3T3-E1 cells towards osteocyte-like ce...
Source: European Journal of Endocrinology - October 5, 2023 Category: Endocrinology Authors: Danielle M A Ratsma Max Muller Marijke Koedam M Carola Zillikens Bram C J van der Eerden Source Type: research
In vitro regulation of fibroblast growth factor 23 by 25(OH)D and 1,25(OH)2D3 synthesized by osteocyte-like MC3T3-E1 cells
Eur J Endocrinol. 2023 Oct 5:lvad131. doi: 10.1093/ejendo/lvad131. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is produced and secreted by osteocytes and is essential for maintaining phosphate homeostasis. One of the main regulators of FGF23, 1,25-dihydroxyvitamin D (1,25(OH)2D3), is primarily synthesized in the kidney from 25-hydroxyvitamin D (25(OH)D) by 1α-hydroxylase (encoded by CYP27B1). Hitherto, it is unclear whether osteocytes can convert 25(OH)D and thereby allow for 1,25(OH)2D3 to induce FGF23 production and secretion locally. Here, we differentiated MC3T3-E1 cells towards osteocyte-like ce...
Source: European Journal of Endocrinology - October 5, 2023 Category: Endocrinology Authors: Danielle M A Ratsma Max Muller Marijke Koedam M Carola Zillikens Bram C J van der Eerden Source Type: research
