Age-Related Variation in Malignant Cytology Rates of Thyroid Nodules: Insights from a Retrospective Observational Study Assessing the ACR TI-RADS
CONCLUSIONS: Our study demonstrated that, as patient age increased, the rate of malignant cytology in thyroid nodules decreased. Moreover, age significantly influences the malignancy rates of thyroid nodules classified according to the ACR TI-RADS.PMID:38033287 | DOI:10.1093/ejendo/lvad162 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 30, 2023 Category: Endocrinology Authors: Leonardo Barbi Walter Paula Martins Fernandes D ébora Lunkes Strieder Anita Lavarda Scheinpflug Andr é Borsatto Zanella Carlo Sasso Faccin Mauricio Farenzena Laura Fernandes Xavier Bianca Dalla Costa Zorzi Marcia Silveira Graudenz Rafael Selbach Scheffe Source Type: research

Metabolomic profile of neuroendocrine tumors (NETs) identifies methionine, porphyrin and tryptophan metabolism as key dysregulated pathways associated with patient survival
CONCLUSIONS: We identified a metabolomic signature that improves prognostic stratification of NET patients beyond classical prognostic factors for clinical decisions. The enriched metabolic pathways identified reveal novel tumor vulnerabilities that may foster the development of new therapeutic strategies for these patients.PMID:38033321 | DOI:10.1093/ejendo/lvad160 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 30, 2023 Category: Endocrinology Authors: A La Salvia A Lens-Pardo A L ópez-López C Carretero-Puche J Capdevila M Benavent P Jim énez-Fonseca D Castellano T Alonso A Teule Ana Custodio Salvatore Tafuto Adelaida La Casta Francesca Spada A Lopez-Gonzalvez B Gil-Calderon P Espinosa-Olarte C Barba Source Type: research

Oral Glucose has Little or no Effect on Appetite and Satiety Sensations Despite a Significant Gastrointestinal Response
CONCLUSIONS: Despite eliciting robust responses of appetite-reducing and/or satiety-promoting gut hormones, we found that oral glucose administration has little or no effect on appetite and satiety as compared to an IIGI, not affecting the release of appetite-modulating hormones.TRIAL REGISTRY NO: ClinicalTrials.gov: NCT01492283 and NCT06064084.PMID:38035766 | DOI:10.1093/ejendo/lvad161 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 30, 2023 Category: Endocrinology Authors: Julius V Lauritsen Natasha Bergmann Anders E Junker Mette Gyldenl øve Lone Skov Lise L Gluud Bolette Hartmann Jens J Holst Tina Vilsb øll Filip K Knop Source Type: research

Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study
CONCLUSION: Higher glucocorticoid dosages in high-risk patients, despite unaffected cortisol metabolism, may be linked to decreased cortisol sensitivity or impaired glucocorticoid absorption. Proactive dose adjustments show a protective effect against AC, regardless of biological vulnerability.PMID:38006230 | DOI:10.1093/ejendo/lvad149 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 25, 2023 Category: Endocrinology Authors: Irina Chifu Stephanie Burger-Stritt Anna Schrader Sabine Herterich Janik Freytag Max Kurlbaum Nora Vogg Johanna Werner Marcus Quinkler Stefanie Hahner Source Type: research

Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study
CONCLUSION: Higher glucocorticoid dosages in high-risk patients, despite unaffected cortisol metabolism, may be linked to decreased cortisol sensitivity or impaired glucocorticoid absorption. Proactive dose adjustments show a protective effect against AC, regardless of biological vulnerability.PMID:38006230 | DOI:10.1093/ejendo/lvad149 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 25, 2023 Category: Endocrinology Authors: Irina Chifu Stephanie Burger-Stritt Anna Schrader Sabine Herterich Janik Freytag Max Kurlbaum Nora Vogg Johanna Werner Marcus Quinkler Stefanie Hahner Source Type: research

Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study
CONCLUSION: Higher glucocorticoid dosages in high-risk patients, despite unaffected cortisol metabolism, may be linked to decreased cortisol sensitivity or impaired glucocorticoid absorption. Proactive dose adjustments show a protective effect against AC, regardless of biological vulnerability.PMID:38006230 | DOI:10.1093/ejendo/lvad149 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 25, 2023 Category: Endocrinology Authors: Irina Chifu Stephanie Burger-Stritt Anna Schrader Sabine Herterich Janik Freytag Max Kurlbaum Nora Vogg Johanna Werner Marcus Quinkler Stefanie Hahner Source Type: research

Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study
CONCLUSION: Higher glucocorticoid dosages in high-risk patients, despite unaffected cortisol metabolism, may be linked to decreased cortisol sensitivity or impaired glucocorticoid absorption. Proactive dose adjustments show a protective effect against AC, regardless of biological vulnerability.PMID:38006230 | DOI:10.1093/ejendo/lvad149 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 25, 2023 Category: Endocrinology Authors: Irina Chifu Stephanie Burger-Stritt Anna Schrader Sabine Herterich Janik Freytag Max Kurlbaum Nora Vogg Johanna Werner Marcus Quinkler Stefanie Hahner Source Type: research

Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study
CONCLUSION: Higher glucocorticoid dosages in high-risk patients, despite unaffected cortisol metabolism, may be linked to decreased cortisol sensitivity or impaired glucocorticoid absorption. Proactive dose adjustments show a protective effect against AC, regardless of biological vulnerability.PMID:38006230 | DOI:10.1093/ejendo/lvad149 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 25, 2023 Category: Endocrinology Authors: Irina Chifu Stephanie Burger-Stritt Anna Schrader Sabine Herterich Janik Freytag Max Kurlbaum Nora Vogg Johanna Werner Marcus Quinkler Stefanie Hahner Source Type: research

Associations between body composition and the risk of fracture according to bone mineral density in postmenopausal women: a population-based database cohort study
CONCLUSIONS: General obesity and central obesity are not protective against any fracture, VF and HF in postmenopausal women with osteopenia or osteoporosis.PMID:37995142 | DOI:10.1093/ejendo/lvad156 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 23, 2023 Category: Endocrinology Authors: Jeongmin Lee Jin-Hyung Jung Jinyoung Kim Chaiho Jeong Jeonghoon Ha Min-Hee Kim Jung-Min Lee Sang-Ah Chang Ki-Hyun Baek Kyungdo Han Dong-Jun Lim Source Type: research

Associations between body composition and the risk of fracture according to bone mineral density in postmenopausal women: a population-based database cohort study
CONCLUSIONS: General obesity and central obesity are not protective against any fracture, VF and HF in postmenopausal women with osteopenia or osteoporosis.PMID:37995142 | DOI:10.1093/ejendo/lvad156 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 23, 2023 Category: Endocrinology Authors: Jeongmin Lee Jin-Hyung Jung Jinyoung Kim Chaiho Jeong Jeonghoon Ha Min-Hee Kim Jung-Min Lee Sang-Ah Chang Ki-Hyun Baek Kyungdo Han Dong-Jun Lim Source Type: research

Inflammation-based scores in benign adrenocortical tumours are linked to the degree of cortisol excess: a retrospective single-centre study
CONCLUSIONS: Neutrophil-to-lymphocyte ratio, SII, and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research

Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research

Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research

Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research

Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research