Acute reversible parkinsonism post-influenza infection
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - October 14, 2019 Category: Neurology Source Type: research

Angiographically occult cerebral vascular malformation mimicking cortical venous sinus thrombosis: case report
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - October 9, 2019 Category: Neurology Source Type: research

Gradenigo ’s syndrome in a woman with systemic lupus erythematosus
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - October 4, 2019 Category: Neurology Source Type: research

Coping strategies in relapsing –remitting multiple sclerosis non-depressed patients and their associations with disease activity
AbstractFew studies evaluated coping strategies in people with multiple sclerosis (pwMS) in relation to annualized relapse rate (ARR) and lesion load (LL). Overall, results might have been influenced by the inclusion of depressed patients. To investigate the coping strategies and their association to disease activity, we studied relapsing –remitting pwMS accurately selected to avoid the confounding effect of depression. Sixty-seven relapsing–remitting pwMS and 67 healthy subjects (HS) underwent to Coping Orientation to Problems Experienced (I-COPE) and Coping Inventory for Stressful Situation (CISS) and Beck De...
Source: Acta Neurologica Belgica - September 30, 2019 Category: Neurology Source Type: research

Bright light therapy with a head-mounted device for anxiety, depression, sleepiness and fatigue in patients with Parkinson ’s disease
The objective of this study was to investigate if daily BLT, with a head-mounted device (Luminette®), has a beneficial effect on depression, anxiety, daytime sleepiness and fatigue in patients with PD. In this double-blind, placebo-controlled study, 16 patients with PD were randomized to receive either 1  month of BLT or 1 month of placebo therapy, separated by a 2-week washout period, in a crossover fashion. Patients completed questionnaires for the Hospital Anxiety and Depression Scale (HADS), the Epworth Sleepiness Scale (ESS) and the Fatigue Impact Scale (FIS) before and after each treatment p eriod. The ...
Source: Acta Neurologica Belgica - September 30, 2019 Category: Neurology Source Type: research

Medication adherence in patients with myasthenia gravis in Brazil: a cross-sectional study
AbstractAdvances in the treatment of MG have allowed most patients to effectively treat their disorder with oral medications. In parallel, non-adherence to medication treatment regimens is a worldwide health problem. Other chronic neurological disorders have already been associated with low adherence to treatment. However, the literature regarding adherence among patients with MG is definitely poor. The purpose of this study was to capture the prevalence and the associated factors of non-adherence to pharmacological treatment in patients with MG. We carried out a cross-sectional cohort study with 58 consecutive patients wi...
Source: Acta Neurologica Belgica - September 25, 2019 Category: Neurology Source Type: research

Myxopapillary ependymoma of the sacrum
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - September 25, 2019 Category: Neurology Source Type: research

Erythropoietin-induced cluster of seizures in two children with cerebral palsy
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - September 25, 2019 Category: Neurology Source Type: research

Uncommon and/or bizarre features of dementia: part IV
This study aimed at describing uncommon or bizarre symptoms/syndromes observed in patients suffering from dementia. Medline and Google scholar searches were conducted for relevant articles, chapters, and books published before 2019. Search terms used included dementia, déjà vu, zoophilia, pathological lying, and somatic sympto m disorder. Publications found through this indexed search were reviewed for further relevant references. Uncommon/bizarre features of dementia were described as case reports and there were no systematic investigations. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - September 24, 2019 Category: Neurology Source Type: research

Graft-versus-host disease-related neuropathy: AMAN phenotype with improvement after plasmapheresis
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - September 24, 2019 Category: Neurology Source Type: research

Alpha 1-antichymotrypsin may be a biomarker for the progression of amnestic mild cognitive impairment
AbstractAlpha 1-antichymotrypsin (ACT), an acute-phase protein, has been reported to be increased in the brain and blood of Alzheimer ’s disease (AD) patients. However, few previous studies have focused on amnestic mild cognitive impairment (aMCI) patients. The aim of our study was to investigate the changing trend in ACT concentrations during the progression of aMCI. Hence, we measured the cerebrospinal fluid (CSF) and serum le vels of ACT in aMCI subjects and normal controls (NC) at 2-year follow-up assessments using ELISA and Western blot. Forty-four NCs, 28 stable aMCI (sMCI) patients, and 20 progressive aMCI (pM...
Source: Acta Neurologica Belgica - September 7, 2019 Category: Neurology Source Type: research

