Risk of Dementia and Psychiatric or Sleep Disorders after Diagnosis of Adrenal Adenomas: A Population-Based Cohort Study
CONCLUSIONS: Patients with adenomas demonstrate a higher incidence of psychiatric and sleep disorders, possibly due to the underlying subtle increase in cortisol secretion.PMID:37801659 | DOI:10.1093/ejendo/lvad135 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2023 Category: Endocrinology Authors: Dingfeng Li Sumitabh Singh Catherine D Zhang Ravinder Jeet Kaur Andreas Ebbehoj Elizabeth J Atkinson Sara J Achenbach Nikki H Stricker Michelle M Mielke Walter Rocca Irina Bancos Source Type: research
In vitro regulation of fibroblast growth factor 23 by 25(OH)D and 1,25(OH)2D3 synthesized by osteocyte-like MC3T3-E1 cells
Eur J Endocrinol. 2023 Oct 5:lvad131. doi: 10.1093/ejendo/lvad131. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is produced and secreted by osteocytes and is essential for maintaining phosphate homeostasis. One of the main regulators of FGF23, 1,25-dihydroxyvitamin D (1,25(OH)2D3), is primarily synthesized in the kidney from 25-hydroxyvitamin D (25(OH)D) by 1α-hydroxylase (encoded by CYP27B1). Hitherto, it is unclear whether osteocytes can convert 25(OH)D and thereby allow for 1,25(OH)2D3 to induce FGF23 production and secretion locally. Here, we differentiated MC3T3-E1 cells towards osteocyte-like ce...
Source: European Journal of Endocrinology - October 5, 2023 Category: Endocrinology Authors: Danielle M A Ratsma Max Muller Marijke Koedam M Carola Zillikens Bram C J van der Eerden Source Type: research
In vitro regulation of fibroblast growth factor 23 by 25(OH)D and 1,25(OH)2D3 synthesized by osteocyte-like MC3T3-E1 cells
Eur J Endocrinol. 2023 Oct 5:lvad131. doi: 10.1093/ejendo/lvad131. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is produced and secreted by osteocytes and is essential for maintaining phosphate homeostasis. One of the main regulators of FGF23, 1,25-dihydroxyvitamin D (1,25(OH)2D3), is primarily synthesized in the kidney from 25-hydroxyvitamin D (25(OH)D) by 1α-hydroxylase (encoded by CYP27B1). Hitherto, it is unclear whether osteocytes can convert 25(OH)D and thereby allow for 1,25(OH)2D3 to induce FGF23 production and secretion locally. Here, we differentiated MC3T3-E1 cells towards osteocyte-like ce...
Source: European Journal of Endocrinology - October 5, 2023 Category: Endocrinology Authors: Danielle M A Ratsma Max Muller Marijke Koedam M Carola Zillikens Bram C J van der Eerden Source Type: research
A preoperative CT radiomics model to predict disease-free survival in patients with pancreatic neuroendocrine tumors
CONCLUSION: The proposed radiomics index allows identifying patients with shorter RFS after pNET surgery. This result, however, requires prospective validation but may improve patient' care by intensifying imaging follow-up for those identified at high risk of recurrence.PMID:37787635 | DOI:10.1093/ejendo/lvad130 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 3, 2023 Category: Endocrinology Authors: Margaux Homps Philippe Soyer Romain Coriat Sol ène Dermine Anna Pellat David Fuks Ugo Marchese Benoit Terris Lionel Groussin Anthony Dohan Maxime Barat Source Type: research
A preoperative CT radiomics model to predict disease-free survival in patients with pancreatic neuroendocrine tumors
CONCLUSION: The proposed radiomics index allows identifying patients with shorter RFS after pNET surgery. This result, however, requires prospective validation but may improve patient' care by intensifying imaging follow-up for those identified at high risk of recurrence.PMID:37787635 | DOI:10.1093/ejendo/lvad130 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 3, 2023 Category: Endocrinology Authors: Margaux Homps Philippe Soyer Romain Coriat Sol ène Dermine Anna Pellat David Fuks Ugo Marchese Benoit Terris Lionel Groussin Anthony Dohan Maxime Barat Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis
In conclusion, FIGNL1 loss of function is a newly characterized OD gene, highlighting the DDR pathway's role in ovarian development and maintenance and suggesting chromosomal breakage as an assessment tool in XX-DSD patients.PMID:37740949 | DOI:10.1093/ejendo/lvad127 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 23, 2023 Category: Endocrinology Authors: Natan Florsheim Larisa Naugolni Fouad Zahdeh Orit Lobel Batel Terespolsky Rachel Michaelson-Cohen Merav Y Gold Michal Goldberg Paul Renbaum Ephrat Levy-Lahad David Zangen Source Type: research
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours
CONCLUSIONS: SF3B1 variants are uncommon in lactotroph tumours but may be frequent in metastatic lactotroph tumours. When present, they associate with aggressive tumour behaviour and worse clinical outcome.PMID:37721395 | DOI:10.1093/ejendo/lvad114 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 18, 2023 Category: Endocrinology Authors: Julia Simon Luis Gustavo Perez-Rivas Yining Zhao Fanny Chasseloup Helene Lasolle Christine Cortet Francoise Descotes Chiara Villa Bertrand Baussart Pia Burman Dominique Maiter Vivian von Selzam Roman Rotermund J örg Flitsch Jun Thorsteinsdottir Emmanuel Source Type: research
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours
CONCLUSIONS: SF3B1 variants are uncommon in lactotroph tumours but may be frequent in metastatic lactotroph tumours. When present, they associate with aggressive tumour behaviour and worse clinical outcome.PMID:37721395 | DOI:10.1093/ejendo/lvad114 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 18, 2023 Category: Endocrinology Authors: Julia Simon Luis Gustavo Perez-Rivas Yining Zhao Fanny Chasseloup Helene Lasolle Christine Cortet Francoise Descotes Chiara Villa Bertrand Baussart Pia Burman Dominique Maiter Vivian von Selzam Roman Rotermund J örg Flitsch Jun Thorsteinsdottir Emmanuel Source Type: research
