Diabetes Insipidus Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research

Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00320.2022. Online ahead of print.ABSTRACTCannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the ...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Joshua L Rein Ken Mackie Thomas R Kleyman Lisa M Satlin Source Type: research

Informed non-dissent for brain death testing in children: ethical and legal perspectives
A 14-year-old girl, Hana, is admitted to the paediatric intensive care unit following a sudden collapse at home. She is found to have sustained a severe haemorrhagic stroke. Despite emergency neurosurgical intervention, she deteriorates over several days. Her family have been struggling to accept the possibility that she would not recover. Hana remains unresponsive, has fixed dilated pupils and has developed diabetes insipidus. The clinical team suspect that she is brain dead. Should the family’s consent be sought for brain death testing? (This case is fictitious.) In mid-2022, the high profile case of Archie Batters...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Wilkinson, D., Miller, C., Turner, S. W. Tags: Ethics and law for clinical practice Source Type: research

Genetic analysis of nephrogenic diabetes insipidus patients: A study on the Iranian population
In this study, 6 different mutations were identified in the patients, including 5 in the AQP2 gene (c.439G>A, c.538G>A, c.140C>T, c.450T>A, and the novel c.668T>C) and 1 in the AVPR2 gene (c.337C>T) in the present study.DISCUSSION: As expected, all the detected mutations in this study were missense. According to the ACMG guideline, the identified mutations were categorized as pathogenic or likely pathogenic. Unlike previous studies which showed more than 90% of mutations were in the AVPR2 gene, and only less than 10% of the mutations were in the AQP2 gene, it was found that more than 90% of our identified...
Source: Molecular Medicine - April 16, 2024 Category: Molecular Biology Authors: Saeed Ghasemi Marzieh Mojbafan Saeed Talebi Nakysa Hooman Rozita Hoseini Source Type: research

Genetic analysis of nephrogenic diabetes insipidus patients: A study on the Iranian population
In this study, 6 different mutations were identified in the patients, including 5 in the AQP2 gene (c.439G>A, c.538G>A, c.140C>T, c.450T>A, and the novel c.668T>C) and 1 in the AVPR2 gene (c.337C>T) in the present study.DiscussionAs expected, all the detected mutations in this study were missense. According to the ACMG guideline, the identified mutations were categorized as pathogenic or likely pathogenic. Unlike previous studies which showed more than 90% of mutations were in theAVPR2 gene, and only less than 10% of the mutations were in theAQP2 gene, it was found that more than 90% of our identified mut...
Source: Molecular Genetics & Genomic Medicine - April 16, 2024 Category: Genetics & Stem Cells Authors: Saeed Ghasemi, Marzieh Mojbafan, Saeed Talebi, Nakysa Hooman, Rozita Hoseini Tags: ORIGINAL ARTICLE Source Type: research

Antidiuretic hormone deficiency secondary to inactive hydrocephalus: a case report
ConclusionsCentral diabetes insipidus due to hydrocephalus, though rare, can have serious complications including the predilection to develop a deficit of other pituitary hormones. Thus, even if hydrocephalus is dormant with normal intracranial pressure, it must be addressed during investigations of central diabetes insipidus. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 31, 2024 Category: General Medicine Source Type: research

Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls
CONCLUSION: This study reveals heightened anxiety, alexithymia, depression, and diminished overall mental health in patients with AVP-D and PP. The results emphasize the need for careful interpretation of psychopathological characteristics to differentiate between AVP-D and PP.PMID:38551325 | DOI:10.1093/ejendo/lvae040 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Cihan Atila Julia Beck Julie Refardt Zoran Erlic Juliana B Drummond Clara O Sailer Matthias E Liechti Beatriz Santana Soares Rocha Felix Beuschlein Bettina Winzeler Mirjam Christ-Crain Source Type: research

Diagnosis and management of congenital hypopituitarism in children
This article presents recommendations for hormone replacement therapy for each of the respective deficient axes. Lifelong follow-up with an endocrinologist is required, including in adulthood, with multidisciplinary management for patients with syndromic forms or comorbidities. Treatment objectives include alleviating symptoms, preventing comorbidities and acute complications, and optimal social and educational integration.PMID:38538470 | DOI:10.1016/j.arcped.2024.01.003 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - March 27, 2024 Category: Pediatrics Authors: Sarah Castets C écile Thomas-Teinturier Carine Villanueva Jessica Amsellem Pascal Barat Gilles Brun Emmanuel Bui Quoc Jean-Claude Carel Gian Paolo De Filippo Clara Kipnis Laetitia Martinerie Julia Vergier Alexandru Saveanu Natacha Teissier R égis Coutan Source Type: research