Safety and efficacy of percutaneous pulsed radiofrequency treatment at the C1 –C2 level in chronic cluster headache: a retrospective analysis of 21 cases
AbstractWe performed a study of the safety and efficacy of percutaneous pulsed radiofrequency (PRF) treatment directed at C1 and C2 levels as performed at our local pain clinic in refractory chronic cluster headache (CCH) patients. We identified 21 CCH patients treated with PRF (240  s, max. 45 V, max. 42 °C) directed at the ganglion and/or nerve root of C1 and C2. Data were collected through retrospective analysis of patients’ files and include demographic variables, onset and duration of the headache, mean attack frequency, and prior pharmacological treatment. Safety an d reduction of attack freq...
Source: Acta Neurologica Belgica - September 3, 2019 Category: Neurology Source Type: research

Correction to: Clinical approach to neurodegenerative disorders in childhood: an updated overview
The author regret that, in the section “Dietary treatments” the sentence “Ketogenic diet is the gold standard therapy for Glut 1 deficiency and pyruvate kinase deficiency but it can be also applied in severe drug-resistant epileptic encephalopathies [4].” is not correct. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - August 26, 2019 Category: Neurology Source Type: research

Current evidence for treatment with nusinersen for spinal muscular atrophy: a systematic review
AbstractRecent discovery of nusinersen, an antisense oligonucleotide drug, has provided encouragement for improving treatment of spinal muscular atrophy. No therapeutic options currently exist for this autosomal recessive motor neuron disorder. Nusinersen is developed for intrathecal use and binds to a specific sequence within the survival motor neuron 2 pre-messenger RNA, modifying the splicing process to promote expression of full-length survival motor neuron protein. We performed a MEDLINE and CENTRAL search to investigate the current evidence for treatment with nusinersen in patients with spinal muscular atrophy. Four ...
Source: Acta Neurologica Belgica - August 6, 2019 Category: Neurology Source Type: research

Cerebral intraparenchymal extramedullary hematopoiesis in polycythemia vera
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - August 1, 2019 Category: Neurology Source Type: research

Crocin enhances hypothermia therapy in hypoxic ischemia-induced brain injury in mice
AbstractHypoxic –ischemic encephalopathy (HIE) is a serious medical situation at labor which leads to severe brain damage. Hypothermia therapy is the standard treatment for infants with HIE, but the efficacy is limited. Combination treatments are considered to enhance the efficacy of hypothermia. Crocin is an ext ract from saffron which has anti-inflammatory, anti-oxidant, and neuroprotective properties. The present study sought to investigate whether crocin could act as a combined treatment with hypothermia in a mouse model of HIE. C57BL/6J mice at post-natal day 7 were subjected to left common carotid arte ry ligat...
Source: Acta Neurologica Belgica - July 31, 2019 Category: Neurology Source Type: research

Red cell distribution width levels in Parkinson ’s disease patients
In conclusion, RDW levels are higher than the healthy subjects in PD patients but there is no relation between RDW levels and disease duration. Larger studies are needed to explain the role of RDW as an inflammatory marker. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 31, 2019 Category: Neurology Source Type: research

Cyclic vomiting syndrome associated with benign paroxysmal vertigo: a case report
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 26, 2019 Category: Neurology Source Type: research

Levodopa-induced skin disorders in patients with Parkinson disease: a systematic literature review approach
AbstractThe use of levodopa for treatment of Parkinson ’s disease is a well-established clinical practice. Data about the true incidence and severity of cutaneous complications associated with the use of levodopa are largely lacking. Aim of this review was to evaluate the quality of evidence referring to the skin disorders caused by levodopa treatment for Parkinson’s disease. Thirty of 1084 studies were included; 8 randomized controlled trials and 22 case reports in a total of 2749 patients. Malignant melanoma was the most frequent oral levodopa-related skin disorder followed by allergic cutaneous reactions, al...
Source: Acta Neurologica Belgica - July 23, 2019 Category: Neurology Source Type: research

Clinical characteristic of 15 cases of cryptococcal meningitis treated with Ommaya reservoir
AbstractCryptococcal meningitis is a severe subacute fungal meningoencephalitis. Intracerebroventricular (ICV) injection of antifungal medication and aspiration of cerebrospinal fluid (CSF) through Ommaya reservoir were reported to be useful cryptococcal meningitis treatment method. We want to evaluate the role of Ommaya reservoir in the treatment of refractory cryptococcal meningitis. We retrospectively analyzed clinical records and data of 15 refractory cryptococcal meningitis patients who were treated with Ommaya reservoir in Sir Run Run Shaw hospital from June 2013 to June 2017. Fifteen patients who underwent Ommaya re...
Source: Acta Neurologica Belgica - July 18, 2019 Category: Neurology Source Type: research

