The bile-gut axis and metabolic consequences of cholecystectomy
Eur J Endocrinol. 2024 Mar 29:lvae034. doi: 10.1093/ejendo/lvae034. Online ahead of print.ABSTRACTCholelithiasis and cholecystitis affect individuals of all ages and are often treated by surgical removal of the gallbladder (cholecystectomy), which is considered a safe, low-risk procedure. Nevertheless, recent findings show that bile and its regulated storage and excretion may have important metabolic effects and that cholecystectomy is associated with several metabolic diseases postoperatively. Bile acids have long been known as emulsifiers essential to the assimilation of lipids and absorption of lipid-soluble vitamins, b...
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Andreas H Lange Miriam G Pedersen Anne-Marie Ellegaard Henriette H Nerild Andreas Br ønden David P Sonne Filip K Knop Source Type: research
Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls
CONCLUSION: This study reveals heightened anxiety, alexithymia, depression, and diminished overall mental health in patients with AVP-D and PP. The results emphasize the need for careful interpretation of psychopathological characteristics to differentiate between AVP-D and PP.PMID:38551325 | DOI:10.1093/ejendo/lvae040 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Cihan Atila Julia Beck Julie Refardt Zoran Erlic Juliana B Drummond Clara O Sailer Matthias E Liechti Beatriz Santana Soares Rocha Felix Beuschlein Bettina Winzeler Mirjam Christ-Crain Source Type: research
International consensus on mitotane treatment in pediatric patients with adrenal cortical tumors: Indications, therapy, and management of adverse effects
CONCLUSION: Delphi method enabled us to propose an expert consensus statement, which may guide clinicians, further adapted by local norms and the individual patient setting. In order to generate evidence, well-constructed studies should be the focus of future efforts.PMID:38552173 | DOI:10.1093/ejendo/lvae038 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Maria Riedmeier Sonir R R Antonini Silvia Brandalise Tatiana El Jaick B Costa Camila M Daiggi Bonald C de Figueiredo Ronald R de Krijger Karla Em ília De Sá Rodrigues Cheri Deal Jaydira Del Rivero Gernot Engstler Martin Fassnacht Gabriela C Fernandes Lu Source Type: research
Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling
CONCLUSION: Single-dose colesevelam had no effect on postprandial GLP-1 responses or glucose tolerance but disrupted postprandial gallbladder refilling by increasing CCK secretion and reducing circulating concentrations of FGF19 and bile acids. These findings leave the antidiabetic actions of colesevelam unresolved but provide mechanistic insights into its effect on gallbladder motility.PMID:38551029 | DOI:10.1093/ejendo/lvae033 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Ida M Gether Emilie Bahne Henriette H Nerild Jens F Rehfeld Bolette Hartmann Jens J Holst Tina Vilsb øll David P Sonne Filip K Knop Source Type: research
The bile-gut axis and metabolic consequences of cholecystectomy
Eur J Endocrinol. 2024 Mar 29:lvae034. doi: 10.1093/ejendo/lvae034. Online ahead of print.ABSTRACTCholelithiasis and cholecystitis affect individuals of all ages and are often treated by surgical removal of the gallbladder (cholecystectomy), which is considered a safe, low-risk procedure. Nevertheless, recent findings show that bile and its regulated storage and excretion may have important metabolic effects and that cholecystectomy is associated with several metabolic diseases postoperatively. Bile acids have long been known as emulsifiers essential to the assimilation of lipids and absorption of lipid-soluble vitamins, b...
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Andreas H Lange Miriam G Pedersen Anne-Marie Ellegaard Henriette H Nerild Andreas Br ønden David P Sonne Filip K Knop Source Type: research
Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls
CONCLUSION: This study reveals heightened anxiety, alexithymia, depression, and diminished overall mental health in patients with AVP-D and PP. The results emphasize the need for careful interpretation of psychopathological characteristics to differentiate between AVP-D and PP.PMID:38551325 | DOI:10.1093/ejendo/lvae040 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Cihan Atila Julia Beck Julie Refardt Zoran Erlic Juliana B Drummond Clara O Sailer Matthias E Liechti Beatriz Santana Soares Rocha Felix Beuschlein Bettina Winzeler Mirjam Christ-Crain Source Type: research
International consensus on mitotane treatment in pediatric patients with adrenal cortical tumors: Indications, therapy, and management of adverse effects
CONCLUSION: Delphi method enabled us to propose an expert consensus statement, which may guide clinicians, further adapted by local norms and the individual patient setting. In order to generate evidence, well-constructed studies should be the focus of future efforts.PMID:38552173 | DOI:10.1093/ejendo/lvae038 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Maria Riedmeier Sonir R R Antonini Silvia Brandalise Tatiana El Jaick B Costa Camila M Daiggi Bonald C de Figueiredo Ronald R de Krijger Karla Em ília De Sá Rodrigues Cheri Deal Jaydira Del Rivero Gernot Engstler Martin Fassnacht Gabriela C Fernandes Lu Source Type: research
Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling
CONCLUSION: Single-dose colesevelam had no effect on postprandial GLP-1 responses or glucose tolerance but disrupted postprandial gallbladder refilling by increasing CCK secretion and reducing circulating concentrations of FGF19 and bile acids. These findings leave the antidiabetic actions of colesevelam unresolved but provide mechanistic insights into its effect on gallbladder motility.PMID:38551029 | DOI:10.1093/ejendo/lvae033 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Ida M Gether Emilie Bahne Henriette H Nerild Jens F Rehfeld Bolette Hartmann Jens J Holst Tina Vilsb øll David P Sonne Filip K Knop Source Type: research
Increased risk of diabetes mellitus and hyperlipidemia in patients with differentiated thyroid cancer
CONCLUSIONS: Patients with DTC had an increased risk of CMD, especially DM and hyperlipidemia, but a low risk of CMD mortality. Special attention to metabolic diseases is required in the long-term follow-up of patients with DTC.PMID:38536878 | DOI:10.1093/ejendo/lvae026 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 27, 2024 Category: Endocrinology Authors: Hwa Young Ahn Jooyoung Lee Jinmo Kang Eun Kyung Lee Source Type: research
Increased risk of diabetes mellitus and hyperlipidemia in patients with differentiated thyroid cancer
CONCLUSIONS: Patients with DTC had an increased risk of CMD, especially DM and hyperlipidemia, but a low risk of CMD mortality. Special attention to metabolic diseases is required in the long-term follow-up of patients with DTC.PMID:38536878 | DOI:10.1093/ejendo/lvae026 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 27, 2024 Category: Endocrinology Authors: Hwa Young Ahn Jooyoung Lee Jinmo Kang Eun Kyung Lee Source Type: research
Directed Acyclic Graphs (DAGs) in clinical research
Eur J Endocrinol. 2024 Mar 26:lvae032. doi: 10.1093/ejendo/lvae032. Online ahead of print.ABSTRACTDirected acyclic graphs (DAGs), or causal diagrams, are graphical representations of causal structures that can be used in medical research to understand and illustrate potential bias, including bias arising from confounding, selection, and misclassification. Further, they provide guidance for researchers about how to address a potential bias.PMID:38529789 | DOI:10.1093/ejendo/lvae032 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 26, 2024 Category: Endocrinology Authors: Olaf M Dekkers Kristina Laugesen Rolf H H Groenwold Source Type: research
Directed Acyclic Graphs (DAGs) in clinical research
Eur J Endocrinol. 2024 Mar 26:lvae032. doi: 10.1093/ejendo/lvae032. Online ahead of print.ABSTRACTDirected acyclic graphs (DAGs), or causal diagrams, are graphical representations of causal structures that can be used in medical research to understand and illustrate potential bias, including bias arising from confounding, selection, and misclassification. Further, they provide guidance for researchers about how to address a potential bias.PMID:38529789 | DOI:10.1093/ejendo/lvae032 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 26, 2024 Category: Endocrinology Authors: Olaf M Dekkers Kristina Laugesen Rolf H H Groenwold Source Type: research
Central precocious puberty in boys: secular trend and clinical features
CONCLUSIONS: The estimated incidence of CPP in boys was 0.34 per 10 000, with 26% of cases associated with intracranial pathology. The increase in CPP incidence was driven by rising ICPP rates. Patients with OCPP were characterized by shorter stature, younger age, and higher basal testosterone levels, providing valuable cues for differentiation in addition to brain MRI. Utilizing multiple cues could guide diagnostic decision-making.PMID:38523472 | DOI:10.1093/ejendo/lvae021 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 25, 2024 Category: Endocrinology Authors: Heta Huttunen Juho K ärkinen Tero Varimo P äivi J Miettinen Taneli Raivio Matti Hero Source Type: research
Real-world experience with 11C-methionine PET in the management of acromegaly
CONCLUSION: In patients with persistent/recurrent acromegaly or occult tumours, Met-PET can facilitate further targeted intervention (surgery/radiosurgery). This led to complete remission in most cases (24/33) or significant improvement with comparatively low risk of complications. Met-PET should therefore be considered in all patients who are potential candidates for further surgical intervention, but present no clear target on MRI.PMID:38482632 | DOI:10.1093/ejendo/lvae028 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 14, 2024 Category: Endocrinology Authors: Linus Haberbosch James MacFarlane Olympia Koulouri Daniel Gillett Andrew S Powlson Sue Oddy David J Halsall Kevin A Huynh Jonathan Jones Heok K Cheow Joachim Spranger Knut Mai Christian Strasburger Richard J Mannion Mark Gurnell Source Type: research
Real-world experience with 11C-methionine PET in the management of acromegaly
CONCLUSION: In patients with persistent/recurrent acromegaly or occult tumours, Met-PET can facilitate further targeted intervention (surgery/radiosurgery). This led to complete remission in most cases (24/33) or significant improvement with comparatively low risk of complications. Met-PET should therefore be considered in all patients who are potential candidates for further surgical intervention, but present no clear target on MRI.PMID:38482632 | DOI:10.1093/ejendo/lvae028 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 14, 2024 Category: Endocrinology Authors: Linus Haberbosch James MacFarlane Olympia Koulouri Daniel Gillett Andrew S Powlson Sue Oddy David J Halsall Kevin A Huynh Jonathan Jones Heok K Cheow Joachim Spranger Knut Mai Christian Strasburger Richard J Mannion Mark Gurnell Source Type: research