Correction to: Prognostic factors in patients with glioblastoma multiforme: focus on the pathologic variants
Unfortunately, the third author name was incorrectly published in the original publication. The complete correct name should read as follows. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 16, 2019 Category: Neurology Source Type: research

Hashimoto ’s encephalopathy in children: different manifestations of five cases
AbstractHashimoto ’s encephalopathy (HE) is a rare, poorly understood, progressive and relapsing, steroid-responsive multiform disease. HE presents with subacute cognitive dysfunction, psychiatric symptoms, seizures, and movement disorders. The disorder is usually related to thyroid disease and the most frequent fe ature is the presence of anti-thyroperoxidase antibodies. Patients are generally euthyroid or mildly hypothyroid. The clinical features of two patients at presentation included refractory seizures and confusion, another patient had behavioral problems and altered cognitive status, one patient presen ted wi...
Source: Acta Neurologica Belgica - July 16, 2019 Category: Neurology Source Type: research

Microsurgical treatment for spinal epidural angiolipomas
AbstractSpinal epidural angiolipomas are rare lesions composed of mature lipomatous and angiomatous elements. In this paper, the authors review a surgical series of ten patients with epidural angiolipomas. All patients had performed preoperative and postoperative magnetic resonance imaging. The diagnosis of angiolipoma was based on pathology. All the follow-up data were obtained during office visits. There were 5 males and 5 females with a mean age of 53.6  years. One tumor was located in the cervicothoracic, six in the thoracic, and three in the lumbar spine. The most common symptom was progressive motor deficit. Gro...
Source: Acta Neurologica Belgica - July 15, 2019 Category: Neurology Source Type: research

The role of zinc supplementation on the metallothionein system in children with autism spectrum disorder
In conclusion, Zn supplementation might be an important factor in the treatment of children with ASD. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 13, 2019 Category: Neurology Source Type: research

Comparison of the effect of anterior and posterior neurosurgical treatment for cervical spondylotic myelopathy: a clinical outcome
AbstractCervical degenerative disease is the most common cause of acquired disability in patients over the age of 50. The incidence of cervical spondylotic myelopathy (CSM) is increasing with aging of the population. Surgical decompression is indicated for severe CSM. There is, however, insufficient evidence to prefer anterior over posterior surgical decompression technique for CSM. Our purpose was to identify groups of patients that would benefit from a chosen surgical approach with a better clinical outcome. We conducted a retrospective analysis of patients operated for CSM between 2007 and 2011. Patients were assessed a...
Source: Acta Neurologica Belgica - July 12, 2019 Category: Neurology Source Type: research

Case report of primary dural lymphoma mimicking a cerebellar meningioma and brief review of literature
We present a case of primary diffuse large B-cell lymphoma, presenting as PDL in the posterior fossa, originating from the dura mater of the petrous bone covering the surface of the left cerebellum, a location not previously described. A 65-year-old woman presented with sudden onset of severe dizziness was admitted in otolaryngology department then transferred to neurosurgery ward. CT scan revealed a large lesion involving left cerebellum, subsequent MRI of the brain demonstrated an enhancing mass suggestive for petrous bone meningioma. The tumor was excised, and the histopathological examination unexpectedly revealed a di...
Source: Acta Neurologica Belgica - July 12, 2019 Category: Neurology Source Type: research

Evaluation of electrocardiographic parameters in patients with epileptic seizure
AbstractThe aim of the study is to evaluate the changes in electrocardiographic parameters, including QTc dispersion (QTcd), Tpeak-Tend (Tp-e)/QTc ratio and P-wave dispersion (Pd), during the period without seizure activation in patients, presented to the emergency department (ED) with epileptic seizures. This prospective case –control study was conducted between January 2017 and January 2018. Patients, over 18 years old and presented to the ED with epileptic seizure, were consecutively included in the study. Interictal period ECGs of patients were obtained at least 2 hours after the end of the postictal period....
Source: Acta Neurologica Belgica - July 11, 2019 Category: Neurology Source Type: research

A rare case of spinal epidural sarcoidosis: case report and review of the literature
AbstractSarcoidosis is a rare systemic disease characterized by growth and organization of inflammatory cells in a granuloma. Granulomas can localize in any parts of the human body. The main localization is represented by lungs, lymph nodes, eyes and skin. Any organ, however, can be affected. Central nervous system (CNS) represents a rare localization of sarcoidosis, in fact, only 1% of patient with sarcoidosis present brain and/or spinal cord localization of the granulomas associated with this disease. This condition takes the name of Neurosarcoidosis. Its diagnosis and management pose a significant challenge, as its clin...
Source: Acta Neurologica Belgica - July 11, 2019 Category: Neurology Source Type: research

The effects of head posture on nerve conduction studies in patients with ankylosing spondylitis
AbstractAnkylosing spondylitis (AS) is a chronic inflammatory disease which effects cervical posture of patients. The aim of this study was to evaluate AS patients according to the degree of cervical disorder and was evaluate them electrophysiologically, functionality, and disease parameters. Our study comprised 64 AS patients and 30 healthy controls. The head posture of patients was evaluated by craniovertebral angle (CVA) measurement. Nerve conduction of bilateral median, radial, ulnar, and medial antebrachial cutaneous (MAC) nerves were studied in all patients. The most important nerve conduction differences in AS patie...
Source: Acta Neurologica Belgica - July 10, 2019 Category: Neurology Source Type: research

Mosaic chromosome 5p tetrasomy: eye closure-induced seizures in a rare neurocutaneous syndrome
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 10, 2019 Category: Neurology Source Type: research

Very short multifocal myelitis lesions as initial signs of neuromyelitis optica spectrum disorder
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 9, 2019 Category: Neurology Source Type: research

Therapeutic approach to Lennox –Gastaut syndrome: a systematic review
AbstractLennox –Gastaut syndrome (LGS) is a rare, age-related syndrome, characterized by multiple seizure types, mental regression, and specific EEG abnormalities. It is one of the most challenging epilepsy: treatment is rarely effective and the final prognosis remains poor, despite the availability of several antiepileptic drugs, validated through well-designed, randomized, controlled trials. However, it is reasonable to consider non-medical treatments, such as surgery, after failure of two-to-three drugs. This review has as goal to describe systematically the different therapeutic options for LGS, incl ud...
Source: Acta Neurologica Belgica - July 8, 2019 Category: Neurology Source Type: research

Ventriculoatrial shunt as a feasible regimen for certain patients of hydrocephalus: clinical features and surgical management
AbstractVentriculoatrial (VA) shunt is one of the most commonly used solutions for hydrocephalus. In recent years, the number of VA shunt has decreased worldwide, given the perceived technical challenges and the potentially serious complications associated with VA shunt. However, VA shunt remains as a viable treatment option for hydrocephalus in selected patients. Novel placement strategies and monitoring methods have been developed to reduce complications following VA shunt. In this article, we reported that seven consecutive cases who received a VA shunt. VA shunts were applied in seven hydrocephalic patients who experie...
Source: Acta Neurologica Belgica - July 4, 2019 Category: Neurology Source Type: research

Frequency of autoimmune disorders and autoantibodies in European patients with neuromyelitis optica spectrum disorders
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 1, 2019 Category: Neurology Source Type: research

Anti-Ma2/Ta paraneoplastic rhombencephalitis in a patient with lung cancer responsive to anti-PD1 therapy
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 1, 2019 Category: Neurology Source Type: research

A hypomyelinating leukodystrophy with calcification: oculodentodigital dysplasia
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 25, 2019 Category: Neurology Source Type: research

Non-routine cardiac tests still have no defined role in assessment of myotonic dystrophy type 2
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 21, 2019 Category: Neurology Source Type: research

Assessment of serum uric acid levels in patients with restless legs syndrome
AbstractIn our study, the aim was to collect data in relation to our hypothesis that oxidative stress is effective in the etiopathogenesis of restless legs syndrome (RLS) by assessing the serum uric acid levels, an important biomarker of oxidative stress, among RLS patients. The study included a total of 281 patients with restless legs syndrome diagnosis according to the “2012 Revised International Restless Legs Syndrome Study Group Diagnostic Criteria”. Disease severity was assessed according to the “International Restless Legs Syndrome Study Group Severity Scale”. The control group comprised 237 h...
Source: Acta Neurologica Belgica - June 21, 2019 Category: Neurology Source Type: research

Brachial artery occlusion mimicking stroke in patients at high risk of cardioembolic stroke
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 21, 2019 Category: Neurology Source Type: research

Posterior reversible encephalopathy syndrome caused by cerebral amyloid angiopathy-related inflammation
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 21, 2019 Category: Neurology Source Type: research

Prognostic factors in patients with glioblastoma multiforme: focus on the pathologic variants
AbstractThe aim of this study was to offer predicting factors for survival in adult patients with glioblastoma multiforme. 153 consecutive patients with high-grade glioma (WHO grade IV) were studied in Imam Reza hospital, Kermanshah University of Medical Science, Kermanshah, Iran, between April 2003 and April 2017. All patients treated with surgical resection and standard postoperative radiotherapy (54  Gy). Using the patients’ charts and electronic medical records system, the following data were obtained: gender, age, Karnofsky performance status (KPS) score on admission, primary vs. secondary type, extent of s...
Source: Acta Neurologica Belgica - June 20, 2019 Category: Neurology Source Type: research

Primary creatine deficiency syndrome as a potential missed diagnosis in children with psychomotor delay and seizure: case presentation with two novel variants and literature review
We report two patients with creatine deficiency among a cohort of 550 registered cases out of which 200 patients had a genetically confirmed neurodegenerative disorder diagnosis. The main complain in the first patient with creatine transporter (CRTR) deficiency was seizure and genetic study in this patient identified a novel hemizygote variant of “c.92 >  T; p.Pro31Leu” in the first exon ofSLC6A8 gene. The second patient with guanidinoacetate methyltransferase (GAMT) deficiency had an unknown motor and speech delay as the striking manifestation and molecular assay revealed a novel homozygote va...
Source: Acta Neurologica Belgica - June 20, 2019 Category: Neurology Source Type: research

Subependymal giant cell astrocytoma: an unexpected finding during a forensic autopsy
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 18, 2019 Category: Neurology Source Type: research

Spontaneous intracranial hypotension: review and expert opinion
AbstractSpontaneous intracranial hypotension (SIH) results from spinal cerebrospinal fluid (CSF) leaking. An underlying connective tissue disorder that predisposes to weakness of the dura is implicated in spontaneous spinal CSF leaks. During the last decades, a much larger number of spontaneous cases are identified and a far broader clinical SIH spectrum is recognized. Orthostatic headache is the main presentation symptom of SIH; some patients also have other manifestations, mainly cochlear –vestibular signs and symptoms. Differential diagnosis with other syndromes presenting with orthostatic headache is crucial. Bra...
Source: Acta Neurologica Belgica - June 18, 2019 Category: Neurology Source Type: research

Impaired cerebrovascular reactivity in chronic obstructive pulmonary disease
AbstractImpaired cerebrovascular reactivity (CVR) is associated with stroke. Cerebrovascular diseases are common comorbidity in chronic obstructive pulmonary disease (COPD) patients. The aim of our study was to quantify CVR in the anterior and posterior cerebral circulation during voluntary breath-holding in COPD patients according to airflow limitation severity. In this cross-sectional study, we compared 90 COPD patients without previous cerebrovascular disease and 30 age- and sex-matched healthy volunteers (mean age 67  ± 7.9, 87 males). Using transcranial Doppler ultrasound and breath-holding index ...
Source: Acta Neurologica Belgica - June 18, 2019 Category: Neurology Source Type: research

Cerebrovascular events after surgery versus conservative therapy for moyamoya disease: a meta-analysis
AbstractThe background of this article is to determine the effect of a neurosurgical intervention in patients with moyamoya disease (MMD) on the risk of cerebrovascular events. We included studies with at least ten MMD patients in either intervention or control group which investigated cerebrovascular events during a minimal follow-up period of 1 year after neurosurgical intervention vs. conservative therapy. The primary outcome was all strokes; secondary outcome events were mortality, hemorrhagic, and ischemic stroke. Effects were evaluated for three prespecified subpopulations: adult, ischemic, and hemorrhagic moyamoya p...
Source: Acta Neurologica Belgica - June 18, 2019 Category: Neurology Source Type: research

Hypertrophic olivary degeneration: a single case report
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 18, 2019 Category: Neurology Source Type: research

Comments on and assessment of “The rs498872 polymorphism is associated with an elevated susceptibility to glioma: a meta-analysis of 36,264 subjects”
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 17, 2019 Category: Neurology Source Type: research

Quality of life in patients with polyneuropathy associated with different types of monoclonal gammopathy of undetermined significance
AbstractPolyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS-PNP) has a chronic and slowly progressive course but can lead to significant disability and reduced quality of life (QoL). The aim of this study was to analyze QoL in MGUS-PNP patients and to determine its predictors. Our study included 51 patients diagnosed with MGUS-PNP (23.5% with IgM, 66.7% IgG or IgA, 7.8% undetermined paraprotein, 2.0% light chains). QoL was assessed using the SF-36 questionnaire. The Medical Research Council Sum Score (MRC-SS), INCAT disability and sensory scores, ataxia score, Krupp ’s Fatigue Seve...
Source: Acta Neurologica Belgica - June 14, 2019 Category: Neurology Source Type: research

Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT): do not touch
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - June 14, 2019 Category: Neurology Source Type: research